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In implicit collaborative filtering, hard negative mining techniques are developed to accelerate and enhance the recommendation model learning. However, the inadvertent selection of false negatives remains a major concern in hard negative sampling, as these false negatives can provide incorrect information and mislead the model learning. To date, only a small number of studies have been committed to solve the false negative problem, primarily focusing on designing sophisticated sampling algorithms to filter false negatives. In contrast, this paper shifts its focus to refining the loss function. We find that the original Bayesian Personalized Ranking (BPR), initially designed for uniform negative sampling, is inadequate in adapting to hard sampling scenarios. Hence, we introduce an enhanced Bayesian Personalized Ranking objective, named as Hard-BPR, which is specifically crafted for dynamic hard negative sampling to mitigate the influence of false negatives. This method is simple yet efficient for real-world deployment. Extensive experiments conducted on three real-world datasets demonstrate the effectiveness and robustness of our approach, along with the enhanced ability to distinguish false negatives., Comment: 9 pages

Motivation Effective drug delivery systems are paramount in enhancing pharmaceutical outcomes, particularly through the use of cell-penetrating peptides (CPPs). These peptides are gaining prominence due to their ability to penetrate eukaryotic cells efficiently without inflicting significant damage to the cellular membrane, thereby ensuring optimal drug delivery. However, the identification and characterization of CPPs remain a challenge due to the laborious and time-consuming nature of conventional methods, despite advances in proteomics. Current computational models, however, are predominantly tailored for balanced datasets, an approach that falls short in real-world applications characterized by a scarcity of known positive CPP instances.Results To navigate this shortfall, we introduce PractiCPP, a novel deep-learning framework tailored for CPP prediction in highly imbalanced data scenarios. Uniquely designed with the integration of hard negative sampling and a sophisticated feature extraction and prediction module, PractiCPP facilitates an intricate understanding and learning from imbalanced data. Our extensive computational validations highlight PractiCPP's exceptional ability to outperform existing state-of-the-art methods, demonstrating remarkable accuracy, even in datasets with an extreme positive-to-negative ratio of 1:1000. Furthermore, through methodical embedding visualizations, we have established that models trained on balanced datasets are not conducive to practical, large-scale CPP identification, as they do not accurately reflect real-world complexities. In summary, PractiCPP potentially offers new perspectives in CPP prediction methodologies. Its design and validation, informed by real-world dataset constraints, suggest its utility as a valuable tool in supporting the acceleration of drug delivery advancements.Availability and implementation The source code of PractiCPP is available on Figshare at https://doi.org/10.6084/m9.figshare.25053878.v1.

Recently, neural control policies have outperformed existing model-based planning-and-control methods for autonomously navigating quadrotors through cluttered environments in minimum time. However, they are not perception aware, a crucial requirement in vision-based navigation due to the camera's limited field of view and the underactuated nature of a quadrotor. We propose a learning-based system that achieves perception-aware, agile flight in cluttered environments. Our method combines imitation learning with reinforcement learning (RL) by leveraging a privileged learning-by-cheating framework. Using RL, we first train a perception-aware teacher policy with full-state information to fly in minimum time through cluttered environments. Then, we use imitation learning to distill its knowledge into a vision-based student policy that only perceives the environment via a camera. Our approach tightly couples perception and control, showing a significant advantage in computation speed (10×faster) and success rate. We demonstrate the closed-loop control performance using hardware-in-the-loop simulation.

Humans can perform parkour by traversing obstacles in a highly dynamic fashion requiring precise eye-muscle coordination and movement. Getting robots to do the same task requires overcoming similar challenges. Classically, this is done by independently engineering perception, actuation, and control systems to very low tolerances. This restricts them to tightly controlled settings such as a predetermined obstacle course in labs. In contrast, humans are able to learn parkour through practice without significantly changing their underlying biology. In this paper, we take a similar approach to developing robot parkour on a small low-cost robot with imprecise actuation and a single front-facing depth camera for perception which is low-frequency, jittery, and prone to artifacts. We show how a single neural net policy operating directly from a camera image, trained in simulation with large-scale RL, can overcome imprecise sensing and actuation to output highly precise control behavior end-to-end. We show our robot can perform a high jump on obstacles 2x its height, long jump across gaps 2x its length, do a handstand and run across tilted ramps, and generalize to novel obstacle courses with different physical properties. Parkour videos at https://extreme-parkour.github.io, Comment: Website and videos at https://extreme-parkour.github.io

In implicit collaborative filtering (CF) task of recommender systems, recent works mainly focus on model structure design with promising techniques like graph neural networks (GNNs). Effective and efficient negative sampling methods that suit these models, however, remain underdeveloped. One challenge is that existing hard negative samplers tend to suffer from severer over-fitting in model training. In this work, we first study the reason behind the over-fitting, and illustrate it with the incorrect selection of false negative instances with the support of experiments. In addition, we empirically observe a counter-intuitive phenomenon, that is, polluting hard negative samples' embeddings with a quite large proportional of positive samples' embeddings will lead to remarkable performance gains for prediction accuracy. On top of this finding, we present a novel negative sampling strategy, i.e., positive-dominated negative synthesizing (PDNS). Moreover, we provide theoretical analysis and derive a simple equivalent algorithm of PDNS, where only a soft factor is added in the loss function. Comprehensive experiments on three real-world datasets demonstrate the superiority of our proposed method in terms of both effectiveness and robustness., Comment: 9 pages, 16 figures

Recently, neural control policies have outperformed existing model-based planning-and-control methods for autonomously navigating quadrotors through cluttered environments in minimum time. However, they are not perception aware, a crucial requirement in vision-based navigation due to the camera's limited field of view and the underactuated nature of a quadrotor. We propose a learning-based system that achieves perception-aware, agile flight in cluttered environments. Our method combines imitation learning with reinforcement learning (RL) by leveraging a privileged learning-by-cheating framework. Using RL, we first train a perception-aware teacher policy with full-state information to fly in minimum time through cluttered environments. Then, we use imitation learning to distill its knowledge into a vision-based student policy that only perceives the environment via a camera. Our approach tightly couples perception and control, showing a significant advantage in computation speed (10 times faster) and success rate. We demonstrate the closed-loop control performance using hardware-in-the-loop simulation.

With the more and more extensive application of blockchain, blockchain security has been widely concerned by the society and deeply studied by scholars. Moreover, the security of blockchain data directly affects the security of various applications of blockchain. In this survey, we perform a comprehensive classification and summary of the security of blockchain data. First, we present classification of blockchain data attacks. Subsequently, we present the attacks and defenses of blockchain data in terms of privacy, availability, integrity and controllability. Data privacy attacks present data leakage or data obtained by attackers through analysis. Data availability attacks present abnormal or incorrect access to blockchain data. Data integrity attacks present blockchain data being tampered. Data controllability attacks present blockchain data accidentally manipulated by smart contract vulnerability. Finally, we present several important open research directions to identify follow-up studies in this area.