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OBJECTIVES: The Hypoglycemia During Hospitalization (HyDHo) score predicts hypoglycemia in a population of Canadian inpatients by assigning various weightings to 5 key clinical criteria known at the time of admission, in particular age, recent presentation to an emergency department, insulin use, use of oral hypoglycemic agents, and chronic kidney disease. Our aim in this study was to externally validate the HyDHo score by applying this risk calculator to an Australian population of inpatients with diabetes. METHODS: This study was a retrospective data analysis of a subset of the Diabetes IN-hospital: Glucose & Outcomes (DINGO) cohort. The HyDHo score was applied based on clinical information known at the time of admission to stratify risk of inpatient hypoglycemia. RESULTS: The HyDHo score was applied to 1,015 patients, generating a receiver-operating characteristic c-statistic of 0.607. A threshold of ≥9, as per the original study, generated a sensitivity of 83% and a specificity of 20%. A threshold of ≥10, to better suit this Australian population, generated a sensitivity of 90% and a specificity of 34%. The HyDHo score has been externally valid in a geographically different population; in fact, it outperformed the original study after accounting for local hypoglycemia rates. CONCLUSIONS: Our findings support the external validity of the HyDHo score in a geographically different population. Application of this simple and accessible tool can serve as an adjunct to predict an inpatient's risk of hypoglycemia and guide more appropriate glucose monitoring and diabetes management.

This Letter reports the first observational estimate of the heating rate in the slowly expanding solar corona. The analysis exploits the simultaneous remote and local observations of the same coronal plasma volume with the Solar Orbiter/Metis and the Parker Solar Probe instruments, respectively, and relies on the basic solar wind magnetohydrodynamic equations. As expected, energy losses are a minor fraction of the solar wind energy flux, since most of the energy dissipation that feeds the heating and acceleration of the coronal flow occurs much closer to the Sun than the heights probed in the present study, which range from 6.3 to 13.3 solar radii. The energy deposited to the supersonic wind is then used to explain the observed slight residual wind acceleration and to maintain the plasma in a non-adiabatic state. As derived in the Wentzel-Kramers-Brillouin limit, the present energy transfer rate estimates provide a lower limit, which can be very useful in refining the turbulence-based modeling of coronal heating and subsequent solar wind acceleration.

Particle acceleration is a fundamental process arising in many astrophysical objects, including active galactic nuclei, black holes, neutron stars, gamma-ray bursts, accretion disks, solar and stellar coronae, and planetary magnetospheres. Its ubiquity means energetic particles permeate the Universe and influence the conditions for the emergence and continuation of life. In our solar system, the Sun is the most energetic particle accelerator, and its proximity makes it a unique laboratory in which to explore astrophysical particle acceleration. However, despite its importance, the physics underlying solar particle acceleration remain poorly understood. The SPARK mission will reveal new discoveries about particle acceleration through a uniquely powerful and complete combination of γ-ray, X-ray, and EUV imaging and spectroscopy at high spectral, spatial, and temporal resolutions. SPARK’s instruments will provide a step change in observational capability, enabling fundamental breakthroughs in our understanding of solar particle acceleration and the phenomena associated with it, such as the evolution of solar eruptive events. By providing essential diagnostics of the processes that drive the onset and evolution of solar flares and coronal mass ejections, SPARK will elucidate the underlying physics of space weather events that can damage satellites and power grids, disrupt telecommunications and GPS navigation, and endanger astronauts in space. The prediction of such events and the mitigation of their potential impacts are crucial in protecting our terrestrial and space-based infrastructure.

The solar wind measured in situ by Parker Solar Probe in the very inner heliosphere is studied in combination with the remote-sensing observation of the coronal source region provided by the METIS coronagraph aboard Solar Orbiter. The coronal outflows observed near the ecliptic by Metis on 2021 January 17 at 16:30 UT, between 3.5 and 6.3 R (circle dot) above the eastern solar limb, can be associated with the streams sampled by PSP at 0.11 and 0.26 au from the Sun, in two time intervals almost 5 days apart. The two plasma flows come from two distinct source regions, characterized by different magnetic field polarity and intensity at the coronal base. It follows that both the global and local properties of the two streams are different. Specifically, the solar wind emanating from the stronger magnetic field region has a lower bulk flux density, as expected, and is in a state of well-developed Alfvenic turbulence, with low intermittency. This is interpreted in terms of slab turbulence in the context of nearly incompressible magnetohydrodynamics. Conversely, the highly intermittent and poorly developed turbulent behavior of the solar wind from the weaker magnetic field region is presumably due to large magnetic deflections most likely attributed to the presence of switchbacks of interchange reconnection origin.

The solar wind measured in situ by Parker Solar Probe in the very inner heliosphere is studied in combination with the remote-sensing observation of the coronal source region provided by the METIS coronagraph aboard Solar Orbiter. The coronal outflows observed near the ecliptic by Metis on 2021 January 17 at 16:30 UT, between 3.5 and 6.3 R (circle dot) above the eastern solar limb, can be associated with the streams sampled by PSP at 0.11 and 0.26 au from the Sun, in two time intervals almost 5 days apart. The two plasma flows come from two distinct source regions, characterized by different magnetic field polarity and intensity at the coronal base. It follows that both the global and local properties of the two streams are different. Specifically, the solar wind emanating from the stronger magnetic field region has a lower bulk flux density, as expected, and is in a state of well-developed Alfvenic turbulence, with low intermittency. This is interpreted in terms of slab turbulence in the context of nearly incompressible magnetohydrodynamics. Conversely, the highly intermittent and poorly developed turbulent behavior of the solar wind from the weaker magnetic field region is presumably due to large magnetic deflections most likely attributed to the presence of switchbacks of interchange reconnection origin.

The solar wind measured in situ by Parker Solar Probe in the very inner heliosphere is studied in combination with the remote-sensing observation of the coronal source region provided by the METIS coronagraph aboard Solar Orbiter. The coronal outflows observed near the ecliptic by Metis on 2021 January 17 at 16:30 UT, between 3.5 and 6.3 R (circle dot) above the eastern solar limb, can be associated with the streams sampled by PSP at 0.11 and 0.26 au from the Sun, in two time intervals almost 5 days apart. The two plasma flows come from two distinct source regions, characterized by different magnetic field polarity and intensity at the coronal base. It follows that both the global and local properties of the two streams are different. Specifically, the solar wind emanating from the stronger magnetic field region has a lower bulk flux density, as expected, and is in a state of well-developed Alfvenic turbulence, with low intermittency. This is interpreted in terms of slab turbulence in the context of nearly incompressible magnetohydrodynamics. Conversely, the highly intermittent and poorly developed turbulent behavior of the solar wind from the weaker magnetic field region is presumably due to large magnetic deflections most likely attributed to the presence of switchbacks of interchange reconnection origin.

The solar wind measured in situ by Parker Solar Probe in the very inner heliosphere is studied in combination with the remote-sensing observation of the coronal source region provided by the METIS coronagraph aboard Solar Orbiter. The coronal outflows observed near the ecliptic by Metis on 2021 January 17 at 16:30 UT, between 3.5 and 6.3 R (circle dot) above the eastern solar limb, can be associated with the streams sampled by PSP at 0.11 and 0.26 au from the Sun, in two time intervals almost 5 days apart. The two plasma flows come from two distinct source regions, characterized by different magnetic field polarity and intensity at the coronal base. It follows that both the global and local properties of the two streams are different. Specifically, the solar wind emanating from the stronger magnetic field region has a lower bulk flux density, as expected, and is in a state of well-developed Alfvenic turbulence, with low intermittency. This is interpreted in terms of slab turbulence in the context of nearly incompressible magnetohydrodynamics. Conversely, the highly intermittent and poorly developed turbulent behavior of the solar wind from the weaker magnetic field region is presumably due to large magnetic deflections most likely attributed to the presence of switchbacks of interchange reconnection origin.

The solar wind measured in situ by Parker Solar Probe in the very inner heliosphere is studied in combination with the remote-sensing observation of the coronal source region provided by the METIS coronagraph aboard Solar Orbiter. The coronal outflows observed near the ecliptic by Metis on 2021 January 17 at 16:30 UT, between 3.5 and 6.3 R (circle dot) above the eastern solar limb, can be associated with the streams sampled by PSP at 0.11 and 0.26 au from the Sun, in two time intervals almost 5 days apart. The two plasma flows come from two distinct source regions, characterized by different magnetic field polarity and intensity at the coronal base. It follows that both the global and local properties of the two streams are different. Specifically, the solar wind emanating from the stronger magnetic field region has a lower bulk flux density, as expected, and is in a state of well-developed Alfvenic turbulence, with low intermittency. This is interpreted in terms of slab turbulence in the context of nearly incompressible magnetohydrodynamics. Conversely, the highly intermittent and poorly developed turbulent behavior of the solar wind from the weaker magnetic field region is presumably due to large magnetic deflections most likely attributed to the presence of switchbacks of interchange reconnection origin.

Solar flares are occasionally responsible for severe Space Weather events, which can affect space-borne and ground-based infrastructures, endangering anthropic technological activities and even human health and safety. Thus, an essential activity in the framework of Space Weather monitoring is devoted to the observation of the activity level of the Sun. In this context, the acquisition system of the Catania Solar Telescope has been recently upgraded in order to improve its contribution to the European Space Agency (ESA) - Space Weather Service Network through the ESA Portal, which represents the main asset for Space Weather in Europe. Here, we describe the hardware and software upgrades of the Catania Solar Telescope and the main data products provided by this facility, which include full-disc images of the photosphere and chromosphere, together with a detailed characterization of the sunspot groups. As a showcase of the observational capabilities of the revamped Catania Solar Telescope, we report the analysis of a B5.4 class flare occurred on 2020 December 7, simultaneously observed by the IRIS and SDO satellites.

This Letter addresses the first Solar Orbiter (SO) -- Parker Solar Probe (PSP) quadrature, occurring on January 18, 2021, to investigate the evolution of solar wind from the extended corona to the inner heliosphere. Assuming ballistic propagation, the same plasma volume observed remotely in corona at altitudes between 3.5 and 6.3 solar radii above the solar limb with the Metis coronagraph on SO can be tracked to PSP, orbiting at 0.1 au, thus allowing the local properties of the solar wind to be linked to the coronal source region from where it originated. Thanks to the close approach of PSP to the Sun and the simultaneous Metis observation of the solar corona, the flow-aligned magnetic field and the bulk kinetic energy flux density can be empirically inferred along the coronal current sheet with an unprecedented accuracy, allowing in particular estimation of the Alfv\'en radius at 8.7 solar radii during the time of this event. This is thus the very first study of the same solar wind plasma as it expands from the sub-Alfv\'enic solar corona to just above the Alfv\'en surface., Comment: 10 pages, 4 figures

Solar eruptive events, like flares and coronal mass ejections, are characterized by the rapid release of energy that can give rise to emission of radiation across the entire electromagnetic spectrum and to an abrupt significant increase in the kinetic energy of particles. These energetic phenomena can have important effects on the Space Weather conditions and therefore it is necessary to understand their origin, in particular, what is the eruptive potential of an active region (AR). In these case studies, we compare two distinct methods that were used in previous works to investigate the variations of some characteristic physical parameters during the pre-flare states of flaring ARs. These methods consider: i) the magnetic flux evolution and the magnetic helicity accumulation, and ii) the fractal and multi-fractal properties of flux concentrations in ARs. Our comparative analysis is based on time series of photospheric data obtained by the Solar Dynamics Observatory between March 2011 and June 2013. We selected two distinct samples of ARs: one is distinguished by the occurrence of more energetic M- and X-class flare events, that may have a rapid effect on not just the near-Earth space, but also on the terrestrial environment; the second is characterized by no-flares or having just few C- and B-class flares. We found that the two tested methods complement each other in their ability to assess the eruptive potentials of ARs and could be employed to identify ARs prone to flaring activity. Based on the presented case study, we suggest that using a combination of different methods may aid to identify more reliably the eruptive potentials of ARs and help to better understand the pre-flare states.

This Letter addresses the first Solar Orbiter (SO)-Parker Solar Probe (PSP) quadrature, occurring on 2021 January 18 to investigate the evolution of solar wind from the extended corona to the inner heliosphere. Assuming ballistic propagation, the same plasma volume observed remotely in the corona at altitudes between 3.5 and 6.3 solar radii above the solar limb with the Metis coronagraph on SO can be tracked to PSP, orbiting at 0.1 au, thus allowing the local properties of the solar wind to be linked to the coronal source region from where it originated. Thanks to the close approach of PSP to the Sun and the simultaneous Metis observation of the solar corona, the flow-aligned magnetic field and the bulk kinetic energy flux density can be empirically inferred along the coronal current sheet with an unprecedented accuracy, allowing in particular estimation of the Alfven radius at 8.7 solar radii during the time of this event. This is thus the very first study of the same solar wind plasma as it expands from the sub-Alfvenic solar corona to just above the Alfven surface.

Solar flares are occasionally responsible for severe Space Weather events, which can affect space-borne and ground-based infrastructures, endangering anthropic technological activities and even human health and safety. Thus, an essential activity in the framework of Space Weather monitoring is devoted to the observation of the activity level of the Sun. In this context, the acquisition system of the Catania Solar Telescope has been recently upgraded in order to improve its contribution to the European Space Agency (ESA) - Space Weather Service Network through the ESA Portal, which represents the main asset for Space Weather in Europe. Here, we describe the hardware and software upgrades of the Catania Solar Telescope and the main data products provided by this facility, which include full-disc images of the photosphere and chromosphere, together with a detailed characterization of the sunspot groups. As a showcase of the observational capabilities of the revamped Catania Solar Telescope, we report the analysis of a B5.4 class flare occurred on 2020 December 7, simultaneously observed by the IRIS and SDO satellites.

This Letter addresses the first Solar Orbiter (SO) -- Parker Solar Probe (PSP) quadrature, occurring on January 18, 2021, to investigate the evolution of solar wind from the extended corona to the inner heliosphere. Assuming ballistic propagation, the same plasma volume observed remotely in corona at altitudes between 3.5 and 6.3 solar radii above the solar limb with the Metis coronagraph on SO can be tracked to PSP, orbiting at 0.1 au, thus allowing the local properties of the solar wind to be linked to the coronal source region from where it originated. Thanks to the close approach of PSP to the Sun and the simultaneous Metis observation of the solar corona, the flow-aligned magnetic field and the bulk kinetic energy flux density can be empirically inferred along the coronal current sheet with an unprecedented accuracy, allowing in particular estimation of the Alfv\'en radius at 8.7 solar radii during the time of this event. This is thus the very first study of the same solar wind plasma as it expands from the sub-Alfv\'enic solar corona to just above the Alfv\'en surface., Comment: 10 pages, 4 figures

Solar eruptive events, like flares and coronal mass ejections, are characterized by the rapid release of energy that can give rise to emission of radiation across the entire electromagnetic spectrum and to an abrupt significant increase in the kinetic energy of particles. These energetic phenomena can have important effects on the Space Weather conditions and therefore it is necessary to understand their origin, in particular, what is the eruptive potential of an active region (AR). In these case studies, we compare two distinct methods that were used in previous works to investigate the variations of some characteristic physical parameters during the pre-flare states of flaring ARs. These methods consider: i) the magnetic flux evolution and the magnetic helicity accumulation, and ii) the fractal and multi-fractal properties of flux concentrations in ARs. Our comparative analysis is based on time series of photospheric data obtained by the Solar Dynamics Observatory between March 2011 and June 2013. We selected two distinct samples of ARs: one is distinguished by the occurrence of more energetic M- and X-class flare events, that may have a rapid effect on not just the near-Earth space, but also on the terrestrial environment; the second is characterized by no-flares or having just few C- and B-class flares. We found that the two tested methods complement each other in their ability to assess the eruptive potentials of ARs and could be employed to identify ARs prone to flaring activity. Based on the presented case study, we suggest that using a combination of different methods may aid to identify more reliably the eruptive potentials of ARs and help to better understand the pre-flare states.

We study the photospheric evolution of an exploding granule observed in the quiet Sun at high spatial (similar to 03) and temporal (31.5 s) resolution by the imaging magnetographSunrise/IMaX in 2009 June. These observations show that the exploding granule is cospatial to a magnetic flux emergence event occurring at mesogranular scale (up to similar to 12 Mm(2)area). Using a modified version of the SIR code for inverting the IMaX spectropolarimetric measurements, we obtain information about the magnetic configuration of this photospheric feature. In particular, we find evidence of highly inclined emerging fields in the structure, carrying a magnetic flux content up to similar to 4 x 10(18)Mx. The balance between gas and magnetic pressure in the region of flux emergence, compared with a very quiet region of the Sun, indicates that the additional pressure carried by the emerging flux increases the total pressure by about 5% and appears to allow the granulation to be modified, as predicted by numerical simulations. The overall characteristics suggest that a multipolar structure emerges into the photosphere, resembling an almost horizontal flux sheet. This seems to be associated with exploding granules. Finally, we discuss the origin of such flux emergence events. © 2020. The Author(s). Published by the American Astronomical Society.

During solar flares, magnetic energy can be converted into electromagnetic radiation from radio waves to $\gamma$ rays. Enhancements in the continuum at visible wavelengths give rise to white-light flares, as well as continuum enhancements in the FUV and NUV passbands. In addition, the strong energy release in these events can lead to the rearrangement of the magnetic field at the photospheric level, causing morphological changes in large and stable magnetic structures like sunspots. In this context, we describe observations acquired by satellite instruments (IRIS, SDO/HMI, Hinode/SOT) and ground-based telescopes (ROSA/DST) during two consecutive C7.0 and X1.6 flares occurred in active region NOAA 12205 on 2014 November 7. The flare was accompanied by an eruption. The results of the analysis show the presence of continuum enhancements during the evolution of the events, observed both in ROSA images and in \textit{IRIS} spectra. In the latter, a prominent blue-shifted component is observed at the onset of the eruption. We investigate the role played by the evolution of the $\delta$ sunspots of the active region in the flare triggering, and finally we discuss the changes in the penumbrae surrounding these sunspots as a further consequence of these flares., Comment: 19 pages, accepted for ApJ; some figures are in B/W to accomplish size limits

Here we present the little explored Ca II K archives from the Rome and the Catania observatories and analyse the digitised images from these archives to derive plage areas., Comment: 5 pages, 3 figures, to be published in "Nuovo Cimento C" as proceeding of the Third Meeting of the Italian Solar and Heliospheric Community

Here we present the little explored Ca II K archives from the Rome and the Catania observatories and analyse the digitised images from these archives to derive plage areas., Comment: 5 pages, 3 figures, to be published in "Nuovo Cimento C" as proceeding of the Third Meeting of the Italian Solar and Heliospheric Community

During solar flares, magnetic energy can be converted into electromagnetic radiation from radio waves to $\gamma$ rays. Enhancements in the continuum at visible wavelengths give rise to white-light flares, as well as continuum enhancements in the FUV and NUV passbands. In addition, the strong energy release in these events can lead to the rearrangement of the magnetic field at the photospheric level, causing morphological changes in large and stable magnetic structures like sunspots. In this context, we describe observations acquired by satellite instruments (IRIS, SDO/HMI, Hinode/SOT) and ground-based telescopes (ROSA/DST) during two consecutive C7.0 and X1.6 flares occurred in active region NOAA 12205 on 2014 November 7. The flare was accompanied by an eruption. The results of the analysis show the presence of continuum enhancements during the evolution of the events, observed both in ROSA images and in \textit{IRIS} spectra. In the latter, a prominent blue-shifted component is observed at the onset of the eruption. We investigate the role played by the evolution of the $\delta$ sunspots of the active region in the flare triggering, and finally we discuss the changes in the penumbrae surrounding these sunspots as a further consequence of these flares., Comment: 19 pages, accepted for ApJ; some figures are in B/W to accomplish size limits

Multi-wavelength ultraviolet (UV) observations by the IRIS satellite in active region NOAA 12529 have recently pointed out the presence of long-lasting brightenings, akin to UV bursts, and simultaneous plasma ejections occurring in the upper chromosphere and transition region during secondary flux emergence. These signatures have been interpreted as evidence of small-scale, recurrent magnetic reconnection episodes between the emerging flux region (EFR) and the pre-existing plage field. Here, we characterize the UV emission of these strong, intermittent brightenings and we study the surge activity above the chromospheric arch filament system (AFS) overlying the EFR. We analyze the surges and the cospatial brightenings observed at different wavelengths. We find an asymmetry in the emission between the blue and red wings of the Si IV 1402 \AA{} and Mg II k 2796.3 \AA{} lines, which clearly outlines the dynamics of the structures above the AFS that form during the small-scale eruptive phenomena. We also detect a correlation between the Doppler velocity and skewness of the Si IV 1394 \AA{} and 1402 \AA{} line profiles in the UV burst pixels. Finally, we show that genuine emission in the Fe XII 1349.4 \AA{} line is cospatial to the Si IV brightenings. This definitely reveals a pure coronal counterpart to the reconnection event., Comment: 19 pages, 8 figures + 3 figures in the Appendix; accepted in ApJ

We report multi-wavelength ultraviolet observations taken with the IRIS satellite, concerning the emergence phase in the upper chromosphere and transition region of an emerging flux region (EFR) embedded in the pre-existing field of active region NOAA 12529. IRIS data are complemented by full-disk observations of the Solar Dynamics Observatory satellite, relevant to the photosphere and the corona. The photospheric configuration of the EFR is also analyzed by measurements taken with the spectropolarimeter aboard the Hinode satellite, when the EFR was fully developed. Recurrent intense brightenings that resemble UV bursts, with counterparts in all coronal passbands, are identified at the edges of the EFR. Jet activity is also observed at chromospheric and coronal levels, near the observed brightenings. The analysis of the IRIS line profiles reveals the heating of dense plasma in the low solar atmosphere and the driving of bi-directional high-velocity flows with speed up to 100 km/s at the same locations. Compared with previous observations and numerical models, these signatures suggest evidence of several long-lasting, small-scale magnetic reconnection episodes between the emerging bipole and the ambient field. This process leads to the cancellation of a pre-existing photospheric flux concentration and appears to occur higher in the atmosphere than usually found in UV bursts, explaining the observed coronal counterparts., Comment: 12 figures, accepted in ApJ

Multi-wavelength ultraviolet (UV) observations by the IRIS satellite in active region NOAA 12529 have recently pointed out the presence of long-lasting brightenings, akin to UV bursts, and simultaneous plasma ejections occurring in the upper chromosphere and transition region during secondary flux emergence. These signatures have been interpreted as evidence of small-scale, recurrent magnetic reconnection episodes between the emerging flux region (EFR) and the pre-existing plage field. Here, we characterize the UV emission of these strong, intermittent brightenings and we study the surge activity above the chromospheric arch filament system (AFS) overlying the EFR. We analyze the surges and the cospatial brightenings observed at different wavelengths. We find an asymmetry in the emission between the blue and red wings of the Si IV 1402 \AA{} and Mg II k 2796.3 \AA{} lines, which clearly outlines the dynamics of the structures above the AFS that form during the small-scale eruptive phenomena. We also detect a correlation between the Doppler velocity and skewness of the Si IV 1394 \AA{} and 1402 \AA{} line profiles in the UV burst pixels. Finally, we show that genuine emission in the Fe XII 1349.4 \AA{} line is cospatial to the Si IV brightenings. This definitely reveals a pure coronal counterpart to the reconnection event., Comment: 19 pages, 8 figures + 3 figures in the Appendix; accepted in ApJ

We report multi-wavelength ultraviolet observations taken with the IRIS satellite, concerning the emergence phase in the upper chromosphere and transition region of an emerging flux region (EFR) embedded in the pre-existing field of active region NOAA 12529. IRIS data are complemented by full-disk observations of the Solar Dynamics Observatory satellite, relevant to the photosphere and the corona. The photospheric configuration of the EFR is also analyzed by measurements taken with the spectropolarimeter aboard the Hinode satellite, when the EFR was fully developed. Recurrent intense brightenings that resemble UV bursts, with counterparts in all coronal passbands, are identified at the edges of the EFR. Jet activity is also observed at chromospheric and coronal levels, near the observed brightenings. The analysis of the IRIS line profiles reveals the heating of dense plasma in the low solar atmosphere and the driving of bi-directional high-velocity flows with speed up to 100 km/s at the same locations. Compared with previous observations and numerical models, these signatures suggest evidence of several long-lasting, small-scale magnetic reconnection episodes between the emerging bipole and the ambient field. This process leads to the cancellation of a pre-existing photospheric flux concentration and appears to occur higher in the atmosphere than usually found in UV bursts, explaining the observed coronal counterparts., Comment: 12 figures, accepted in ApJ

Background: Clear cell RCC (ccRCC) accounts for approximately 75% of the renal cancer cases. Surgery treatment seems to be the best efficacious approach for the majority of patients. However, a consistent fraction (30%) of cases progress after surgery with curative intent. It is currently largely debated the use of adjuvant therapy for high-risk patients and the clinical and molecular parameters for stratifying beneficiary categories. In addition, the treatment of advanced forms lacks reliable driver biomarkers for the appropriated therapeutic choice. Thus, renal cancer patient management urges predictive molecular indicators and models for therapy-decision making. Methods: Here, we developed and optimized new models and tools for ameliorating renal cancer patient management. We isolated from fresh tumor specimens heterogeneous multi-clonal populations showing epithelial and mesenchymal characteristics coupled to stem cell phenotype. These cells retained long lasting-tumor-propagating capacity provided a therapy monitoring approach in vitro and in vivo while being able to form parental tumors when orthotopically injected and serially transplanted in immunocompromised murine hosts. Results: In line with recent evidence of multiclonal cancer composition, we optimized in vitro cultures enriched of multiple tumor-propagating populations. Orthotopic xenograft masses recapitulated morphology, grading and malignancy of parental cancers. High-grade but not the low-grade neoplasias, resulted in efficient serial transplantation in mice. Engraftment capacity paralleled grading and recurrence frequency advocating for a prognostic value of our developed model system. Therefore, in search of novel molecular indicators for therapy decision-making, we used Reverse-Phase Protein Arrays (RPPA) to analyze a panel of total and phosphorylated proteins in the isolated populations. Tumor-propagating cells showed several deregulated kinase cascades associated with grading, including angiog

Sunquakes are created by the hydrodynamic response of the lower atmosphere to a sudden deposition of energy and momentum. In this study we investigate a sunquake that occurred in NOAA active region 11675 on 17 February 2013. Observations of the corona, chromosphere and photosphere are brought together for the first time with a non-linear force-free model of the active region's magnetic field in order to probe the magnetic environment in which the sunquake was initiated. We find that the sunquake was associated with the destabilization of a flux rope and an associated M-class GOES flare. Active region 11675 was in its emergence phase at the time of the sunquake and photospheric motions caused by the emergence heavily modified the flux rope and its associated quasi-separatrix layers, eventually triggering the flux rope's instability. The flux rope was surrounded by an extended envelope of field lines rooted in a small area at the approximate position of the sunquake. We argue that the configuration of the envelope, by interacting with the expanding flux rope, created a "magnetic lens" that may have focussed energy in one particular location the photosphere, creating the necessary conditions for the initiation of the sunquake., Comment: 20 pages, 16 Figures. Some figures have lower resolution than published version

We observed an elongated filamentary bright structure inside the umbra of the big sunspot in active region NOAA 12529, which differs from the light bridges usually observed in sunspots for its morphology, magnetic configuration, and velocity field. We used observations taken with the Solar Dynamic Observatory satellite to characterize this feature. Its lifetime is 5 days, during which it reaches a maximum length of about 30". In the maps of the vertical component of the photospheric magnetic field, a portion of the feature has a polarity opposite to that of the hosting sunspot. At the same time, in the entire feature the horizontal component of the magnetic field is about 2000 G, substantially stronger than in the surrounding penumbral filaments. Doppler velocity maps reveal the presence of both upward and downward plasma motions along the structure at the photospheric level. Moreover, looking at the chromospheric level, we noted that it is located in a region corresponding to the edge of a small filament which seems rooted in the sunspot umbra. Therefore, we interpreted the bright structure as the photospheric counterpart of a flux rope touching the sunspot and giving rise to penumbral-like filaments in the umbra., Comment: 6 pages, 3 figures, accepted for ApJL

Sunquakes are created by the hydrodynamic response of the lower atmosphere to a sudden deposition of energy and momentum. In this study we investigate a sunquake that occurred in NOAA active region 11675 on 17 February 2013. Observations of the corona, chromosphere and photosphere are brought together for the first time with a non-linear force-free model of the active region's magnetic field in order to probe the magnetic environment in which the sunquake was initiated. We find that the sunquake was associated with the destabilization of a flux rope and an associated M-class GOES flare. Active region 11675 was in its emergence phase at the time of the sunquake and photospheric motions caused by the emergence heavily modified the flux rope and its associated quasi-separatrix layers, eventually triggering the flux rope's instability. The flux rope was surrounded by an extended envelope of field lines rooted in a small area at the approximate position of the sunquake. We argue that the configuration of the envelope, by interacting with the expanding flux rope, created a "magnetic lens" that may have focussed energy in one particular location the photosphere, creating the necessary conditions for the initiation of the sunquake., Comment: 20 pages, 16 Figures. Some figures have lower resolution than published version

We observed an elongated filamentary bright structure inside the umbra of the big sunspot in active region NOAA 12529, which differs from the light bridges usually observed in sunspots for its morphology, magnetic configuration, and velocity field. We used observations taken with the Solar Dynamic Observatory satellite to characterize this feature. Its lifetime is 5 days, during which it reaches a maximum length of about 30". In the maps of the vertical component of the photospheric magnetic field, a portion of the feature has a polarity opposite to that of the hosting sunspot. At the same time, in the entire feature the horizontal component of the magnetic field is about 2000 G, substantially stronger than in the surrounding penumbral filaments. Doppler velocity maps reveal the presence of both upward and downward plasma motions along the structure at the photospheric level. Moreover, looking at the chromospheric level, we noted that it is located in a region corresponding to the edge of a small filament which seems rooted in the sunspot umbra. Therefore, we interpreted the bright structure as the photospheric counterpart of a flux rope touching the sunspot and giving rise to penumbral-like filaments in the umbra., Comment: 6 pages, 3 figures, accepted for ApJL

Although a significant subset of prostate tumors remain indolent during the entire life, the advanced forms are still one of the leading cause of cancer-related death. There are not reliable markers distinguishing indolent from aggressive forms. Here we highlighted a new molecular circuitry involving microRNA and coding genes promoting cancer progression and castration resistance. Our preclinical and clinical data demonstrated that c-Met activation increases miR-130b levels, inhibits androgen receptor expression, promotes cancer spreading and resistance to hormone ablation therapy. The relevance of these findings was confirmed on patients' samples and by in silico analysis on an independent patient cohort from Taylor's platform. Data suggest c-Met/miR-130b axis as a new prognostic marker for patients' risk assessment and as an indicator of therapy resistance. Our results propose new biomarkers for therapy decision-making in all phases of the pathology. Data may help identify high-risk patients to be treated with adjuvant therapy together with alternative cure for castration-resistant forms while facilitating the identification of possible patients candidates for anti-Met therapy. In addition, we demonstrated that it is possible to evaluate Met/miR-130b axis expression in exosomes isolated from peripheral blood of surgery candidates and advanced patients offering a new non-invasive tool for active surveillance and therapy monitoring.

Although a significant subset of prostate tumors remain indolent during the entire life, the advanced forms are still one of the leading cause of cancer-related death. There are not reliable markers distinguishing indolent from aggressive forms. Here we highlighted a new molecular circuitry involving microRNA and coding genes promoting cancer progression and castration resistance. Our preclinical and clinical data demonstrated that c-Met activation increases miR-130b levels, inhibits androgen receptor expression, promotes cancer spreading and resistance to hormone ablation therapy. The relevance of these findings was confirmed on patients’ samples and by in silico analysis on an independent patient cohort from Taylor’s platform. Data suggest c-Met/miR-130b axis as a new prognostic marker for patients’ risk assessment and as an indicator of therapy resistance. Our results propose new biomarkers for therapy decision-making in all phases of the pathology. Data may help identify high-risk patients to be treated with adjuvant therapy together with alternative cure for castration-resistant forms while facilitating the identification of possible patients candidates for anti-Met therapy. In addition, we demonstrated that it is possible to evaluate Met/miR-130b axis expression in exosomes isolated from peripheral blood of surgery candidates and advanced patients offering a new non-invasive tool for active surveillance and therapy monitoring.Oncogene advance online publication, 13 February 2017; doi:10.1038/onc.2016.505.

Critical Edition of Cassiodorus'Variae with the first complete translation into a modern language and a historical and philological commentary

Critical Edition of Cassiodorus'Variae with the first complete translation into a modern language and a historical and philological commentary

Se describen cinco casos de leucemias positivas para el virus humano de leucemia/linfoma tipo I (HTLV-1). Tres de los pacientes eran nativos de una región de alta endemicidad para este virus, (Estado Zulia, Venezuela) y padecían de leucemia aguda linfoblástica o indiferenciada. Los otros dos pacientes eran originarios de una zona de baja endemicidad (Caracas), con leucemia linfocítica crónica y promielocítica aguda. El estudio de los marcadores de superficie celular no mostró evidencia de un fenotipo de leucemia de célula T del adulto en ningún caso y sugiere que la infección por HTLV-1 puede estar asociada con desórdenes proliferativos no T. Alternativamente HUV-1 puede ser el agente etiológico de una variedad de formas de leucemias, específicamente en las áreas de alta endemicidad en el Caribe.

En este trabajo se cuantifica la variabilidad radial y apical de los canales resiníferos de pino radiata (Pinus radiata) de 14 años. Se determinó la frecuencia y el tamaño de los canales resiníferos en muestras microtomadas usando un software comercial. Las muestras fueron extraídas de árboles en pie presentando tres niveles diferentes de resinación externa, es decir, moderada/leve, e intensa. Se evaluó la variabilidad de los canales resiníferos según la posición radial a tres diferentes alturas: base, DAP, y al comienzo de la copa del árbol. Los resultados muestran que la variación radial y apical del tamaño y la frecuencia de canales resiníferos aparece débilmente correlacionada con el nivel de intensidad de resinación observada en árboles en pie de pino radiata.

En este trabajo se cuantifica la variabilidad radial y apical de los canales resiníferos de pino radiata (Pinus radiata) de 14 años. Se determinó la frecuencia y el tamaño de los canales resiníferos en muestras microtomadas usando un software comercial. Las muestras fueron extraídas de árboles en pie presentando tres niveles diferentes de resinación externa, es decir, moderada/leve, e intensa. Se evaluó la variabilidad de los canales resiníferos según la posición radial a tres diferentes alturas: base, DAP, y al comienzo de la copa del árbol. Los resultados muestran que la variación radial y apical del tamaño y la frecuencia de canales resiníferos aparece débilmente correlacionada con el nivel de intensidad de resinación observada en árboles en pie de pino radiata.

En este trabajo se cuantifica la variabilidad radial y apical de los canales resiníferos de pino radiata (Pinus radiata) de 14 años. Se determinó la frecuencia y el tamaño de los canales resiníferos en muestras microtomadas usando un software comercial. Las muestras fueron extraídas de árboles en pie presentando tres niveles diferentes de resinación externa, es decir, moderada/leve, e intensa. Se evaluó la variabilidad de los canales resiníferos según la posición radial a tres diferentes alturas: base, DAP, y al comienzo de la copa del árbol. Los resultados muestran que la variación radial y apical del tamaño y la frecuencia de canales resiníferos aparece débilmente correlacionada con el nivel de intensidad de resinación observada en árboles en pie de pino radiata.

En este trabajo se cuantifica la variabilidad radial y apical de los canales resiníferos de pino radiata (Pinus radiata) de 14 años. Se determinó la frecuencia y el tamaño de los canales resiníferos en muestras microtomadas usando un software comercial. Las muestras fueron extraídas de árboles en pie presentando tres niveles diferentes de resinación externa, es decir, moderada/leve, e intensa. Se evaluó la variabilidad de los canales resiníferos según la posición radial a tres diferentes alturas: base, DAP, y al comienzo de la copa del árbol. Los resultados muestran que la variación radial y apical del tamaño y la frecuencia de canales resiníferos aparece débilmente correlacionada con el nivel de intensidad de resinación observada en árboles en pie de pino radiata.