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Graphene oxide foils implanted with copper ions at low energy and high dose, have been proposed as hybrid graphene-based materials suitable to be laser irradiated in vacuum to produce hot plasmas. The special lattice structure of the graphene oxide foil can improve the propagation of the laser accelerated electrons inside the foil and to enhance the electron density emerging from the rear foil surface. In such conditions the electric field developed in the non-equilibrium plasma increases and consequently in the forward ion acceleration. The foils have been optimized in thickness and they were irradiated with optimized laser parameters in order to produce high energy and quasi-monoenergetic proton beams by the femtosecond laser at the Institute of Plasma Physics and Laser Microfusion in Warsaw, Poland. Gaf chromic film and silicon carbide detectors were used to monitor the plasma properties and to measure the velocity of the emitted protons and carbon ions from plasma.

Thomson Spectrometers (TPs) are widely used for beam diagnostic as they provide simultaneous information on charge over mass ratio, energy and momentum of detected ions. A new TP design has been realized at INFN-LNS within the LILIA (Laser Induced Light Ion Acceleration) and ELIMED (MEDical application at ELI-Beamlines) projects. This paper reports on the construction details of the TP and on its experimental tests performed at PALS laboratory in Prague, with the ASTERIX IV laser system. Reported data are obtained with polyethylene and polyvinyl alcohol solid targets, they have been compared with data obtained from other detectors. Consistency among results confirms the correct functioning of the new TP. The main features, characterizing the design, are a wide acceptance of the deflection sector and a tunability of the, partially overlapping, magnetic and electric fields that allow to resolve ions with energy up to about 40 MeV for protons.

ELI-Beamlines is one of the pillars of the pan-European project ELI (Extreme Light Infrastructure). It will be an ultra high-intensity, high repetition-rate, femtosecond laser facility whose main goal is generation and applications of high-brightness X-ray sources and accelerated charged particles in different fields. Particular care will be devoted to the potential applicability of laser-driven ion beams for medical treatments of tumors. Indeed, such kind of beams show very interesting peculiarities and, moreover, laser-driven based accelerators can really represent a competitive alternative to conventional machines since they are expected to be more compact in size and less expensive. The ELIMED project was launched thanks to a collaboration established between FZU-ASCR (ELI-Beamlines) and INFN-LNS researchers. Several European institutes have already shown a great interest in the project aiming to explore the possibility to use laser-driven ion (mostly proton) beams for several applications with a particular regard for medical ones. To reach the project goal several tasks need to be fulfilled, starting from the optimization of laser-target interaction to dosimetric studies at the irradiation point at the end of a proper designed transport beam-line. Researchers from LNS have already developed and successfully tested a high-dispersive power Thomson Parabola Spectrometer, which is the first prototype of a more performing device to be used within the ELIMED project. Also a Magnetic Selection System able to produce a small pencil beam out of a wide energy distribution of ions produced in laser-target interaction has been realized and some preliminary work for its testing and characterization is in progress. In this contribution the status of the project will be reported together with a short description of the of the features of device recently developed.

Laser accelerated proton beams represent nowadays an attractive alternative to the conventional ones and they have been proposed in different research fields. In particular, the interest has been focused in the possibility of replacing conventional accelerating machines with laser-based accelerators in order to develop a new concept of hadrontherapy facilities, which could result more compact and less expensive. With this background the ELIMED (ELIMED: ELI-Beamlines MEDical applications) research project has been launched by LNS-INFN researchers (Laboratori Nazionali del Sud-Istituto Nazionale di Fisica Nucleare, Catania, IT) and ASCR-FZU researchers (Academy of Sciences of the Czech Republic-Fyzikální ústar, Prague, Cz), within the pan-European ELI-Beamlines facility framework. Its main purposes are the demonstration of future applications in hadrontherapy of optically accelerated protons and the realization of a laser-accelerated ion transport beamline for multidisciplinary applications. Several challenges, starting from laser-target interaction and beam transport development, up to dosimetric and radiobiological issues, need to be overcome in order to reach the final goals. The design and the realization of a preliminary beam handling and dosimetric system and of an advanced spectrometer for high energy (multi-MeV) laser-accelerated ion beams will be shortly presented in this work.

ELI-Beamlines is one of the pillars of the pan-European project ELI (Extreme Light Infrastructure). It will be an ultra high-intensity, high repetition-rate, femtosecond laser facility whose main goal is generation and applications of high-brightness X-ray sources and accelerated charged particles in different fields. Particular care will be devoted to the potential applicability of laser-driven ion beams for medical treatments of tumors. Indeed, such kind of beams show very interesting peculiarities and, moreover, laser-driven based accelerators can really represent a competitive alternative to conventional machines since they are expected to be more compact in size and less expensive. The ELIMED project was launched thanks to a collaboration established between FZU-ASCR (ELI-Beamlines) and INFN-LNS researchers. Several European institutes have already shown a great interest in the project aiming to explore the possibility to use laser-driven ion (mostly proton) beams for several applications with a particular regard for medical ones. To reach the project goal several tasks need to be fulfilled, starting from the optimization of laser-target interaction to dosimetric studies at the irradiation point at the end of a proper designed transport beam-line. Researchers from LNS have already developed and successfully tested a high-dispersive power Thomson Parabola Spectrometer, which is the first prototype of a more performing device to be used within the ELIMED project. Also a Magnetic Selection System able to produce a small pencil beam out of a wide energy distribution of ions produced in laser-target interaction has been realized and some preliminary work for its testing and characterization is in progress. In this contribution the status of the project will be reported together with a short description of the of the features of device recently developed.

ELI-Beamlines is one of the pillars of the pan-European project ELI (Extreme Light Infrastructure). It will be an ultra high-intensity, high repetition-rate, femtosecond laser facility whose main goal is generation and applications of high-brightness X-ray sources and accelerated charged particles in different fields. Particular care will be devoted to the potential applicability of laser-driven ion beams for medical treatments of tumors. Indeed, such kind of beams show very interesting peculiarities and, moreover, laser-driven based accelerators can really represent a competitive alternative to conventional machines since they are expected to be more compact in size and less expensive. The ELIMED project was launched thanks to a collaboration established between FZU-ASCR (ELI-Beamlines) and INFN-LNS researchers. Several European institutes have already shown a great interest in the project aiming to explore the possibility to use laser-driven ion (mostly proton) beams for several applications with a particular regard for medical ones. To reach the project goal several tasks need to be fulfilled, starting from the optimization of laser-target interaction to dosimetric studies at the irradiation point at the end of a proper designed transport beam-line. Researchers from LNS have already developed and successfully tested a high-dispersive power Thomson Parabola Spectrometer, which is the first prototype of a more performing device to be used within the ELIMED project. Also a Magnetic Selection System able to produce a small pencil beam out of a wide energy distribution of ions produced in laser-target interaction has been realized and some preliminary work for its testing and characterization is in progress. In this contribution the status of the project will be reported together with a short description of the of the features of device recently developed.

Laser-ion acceleration has recently gained a great interest as an alternative to conventional and more expensive acceleration techniques. These ion beams have desirable qualities such as small source size, high luminosity and small emittance to be used in different fields as Nuclear Physics, Medical Physics, etc. This is very promising specially for the future perspective of a new concept of hadrontherapy based on laser-based devices could be developed, replacing traditional accelerating machines. Before delivering laser-driven beams for treatments they have to be handled, cleaned from unwanted particles and characterized in order to have the clinical requirements. In fact ion energy spectra have exponential trend, almost 100% energy spread and a wide angular divergence which is the biggest issue in the beam transport and, hence, in a wider use of this technology. In order to demonstrate the clinical applicability of laser-driven beams new collaboration between ELI-Beamlines project researchers from Prague (Cz) and a INFN-LNS group from Catania (I) has been already launched and scientists from different countries have already express their will in joining the project. This cooperation has been named ELIMED (MEDical application at ELIBeamlines) and will take place inside the ELI-Beamlines infrastructure located in Prague. This work describes the schedule of the ELIMED project and the design of the energy selector which will be realized at INFN-LNS. The device is an important part of the whole transport beam line which will be realised in order to make the ion beams suitable for medical applications.

The prediction of surface drift of floating objects is an important task, with applications such as marine transport, pollutant dispersion, and search-and-rescue activities. But forecasting even the drift of surface waters is very challenging, because it depends on complex interactions of currents driven by the wind, the wave field and the general prevailing circulation. Furthermore, although each of those can be forecasted by deterministic models, the latter all suffer from limitations, resulting in imperfect predictions. In the present study, we try and predict the drift of two buoys launched during the DART06 (Dynamics of the Adriatic sea in Real-Time 2006) and MREA07 (Maritime Rapid Environmental Assessment 2007) sea trials, using the so-called hyper-ensemble technique: different models are combined in order to minimize departure from independent observations during a training period; the obtained combination is then used in forecasting mode. We review and try out different hyper-ensemble techniques, such as the simple ensemble mean, least-squares weighted linear combinations, and techniques based on data assimilation, which dynamically update the model's weights in the combination when new observations become available. We show that the latter methods alleviate the need of fixing the training length a priori, as older information is automatically discarded., The original document contains color images. All DTIC reproductions will be in black and white. Published in Progress in Oceanography v82 p149-167, 2009.

The genetic progressive myoclonus epilepsies (PMEs) are clinically characterized by the triad of stimulus sensitive myoclonus (segmental lightning like muscular jerks), epilepsy (grand mal and absences) and progressive neurologic deterioration (dementia, ataxia, and various neurologic signs depending on the cause). Etiologically heterogenous, PMEs are rare and mostly autosomal recessive disorders, with the exception of autosomal dominant dentatorubral-pallidoluysian atrophy and mitochondrial encephalomyopathy with ragged red fibers (MERRF). In the last five years, specific mutations have been defined in Lafora disease (gene for laforin or dual specificity phosphatase in 6q24), Unverricht-Lundborg disease (cystatin B in 21q22.3), Jansky-Bielschowsky ceroid lipofuscinoses (CLN2 gene for tripeptidyl peptidase 1 in 11q15), Finnish variant of late infantile ceroid lipofuscinoses (CLN5 gene in 13q21-32 encodes 407 amino acids with two transmembrane helices of unknown function), juvenile ceroid lipofuscinoses or Batten disease (CLN3 gene in 16p encodes 438 amino acid protein of unknown function), a subtype of Batten disease and infantile ceroid lipofuscinoses of the Haltia-Santavuori type (both are caused by mutations in palmitoyl-protein thiosterase gene at 1p32), dentadorubropallidoluysian atrophy (CAG repeats in a gene in 12p13.31) and the mitochondrial syndrome MERRF (tRNA Lys mutation in mitochondrial DNA). In this review, we cover mainly these rapid advances. © 2001 Wiley-Liss, Inc.

Mosaicism for trisomy 17 in amniocyte cultures is a rare finding, whilst postnatal cases are exceptional. In order to gain insight into the possible effects of the distribution of the trisomic line and of uniparental disomy (UPD) on embryofoetal development, we have performed follow-up clinical, cytogenetic and molecular investigations into three newly detected prenatal cases of trisomy 17 mosaicism identified in cultured amniotic fluid. In the first case, the pregnancy ended normally with the birth of a healthy girl, and analysis of newborn lymphocytes and of multiple extra-embryonic tissues was indicative of confined placental mosaicism. The second case was also associated with a normal pregnancy outcome and postnatal development, and only euploid cells were found in peripheral blood after birth. However, maternal isodisomy 17 consequent to a meiosis II error and loss of a chromosome 17 homologue was detected in peripheral lymphocytes postnatally. In the third case, pathological examination after termination of pregnancy showed growth retardation and minor dysmorphisms, and the trisomic line was detected in foetal skin fibroblasts. In addition, biparental derivation of chromosome 17 was demonstrated in the euploid lineage. These results, together with previously reported data, indicate that true amniotic trisomy 17 mosaicism is more commonly of extra-embryonic origin and associated with normal foetal development. Phenotypic consequences may arise when the trisomic line is present in foetal tissues. Case 2 also represents the first observation of maternal UPD involving chromosome 17; the absence of phenotypic anomalies in the child suggests that chromosome 17 is not likely to be subject to imprinting in maternal gametes.

NO ABSTRACT

Duplications of chromosome 15 have been reported in individuals with atypical autism, varying degrees of mental retardation, and epilepsy. The authors report the molecular analysis, neurophysiologic, and clinical evaluation of a 12-year-old boy with atypical autism and epilepsy due to a maternally derived 15q11-q13 duplication. Their findings suggest that this chromosomal region harbors genes for autism and possibly for partial epilepsy that may act in a dose-dependent manner.

Prototypes “intelligent” membrane, whose properties are modified by external parameter (ex. temperature, pH, chemical agents, et.), can be realized by high energy ion beams irradiation. Biocompatible polymers (PVDF, PTFE, PE, ecc.) are irradiated in oxygen atmosphere by Tandem (lithium, carbon, oxygen) in the energy range 1-100 MeV and dose rate in the range 1-50 kGy. The anisotropic interaction of ion beam with polymeric chains, togheter to an etching process, produces micrometric pores. Immiscible chains are then introduced into these pores to produce active membranes. Unlike the conventional membranes, obtained by chemical processes, these ones posses an high permeability which can be tailored by the irradiating parameters.

Bioglasses composed of $SiO_2-CaO-Na_2O-P_2O_5$ are very biocompatible and active if their silicon oxide content is of about 45% in weight. Inside a biological environment bioglass elicits a specific chemical response at the glass surface, which results in the formation of a strong bond between the tissues and the material. The coverage of bio-medical prostheses and implants with bioactive films improve their surface biocompatibility, osteoconduction and osteointegration. A pulsed excimer laser, using a XeCl mixture (308 nm wavelength), 15 nsec pulse with, 20 Hz repetition rate and 200 mJ pulse energy, was used to photodeposit bioglass films on biocompatible substrates (titanium alloys and polymers). Pulsed Laser Deposition (PLD) occurs in vacuum ($10^-^6$Torr) and the glass etching is induced by fluences ranging between 0.1 and 50 J/cm^2. Deposition rates are of the order of 1 ?n/min. Obtained films are stoichiometric, are composed by a micrometric granular component and, if deposition occurs on a heated substrate, adhere well to the substrate surface. Applications of bioglass coverage concern the middle ear devices, dental implants, orthopaedic prostheses and cardiovascular devices with a restriction to devices with a low load bearing.

Prototypes “intelligent” membrane, whose properties are modified by external parameter (ex. temperature, pH, chemical agents, et.), can be realized by high energy ion beams irradiation. Biocompatible polymers (PVDF, PTFE, PE, ecc.) are irradiated in oxygen atmosphere by Tandem (lithium, carbon, oxygen) in the energy range 1-100 MeV and dose rate in the range 1-50 kGy. The anisotropic interaction of ion beam with polymeric chains, togheter to an etching process, produces micrometric pores. Immiscible chains are then introduced into these pores to produce active membranes. Unlike the conventional membranes, obtained by chemical processes, these ones posses an high permeability which can be tailored by the irradiating parameters.

Bioglasses composed of $SiO_2-CaO-Na_2O-P_2O_5$ are very biocompatible and active if their silicon oxide content is of about 45% in weight. Inside a biological environment bioglass elicits a specific chemical response at the glass surface, which results in the formation of a strong bond between the tissues and the material. The coverage of bio-medical prostheses and implants with bioactive films improve their surface biocompatibility, osteoconduction and osteointegration. A pulsed excimer laser, using a XeCl mixture (308 nm wavelength), 15 nsec pulse with, 20 Hz repetition rate and 200 mJ pulse energy, was used to photodeposit bioglass films on biocompatible substrates (titanium alloys and polymers). Pulsed Laser Deposition (PLD) occurs in vacuum ($10^-^6$Torr) and the glass etching is induced by fluences ranging between 0.1 and 50 J/cm^2. Deposition rates are of the order of 1 ?n/min. Obtained films are stoichiometric, are composed by a micrometric granular component and, if deposition occurs on a heated substrate, adhere well to the substrate surface. Applications of bioglass coverage concern the middle ear devices, dental implants, orthopaedic prostheses and cardiovascular devices with a restriction to devices with a low load bearing.