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Baiheremujiang Abuduaini,1,* Long Yang,2,* Nueraihemaiti Jiamali,1 Zulihuma Seyiti,2 Xue-Feng Shan,3– 5 Xiao-Ming Gao4– 6 1First Clinical Medical College, Xinjiang Medical University, Urumqi, People’s Republic of China; 2College of Pediatrics, Xinjiang Medical University, Urumqi, People’s Republic of China; 3Pediatric Cardiothoracic Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of China; 4State Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia, Department of Cardiology of the First Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of China; 5Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, People’s Republic of China; 6Clinical Medical Research Institute of Xinjiang Medical University, Urumqi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao-Ming Gao, State Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia, 137 Liyushan South Road, Urumqi, 830054, People’s Republic of China, Tel/Fax +86-991-4362844, Email xiaominggao2017@163.com Xue-Feng Shan, Pediatric cardiothoracic Surgery, First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, People’s Republic of China, Tel/Fax +86-991-4362844, Email xuefengShan1982@163.comBackground: The triglyceride-glucose (TyG) index is regarded as an independent predictor of cardiovascular (CV) consequences and a reliable surrogate measure of insulin resistance (IR). However, the predictive significance of the TyG index in patients with type 2 diabetes mellitus (T2DM) and ischemic cardiomyopathy (ICM) remains unknown.Methods: This study included 1514 consecutive subjects with ICM and T2DM. The tertile of the TyG index values was used to categorize these patients into three groups. Major adverse cardiac and cerebral even