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22 results on '"Rittig S"'

2. Short-term effects of liraglutide on kidney function and vasoactive hormones in type 2 diabetes:a randomized clinical trial

Author

Skov, J., Pedersen, M., Holst, Jens Juul, Madsen, B, Goetze, Jens P, Rittig, S., Jonassen, Thomas, Frøkiær, J, Dejgaard, A., Christiansen, J. S., Skov, J., Pedersen, M., Holst, Jens Juul, Madsen, B, Goetze, Jens P, Rittig, S., Jonassen, Thomas, Frøkiær, J, Dejgaard, A., and Christiansen, J. S.

Abstract

AIMS: To investigate the effects of a single dose of 1.2 mg liraglutide, a once-daily glucagon-like peptide-1 (GLP-1) receptor agonist, on key renal parameters in patients with type 2 diabetes.METHODS: The study was a placebo-controlled, double-blind, cross-over in 11 male patients with type 2 diabetes. Measurements included (51) Cr-EDTA plasma clearance estimated glomerular filtration rate (GFR) and MRI-based renal blood flow (RBF), tissue perfusion and - oxygenation.RESULTS: Liraglutide had no effect on GFR (95% CI -6.8 to 3.6 ml/min/1.73 m(2) ) or RBF (95% CI -39 to 30 ml/min) and did not change local renal blood perfusion or oxygenation. The fractional excretion of lithium increased 14% (p = 0.01) and sodium clearance tended to increase (p = 0.06). Liraglutide increased diastolic and systolic blood pressure (3 and 6 mm Hg) and heart rate (3 min(-1) ) (all p < 0.05). Angiotensin II concentration decreased 21% (p = 0.02), but there were no effects on other renin-angiotensin system components, atrial natriuretic peptides (ANP), methanephrines or the excretion of catecholamines.CONCLUSIONS: Short-term liraglutide treatment did not affect renal hemodynamics but decreased the proximal tubular sodium reabsorption. Blood pressure increased as opposed to long-term treatment. Catecholamine levels were unchanged and the results did not support a GLP-1-ANP axis. Angiotensin II levels decreased, which may contribute to renal protection by GLP-1 receptor agonists.

Published
2016

3. ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3

Author

Hoff, S., Halbritter, J., Epting, D., Frank, V., Nguyen, T.M., Reeuwijk, J. van, Boehlke, C., Schell, C., Yasunaga, T., Helmstadter, M., Mergen, M., Filhol, E., Boldt, K., Horn, N., Ueffing, M., Otto, E.A., Eisenberger, T., Elting, M.W., Wijk, J.A. van, Bockenhauer, D., Sebire, N.J., Rittig, S., Vyberg, M., Ring, T., Pohl, M., Pape, L., Neuhaus, T.J., Elshakhs, N.A., Koon, S.J., Harris, P.C., Grahammer, F., Huber, T.B., Kuehn, E.W., Kramer-Zucker, A., Bolz, H.J., Roepman, R., Saunier, S., Walz, G., Hildebrandt, F., Bergmann, C., Lienkamp, S.S., Hoff, S., Halbritter, J., Epting, D., Frank, V., Nguyen, T.M., Reeuwijk, J. van, Boehlke, C., Schell, C., Yasunaga, T., Helmstadter, M., Mergen, M., Filhol, E., Boldt, K., Horn, N., Ueffing, M., Otto, E.A., Eisenberger, T., Elting, M.W., Wijk, J.A. van, Bockenhauer, D., Sebire, N.J., Rittig, S., Vyberg, M., Ring, T., Pohl, M., Pape, L., Neuhaus, T.J., Elshakhs, N.A., Koon, S.J., Harris, P.C., Grahammer, F., Huber, T.B., Kuehn, E.W., Kramer-Zucker, A., Bolz, H.J., Roepman, R., Saunier, S., Walz, G., Hildebrandt, F., Bergmann, C., and Lienkamp, S.S.

Abstract

Item does not contain fulltext, Nephronophthisis is an autosomal recessive cystic kidney disease that leads to renal failure in childhood or adolescence. Most NPHP gene products form molecular networks. Here we identify ANKS6 as a new NPHP family member that connects NEK8 (NPHP9) to INVS (NPHP2) and NPHP3. We show that ANKS6 localizes to the proximal cilium and confirm its role in renal development through knockdown experiments in zebrafish and Xenopus laevis. We also identify six families with ANKS6 mutations affected by nephronophthisis, including severe cardiovascular abnormalities, liver fibrosis and situs inversus. The oxygen sensor HIF1AN hydroxylates ANKS6 and INVS and alters the composition of the ANKS6-INVS-NPHP3 module. Knockdown of Hif1an in Xenopus results in a phenotype that resembles loss of other NPHP proteins. Network analyses uncovered additional putative NPHP proteins and placed ANKS6 at the center of this NPHP module, explaining the overlapping disease manifestation caused by mutation in ANKS6, NEK8, INVS or NPHP3.

Published
2013

4. ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3

Author

Hoff, S., Halbritter, J., Epting, D., Frank, V., Nguyen, T.M., Reeuwijk, J. van, Boehlke, C., Schell, C., Yasunaga, T., Helmstadter, M., Mergen, M., Filhol, E., Boldt, K., Horn, N., Ueffing, M., Otto, E.A., Eisenberger, T., Elting, M.W., Wijk, J.A. van, Bockenhauer, D., Sebire, N.J., Rittig, S., Vyberg, M., Ring, T., Pohl, M., Pape, L., Neuhaus, T.J., Elshakhs, N.A., Koon, S.J., Harris, P.C., Grahammer, F., Huber, T.B., Kuehn, E.W., Kramer-Zucker, A., Bolz, H.J., Roepman, R., Saunier, S., Walz, G., Hildebrandt, F., Bergmann, C., Lienkamp, S.S., Hoff, S., Halbritter, J., Epting, D., Frank, V., Nguyen, T.M., Reeuwijk, J. van, Boehlke, C., Schell, C., Yasunaga, T., Helmstadter, M., Mergen, M., Filhol, E., Boldt, K., Horn, N., Ueffing, M., Otto, E.A., Eisenberger, T., Elting, M.W., Wijk, J.A. van, Bockenhauer, D., Sebire, N.J., Rittig, S., Vyberg, M., Ring, T., Pohl, M., Pape, L., Neuhaus, T.J., Elshakhs, N.A., Koon, S.J., Harris, P.C., Grahammer, F., Huber, T.B., Kuehn, E.W., Kramer-Zucker, A., Bolz, H.J., Roepman, R., Saunier, S., Walz, G., Hildebrandt, F., Bergmann, C., and Lienkamp, S.S.

Abstract

Item does not contain fulltext, Nephronophthisis is an autosomal recessive cystic kidney disease that leads to renal failure in childhood or adolescence. Most NPHP gene products form molecular networks. Here we identify ANKS6 as a new NPHP family member that connects NEK8 (NPHP9) to INVS (NPHP2) and NPHP3. We show that ANKS6 localizes to the proximal cilium and confirm its role in renal development through knockdown experiments in zebrafish and Xenopus laevis. We also identify six families with ANKS6 mutations affected by nephronophthisis, including severe cardiovascular abnormalities, liver fibrosis and situs inversus. The oxygen sensor HIF1AN hydroxylates ANKS6 and INVS and alters the composition of the ANKS6-INVS-NPHP3 module. Knockdown of Hif1an in Xenopus results in a phenotype that resembles loss of other NPHP proteins. Network analyses uncovered additional putative NPHP proteins and placed ANKS6 at the center of this NPHP module, explaining the overlapping disease manifestation caused by mutation in ANKS6, NEK8, INVS or NPHP3.

Published
2013

5. Hereditary henotypes in nocturnal enuresis

Author

Schaumburg, H.L., Kapilin, U., Blasvaer, C., Eiberg, H., Gontard, A. von, Djurhuus, J.C., Rittig, S., Schaumburg, H.L., Kapilin, U., Blasvaer, C., Eiberg, H., Gontard, A. von, Djurhuus, J.C., and Rittig, S.

Abstract

Udgivelsesdato: 2008/10

Published
2008

6. Hereditary henotypes in nocturnal enuresis

Author

Schaumburg, H.L., Kapilin, U., Blasvaer, C., Eiberg, H., Gontard, A. von, Djurhuus, J.C., Rittig, S., Schaumburg, H.L., Kapilin, U., Blasvaer, C., Eiberg, H., Gontard, A. von, Djurhuus, J.C., and Rittig, S.

Abstract

Udgivelsesdato: 2008/10

Published
2008

7. The genetics of enuresis: a review

Author

von Gontard, A., Schaumburg, H., Hollmann, E., Eiberg, Hans Rudolf Lytchoff, Rittig, S., von Gontard, A., Schaumburg, H., Hollmann, E., Eiberg, Hans Rudolf Lytchoff, and Rittig, S.

Published
2001

9. The genetics of enuresis: a review

Author

von Gontard, A., Schaumburg, H., Hollmann, E., Eiberg, Hans Rudolf Lytchoff, Rittig, S., von Gontard, A., Schaumburg, H., Hollmann, E., Eiberg, Hans Rudolf Lytchoff, and Rittig, S.

Published
2001

17. Genetic Heterogeneity in Nocturnal Enuresis

Author

Gontard, A.von, Eiberg, Hans Rudolf Lytchoff, Hollmann, E., Rittig, S., Lehmkuhl, G., Gontard, A.von, Eiberg, Hans Rudolf Lytchoff, Hollmann, E., Rittig, S., and Lehmkuhl, G.

Published
1997

21. Genetic Heterogeneity in Nocturnal Enuresis

Author

Gontard, A.von, Eiberg, Hans Rudolf Lytchoff, Hollmann, E., Rittig, S., Lehmkuhl, G., Gontard, A.von, Eiberg, Hans Rudolf Lytchoff, Hollmann, E., Rittig, S., and Lehmkuhl, G.

Published
1997

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