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1. Erratum to 'IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper' [World Allergy Organ J 13/2 (2020) 100080]

Author

Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Yu-Hor Thong, Bernard, Valenta, Rudolf, Wood, Robert A., Zuberbier, Torsten, Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Yu-Hor Thong, Bernard, Valenta, Rudolf, Wood, Robert A., and Zuberbier, Torsten

Published
2021

2. Erratum to 'IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper' [World Allergy Organ J 13/2 (2020) 100080]

Author

Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Yu-Hor Thong, Bernard, Valenta, Rudolf, Wood, Robert A., Zuberbier, Torsten, Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Yu-Hor Thong, Bernard, Valenta, Rudolf, Wood, Robert A., and Zuberbier, Torsten

Published
2021

3. Erratum to 'IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper' [World Allergy Organ J 13/2 (2020) 100080]

Author

Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Yu-Hor Thong, Bernard, Valenta, Rudolf, Wood, Robert A., Zuberbier, Torsten, Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Yu-Hor Thong, Bernard, Valenta, Rudolf, Wood, Robert A., and Zuberbier, Torsten

Published
2021

4. Erratum to 'IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper' [World Allergy Organ J 13/2 (2020) 100080]

Author

Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Yu-Hor Thong, Bernard, Valenta, Rudolf, Wood, Robert A., Zuberbier, Torsten, Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Yu-Hor Thong, Bernard, Valenta, Rudolf, Wood, Robert A., and Zuberbier, Torsten

Published
2021

5. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper

Author

Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A., Zuberbier, Torsten, Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A., and Zuberbier, Torsten

Abstract

Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.

Published
2020

6. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper

Author

Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A., Zuberbier, Torsten, Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A., and Zuberbier, Torsten

Abstract

Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.

Published
2020

7. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper

Author

Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A., Zuberbier, Torsten, Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A., and Zuberbier, Torsten

Abstract

Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.

Published
2020

8. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper

Author

Ansotegui, Ignacio J, Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis, Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, R Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J, Jensen-Jarolim, Erika, Fischer, David A, Haahtela, Tari, Antila, Martti, Bousquet, Jean J, Cardona, Victoria, Demoly, Pascal M, DuBuske, Lawrence M, Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez-Estrada, Alexei, Jares, Edgardo, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L, Ledford, Dennis K, Monge Ortega, Olga Patricia, Morais Almeida, Mário, Pfaar, Oliver, Poulsen, Lars K, Pawankar, Ruby, Renz, Harald E, Romano, Antonino G, Rosário Filho, Nelson A, Rosenwasser, Lanny, Sánchez Borges, Mario A, Scala, Enrico, Senna, Gian-Enrico, Sisul, Juan Carlos, Tang, Mimi L K, Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A, Zuberbier, Torsten, Ansotegui, Ignacio J, Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis, Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, R Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J, Jensen-Jarolim, Erika, Fischer, David A, Haahtela, Tari, Antila, Martti, Bousquet, Jean J, Cardona, Victoria, Demoly, Pascal M, DuBuske, Lawrence M, Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez-Estrada, Alexei, Jares, Edgardo, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L, Ledford, Dennis K, Monge Ortega, Olga Patricia, Morais Almeida, Mário, Pfaar, Oliver, Poulsen, Lars K, Pawankar, Ruby, Renz, Harald E, Romano, Antonino G, Rosário Filho, Nelson A, Rosenwasser, Lanny, Sánchez Borges, Mario A, Scala, Enrico, Senna, Gian-Enrico, Sisul, Juan Carlos, Tang, Mimi L K, Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A, and Zuberbier, Torsten

Abstract

Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.

Published
2020

9. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper

Author

Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A., Zuberbier, Torsten, Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis R., Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, René Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, Dubuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez Estrada, Alexei, Jares, Edgardo José, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mario, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosario Filho, Nelson Augusto, Rosenwasser, Lanny, Sánchez Borges, Mario, Scala, Enrico, Senna, Gianenrico, Sisul, Juan Carlos, Tang, Mimi L.K., Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A., and Zuberbier, Torsten

Abstract

Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.

Published
2020

10. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper

Author

Ansotegui, Ignacio J, Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis, Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, R Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J, Jensen-Jarolim, Erika, Fischer, David A, Haahtela, Tari, Antila, Martti, Bousquet, Jean J, Cardona, Victoria, Demoly, Pascal M, DuBuske, Lawrence M, Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez-Estrada, Alexei, Jares, Edgardo, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L, Ledford, Dennis K, Monge Ortega, Olga Patricia, Morais Almeida, Mário, Pfaar, Oliver, Poulsen, Lars K, Pawankar, Ruby, Renz, Harald E, Romano, Antonino G, Rosário Filho, Nelson A, Rosenwasser, Lanny, Sánchez Borges, Mario A, Scala, Enrico, Senna, Gian-Enrico, Sisul, Juan Carlos, Tang, Mimi L K, Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A, Zuberbier, Torsten, Ansotegui, Ignacio J, Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis, Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, R Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J, Jensen-Jarolim, Erika, Fischer, David A, Haahtela, Tari, Antila, Martti, Bousquet, Jean J, Cardona, Victoria, Demoly, Pascal M, DuBuske, Lawrence M, Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez-Estrada, Alexei, Jares, Edgardo, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L, Ledford, Dennis K, Monge Ortega, Olga Patricia, Morais Almeida, Mário, Pfaar, Oliver, Poulsen, Lars K, Pawankar, Ruby, Renz, Harald E, Romano, Antonino G, Rosário Filho, Nelson A, Rosenwasser, Lanny, Sánchez Borges, Mario A, Scala, Enrico, Senna, Gian-Enrico, Sisul, Juan Carlos, Tang, Mimi L K, Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A, and Zuberbier, Torsten

Abstract

Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.

Published
2020

11. A WAO - ARIA - GA2LEN consensus document on molecular-based allergy diagnostics

Author

Canonica, Giorgio Walter, Ansotegui, Ignacio J, Pawankar, Ruby, Schmid-Grendelmeier, Peter, van Hage, Marianne, Baena-Cagnani, Carlos E, Melioli, Giovanni, Nunes, Carlos, Passalacqua, Giovanni, Rosenwasser, Lanny, Sampson, Hugh, Sastre, Joaquin, Bousquet, Jean, Zuberbier, Torsten, Allen, Katrina, Asero, Riccardo, Bohle, Barbara, Cox, Linda, de Blay, Frederic, Ebisawa, Motohiro, Maximiliano-Gómez, René, González-Diaz, Sandra, Haahtela, Tari, Holgate, Stephen, Jakob, Thilo, Larché, Mark, Matricardi, Paolo Maria, Oppenheimer, John, Poulsen, Lars K., Renz, Harald E, Rosário, Nelson, Rothenberg, Marc, Sanchez-Borges, Mario, Scala, Enrico, Valenta, Rudolf, Canonica, Giorgio Walter, Ansotegui, Ignacio J, Pawankar, Ruby, Schmid-Grendelmeier, Peter, van Hage, Marianne, Baena-Cagnani, Carlos E, Melioli, Giovanni, Nunes, Carlos, Passalacqua, Giovanni, Rosenwasser, Lanny, Sampson, Hugh, Sastre, Joaquin, Bousquet, Jean, Zuberbier, Torsten, Allen, Katrina, Asero, Riccardo, Bohle, Barbara, Cox, Linda, de Blay, Frederic, Ebisawa, Motohiro, Maximiliano-Gómez, René, González-Diaz, Sandra, Haahtela, Tari, Holgate, Stephen, Jakob, Thilo, Larché, Mark, Matricardi, Paolo Maria, Oppenheimer, John, Poulsen, Lars K., Renz, Harald E, Rosário, Nelson, Rothenberg, Marc, Sanchez-Borges, Mario, Scala, Enrico, and Valenta, Rudolf

Abstract

Molecular-based allergy (MA) diagnostics is an approach used to map the allergen sensitization of a patient at a molecular level, using purified natural or recombinant allergenic molecules (allergen components) instead of allergen extracts. Since its introduction, MA diagnostics has increasingly entered routine care, with currently more than 130 allergenic molecules commercially available for in vitro specific IgE (sIgE) testing.MA diagnostics allows for an increased accuracy in allergy diagnosis and prognosis and plays an important role in three key aspects of allergy diagnosis: (1) resolving genuine versus cross-reactive sensitization in poly-sensitized patients, thereby improving the understanding of triggering allergens; (2) assessing, in selected cases, the risk of severe, systemic versus mild, local reactions in food allergy, thereby reducing unnecessary anxiety for the patient and the need for food challenge testing; and (3) identifying patients and triggering allergens for specific immunotherapy (SIT).Singleplex and multiplex measurement platforms are available for MA diagnostics. The Immuno-Solid phase Allergen Chip (ISAC) is the most comprehensive platform currently available, which involves a biochip technology to measure sIgE antibodies against more than one hundred allergenic molecules in a single assay. As the field of MA diagnostics advances, future work needs to focus on large-scale, population-based studies involving practical applications, elucidation and expansion of additional allergenic molecules, and support for appropriate test interpretation. With the rapidly expanding evidence-base for MA diagnosis, there is a need for allergists to keep abreast of the latest information. The aim of this consensus document is to provide a practical guide for the indications, determination, and interpretation of MA diagnostics for clinicians trained in allergology.

Published
2013

12. A WAO - ARIA - GA2LEN consensus document on molecular-based allergy diagnostics

Author

Canonica, Giorgio Walter, Ansotegui, Ignacio J, Pawankar, Ruby, Schmid-Grendelmeier, Peter, van Hage, Marianne, Baena-Cagnani, Carlos E, Melioli, Giovanni, Nunes, Carlos, Passalacqua, Giovanni, Rosenwasser, Lanny, Sampson, Hugh, Sastre, Joaquin, Bousquet, Jean, Zuberbier, Torsten, Allen, Katrina, Asero, Riccardo, Bohle, Barbara, Cox, Linda, de Blay, Frederic, Ebisawa, Motohiro, Maximiliano-Gómez, René, González-Diaz, Sandra, Haahtela, Tari, Holgate, Stephen, Jakob, Thilo, Larché, Mark, Matricardi, Paolo Maria, Oppenheimer, John, Poulsen, Lars K., Renz, Harald E, Rosário, Nelson, Rothenberg, Marc, Sanchez-Borges, Mario, Scala, Enrico, Valenta, Rudolf, Canonica, Giorgio Walter, Ansotegui, Ignacio J, Pawankar, Ruby, Schmid-Grendelmeier, Peter, van Hage, Marianne, Baena-Cagnani, Carlos E, Melioli, Giovanni, Nunes, Carlos, Passalacqua, Giovanni, Rosenwasser, Lanny, Sampson, Hugh, Sastre, Joaquin, Bousquet, Jean, Zuberbier, Torsten, Allen, Katrina, Asero, Riccardo, Bohle, Barbara, Cox, Linda, de Blay, Frederic, Ebisawa, Motohiro, Maximiliano-Gómez, René, González-Diaz, Sandra, Haahtela, Tari, Holgate, Stephen, Jakob, Thilo, Larché, Mark, Matricardi, Paolo Maria, Oppenheimer, John, Poulsen, Lars K., Renz, Harald E, Rosário, Nelson, Rothenberg, Marc, Sanchez-Borges, Mario, Scala, Enrico, and Valenta, Rudolf

Abstract

Molecular-based allergy (MA) diagnostics is an approach used to map the allergen sensitization of a patient at a molecular level, using purified natural or recombinant allergenic molecules (allergen components) instead of allergen extracts. Since its introduction, MA diagnostics has increasingly entered routine care, with currently more than 130 allergenic molecules commercially available for in vitro specific IgE (sIgE) testing.MA diagnostics allows for an increased accuracy in allergy diagnosis and prognosis and plays an important role in three key aspects of allergy diagnosis: (1) resolving genuine versus cross-reactive sensitization in poly-sensitized patients, thereby improving the understanding of triggering allergens; (2) assessing, in selected cases, the risk of severe, systemic versus mild, local reactions in food allergy, thereby reducing unnecessary anxiety for the patient and the need for food challenge testing; and (3) identifying patients and triggering allergens for specific immunotherapy (SIT).Singleplex and multiplex measurement platforms are available for MA diagnostics. The Immuno-Solid phase Allergen Chip (ISAC) is the most comprehensive platform currently available, which involves a biochip technology to measure sIgE antibodies against more than one hundred allergenic molecules in a single assay. As the field of MA diagnostics advances, future work needs to focus on large-scale, population-based studies involving practical applications, elucidation and expansion of additional allergenic molecules, and support for appropriate test interpretation. With the rapidly expanding evidence-base for MA diagnosis, there is a need for allergists to keep abreast of the latest information. The aim of this consensus document is to provide a practical guide for the indications, determination, and interpretation of MA diagnostics for clinicians trained in allergology.

Published
2013

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