1. Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus
- Author
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Arinjay, Banerjee, Andrew C., Doxey, Benjamin J.-M., Tremblay, Michael J., Mansfield, Sonu, Subudhi, Jeremy A., Hirota, Matthew S., Miller, Andrew G., McArthur, Samira, Mubareka, Karen, Mossman, Arinjay, Banerjee, Andrew C., Doxey, Benjamin J.-M., Tremblay, Michael J., Mansfield, Sonu, Subudhi, Jeremy A., Hirota, Matthew S., Miller, Andrew G., McArthur, Samira, Mubareka, and Karen, Mossman
- Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged to cause widespread infections in humans. SARS-CoV-2 infections have been reported in the Kingdom of Saudi Arabia, where Middle East respiratory syndrome coronavirus (MERS-CoV) causes seasonal outbreaks with a case fatality rate of ~37 %. Here we show that there exists a theoretical possibility of future recombination events between SARS-CoV-2 and MERS-CoV RNA. Through computational analyses, we have identified homologous genomic regions within the ORF1ab and S genes that could facilitate recombination, and have analysed co-expression patterns of the cellular receptors for SARS-CoV-2 and MERS-CoV, ACE2 and DPP4, respectively, to identify human anatomical sites that could facilitate co-infection. Furthermore, we have investigated the likely susceptibility of various animal species to MERS-CoV and SARS-CoV-2 infection by comparing known virus spike protein–receptor interacting residues. In conclusion, we suggest that a recombination between SARS-CoV-2 and MERS-CoV RNA is possible and urge public health laboratories in high-risk areas to develop diagnostic capability for the detection of recombined coronaviruses in patient samples., source:https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001491
- Published
- 2020