1. Recent Advances and Future Directions in Bone Marrow Transplantation
- Author
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INTERNATIONAL SOCIETY FOR EXPERIMENTAL HEMATOLOGY BETHESDA MD, Baum, S. J., Santos, G. W., Takaku, F., INTERNATIONAL SOCIETY FOR EXPERIMENTAL HEMATOLOGY BETHESDA MD, Baum, S. J., Santos, G. W., and Takaku, F. more...
- Abstract
This is a compilation of papers presented at a symposia on Bone Marrow transplantation. Marrow transplantation is now a world wide endeavor. The results of autologous marrow transplantation in lymphomas and the acute leukemias are encouraging and provide potential solutions to the problem of lack of sufficient donors. Whether marrow purging with monoclonal antibodies, chemicals or depletion of leukemic contamination by long term marrow culture is necessary is perhaps controversial but early therapeutic results are quite encouraging. Graft-versus-host disease (GVHD) remains a serious problem in most centers. T cell depletion of marrow may lessen or prevent this complication but often this at the expense of marrow rejection or increase in relapse of leukemia. Leukemic relapses present a continuing problem particularly in allogeneic transplants after T cell depletion, in patients transplanted in second or subsequent remissions and in autologous transplants. New creative approaches with new preparative regimens are needed. A few of the reports in this symposium suggest that there may be very valid regimens such as busulfan and cyclophosphamide and monoclonal antibody directed radiation that do not involve conventional total body irradiation. Deaths due to bacterial, fungal, and viral infections are being reduced in many centers using some of the studies outlined in this symposium. more...
- Published
- 1987