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Identification and localization of a dynamic impact load applied to a structure are crucial for monitoring its health and safety. Traditional methods based on inversion techniques, either in time-domain or frequency-domain, require large computational cost which cannot achieve real-time implementation. This study proposes a novel deep learning algorithm for accurately localizing a dynamic impact load applied to a structure by deploying a limited number of sensors. The development of the deep learning algorithm involves: 1) time history analysis of a structural finite element model subjected to random impact loading to generate training dataset; 2) development of a deep neural network model to extract and regress the inherent relationship in multivariate time series between input loading and output responses. The proposed approach is verified on a rectangular plate structure subjected to simulated impact loading at a total of 88 possible locations. A high accuracy rate of 96% achieved in 1 millisecond demonstrate the superiority of the proposed deep neural network in achieving real-time localization of structural impact load.

Lei Qiao, Yue Chen, Xiaofan Song, Xina Dou, Chunlan Xu The Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, People’s Republic of ChinaCorrespondence: Chunlan Xu, The Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, People’s Republic of China, Tel +86 29-88460543, Fax +86 29-88460332, Email clxu@nwpu.edu.cnPurpose: The bidirectional communication between the gut and the central nervous system mediated by gut microbiota is closely related to the occurrence and development of neurodegenerative diseases, including Alzheimer’s disease (AD). Selenium (Se) has been identified as playing a role against AD. Probiotics have beneficial effects on host brain function and behavior by modulating the microbiota-gut-brain axis. Herein, we evaluated the protective effects of Lactobacillus casei ATCC 393 (L. casei ATCC 393) and selenium nanoparticles-enriched L. casei ATCC 393 (L. casei ATCC 393-SeNPs) against D-galactose/aluminum chloride-induced AD model mice.Methods: The Morris Water Maze (MWM) test was used to assess cognitive function of mice. The morphology and histopathological changes, antioxidant capacity and immune responses in the brain and ileum were evaluated. The alterations in intestinal permeability of the mice were determined using FITC-dextran. Gut microbiota composition was assessed using 16s rRNA sequencing.Results: Thirteen weeks intervention with L. casei ATCC 393 or L. casei ATCC 393-SeNPs significantly improved cognitive dysfunction, and minimized amyloid beta (Aβ) aggregation, hyperphosphorylation of TAU protein, and prevented neuronal death by modulating Akt/cAMP-response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway. Moreover, compared with L. casei ATCC 393, L. casei ATCC 393-SeNPs further effectively mi

How to better integrate urban texture, architecture, and culture organically, and use the architecture as a carrier to transmit more humanistic information? In today's society, people have a variety of ways to explore the culture and understand the culture. However, the most direct experience is a personal experience. As the most important carrier of human activities, architecture cannot be overlooked. From the direct sensory experience and indirect behavioral patterns, architecture is involved in human activities and ways of thinking all the time. Therefore, the combination of culture and architecture organically will give people a better way and angle to understand the culture. The relationship between local culture and local architecture is inextricably linked. However, how to integrate foreign culture into local architecture will be a very difficult problem. Directly transplanting buildings and cultural elements from a foreign culture to a local city will make the building incompatible with the original urban texture. It is not easy for local residents to accept this foreign culture from the aesthetic perspective or psychological perspective. In my thesis, I hope to design a cultural center that can match the texture of the local city and reflect the foreign culture through my thinking about the architecture and the understanding of the foreign culture: design a Chinese cultural center in Chinatown, Washington DC, to find out a reasonable way for cultural communication.