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Peng J, Wang S, Fan W, et al. Onco Targets Ther. 2018;11:6887‒6900. At the authors request, the Editor and Publisher of OncoTargets and Therapy wish to retract the published article. The authors requested to replace western blot images in Figure 4, where images for Figure 4, THP-1, CyclinD1 and THP-1, CDK2 appeared to have been duplicated. Further analysis found evidence for the manipulation of western blot images in Figure 3. Specifically, Images for Figure 3B, panels KG-1; HL-60; K562, p53/p100 all appear to have been duplicated and enhanced to give the appearance of being distinct western blot bands. The authors provided some original western blot data, but it was not satisfactory and was unable to adequately verify the reported findings. The authors requested to retract the article and the Editor agreed with this. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.

This paper has been retracted.Peng J, Wang S, Fan W, et al. Onco Targets Ther. 2018;11:6887‒6900. At the authors request, the Editor and Publisher of OncoTargets and Therapy wish to retract the published article. The authors requested to replace western blot images in Figure 4, where images for Figure 4, THP-1, CyclinD1 and THP-1, CDK2 appeared to have been duplicated. Further analysis found evidence for the manipulation of western blot images in Figure 3. Specifically, Images for Figure 3B, panels KG-1; HL-60; K562, p53/p100 all appear to have been duplicated and enhanced to give the appearance of being distinct western blot bands. The authors provided some original western blot data, but it was not satisfactory and was unable to adequately verify the reported findings. The authors requested to retract the article and the Editor agreed with this. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.

Shibing Wang,1,2,* Jing Shu,3,* Li Chen,4 Xiaopan Chen,3 Jianhong Zhao,4 Shuangshuang Li,1,2 Xiaozhou Mou,1,2 Xiangmin Tong1,2 1Clinical Research Institute, Zhejiang Provincial People’s Hospital, 2Key Laboratory of Cancer Molecular Diagnosis and Individualized Therapy of Zhejiang Province, 3Department of Reproductive Endocrinology, Zhejiang Provincial People’s Hospital, 4Department of Obstetrics and Gynecology, Hangzhou Red Cross Hospital, Hangzhou, People’s Republic of China *These authors contributed equally to this work Abstract: Gene therapy on the basis of oncolytic adenovirus is a novel approach for human cancer therapeutics. We aim to investigate whether it will synergistically reinforce their antiovarian cancer activities when the combined use of ZD55-manganese superoxide dismutase (MnSOD) and cisplatin was performed. The experiments in vitro showed that ZD55-MnSOD enhances cisplatin-induced apoptosis and causes remarkable ovarian cancer cell death. Apoptosis induction by treatment with ZD55-MnSOD and/or cisplatin was detected in SKOV-3 by apoptotic cell staining, flow cytometry, and western blot analysis. In addition, the cytotoxicity caused by ZD55-MnSOD to normal cells was examined by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay and western blot analysis. Animal experiment further confirmed that combination of ZD55-MnSOD and cisplatin achieved significant inhibition of SKOV-3 ovarian tumor xenografted growth. In summary, we have demonstrated that ZD55-MnSOD can sensitize human ovarian cancer cells to cisplatin-induced cell death and apoptosis in vitro and in vivo. These findings indicate that the combined treatment with ZD55-MnSOD and cisplatin could represent a rational approach for antiovarian cancer therapy. Keywords: oncolytic adenovirus, MnSOD, cisplatin, ovarian cancer