Author: "Trichopoulos D" / Publication Type: Electronic Resources - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Trichopoulos D"' showing total 760 results

Start Over Author "Trichopoulos D" Publication Type Electronic Resources

760 results on '"Trichopoulos D"'

1. Children’s and adolescents’ rising animal-source food intakes in 1990–2018 were impacted by age, region, parental education and urbanicity

Author: Miller, V. Webb, P. Cudhea, F. Zhang, J. Reedy, J. Shi, P. Erndt-Marino, J. Coates, J. Micha, R. Mozaffarian, D. Bas, M. Ali, J.H. Abumweis, S. Krishnan, A. Misra, P. Hwalla, N.C. Janakiram, C. Liputo, N.I. Musaiger, A. Pourfarzi, F. Alam, I. DeRidder, K. Termote, C. Memon, A. Turrini, A. Lupotto, E. Piccinelli, R. Sette, S. Anzid, K. Vossenaar, M. Mazumdar, P. Rached, I. Rovirosa, A. Zapata, M.E. Asayehu, T.T. Oduor, F. Boedecker, J. Aluso, L. Ortiz-Ulloa, J. Meenakshi, J.V. Castro, M. Grosso, G. Waskiewicz, A. Khan, U.S. Thanopoulou, A. Malekzadeh, R. Calleja, N. Ocke, M. Etemad, Z. Nsour, M.A. Waswa, L.M. Nurk, E. Arsenault, J. Lopez-Jaramillo, P. Sibai, A.M. Damasceno, A. Arambepola, C. Lopes, C. Severo, M. Lunet, N. Torres, D. Tapanainen, H. Lindstrom, J. Virtanen, S. Palacios, C. Roos, E. Agdeppa, I.A. Desnacido, J. Capanzana, M. Misra, A. Khouw, I. Ng, S.A. Delgado, E.G. Caballero, M. Otero, J. Lee, H.-J. Koksal, E. Guessous, I. Lachat, C. De Henauw, S. Rahbar, A.R. Tedstone, A. Naska, A. Mathee, A. Ling, A. Tedla, B. Hopping, B. Ginnela, B. Leclercq, C. Duante, C. Haerpfer, C. Hotz, C. Pitsavos, C. Rehm, C. van Oosterhout, C. Cerdena, C. Bradshaw, D. Trichopoulos, D. Gauci, D. Fernando, D. Sygnowska, E. Vartiainen, E. Farzadfar, F. Zajkas, G. Swan, G. Ma, G. Pekcan, G. Ibrahim, H.M. Sinkko, H. Barbieri, H.E. Sioen, I. Myhre, J. Gaspoz, J.-M. Odenkirk, J. Bundhamcharoen, K. Nelis, K. Zarina, K. Biro, L. Johansson, L. Steingrimsdottir, L. Riley, L. Yap, M. Inoue, M. Szabo, M. Ovaskainen, M.-L. Lee, M.-S. Chan, M.F. Cowan, M. Kandiah, M. Kally, O. Jonsdottir, O. Palmer, P. Vollenweider, P. Orfanos, P. Asciak, R. Templeton, R. Don, R. Yaakub, R. Selamat, R. Yusof, S. Al-Zenki, S. Hung, S.-Y. Beer-Borst, S. Wu, S. Lukito, W. Hadden, W. Becker, W. Cao, X. Ma, Y. Lai, Y. Hjdaud, Z. Ali, J. Gravel, R. Tao, T. Veerman, J.L. Chiplonkar, S. Arici, M. Ngoan, L.T. Panagiotakos, D. Li, Y. Trichopoulou, A. Barengo, N. Khadilkar, A. Ekbote, V. Mohammadifard, N. Kovalskys, I and Miller, V. Webb, P. Cudhea, F. Zhang, J. Reedy, J. Shi, P. Erndt-Marino, J. Coates, J. Micha, R. Mozaffarian, D. Bas, M. Ali, J.H. Abumweis, S. Krishnan, A. Misra, P. Hwalla, N.C. Janakiram, C. Liputo, N.I. Musaiger, A. Pourfarzi, F. Alam, I. DeRidder, K. Termote, C. Memon, A. Turrini, A. Lupotto, E. Piccinelli, R. Sette, S. Anzid, K. Vossenaar, M. Mazumdar, P. Rached, I. Rovirosa, A. Zapata, M.E. Asayehu, T.T. Oduor, F. Boedecker, J. Aluso, L. Ortiz-Ulloa, J. Meenakshi, J.V. Castro, M. Grosso, G. Waskiewicz, A. Khan, U.S. Thanopoulou, A. Malekzadeh, R. Calleja, N. Ocke, M. Etemad, Z. Nsour, M.A. Waswa, L.M. Nurk, E. Arsenault, J. Lopez-Jaramillo, P. Sibai, A.M. Damasceno, A. Arambepola, C. Lopes, C. Severo, M. Lunet, N. Torres, D. Tapanainen, H. Lindstrom, J. Virtanen, S. Palacios, C. Roos, E. Agdeppa, I.A. Desnacido, J. Capanzana, M. Misra, A. Khouw, I. Ng, S.A. Delgado, E.G. Caballero, M. Otero, J. Lee, H.-J. Koksal, E. Guessous, I. Lachat, C. De Henauw, S. Rahbar, A.R. Tedstone, A. Naska, A. Mathee, A. Ling, A. Tedla, B. Hopping, B. Ginnela, B. Leclercq, C. Duante, C. Haerpfer, C. Hotz, C. Pitsavos, C. Rehm, C. van Oosterhout, C. Cerdena, C. Bradshaw, D. Trichopoulos, D. Gauci, D. Fernando, D. Sygnowska, E. Vartiainen, E. Farzadfar, F. Zajkas, G. Swan, G. Ma, G. Pekcan, G. Ibrahim, H.M. Sinkko, H. Barbieri, H.E. Sioen, I. Myhre, J. Gaspoz, J.-M. Odenkirk, J. Bundhamcharoen, K. Nelis, K. Zarina, K. Biro, L. Johansson, L. Steingrimsdottir, L. Riley, L. Yap, M. Inoue, M. Szabo, M. Ovaskainen, M.-L. Lee, M.-S. Chan, M.F. Cowan, M. Kandiah, M. Kally, O. Jonsdottir, O. Palmer, P. Vollenweider, P. Orfanos, P. Asciak, R. Templeton, R. Don, R. Yaakub, R. Selamat, R. Yusof, S. Al-Zenki, S. Hung, S.-Y. Beer-Borst, S. Wu, S. Lukito, W. Hadden, W. Becker, W. Cao, X. Ma, Y. Lai, Y. Hjdaud, Z. Ali, J. Gravel, R. Tao, T. Veerman, J.L. Chiplonkar, S. Arici, M. Ngoan, L.T. Panagiotakos, D. Li, Y. Trichopoulou, A. Barengo, N. Khadilkar, A. Ekbote, V. Mohammadifard, N. Kovalskys, I
Abstract: Animal-source foods (ASF) provide nutrition for children and adolescents’ physical and cognitive development. Here, we use data from the Global Dietary Database and Bayesian hierarchical models to quantify global, regional and national ASF intakes between 1990 and 2018 by age group across 185 countries, representing 93% of the world’s child population. Mean ASF intake was 1.9 servings per day, representing 16% of children consuming at least three daily servings. Intake was similar between boys and girls, but higher among urban children with educated parents. Consumption varied by age from 0.6 at <1 year to 2.5 servings per day at 15–19 years. Between 1990 and 2018, mean ASF intake increased by 0.5 servings per week, with increases in all regions except sub-Saharan Africa. In 2018, total ASF consumption was highest in Russia, Brazil, Mexico and Turkey, and lowest in Uganda, India, Kenya and Bangladesh. These findings can inform policy to address malnutrition through targeted ASF consumption programmes. © 2023, The Author(s).
Published: 2023

2. Author Correction: Global dietary quality in 185 countries from 1990 to 2018 show wide differences by nation, age, education, and urbanicity (Nature Food, (2022), 3, 9, (694-702), 10.1038/s43016-022-00594-9)

Author: Miller, V. Webb, P. Cudhea, F. Shi, P. Zhang, J. Reedy, J. Erndt-Marino, J. Coates, J. Mozaffarian, D. Bas, M. Ali, J.H. Abumweis, S. Krishnan, A. Misra, P. Hwalla, N.C. Janakiram, C. Liputo, N.I. Musaiger, A. Pourfarzi, F. Alam, I. DeRidder, K. Termote, C. Memon, A. Turrini, A. Lupotto, E. Piccinelli, R. Sette, S. Anzid, K. Vossenaar, M. Mazumdar, P. Rached, I. Rovirosa, A. Zapata, M.E. Asayehu, T.T. Oduor, F. Boedecker, J. Aluso, L. Ortiz-Ulloa, J. Meenakshi, J.V. Castro, M. Grosso, G. Waskiewicz, A. Khan, U.S. Thanopoulou, A. Malekzadeh, R. Calleja, N. Ocke, M. Etemad, Z. Nsour, M.A. Waswa, L.M. Nurk, E. Arsenault, J. Lopez-Jaramillo, P. Sibai, A.M. Damasceno, A. Arambepola, C. Lopes, C. Severo, M. Lunet, N. Torres, D. Tapanainen, H. Lindstrom, J. Virtanen, S. Palacios, C. Roos, E. Agdeppa, I.A. Desnacido, J. Capanzana, M. Misra, A. Khouw, I. Ng, S.A. Delgado, E.G. Caballero, M. Otero, J. Lee, H.-J. Koksal, E. Guessous, I. Lachat, C. De Henauw, S. Rahbar, A.R. Tedstone, A. Naska, A. Mathee, A. Ling, A. Tedla, B. Hopping, B. Ginnela, B. Leclercq, C. Duante, C. Haerpfer, C. Hotz, C. Pitsavos, C. Rehm, C. van Oosterhout, C. Cerdena, C. Bradshaw, D. Trichopoulos, D. Gauci, D. Fernando, D. Sygnowska, E. Vartiainen, E. Farzadfar, F. Zajkas, G. Swan, G. Ma, G. Pekcan, G. Ibrahim, H.M. Sinkko, H. Barbieri, H.E. Sioen, I. Myhre, J. Gaspoz, J.-M. Odenkirk, J. Bundhamcharoen, K. Nelis, K. Zarina, K. Biro, L. Johansson, L. Steingrimsdottir, L. Riley, L. Yap, M. Inoue, M. Szabo, M. Ovaskainen, M.-L. Lee, M.-S. Chan, M.F. Cowan, M. Kandiah, M. Kally, O. Jonsdottir, O. Palmer, P. Vollenweider, P. Orfanos, P. Asciak, R. Templeton, R. Don, R. Yaakub, R. Selamat, R. Yusof, S. Al-Zenki, S. Hung, S.-Y. Beer-Borst, S. Wu, S. Lukito, W. Hadden, W. Becker, W. Cao, X. Ma, Y. Lai, Y. Hjdaud, Z. Garriguet, D. Ali, J. Gravel, R. Tao, T. Veerman, J.L. Chiplonkar, S. Arici, M. Ngoan, L.T. Panagiotakos, D. Li, Y. Trichopoulou, A. Barengo, N. Khadilkar, A. Ekbote, V. Mohammadifard, N. Kovalsky and Miller, V. Webb, P. Cudhea, F. Shi, P. Zhang, J. Reedy, J. Erndt-Marino, J. Coates, J. Mozaffarian, D. Bas, M. Ali, J.H. Abumweis, S. Krishnan, A. Misra, P. Hwalla, N.C. Janakiram, C. Liputo, N.I. Musaiger, A. Pourfarzi, F. Alam, I. DeRidder, K. Termote, C. Memon, A. Turrini, A. Lupotto, E. Piccinelli, R. Sette, S. Anzid, K. Vossenaar, M. Mazumdar, P. Rached, I. Rovirosa, A. Zapata, M.E. Asayehu, T.T. Oduor, F. Boedecker, J. Aluso, L. Ortiz-Ulloa, J. Meenakshi, J.V. Castro, M. Grosso, G. Waskiewicz, A. Khan, U.S. Thanopoulou, A. Malekzadeh, R. Calleja, N. Ocke, M. Etemad, Z. Nsour, M.A. Waswa, L.M. Nurk, E. Arsenault, J. Lopez-Jaramillo, P. Sibai, A.M. Damasceno, A. Arambepola, C. Lopes, C. Severo, M. Lunet, N. Torres, D. Tapanainen, H. Lindstrom, J. Virtanen, S. Palacios, C. Roos, E. Agdeppa, I.A. Desnacido, J. Capanzana, M. Misra, A. Khouw, I. Ng, S.A. Delgado, E.G. Caballero, M. Otero, J. Lee, H.-J. Koksal, E. Guessous, I. Lachat, C. De Henauw, S. Rahbar, A.R. Tedstone, A. Naska, A. Mathee, A. Ling, A. Tedla, B. Hopping, B. Ginnela, B. Leclercq, C. Duante, C. Haerpfer, C. Hotz, C. Pitsavos, C. Rehm, C. van Oosterhout, C. Cerdena, C. Bradshaw, D. Trichopoulos, D. Gauci, D. Fernando, D. Sygnowska, E. Vartiainen, E. Farzadfar, F. Zajkas, G. Swan, G. Ma, G. Pekcan, G. Ibrahim, H.M. Sinkko, H. Barbieri, H.E. Sioen, I. Myhre, J. Gaspoz, J.-M. Odenkirk, J. Bundhamcharoen, K. Nelis, K. Zarina, K. Biro, L. Johansson, L. Steingrimsdottir, L. Riley, L. Yap, M. Inoue, M. Szabo, M. Ovaskainen, M.-L. Lee, M.-S. Chan, M.F. Cowan, M. Kandiah, M. Kally, O. Jonsdottir, O. Palmer, P. Vollenweider, P. Orfanos, P. Asciak, R. Templeton, R. Don, R. Yaakub, R. Selamat, R. Yusof, S. Al-Zenki, S. Hung, S.-Y. Beer-Borst, S. Wu, S. Lukito, W. Hadden, W. Becker, W. Cao, X. Ma, Y. Lai, Y. Hjdaud, Z. Garriguet, D. Ali, J. Gravel, R. Tao, T. Veerman, J.L. Chiplonkar, S. Arici, M. Ngoan, L.T. Panagiotakos, D. Li, Y. Trichopoulou, A. Barengo, N. Khadilkar, A. Ekbote, V. Mohammadifard, N. Kovalsky
Published: 2023

3. Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition

Author: Christakoudi, S. Kakourou, A. Markozannes, G. Tzoulaki, I. Weiderpass, E. Brennan, P. Gunter, M. Dahm, C.C. Overvad, K. Olsen, A. Tjønneland, A. Boutron-Ruault, M.-C. Madika, A.-L. Severi, G. Katzke, V. Kühn, T. Bergmann, M.M. Boeing, H. Karakatsani, A. Martimianaki, G. Thriskos, P. Masala, G. Sieri, S. Panico, S. Tumino, R. Ricceri, F. Agudo, A. Redondo-Sánchez, D. Colorado-Yohar, S.M. Mokoroa, O. Melander, O. Stocks, T. Häggström, C. Harlid, S. Bueno-de-Mesquita, B. van Gils, C.H. Vermeulen, R.C.H. Khaw, K.-T. Wareham, N.J. Tong, T.Y.N. Freisling, H. Johansson, M. Lennon, H. Aune, D. Riboli, E. Trichopoulos, D. Trichopoulou, A. Tsilidis, K.K. and Christakoudi, S. Kakourou, A. Markozannes, G. Tzoulaki, I. Weiderpass, E. Brennan, P. Gunter, M. Dahm, C.C. Overvad, K. Olsen, A. Tjønneland, A. Boutron-Ruault, M.-C. Madika, A.-L. Severi, G. Katzke, V. Kühn, T. Bergmann, M.M. Boeing, H. Karakatsani, A. Martimianaki, G. Thriskos, P. Masala, G. Sieri, S. Panico, S. Tumino, R. Ricceri, F. Agudo, A. Redondo-Sánchez, D. Colorado-Yohar, S.M. Mokoroa, O. Melander, O. Stocks, T. Häggström, C. Harlid, S. Bueno-de-Mesquita, B. van Gils, C.H. Vermeulen, R.C.H. Khaw, K.-T. Wareham, N.J. Tong, T.Y.N. Freisling, H. Johansson, M. Lennon, H. Aune, D. Riboli, E. Trichopoulos, D. Trichopoulou, A. Tsilidis, K.K.
Abstract: Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recruitment, and adjusted for sex, education, smoking, body mass index, physical activity, diabetes and dietary (in women also reproductive) factors. The study included 307,318 men and women, with an average follow-up of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed the expected positive association with renal cell carcinoma: HR = 1.12 (1.08–1.17) per 10 mm Hg higher SBP and HR = 1.23 (1.14–1.32) for DBP. We additionally found positive associations for esophageal squamous cell carcinoma (SCC): HR = 1.16 (1.07–1.26) (SBP), HR = 1.31 (1.13–1.51) (DBP), weaker for head and neck cancers: HR = 1.08 (1.04–1.12) (SBP), HR = 1.09 (1.01–1.17) (DBP) and, similarly, for skin SCC, colon cancer, postmenopausal breast cancer and uterine adenocarcinoma (AC), but not for esophageal AC, lung SCC, lung AC or uterine endometroid cancer. We observed weak inverse associations of SBP with cervical SCC: HR = 0.91 (0.82–1.00) and lymphomas: HR = 0.97 (0.93–1.00). There were no consistent associations with cancers in other locations. Our results are largely compatible with published studies and support weak associations of blood pressure with cancers in specific locations and morphologies. © 2019 UICC
Published: 2020

4. Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition

Author: Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., Tsilidis, K.K., Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., and Tsilidis, K.K.
Abstract: Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recruitment, and adjusted for sex, education, smoking, body mass index, physical activity, diabetes and dietary (in women also reproductive) factors. The study included 307,318 men and women, with an average follow-up of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed the expected positive association with renal cell carcinoma: HR = 1.12 (1.08–1.17) per 10 mm Hg higher SBP and HR = 1.23 (1.14–1.32) for DBP. We additionally found positive associations for esophageal squamous cell carcinoma (SCC): HR = 1.16 (1.07–1.26) (SBP), HR = 1.31 (1.13–1.51) (DBP), weaker for head and neck cancers: HR = 1.08 (1.04–1.12) (SBP), HR = 1.09 (1.01–1.17) (DBP) and, similarly, for skin SCC, colon cancer, postmenopausal breast cancer and uterine adenocarcinoma (AC), but not for esophageal AC, lung SCC, lung AC or uterine endometroid cancer. We observed weak inverse associations of SBP with cervical SCC: HR = 0.91 (0.82–1.00) and lymphomas: HR = 0.97 (0.93–1.00). There were no consistent associations with cancers in other locations. Our results are largely compatible with published studies and support weak associations of blood pressure with cancers in specific locations and morphologies.
Published: 2020

5. Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., Tsilidis, K.K., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., and Tsilidis, K.K.
Published: 2020

6. Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition

Author: Christakoudi, S, Kakourou, A, Markozannes, G, Tzoulaki, I, Weiderpass, E, Brennan, P, Gunter, M, Dahm, CC, Overvad, K, Olsen, A, Tjonneland, A, Boutron-Ruault, M-C, Madika, A-L, Severi, G, Katzke, V, Kuehn, T, Bergmann, MM, Boeing, H, Karakatsani, A, Martimianaki, G, Thriskos, P, Masala, G, Sieri, S, Panico, S, Tumino, R, Ricceri, F, Agudo, A, Redondo-Sanchez, D, Colorado-Yohar, SM, Mokoroa, O, Melander, O, Stocks, T, Haggstrom, C, Harlid, S, Bueno-de-Mesquita, B, van Gils, CH, Vermeulen, RC, Khaw, K-T, Wareham, NJ, Tong, TYN, Freisling, H, Johansson, M, Lennon, H, AUne, D, Ribolil, E, Trichopoulos, D, Trichopoulou, A, Tsilidis, KK, Christakoudi, S, Kakourou, A, Markozannes, G, Tzoulaki, I, Weiderpass, E, Brennan, P, Gunter, M, Dahm, CC, Overvad, K, Olsen, A, Tjonneland, A, Boutron-Ruault, M-C, Madika, A-L, Severi, G, Katzke, V, Kuehn, T, Bergmann, MM, Boeing, H, Karakatsani, A, Martimianaki, G, Thriskos, P, Masala, G, Sieri, S, Panico, S, Tumino, R, Ricceri, F, Agudo, A, Redondo-Sanchez, D, Colorado-Yohar, SM, Mokoroa, O, Melander, O, Stocks, T, Haggstrom, C, Harlid, S, Bueno-de-Mesquita, B, van Gils, CH, Vermeulen, RC, Khaw, K-T, Wareham, NJ, Tong, TYN, Freisling, H, Johansson, M, Lennon, H, AUne, D, Ribolil, E, Trichopoulos, D, Trichopoulou, A, and Tsilidis, KK
Abstract: Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recruitment, and adjusted for sex, education, smoking, body mass index, physical activity, diabetes and dietary (in women also reproductive) factors. The study included 307,318 men and women, with an average follow-up of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed the expected positive association with renal cell carcinoma: HR = 1.12 (1.08-1.17) per 10 mm Hg higher SBP and HR = 1.23 (1.14-1.32) for DBP. We additionally found positive associations for esophageal squamous cell carcinoma (SCC): HR = 1.16 (1.07-1.26) (SBP), HR = 1.31 (1.13-1.51) (DBP), weaker for head and neck cancers: HR = 1.08 (1.04-1.12) (SBP), HR = 1.09 (1.01-1.17) (DBP) and, similarly, for skin SCC, colon cancer, postmenopausal breast cancer and uterine adenocarcinoma (AC), but not for esophageal AC, lung SCC, lung AC or uterine endometroid cancer. We observed weak inverse associations of SBP with cervical SCC: HR = 0.91 (0.82-1.00) and lymphomas: HR = 0.97 (0.93-1.00). There were no consistent associations with cancers in other locations. Our results are largely compatible with published studies and support weak associations of blood pressure with cancers in specific locations and morphologies.
Published: 2020

7. Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., Tsilidis, K.K., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., and Tsilidis, K.K.
Published: 2020

8. Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., Tsilidis, K.K., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., Gunter, M., Dahm, C.C., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M.-C., Madika, A.-L., Severi, G., Katzke, V., Kühn, T., Bergmann, M.M., Boeing, H., Karakatsani, A., Martimianaki, G., Thriskos, P., Masala, G., Sieri, S., Panico, S., Tumino, R., Ricceri, F., Agudo, A., Redondo-Sánchez, D., Colorado-Yohar, S.M., Mokoroa, O., Melander, O., Stocks, T., Häggström, C., Harlid, S., Bueno-de-Mesquita, B., van Gils, C.H., Vermeulen, R.C.H., Khaw, K.-T., Wareham, N.J., Tong, T.Y.N., Freisling, H., Johansson, M., Lennon, H., Aune, D., Riboli, E., Trichopoulos, D., Trichopoulou, A., and Tsilidis, K.K.
Published: 2020

9. Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

Author: Sen, A. Papadimitriou, N. Lagiou, P. Perez-Cornago, A. Travis, R.C. Key, T.J. Murphy, N. Gunter, M. Freisling, H. Tzoulaki, I. Muller, D.C. Cross, A.J. Lopez, D.S. Bergmann, M. Boeing, H. Bamia, C. Kotanidou, A. Karakatsani, A. Tjønneland, A. Kyrø, C. Outzen, M. Redondo, M.-L. Cayssials, V. Chirlaque, M.-D. Barricarte, A. Sánchez, M.-J. Larrañaga, N. Tumino, R. Grioni, S. Palli, D. Caini, S. Sacerdote, C. Bueno-de-Mesquita, B. Kühn, T. Kaaks, R. Nilsson, L.M. Landberg, R. Wallström, P. Drake, I. Bech, B.H. Overvad, K. Aune, D. Khaw, K.-T. Riboli, E. Trichopoulos, D. Trichopoulou, A. Tsilidis, K.K. and Sen, A. Papadimitriou, N. Lagiou, P. Perez-Cornago, A. Travis, R.C. Key, T.J. Murphy, N. Gunter, M. Freisling, H. Tzoulaki, I. Muller, D.C. Cross, A.J. Lopez, D.S. Bergmann, M. Boeing, H. Bamia, C. Kotanidou, A. Karakatsani, A. Tjønneland, A. Kyrø, C. Outzen, M. Redondo, M.-L. Cayssials, V. Chirlaque, M.-D. Barricarte, A. Sánchez, M.-J. Larrañaga, N. Tumino, R. Grioni, S. Palli, D. Caini, S. Sacerdote, C. Bueno-de-Mesquita, B. Kühn, T. Kaaks, R. Nilsson, L.M. Landberg, R. Wallström, P. Drake, I. Bech, B.H. Overvad, K. Aune, D. Khaw, K.-T. Riboli, E. Trichopoulos, D. Trichopoulou, A. Tsilidis, K.K.
Abstract: The epidemiological evidence regarding the association of coffee and tea consumption with prostate cancer risk is inconclusive, and few cohort studies have assessed these associations by disease stage and grade. We examined the associations of coffee (total, caffeinated and decaffeinated) and tea intake with prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition. Among 142,196 men, 7,036 incident prostate cancer cases were diagnosed over 14 years of follow-up. Data on coffee and tea consumption were collected through validated country-specific food questionnaires at baseline. We used Cox proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (CI). Models were stratified by center and age, and adjusted for anthropometric, lifestyle and dietary factors. Median coffee and tea intake were 375 and 106 mL/day, respectively, but large variations existed by country. Comparing the highest (median of 855 mL/day) versus lowest (median of 103 mL/day) consumers of coffee and tea (450 vs. 12 mL/day) the HRs were 1.02 (95% CI, 0.94–1.09) and 0.98 (95% CI, 0.90–1.07) for risk of total prostate cancer and 0.97 (95% CI, 0.79–1.21) and 0.89 (95% CI, 0.70–1.13) for risk of fatal disease, respectively. No evidence of association was seen for consumption of total, caffeinated or decaffeinated coffee or tea and risk of total prostate cancer or cancer by stage, grade or fatality in this large cohort. Further investigations are needed to clarify whether an association exists by different preparations or by concentrations and constituents of these beverages. © 2018 UICC
Published: 2019

10. Hemochromatosis (HFE) gene mutations and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Author: Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili, Agudo A, Bonet C, Sala N, Muñoz X, Aranda N, Fonseca-Nunes A, Clavel-Chapelon F, Boutron-Ruault MC, Vineis P, Panico S, Palli D, Tumino R, Grioni S, Quirós JR, Molina E, Navarro C, Barricarte A, Chamosa S, Allen NE, Khaw KT, Bueno-de-Mesquita HB, Siersema PD, Numans ME, Trichopoulou A, Lagiou P, Trichopoulos D, Kaaks R, Canzian F, Boeing H, Meidtner K, Johansson M, Sund M, Manjer J, Overvad K, Tjonneland A, Lund E, Weiderpass E, Jenab M, Fedirko V, Offerhaus GJ, Riboli E, González CA, Jakszyn P, Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili, and Agudo A, Bonet C, Sala N, Muñoz X, Aranda N, Fonseca-Nunes A, Clavel-Chapelon F, Boutron-Ruault MC, Vineis P, Panico S, Palli D, Tumino R, Grioni S, Quirós JR, Molina E, Navarro C, Barricarte A, Chamosa S, Allen NE, Khaw KT, Bueno-de-Mesquita HB, Siersema PD, Numans ME, Trichopoulou A, Lagiou P, Trichopoulos D, Kaaks R, Canzian F, Boeing H, Meidtner K, Johansson M, Sund M, Manjer J, Overvad K, Tjonneland A, Lund E, Weiderpass E, Jenab M, Fedirko V, Offerhaus GJ, Riboli E, González CA, Jakszyn P
Abstract: Hereditary hemochromatosis (HH) is a strong risk factor for hepatocellular cancer, and mutations in the HFE gene associated with HH and iron overload may be related to other tumors, but no studies have been reported for gastric cancer (GC). A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), including 365 incident gastric adenocarcinoma and 1284 controls matched by center, sex, age and date of blood collection. Genotype analysis was performed for two functional polymorphisms (C282Y/rs1800562 and H63D/rs1799945) and seven tagSNPs of the HFE genomic region. Association with all gastric adenocarcinoma, and according to anatomical localization and histological subtype, was assessed by means of the odds ratio (OR) and 95% confidence interval (CI) estimated by unconditional logistic regression adjusted for the matching variables. We observed a significant association for H63D with OR (per rare allele) of 1.32 (CI = 1.03-1.69). In subgroup analyses, the association was stronger for non-cardia anatomical subsite (OR = 1.60, CI = 1.16-2.21) and intestinal histological subtype (OR = 1.82, CI = 1.27-2.62). Among intestinal cases, two tagSNPs (rs1572982 and rs6918586) also showed a significant association that disappeared after adjustment for H63D. No association with tumors located in the cardia or with diffuse subtype was found for any of the nine SNPs analyzed. Our results suggest that H63D variant in HFE gene seems to be associated with GC risk of the non-cardia region and intestinal type, possibly due to its association with iron overload although a role for other mechanisms cannot be entirely ruled out.
Published: 2019

11. Burden of hip fracture using disability-adjusted life-years: a pooled analysis of prospective cohorts in the CHANCES consortium

Author: Papadimitriou, N. Tsilidis, K.K. Orfanos, P. Benetou, V. Ntzani, E.E. Soerjomataram, I. Künn-Nelen, A. Pettersson-Kymmer, U. Eriksson, S. Brenner, H. Schöttker, B. Saum, K.-U. Holleczek, B. Grodstein, F.D. Feskanich, D. Orsini, N. Wolk, A. Bellavia, A. Wilsgaard, T. Jørgensen, L. Boffetta, P. Trichopoulos, D. Trichopoulou, A. and Papadimitriou, N. Tsilidis, K.K. Orfanos, P. Benetou, V. Ntzani, E.E. Soerjomataram, I. Künn-Nelen, A. Pettersson-Kymmer, U. Eriksson, S. Brenner, H. Schöttker, B. Saum, K.-U. Holleczek, B. Grodstein, F.D. Feskanich, D. Orsini, N. Wolk, A. Bellavia, A. Wilsgaard, T. Jørgensen, L. Boffetta, P. Trichopoulos, D. Trichopoulou, A.
Abstract: Background No studies have estimated disability-adjusted life-years (DALYs) lost due to hip fractures using real-life follow-up cohort data. We aimed to quantify the burden of disease due to incident hip fracture using DALYs in prospective cohorts in the CHANCES consortium, and to calculate population attributable fractions based on DALYs for specific risk factors. Methods We used data from six cohorts of participants aged 50 years or older at recruitment to calculate DALYs. We applied disability weights proposed by the National Osteoporosis Foundation and did a series of sensitivity analyses to examine the robustness of DALY estimates. We calculated population attributable fractions for smoking, body-mass index (BMI), physical activity, alcohol intake, type 2 diabetes and parity, use of hormone replacement therapy, and oral contraceptives in women. We calculated summary risk estimates across cohorts with pooled analysis and random-effects meta-analysis methods. Findings 223 880 men and women were followed up for a mean of 13 years (SD 6). 7724 (3·5%) participants developed an incident hip fracture, of whom 413 (5·3%) died as a result. 5964 DALYs (27 per 1000 individuals) were lost due to hip fractures, 1230 (20·6%) of which were in the group aged 75–79 years. 4150 (69·6%) DALYs were attributed to disability. Current smoking was the risk factor responsible for the greatest hip fracture burden (7·5%, 95% CI 5·2–9·7) followed by physical inactivity (5·5%, 2·1–8·5), history of diabetes (2·8%, 2·1–4·0), and low to average BMI (2·0%, 1·4–2·7), whereas low alcohol consumption (0·01–2·5 g per day) and high BMI had a protective effect. Interpretation Hip fracture can lead to a substantial loss of healthy life-years in elderly people. National public health policies should be strengthened to reduce hip fracture incidence and mortality. Primary prevention measures should be strengthened to prevent falls, and reduce smoking and a sedentary lifestyle. Funding European Community
Published: 2017

12. Self-rated health and all-cause and cause-specific mortality of older adults: Individual data meta-analysis of prospective cohort studies in the CHANCES Consortium

Author: Bamia, C. Orfanos, P. Juerges, H. Schöttker, B. Brenner, H. Lorbeer, R. Aadahl, M. Matthews, C.E. Klinaki, E. Katsoulis, M. Lagiou, P. Bueno-de-mesquita, H.B. Eriksson, S. Mons, U. Saum, K.-U. Kubinova, R. Pajak, A. Tamosiunas, A. Malyutina, S. Gardiner, J. Peasey, A. de Groot, L.C. Wilsgaard, T. Boffetta, P. Trichopoulou, A. Trichopoulos, D. and Bamia, C. Orfanos, P. Juerges, H. Schöttker, B. Brenner, H. Lorbeer, R. Aadahl, M. Matthews, C.E. Klinaki, E. Katsoulis, M. Lagiou, P. Bueno-de-mesquita, H.B. Eriksson, S. Mons, U. Saum, K.-U. Kubinova, R. Pajak, A. Tamosiunas, A. Malyutina, S. Gardiner, J. Peasey, A. de Groot, L.C. Wilsgaard, T. Boffetta, P. Trichopoulou, A. Trichopoulos, D.
Abstract: Objectives To evaluate, among the elderly, the association of self-rated health (SRH) with mortality, and to identify determinants of self-rating health as “at-least-good”. Study design Individual data on SRH and important covariates were obtained for 424,791 European and United States residents, ≥60 years at recruitment (1982–2008), in eight prospective studies in the Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES). In each study, adjusted mortality ratios (hazard ratios, HRs) in relation to SRH were calculated and subsequently combined with random-effect meta-analyses. Main outcome measures All-cause, cardiovascular and cancer mortality. Results Within the median 12.5 years of follow-up, 93,014 (22%) deaths occurred. SRH “fair” or “poor” vs. “at-least-good” was associated with increased mortality: HRs 1.46 (95% CI 1·23–1.74) and 2.31 (1.79–2.99), respectively. These associations were evident: for cardiovascular and, to a lesser extent, cancer mortality, and within-study, within-subgroup analyses. Accounting for lifestyle, sociodemographic, somatometric factors and, subsequently, for medical history explained only a modest amount of the unadjusted associations. Factors favourably associated with SRH were: sex (males), age (younger-old), education (high), marital status (married/cohabiting), physical activity (active), body mass index (non-obese), alcohol consumption (low to moderate) and previous morbidity (absence). Conclusion SRH provides a quick and simple tool for assessing health and identifying groups of elders at risk of early mortality that may be useful also in clinical settings. Modifying determinants of favourably rating health, e.g. by increasing physical activity and/or by eliminating obesity, may be important for older adults to “feel healthy” and “be healthy”. © 2017
Published: 2017

13. Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S

Author: Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., Scelo, G., Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., and Scelo, G.
Published: 2017

14. Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S

Author: Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., Scelo, G., Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., and Scelo, G.
Published: 2017

15. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants

Author: Zhou, B, Bentham, J, Di Cesare, M, Bixby, H, Danaei, G, Cowan, MJ, Paciorek, CJ, Singh, G, Hajifathalian, K, Bennett, JE, Taddei, C, Bilano, V, Carrillo-Larco, RM, Djalalinia, S, Khatibzadeh, S, Lugero, C, Peykari, N, Zhang, WZ, Lu, Y, Stevens, GA, Riley, LM, Bovet, P, Elliott, P, Gu, D, Ikeda, N, Jackson, RT, Joffres, M, Kengne, AP, Laatikainen, T, Lam, TH, Laxmaiah, A, Liu, J, Miranda, JJ, Mondo, CK, Neuhauser, HK, Sundström, J, Smeeth, L, Soric, M, Woodward, M, Ezzati, M, Abarca-Gómez, L, Abdeen, ZA, Rahim, HA, Abu-Rmeileh, NM, Acosta-Cazares, B, Adams, R, Aekplakorn, W, Afsana, K, Aguilar-Salinas, CA, Agyemang, C, Ahmadvand, A, Ahrens, W, Al Raddadi, R, Al Woyatan, R, Ali, MM, Alkerwi, A, Aly, E, Amouyel, P, Amuzu, A, Andersen, LB, Anderssen, SA, Ängquist, L, Anjana, RM, Ansong, D, Aounallah-Skhiri, H, Araújo, J, Ariansen, I, Aris, T, Arlappa, N, Aryal, K, Arveiler, D, Assah, FK, Assun ao, MCF, Avdicová, M, Azevedo, A, Azizi, F, Babu, BV, Bahijri, S, Balakrishna, N, Bandosz, P, Banegas, JR, Barbagallo, CM, Barceló, A, Barkat, A, Barros, AJD, Barros, MV, Bata, I, Batieha, AM, Baur, LA, Beaglehole, R, Romdhane, HB, Benet, M, Benson, LS, Bernabe-Ortiz, A, Bernotiene, G, Bettiol, H, Bhagyalaxmi, A, Bharadwaj, S, Bhargava, SK, Bi, Y, Bikbov, M, Bjerregaard, P, Bjertness, E, Björkelund, C, Blokstra, A, Bo, S, Bobak, M, Boeing, H, Boggia, JG, Boissonnet, CP, Bongard, V, Braeckman, L, Brajkovich, I, Branca, F, Breckenkamp, J, Brenner, H, Brewster, LM, Bruno, G, Bueno-de-Mesquita, HB, Bugge, A, Burns, C, Bursztyn, M, de León, AC, Cacciottolo, J, Cameron, C, Can, G, Cândido, APC, Capuano, V, Cardoso, VC, Carlsson, AC, Carvalho, MJ, Casanueva, FF, Casas, J-P, Caserta, CA, Chamukuttan, S, Chan, AW, Chan, Q, Chaturvedi, HK, Chaturvedi, N, Chen, C-J, Chen, F, Chen, H, Chen, S, Chen, Z, Cheng, C-Y, Dekkaki, IC, Chetrit, A, Chiolero, A, Chiou, S-T, Chirita-Emandi, A, Cho, B, Cho, Y, Chudek, J, Cifkova, R, Claessens, F, Clays, E, Concin, H, Cooper, C, Cooper, R, Coppinger, TC, Costanzo, S, Cottel, D, Cowell, C, Craig, CL, Crujeiras, AB, Cruz, JJ, D Arrigo, G, d Orsi, E, Dallongeville, J, Damasceno, A, Dankner, R, Dantoft, TM, Dauchet, L, De Backer, G, De Bacquer, D, de Gaetano, G, De Henauw, S, De Smedt, D, Deepa, M, Dehghan, A, Delisle, H, Deschamps, V, Dhana, K, Di Castelnuovo, AF, Dias-da-Costa, JS, Diaz, A, Dickerson, TT, Do, HTP, Dobson, AJ, Donfrancesco, C, Donoso, SP, Döring, A, Doua, K, Drygas, W, Dulskiene, V, D akula, A, Dzerve, V, Dziankowska-Zaborszczyk, E, Eggertsen, R, Ekelund, U, El Ati, J, Ellert, U, Elosua, R, Erasmus, RT, Erem, C, Eriksen, L, Escobedo-de la Pe na, J, Evans, A, Faeh, D, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernández-Bergés, D, Ferrante, D, Ferrari, M, Ferreccio, C, Ferrieres, J, Finn, JD, Fischer, K, Föger, B, Foo, LH, Forslund, A-S, Forsner, M, Fortmann, SP, Fouad, HM, Francis, DK, do Carmo Franco, M, Franco, OH, Frontera, G, Fuchs, FD, Fuchs, SC, Fujita, Y, Furusawa, T, Gaciong, Z, Gareta, D, Garnett, SP, Gaspoz, J-M, Gasull, M, Gates, L, Gavrila, D, Geleijnse, JM, Ghasemian, A, Ghimire, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Goldsmith, RA, Gon alves, H, Gross, MG, González Rivas, JP, Gottrand, F, Graff-Iversen, S, Grafnetter, D, Grajda, A, Gregor, RD, Grodzicki, T, Grøntved, A, Gruden, G, Grujic, V, Guan, OP, Gudnason, V, Guerrero, R, Guessous, I, Guimaraes, AL, Gulliford, MC, Gunnlaugsdottir, J, Gunter, M, Gupta, PC, Gureje, O, Gurzkowska, B, Gutierrez, L, Gutzwiller, F, Hadaegh, F, Halkj r, J, Hambleton, IR, Hardy, R, Harikumar, R, Hata, J, Hayes, AJ, He, J, Hendriks, ME, Henriques, A, Cadena, LH, Herqutanto, Herrala, S, Heshmat, R, Hihtaniemi, IT, Ho, SY, Ho, SC, Hobbs, M, Hofman, A, Dinc, GH, Hormiga, CM, Horta, BL, Houti, L, Howitt, C, Htay, TT, Htet, AS, Hu, Y, Huerta, JM, Husseini, AS, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikram, MA, Irazola, VE, Islam, M, Ivkovic, V, Iwasaki, M, Jacobs, JM, Jafar, T, Jamrozik, K, Janszky, I, Jasienska, G, Jelakovic, B, Jiang, CQ, Johansson, M, Jonas, JB, J rgensen, T, Joshi, P, Juolevi, A, Jurak, G, Jure a, V, Kaaks, R, Kafatos, A, Kalter-Leibovici, O, Kamaruddin, NA, Kasaeian, A, Katz, J, Kauhanen, J, Kaur, P, Kavousi, M, Kazakbaeva, G, Keil, U, Boker, LK, Keinänen-Kiukaanniemi, S, Kelishadi, R, Kemper, HCG, Kersting, M, Key, T, Khader, YS, Khalili, D, Khang, Y-H, Khaw, K-T, Kiechl, S, Killewo, J, Kim, J, Klumbiene, J, Kolle, E, Kolsteren, P, Korrovits, P, Koskinen, S, Kouda, K, Koziel, S, Kristensen, PL, Krokstad, S, Kromhout, D, Kruger, HS, Kubinova, R, Kuciene, R, Kuh, D, Kujala, UM, Kula, K, Kulaga, Z, Krishna Kumar, R, Kurjata, P, Kusuma, YS, Kuulasmaa, K, Kyobutungi, C, Lachat, C, Landrove, O, Lanska, V, Lappas, G, Larijani, B, Laugsand, LE, Le Nguyen Bao, K, Le, TD, Leclercq, C, Lee, J, Lehtimäki, T, Lekhraj, R, León-Mu noz, LM, Levitt, NS, Li, Y, Lilly, CL, Lim, W-Y, Lima-Costa, MF, Lin, H-H, Lin, X, Linneberg, A, Lissner, L, Litwin, M, Lorbeer, R, Lotufo, PA, Lozano, JE, Luksiene, D, Lundqvist, A, Lunet, N, Lytsy, P, Ma, G, Ma, J, Machado-Coelho, GLL, Machi, S, Maggi, S, Magliano, DJ, Majer, M, Makdisse, M, Malekzadeh, R, Malhotra, R, Rao, KM, Malyutina, S, Manios, Y, Mann, JI, Manzato, E, Margozzini, P, Marques-Vidal, P, Marrugat, J, Martorell, R, Mathiesen, EB, Matijasevich, A, Matsha, TE, Mbanya, JCN, McDonald Posso, AJ, McFarlane, SR, McGarvey, ST, McLachlan, S, McLean, RM, McNulty, BA, MdKhir, AS, Mediene-Benchekor, S, Medzioniene, J, Meirhaeghe, A, Meisinger, C, Menezes, AMB, Menon, GR, Meshram, II, Metspalu, A, Mi, J, Mikkel, K, Miller, JC, Miquel, JF, Mi igoj-Durakovic, M, Mohamed, MK, Mohammad, K, Mohammadifard, N, Mohan, V, Mohd Yusoff, MF, M ller, NC, Molnár, D, Momenan, A, Monyeki, KDK, Moreira, LB, Morejon, A, Moreno, LA, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mota, J, Motlagh, ME, Motta, J, Muiesan, ML, Müller-Nurasyid, M, Murphy, N, Mursu, J, Musil, V, Nagel, G, Naidu, BM, Nakamura, H, Náme ná, J, Nang, EEK, Nangia, VB, Narake, S, Navarrete-Mu noz, EM, Ndiaye, NC, Neal, WA, Nenko, I, Nervi, F, Nguyen, ND, Nguyen, QN, Nieto-Martínez, RE, Niiranen, TJ, Ning, G, Ninomiya, T, Nishtar, S, Noale, M, Noboa, OA, Noorbala, AA, Norat, T, Noto, D, Al Nsour, M, O Reilly, D, Oh, K, Olinto, MTA, Oliveira, IO, Omar, MA, Onat, A, Ordunez, P, Osmond, C, Ostojic, SM, Otero, JA, Overvad, K, Owusu-Dabo, E, Paccaud, FM, Padez, C, Pahomova, E, Pajak, A, Palli, D, Palmieri, L, Panda-Jonas, S, Panza, F, Papandreou, D, Parnell, WR, Parsaeian, M, Pecin, I, Pednekar, MS, Peer, N, Peeters, PH, Peixoto, SV, Pelletier, C, Peltonen, M, Pereira, AC, Pérez, RM, Peters, A, Petkeviciene, J, Pham, ST, Pigeot, I, Pikhart, H, Pilav, A, Pilotto, L, Pitakaka, F, Plans-Rubió, P, Polakowska, M, Pola ek, O, Porta, M, Portegies, MLP, Pourshams, A, Pradeepa, R, Prashant, M, Price, JF, Puiu, M, Punab, M, Qasrawi, RF, Qorbani, M, Radic, I, Radisauskas, R, Rahman, M, Raitakari, O, Raj, M, Rao, SR, Ramachandran, A, Ramos, E, Rampal, S, Rangel Reina, DA, Rasmussen, F, Redon, J, Reganit, PFM, Ribeiro, R, Riboli, E, Rigo, F, Rinke de Wit, TF, Ritti-Dias, RM, Robinson, SM, Robitaille, C, Rodríguez-Artalejo, F, del Cristo Rodriguez-Perez, M, Rodríguez-Villamizar, LA, Rojas-Martinez, R, Rosengren, A, Rubinstein, A, Rui, O, Ruiz-Betancourt, BS, Russo Horimoto, ARV, Rutkowski, M, Sabanayagam, C, Sachdev, HS, Saidi, O, Sakarya, S, Salanave, B, Martinez, ES, Salmerón, D, Salomaa, V, Salonen, JT, Salvetti, M, Sánchez-Abanto, J, Sans, S, Santos, D, Santos, IS, dos Santos, RN, Santos, R, Saramies, JL, Sardinha, LB, Margolis, GS, Sarrafzadegan, N, Saum, K-U, Savva, SC, Scazufca, M, Schargrodsky, H, Schneider, IJ, Schultsz, C, Schutte, AE, Sen, A, Senbanjo, IO, Sepanlou, SG, Sharma, SK, Shaw, JE, Shibuya, K, Shin, DW, Shin, Y, Siantar, R, Sibai, AM, Santos Silva, DA, Simon, M, Simons, J, Simons, LA, Sjöström, M, Skovbjerg, S, Slowikowska-Hilczer, J, Slusarczyk, P, Smith, MC, Snijder, MB, So, H-K, Sobngwi, E, Söderberg, S, Solfrizzi, V, Sonestedt, E, Song, Y, S rensen, TIA, Jérome, CS, Soumare, A, Staessen, JA, Starc, G, Stathopoulou, MG, Stavreski, B, Steene-Johannessen, J, Stehle, P, Stein, AD, Stergiou, GS, Stessman, J, Stieber, J, Stöckl, D, Stocks, T, Stokwiszewski, J, Stronks, K, Strufaldi, MW, Sun, C-A, Sung, Y-T, Suriyawongpaisal, P, Sy, RG, Tai, ES, Tammesoo, M-L, Tamosiunas, A, Tang, L, Tang, X, Tanser, F, Tao, Y, Tarawneh, MR, Tarqui-Mamani, CB, Taylor, A, Theobald, H, Thijs, L, Thuesen, BH, Tjonneland, A, Tolonen, HK, Tolstrup, JS, Topbas, M, Topór-Madry, R, Tormo, MJ, Torrent, M, Traissac, P, Trichopoulos, D, Trichopoulou, A, Trinh, OTH, Trivedi, A, Tshepo, L, Tulloch-Reid, MK, Tuomainen, T-P, Tuomilehto, J, Turley, ML, Tynelius, P, Tzourio, C, Ueda, P, Ugel, E, Ulmer, H, Uusitalo, HMT, Valdivia, G, Valvi, D, van der Schouw, YT, Van Herck, K, van Rossem, L, van Valkengoed, IGM, Vanderschueren, D, Vanuzzo, D, Vatten, L, Vega, T, Velasquez-Melendez, G, Veronesi, G, Verschuren, WMM, Verstraeten, R, Victora, CG, Viet, L, Viikari-Juntura, E, Vineis, P, Vioque, J, Virtanen, JK, Visvikis-Siest, S, Viswanathan, B, Vollenweider, P, Voutilainen, S, Vrdoljak, A, Vrijheid, M, Wade, AN, Wagner, A, Walton, J, Wan Mohamud, WN, Wang, M-D, Wang, Q, Wang, YX, Wannamethee, SG, Wareham, N, Wederkopp, N, Weerasekera, D, Whincup, PH, Widhalm, K, Widyahening, IS, Wiecek, A, Wijga, AH, Wilks, RJ, Willeit, J, Willeit, P, Williams, EA, Wilsgaard, T, Wojtyniak, B, Wong, TY, Wong-McClure, RA, Woo, J, Wu, AG, Wu, FC, Wu, SL, Xu, H, Yan, W, Yang, X, Ye, X, Yiallouros, PK, Yoshihara, A, Younger-Coleman, NO, Yusoff, AF, Yusoff, MFM, Zambon, S, Zdrojewski, T, Zeng, Y, Zhao, D, Zhao, W, Zheng, Y, Zhu, D, Zimmermann, E, Cisneros, JZ, Zhou, B, Bentham, J, Di Cesare, M, Bixby, H, Danaei, G, Cowan, MJ, Paciorek, CJ, Singh, G, Hajifathalian, K, Bennett, JE, Taddei, C, Bilano, V, Carrillo-Larco, RM, Djalalinia, S, Khatibzadeh, S, Lugero, C, Peykari, N, Zhang, WZ, Lu, Y, Stevens, GA, Riley, LM, Bovet, P, Elliott, P, Gu, D, Ikeda, N, Jackson, RT, Joffres, M, Kengne, AP, Laatikainen, T, Lam, TH, Laxmaiah, A, Liu, J, Miranda, JJ, Mondo, CK, Neuhauser, HK, Sundström, J, Smeeth, L, Soric, M, Woodward, M, Ezzati, M, Abarca-Gómez, L, Abdeen, ZA, Rahim, HA, Abu-Rmeileh, NM, Acosta-Cazares, B, Adams, R, Aekplakorn, W, Afsana, K, Aguilar-Salinas, CA, Agyemang, C, Ahmadvand, A, Ahrens, W, Al Raddadi, R, Al Woyatan, R, Ali, MM, Alkerwi, A, Aly, E, Amouyel, P, Amuzu, A, Andersen, LB, Anderssen, SA, Ängquist, L, Anjana, RM, Ansong, D, Aounallah-Skhiri, H, Araújo, J, Ariansen, I, Aris, T, Arlappa, N, Aryal, K, Arveiler, D, Assah, FK, Assun ao, MCF, Avdicová, M, Azevedo, A, Azizi, F, Babu, BV, Bahijri, S, Balakrishna, N, Bandosz, P, Banegas, JR, Barbagallo, CM, Barceló, A, Barkat, A, Barros, AJD, Barros, MV, Bata, I, Batieha, AM, Baur, LA, Beaglehole, R, Romdhane, HB, Benet, M, Benson, LS, Bernabe-Ortiz, A, Bernotiene, G, Bettiol, H, Bhagyalaxmi, A, Bharadwaj, S, Bhargava, SK, Bi, Y, Bikbov, M, Bjerregaard, P, Bjertness, E, Björkelund, C, Blokstra, A, Bo, S, Bobak, M, Boeing, H, Boggia, JG, Boissonnet, CP, Bongard, V, Braeckman, L, Brajkovich, I, Branca, F, Breckenkamp, J, Brenner, H, Brewster, LM, Bruno, G, Bueno-de-Mesquita, HB, Bugge, A, Burns, C, Bursztyn, M, de León, AC, Cacciottolo, J, Cameron, C, Can, G, Cândido, APC, Capuano, V, Cardoso, VC, Carlsson, AC, Carvalho, MJ, Casanueva, FF, Casas, J-P, Caserta, CA, Chamukuttan, S, Chan, AW, Chan, Q, Chaturvedi, HK, Chaturvedi, N, Chen, C-J, Chen, F, Chen, H, Chen, S, Chen, Z, Cheng, C-Y, Dekkaki, IC, Chetrit, A, Chiolero, A, Chiou, S-T, Chirita-Emandi, A, Cho, B, Cho, Y, Chudek, J, Cifkova, R, Claessens, F, Clays, E, Concin, H, Cooper, C, Cooper, R, Coppinger, TC, Costanzo, S, Cottel, D, Cowell, C, Craig, CL, Crujeiras, AB, Cruz, JJ, D Arrigo, G, d Orsi, E, Dallongeville, J, Damasceno, A, Dankner, R, Dantoft, TM, Dauchet, L, De Backer, G, De Bacquer, D, de Gaetano, G, De Henauw, S, De Smedt, D, Deepa, M, Dehghan, A, Delisle, H, Deschamps, V, Dhana, K, Di Castelnuovo, AF, Dias-da-Costa, JS, Diaz, A, Dickerson, TT, Do, HTP, Dobson, AJ, Donfrancesco, C, Donoso, SP, Döring, A, Doua, K, Drygas, W, Dulskiene, V, D akula, A, Dzerve, V, Dziankowska-Zaborszczyk, E, Eggertsen, R, Ekelund, U, El Ati, J, Ellert, U, Elosua, R, Erasmus, RT, Erem, C, Eriksen, L, Escobedo-de la Pe na, J, Evans, A, Faeh, D, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernández-Bergés, D, Ferrante, D, Ferrari, M, Ferreccio, C, Ferrieres, J, Finn, JD, Fischer, K, Föger, B, Foo, LH, Forslund, A-S, Forsner, M, Fortmann, SP, Fouad, HM, Francis, DK, do Carmo Franco, M, Franco, OH, Frontera, G, Fuchs, FD, Fuchs, SC, Fujita, Y, Furusawa, T, Gaciong, Z, Gareta, D, Garnett, SP, Gaspoz, J-M, Gasull, M, Gates, L, Gavrila, D, Geleijnse, JM, Ghasemian, A, Ghimire, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Goldsmith, RA, Gon alves, H, Gross, MG, González Rivas, JP, Gottrand, F, Graff-Iversen, S, Grafnetter, D, Grajda, A, Gregor, RD, Grodzicki, T, Grøntved, A, Gruden, G, Grujic, V, Guan, OP, Gudnason, V, Guerrero, R, Guessous, I, Guimaraes, AL, Gulliford, MC, Gunnlaugsdottir, J, Gunter, M, Gupta, PC, Gureje, O, Gurzkowska, B, Gutierrez, L, Gutzwiller, F, Hadaegh, F, Halkj r, J, Hambleton, IR, Hardy, R, Harikumar, R, Hata, J, Hayes, AJ, He, J, Hendriks, ME, Henriques, A, Cadena, LH, Herqutanto, Herrala, S, Heshmat, R, Hihtaniemi, IT, Ho, SY, Ho, SC, Hobbs, M, Hofman, A, Dinc, GH, Hormiga, CM, Horta, BL, Houti, L, Howitt, C, Htay, TT, Htet, AS, Hu, Y, Huerta, JM, Husseini, AS, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikram, MA, Irazola, VE, Islam, M, Ivkovic, V, Iwasaki, M, Jacobs, JM, Jafar, T, Jamrozik, K, Janszky, I, Jasienska, G, Jelakovic, B, Jiang, CQ, Johansson, M, Jonas, JB, J rgensen, T, Joshi, P, Juolevi, A, Jurak, G, Jure a, V, Kaaks, R, Kafatos, A, Kalter-Leibovici, O, Kamaruddin, NA, Kasaeian, A, Katz, J, Kauhanen, J, Kaur, P, Kavousi, M, Kazakbaeva, G, Keil, U, Boker, LK, Keinänen-Kiukaanniemi, S, Kelishadi, R, Kemper, HCG, Kersting, M, Key, T, Khader, YS, Khalili, D, Khang, Y-H, Khaw, K-T, Kiechl, S, Killewo, J, Kim, J, Klumbiene, J, Kolle, E, Kolsteren, P, Korrovits, P, Koskinen, S, Kouda, K, Koziel, S, Kristensen, PL, Krokstad, S, Kromhout, D, Kruger, HS, Kubinova, R, Kuciene, R, Kuh, D, Kujala, UM, Kula, K, Kulaga, Z, Krishna Kumar, R, Kurjata, P, Kusuma, YS, Kuulasmaa, K, Kyobutungi, C, Lachat, C, Landrove, O, Lanska, V, Lappas, G, Larijani, B, Laugsand, LE, Le Nguyen Bao, K, Le, TD, Leclercq, C, Lee, J, Lehtimäki, T, Lekhraj, R, León-Mu noz, LM, Levitt, NS, Li, Y, Lilly, CL, Lim, W-Y, Lima-Costa, MF, Lin, H-H, Lin, X, Linneberg, A, Lissner, L, Litwin, M, Lorbeer, R, Lotufo, PA, Lozano, JE, Luksiene, D, Lundqvist, A, Lunet, N, Lytsy, P, Ma, G, Ma, J, Machado-Coelho, GLL, Machi, S, Maggi, S, Magliano, DJ, Majer, M, Makdisse, M, Malekzadeh, R, Malhotra, R, Rao, KM, Malyutina, S, Manios, Y, Mann, JI, Manzato, E, Margozzini, P, Marques-Vidal, P, Marrugat, J, Martorell, R, Mathiesen, EB, Matijasevich, A, Matsha, TE, Mbanya, JCN, McDonald Posso, AJ, McFarlane, SR, McGarvey, ST, McLachlan, S, McLean, RM, McNulty, BA, MdKhir, AS, Mediene-Benchekor, S, Medzioniene, J, Meirhaeghe, A, Meisinger, C, Menezes, AMB, Menon, GR, Meshram, II, Metspalu, A, Mi, J, Mikkel, K, Miller, JC, Miquel, JF, Mi igoj-Durakovic, M, Mohamed, MK, Mohammad, K, Mohammadifard, N, Mohan, V, Mohd Yusoff, MF, M ller, NC, Molnár, D, Momenan, A, Monyeki, KDK, Moreira, LB, Morejon, A, Moreno, LA, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mota, J, Motlagh, ME, Motta, J, Muiesan, ML, Müller-Nurasyid, M, Murphy, N, Mursu, J, Musil, V, Nagel, G, Naidu, BM, Nakamura, H, Náme ná, J, Nang, EEK, Nangia, VB, Narake, S, Navarrete-Mu noz, EM, Ndiaye, NC, Neal, WA, Nenko, I, Nervi, F, Nguyen, ND, Nguyen, QN, Nieto-Martínez, RE, Niiranen, TJ, Ning, G, Ninomiya, T, Nishtar, S, Noale, M, Noboa, OA, Noorbala, AA, Norat, T, Noto, D, Al Nsour, M, O Reilly, D, Oh, K, Olinto, MTA, Oliveira, IO, Omar, MA, Onat, A, Ordunez, P, Osmond, C, Ostojic, SM, Otero, JA, Overvad, K, Owusu-Dabo, E, Paccaud, FM, Padez, C, Pahomova, E, Pajak, A, Palli, D, Palmieri, L, Panda-Jonas, S, Panza, F, Papandreou, D, Parnell, WR, Parsaeian, M, Pecin, I, Pednekar, MS, Peer, N, Peeters, PH, Peixoto, SV, Pelletier, C, Peltonen, M, Pereira, AC, Pérez, RM, Peters, A, Petkeviciene, J, Pham, ST, Pigeot, I, Pikhart, H, Pilav, A, Pilotto, L, Pitakaka, F, Plans-Rubió, P, Polakowska, M, Pola ek, O, Porta, M, Portegies, MLP, Pourshams, A, Pradeepa, R, Prashant, M, Price, JF, Puiu, M, Punab, M, Qasrawi, RF, Qorbani, M, Radic, I, Radisauskas, R, Rahman, M, Raitakari, O, Raj, M, Rao, SR, Ramachandran, A, Ramos, E, Rampal, S, Rangel Reina, DA, Rasmussen, F, Redon, J, Reganit, PFM, Ribeiro, R, Riboli, E, Rigo, F, Rinke de Wit, TF, Ritti-Dias, RM, Robinson, SM, Robitaille, C, Rodríguez-Artalejo, F, del Cristo Rodriguez-Perez, M, Rodríguez-Villamizar, LA, Rojas-Martinez, R, Rosengren, A, Rubinstein, A, Rui, O, Ruiz-Betancourt, BS, Russo Horimoto, ARV, Rutkowski, M, Sabanayagam, C, Sachdev, HS, Saidi, O, Sakarya, S, Salanave, B, Martinez, ES, Salmerón, D, Salomaa, V, Salonen, JT, Salvetti, M, Sánchez-Abanto, J, Sans, S, Santos, D, Santos, IS, dos Santos, RN, Santos, R, Saramies, JL, Sardinha, LB, Margolis, GS, Sarrafzadegan, N, Saum, K-U, Savva, SC, Scazufca, M, Schargrodsky, H, Schneider, IJ, Schultsz, C, Schutte, AE, Sen, A, Senbanjo, IO, Sepanlou, SG, Sharma, SK, Shaw, JE, Shibuya, K, Shin, DW, Shin, Y, Siantar, R, Sibai, AM, Santos Silva, DA, Simon, M, Simons, J, Simons, LA, Sjöström, M, Skovbjerg, S, Slowikowska-Hilczer, J, Slusarczyk, P, Smith, MC, Snijder, MB, So, H-K, Sobngwi, E, Söderberg, S, Solfrizzi, V, Sonestedt, E, Song, Y, S rensen, TIA, Jérome, CS, Soumare, A, Staessen, JA, Starc, G, Stathopoulou, MG, Stavreski, B, Steene-Johannessen, J, Stehle, P, Stein, AD, Stergiou, GS, Stessman, J, Stieber, J, Stöckl, D, Stocks, T, Stokwiszewski, J, Stronks, K, Strufaldi, MW, Sun, C-A, Sung, Y-T, Suriyawongpaisal, P, Sy, RG, Tai, ES, Tammesoo, M-L, Tamosiunas, A, Tang, L, Tang, X, Tanser, F, Tao, Y, Tarawneh, MR, Tarqui-Mamani, CB, Taylor, A, Theobald, H, Thijs, L, Thuesen, BH, Tjonneland, A, Tolonen, HK, Tolstrup, JS, Topbas, M, Topór-Madry, R, Tormo, MJ, Torrent, M, Traissac, P, Trichopoulos, D, Trichopoulou, A, Trinh, OTH, Trivedi, A, Tshepo, L, Tulloch-Reid, MK, Tuomainen, T-P, Tuomilehto, J, Turley, ML, Tynelius, P, Tzourio, C, Ueda, P, Ugel, E, Ulmer, H, Uusitalo, HMT, Valdivia, G, Valvi, D, van der Schouw, YT, Van Herck, K, van Rossem, L, van Valkengoed, IGM, Vanderschueren, D, Vanuzzo, D, Vatten, L, Vega, T, Velasquez-Melendez, G, Veronesi, G, Verschuren, WMM, Verstraeten, R, Victora, CG, Viet, L, Viikari-Juntura, E, Vineis, P, Vioque, J, Virtanen, JK, Visvikis-Siest, S, Viswanathan, B, Vollenweider, P, Voutilainen, S, Vrdoljak, A, Vrijheid, M, Wade, AN, Wagner, A, Walton, J, Wan Mohamud, WN, Wang, M-D, Wang, Q, Wang, YX, Wannamethee, SG, Wareham, N, Wederkopp, N, Weerasekera, D, Whincup, PH, Widhalm, K, Widyahening, IS, Wiecek, A, Wijga, AH, Wilks, RJ, Willeit, J, Willeit, P, Williams, EA, Wilsgaard, T, Wojtyniak, B, Wong, TY, Wong-McClure, RA, Woo, J, Wu, AG, Wu, FC, Wu, SL, Xu, H, Yan, W, Yang, X, Ye, X, Yiallouros, PK, Yoshihara, A, Younger-Coleman, NO, Yusoff, AF, Yusoff, MFM, Zambon, S, Zdrojewski, T, Zeng, Y, Zhao, D, Zhao, W, Zheng, Y, Zhu, D, Zimmermann, E, and Cisneros, JZ
Abstract: Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of raised blood pressure for 200 countries. We calculated the contributions of changes in prevalence versus population growth and ageing to the increase in the number of adults with raised blood pressure. Findings We pooled 1479 studies that had measured the blood pressures of 19·1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127·0 mm Hg (95% credible interval 125·7–128·3) in men and 122·3 mm Hg (121·0–123·6) in women; age-standardised mean diastolic blood pressure was 78·7 mm Hg (77·9–79·5) for men and 76·7 mm Hg (75·9–77·6) for women. Global age-standardised prevalence of raised blood pressure was 24·1% (21·4–27·1) in men and 20·1% (17·8–22·5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also decreased in women in central and eastern Europe, Latin America and the Caribbean, and, more recently, central Asia, Middle East, and north Africa, but the estimated trends in these super-regions had larger uncertainty than in high-income super-regions. By contrast, mean blood pressure might have increased in east and so
Published: 2017

16. Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study

Author: Gunter, M.J., Murphy, N., Cross, A.J., Dossus, L., Dartois, L., Fagherazzi, G., Kaaks, R., Kuhn, T., Boeing, H., Aleksandrova, K., Tjonneland, A., Olsen, A., Overvad, K., Larsen, S.C., Cornejo, M.L. Redondo, Agudo, A., Perez, M.J., Altzibar, J.M., Navarro, C, Ardanaz, E., Khaw, K.T., Butterworth, A., Bradbury, K.E., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Grioni, S., Vineis, P., Panico, S., Tumino, R., Bueno-de-Mesquita, B., Siersema, P.D., Leenders, M., Beulens, J.W., Uiterwaal, C.U., Wallstrom, P., Nilsson, L.M., Landberg, R., Weiderpass, E., Skeie, G., Braaten, T., Brennan, P., Licaj, I., Muller, D.C., Sinha, R., Wareham, N., Riboli, E., Gunter, M.J., Murphy, N., Cross, A.J., Dossus, L., Dartois, L., Fagherazzi, G., Kaaks, R., Kuhn, T., Boeing, H., Aleksandrova, K., Tjonneland, A., Olsen, A., Overvad, K., Larsen, S.C., Cornejo, M.L. Redondo, Agudo, A., Perez, M.J., Altzibar, J.M., Navarro, C, Ardanaz, E., Khaw, K.T., Butterworth, A., Bradbury, K.E., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Grioni, S., Vineis, P., Panico, S., Tumino, R., Bueno-de-Mesquita, B., Siersema, P.D., Leenders, M., Beulens, J.W., Uiterwaal, C.U., Wallstrom, P., Nilsson, L.M., Landberg, R., Weiderpass, E., Skeie, G., Braaten, T., Brennan, P., Licaj, I., Muller, D.C., Sinha, R., Wareham, N., and Riboli, E.
Abstract: Item does not contain fulltext, Background: The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective: To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design: Prospective cohort study. Setting: 10 European countries. Participants: 521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition). Measurements: Hazard ratios (HRs) and 95% CIs estimated using multivariable Cox proportional hazards models. The association of coffee consumption with serum biomarkers of liver function, inflammation, and metabolic health was evaluated in the EPIC Biomarkers subcohort (n = 14 800). Results: During a mean follow-up of 16.4 years, 41 693 deaths occurred. Compared with nonconsumers, participants in the highest quartile of coffee consumption had statistically significantly lower all-cause mortality (men: HR, 0.88 [95% CI, 0.82 to 0.95]; P for trend < 0.001; women: HR, 0.93 [CI, 0.87 to 0.98]; P for trend = 0.009). Inverse associations were also observed for digestive disease mortality for men (HR, 0.41 [CI, 0.32 to 0.54]; P for trend < 0.001) and women (HR, 0.60 [CI, 0.46 to 0.78]; P for trend < 0.001). Among women, there was a statistically significant inverse association of coffee drinking with circulatory disease mortality (HR, 0.78 [CI, 0.68 to 0.90]; P for trend < 0.001) and cerebrovascular disease mortality (HR, 0.70 [CI, 0.55 to 0.90]; P for trend = 0.002) and a positive association with ovarian cancer mortality (HR, 1.31 [CI, 1.07 to 1.61]; P for trend = 0.015). In the EPIC Biomarkers subcohort, higher coffee consumption was associated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotransferase; gamma-glutamyltransferase; and, in women, C-reactive protein, lipoprotein(a), and glycated hemoglobin levels. Limitations: Reverse causality may have biased the findings; however, results did not differ aft
Published: 2017

17. Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study

Author: Gunter, M.J., Murphy, N., Cross, A.J., Dossus, L., Dartois, L., Fagherazzi, G., Kaaks, R., Kuhn, T., Boeing, H., Aleksandrova, K., Tjonneland, A., Olsen, A., Overvad, K., Larsen, S.C., Cornejo, M.L. Redondo, Agudo, A., Perez, M.J., Altzibar, J.M., Navarro, C, Ardanaz, E., Khaw, K.T., Butterworth, A., Bradbury, K.E., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Grioni, S., Vineis, P., Panico, S., Tumino, R., Bueno-de-Mesquita, B., Siersema, P.D., Leenders, M., Beulens, J.W., Uiterwaal, C.U., Wallstrom, P., Nilsson, L.M., Landberg, R., Weiderpass, E., Skeie, G., Braaten, T., Brennan, P., Licaj, I., Muller, D.C., Sinha, R., Wareham, N., Riboli, E., Gunter, M.J., Murphy, N., Cross, A.J., Dossus, L., Dartois, L., Fagherazzi, G., Kaaks, R., Kuhn, T., Boeing, H., Aleksandrova, K., Tjonneland, A., Olsen, A., Overvad, K., Larsen, S.C., Cornejo, M.L. Redondo, Agudo, A., Perez, M.J., Altzibar, J.M., Navarro, C, Ardanaz, E., Khaw, K.T., Butterworth, A., Bradbury, K.E., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Grioni, S., Vineis, P., Panico, S., Tumino, R., Bueno-de-Mesquita, B., Siersema, P.D., Leenders, M., Beulens, J.W., Uiterwaal, C.U., Wallstrom, P., Nilsson, L.M., Landberg, R., Weiderpass, E., Skeie, G., Braaten, T., Brennan, P., Licaj, I., Muller, D.C., Sinha, R., Wareham, N., and Riboli, E.
Abstract: Item does not contain fulltext, Background: The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective: To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design: Prospective cohort study. Setting: 10 European countries. Participants: 521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition). Measurements: Hazard ratios (HRs) and 95% CIs estimated using multivariable Cox proportional hazards models. The association of coffee consumption with serum biomarkers of liver function, inflammation, and metabolic health was evaluated in the EPIC Biomarkers subcohort (n = 14 800). Results: During a mean follow-up of 16.4 years, 41 693 deaths occurred. Compared with nonconsumers, participants in the highest quartile of coffee consumption had statistically significantly lower all-cause mortality (men: HR, 0.88 [95% CI, 0.82 to 0.95]; P for trend < 0.001; women: HR, 0.93 [CI, 0.87 to 0.98]; P for trend = 0.009). Inverse associations were also observed for digestive disease mortality for men (HR, 0.41 [CI, 0.32 to 0.54]; P for trend < 0.001) and women (HR, 0.60 [CI, 0.46 to 0.78]; P for trend < 0.001). Among women, there was a statistically significant inverse association of coffee drinking with circulatory disease mortality (HR, 0.78 [CI, 0.68 to 0.90]; P for trend < 0.001) and cerebrovascular disease mortality (HR, 0.70 [CI, 0.55 to 0.90]; P for trend = 0.002) and a positive association with ovarian cancer mortality (HR, 1.31 [CI, 1.07 to 1.61]; P for trend = 0.015). In the EPIC Biomarkers subcohort, higher coffee consumption was associated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotransferase; gamma-glutamyltransferase; and, in women, C-reactive protein, lipoprotein(a), and glycated hemoglobin levels. Limitations: Reverse causality may have biased the findings; however, results did not differ aft
Published: 2017

18. Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S

Author: Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., Scelo, G., Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., and Scelo, G.
Published: 2017

19. Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study

Author: Gunter, M.J., Murphy, N., Cross, A.J., Dossus, L., Dartois, L., Fagherazzi, G., Kaaks, R., Kuhn, T., Boeing, H., Aleksandrova, K., Tjonneland, A., Olsen, A., Overvad, K., Larsen, S.C., Cornejo, M.L. Redondo, Agudo, A., Perez, M.J., Altzibar, J.M., Navarro, C, Ardanaz, E., Khaw, K.T., Butterworth, A., Bradbury, K.E., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Grioni, S., Vineis, P., Panico, S., Tumino, R., Bueno-de-Mesquita, B., Siersema, P.D., Leenders, M., Beulens, J.W., Uiterwaal, C.U., Wallstrom, P., Nilsson, L.M., Landberg, R., Weiderpass, E., Skeie, G., Braaten, T., Brennan, P., Licaj, I., Muller, D.C., Sinha, R., Wareham, N., Riboli, E., Gunter, M.J., Murphy, N., Cross, A.J., Dossus, L., Dartois, L., Fagherazzi, G., Kaaks, R., Kuhn, T., Boeing, H., Aleksandrova, K., Tjonneland, A., Olsen, A., Overvad, K., Larsen, S.C., Cornejo, M.L. Redondo, Agudo, A., Perez, M.J., Altzibar, J.M., Navarro, C, Ardanaz, E., Khaw, K.T., Butterworth, A., Bradbury, K.E., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Grioni, S., Vineis, P., Panico, S., Tumino, R., Bueno-de-Mesquita, B., Siersema, P.D., Leenders, M., Beulens, J.W., Uiterwaal, C.U., Wallstrom, P., Nilsson, L.M., Landberg, R., Weiderpass, E., Skeie, G., Braaten, T., Brennan, P., Licaj, I., Muller, D.C., Sinha, R., Wareham, N., and Riboli, E.
Abstract: Item does not contain fulltext, Background: The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective: To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design: Prospective cohort study. Setting: 10 European countries. Participants: 521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition). Measurements: Hazard ratios (HRs) and 95% CIs estimated using multivariable Cox proportional hazards models. The association of coffee consumption with serum biomarkers of liver function, inflammation, and metabolic health was evaluated in the EPIC Biomarkers subcohort (n = 14 800). Results: During a mean follow-up of 16.4 years, 41 693 deaths occurred. Compared with nonconsumers, participants in the highest quartile of coffee consumption had statistically significantly lower all-cause mortality (men: HR, 0.88 [95% CI, 0.82 to 0.95]; P for trend < 0.001; women: HR, 0.93 [CI, 0.87 to 0.98]; P for trend = 0.009). Inverse associations were also observed for digestive disease mortality for men (HR, 0.41 [CI, 0.32 to 0.54]; P for trend < 0.001) and women (HR, 0.60 [CI, 0.46 to 0.78]; P for trend < 0.001). Among women, there was a statistically significant inverse association of coffee drinking with circulatory disease mortality (HR, 0.78 [CI, 0.68 to 0.90]; P for trend < 0.001) and cerebrovascular disease mortality (HR, 0.70 [CI, 0.55 to 0.90]; P for trend = 0.002) and a positive association with ovarian cancer mortality (HR, 1.31 [CI, 1.07 to 1.61]; P for trend = 0.015). In the EPIC Biomarkers subcohort, higher coffee consumption was associated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotransferase; gamma-glutamyltransferase; and, in women, C-reactive protein, lipoprotein(a), and glycated hemoglobin levels. Limitations: Reverse causality may have biased the findings; however, results did not differ aft
Published: 2017

20. Worldwide trends in blood pressure from 1975 to 2015:a pooled analysis of 1479 population-based measurement studies with 19.1 million participants

Author: Zhou, B. (Bin), Bentham, J. (James), Di Cesare, M. (Mariachiara), Bixby, H. (Honor), Danaei, G. (Goodarz), Cowan, M. J. (Melanie J.), Paciorek, C. J. (Christopher J.), Singh, G. (Gitanjali), Hajifathalian, K. (Kaveh), Bennett, J. E. (James E.), Taddei, C. (Cristina), Bilano, V. (Ver), Carrillo-Larco, R. M. (Rodrigo M.), Djalalinia, S. (Shirin), Khatibzadeh, S. (Shahab), Lugero, C. (Charles), Peykari, N. (Niloofar), Zhang, W. Z. (Wan Zhu), Lu, Y. (Yuan), Stevens, G. A. (Gretchen A.), Riley, L. M. (Leanne M.), Bovet, P. (Pascal), Elliott, P. (Paul), Gu, D. (Dongfeng), Ikeda, N. (Nayu), Jackson, R. T. (Rod T.), Joffres, M. (Michel), Kengne, A. P. (Andre Pascal), Laatikainen, T. (Tiina), Lam, T. H. (Tai Hing), Laxmaiah, A. (Avula), Liu, J. (Jing), Miranda, J. J. (J. Jaime), Mondo, C. K. (Charles K.), Neuhauser, H. K. (Hannelore K.), Sundstrom, J. (Johan), Smeeth, L. (Liam), Soric, M. (Maroje), Woodward, M. (Mark), Ezzati, M. (Majid), Abarca-Gomez, L. (Leandra), Abdeen, Z. A. (Ziad A.), Rahim, H. A. (Hanan Abdul), Abu-Rmeileh, N. M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Afsana, K. (Kaosar), Aguilar-Salinas, C. A. (Carlos A.), Agyemang, C. (Charles), Ahmadvand, A. (Alireza), Ahrens, W. (Wolfgang), Al Raddadi, R. (Rajaa), Al Woyatan, R. (Rihab), Ali, M. M. (Mohamed M.), Alkerwi, A. (Ala'a), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L. B. (Lars Bo), Anderssen, S. A. (Sigmund A.), Angquist, L. (Lars), Anjana, R. M. (Ranjit Mohan), Ansong, D. (Daniel), Aounallah-Skhiri, H. (Hajer), Araujo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Aryal, K. (Krishna), Arveiler, D. (Dominique), Assah, F. K. (Felix K.), Assuncao, M. C. (Maria Cecilia F.), Avdicova, M. (Maria), Azevedo, A. (Ana), Azizi, F. (Fereidoun), Babu, B. V. (Bontha V.), Bahijri, S. (Suhad), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J. R. (Jose R.), Barbagallo, C. M. (Carlo M.), Barcelo, A. (Alberto), Barkat, A. (Amina), Barros, A. J. (Aluisio J. D.), Barros, M. V. (Mauro V.), Bata, I. (Iqbal), Batieha, A. M. (Anwar M.), Baur, L. A. (Louise A.), Beaglehole, R. (Robert), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benson, L. S. (Lowell S.), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S. K. (Santosh K.), Bi, Y. (Yufang), Bikbov, M. (Mukharram), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjokelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boeing, H. (Heiner), Boggia, J. G. (Jose G.), Boissonnet, C. P. (Carlos P.), Bongard, V. (Vanina), Braeckman, L. (Lutgart), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L. M. (Lizzy M.), Bruno, G. (Graziella), Bueno-de-Mesquita, H. B. (H. B. (as)), Bugge, A. (Anna), Burns, C. (Con), Bursztyn, M. (Michael), de Leon, A. C. (Antonio Cabrera), Cameron, C. (Christine), Can, G. (Gunay), Candido, A. P. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V. C. (Viviane C.), Carlsson, A. C. (Axel C.), Carvalho, M. J. (Maria J.), Casanueva, F. F. (Felipe F.), Casas, J.-P. (Juan-Pablo), Caserta, C. A. (Carmelo A.), Chamukuttan, S. (Snehalatha), Chan, A. W. (Angelique W.), Chan, Q. (Queenie), Chaturvedi, H. K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Dekkaki, I. C. (Imane Cherkaoui), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F. (Frank), Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Cyrus), Cooper, R. (Rachel), Coppinger, T. C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C. L. (Cora L.), Crujeiras, A. B. (Ana B.), Cruz, J. J. (Juan J.), D'Arrigo, G. (Graziella), d'Orsi, E. (Eleonora), Dallongeville, J. (Jean), Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T. M. (Thomas M.), Dauchet, L. (Luc), De Backer, G. (Guy), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Dehghan, A. (Abbas), Delisle, H. (Helene), Deschamps, V. (Valerie), Dhana, K. (Klodian), Di Castelnuovo, A. F. (Augusto F.), Dias-da-Costa, J. S. (Juvenal Soares), Diaz, A. (Alejandro), Dickerson, T. T. (Ty T.), Do, H. T. (Ha T. P.), Dobson, A. J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S. P. (Silvana P.), Doering, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Dulskiene, V. (Virginija), Dzakula, A. (Aleksandar), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Ellert, U. (Ute), Elosua, R. (Roberto), Erasmus, R. T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), Escobedo-de la Pena, J. (Jorge), Evans, A. (Alun), Faeh, D. (David), Fall, C. H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F. J. (Francisco J.), Ferguson, T. S. (Trevor S.), Fernandez-Berges, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J. D. (Joseph D.), Fischer, K. (Krista), Foeger, B. (Bernhard), Foo, L. H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fortmann, S. P. (Stephen P.), Fouad, H. M. (Heba M.), Francis, D. K. (Damian K.), Franco, M. d. (Maria do Carmo), Franco, O. H. (Oscar H.), Frontera, G. (Guillermo), Fuchs, F. D. (Flavio D.), Fuchs, S. C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gareta, D. (Dickman), Garnett, S. P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Gavrila, D. (Diana), Geleijnse, J. M. (Johanna M.), Ghasemian, A. (Anoosheh), Ghimire, A. (Anup), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Goldsmith, R. A. (Rebecca A.), Goncalves, H. (Helen), Gonzalez Gross, M. (Marcela), Gonzalez Rivas, J. P. (Juan P.), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dusan), Grajda, A. (Aneta), Gregor, R. D. (Ronald D.), Grodzicki, T. (Tomasz), Grontved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Guan, O. P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A. L. (Andre L.), Gulliford, M. C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Gunter, M. (Marc), Gupta, P. C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Hadaegh, F. (Farzad), Halkjaer, J. (Jytte), Hambleton, I. R. (Ian R.), Hardy, R. (Rebecca), Harikumar, R. (Rachakulla), Hata, J. (Jun), Hayes, A. J. (Alison J.), He, J. (Jiang), Hendriks, M. E. (Marleen Elisabeth), Henriques, A. (Ana), Hernandez Cadena, L. (Leticia), . (), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hihtaniemi, I. T. (Ilpo Tapani), Ho, S. Y. (Sai Yin), Ho, S. C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Dinc, G. H. (Gonul Horasan), Hormiga, C. M. (Claudia M.), Horta, B. L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T. T. (Thein Thein), Htet, A. S. (Aung Soe), Hu, Y. (Yonghua), Maria Huerta, J. (Jose), Husseini, A. S. (Abdullatif S.), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A. G. (Anna G.), Ibrahim, M. M. (M. Mohsen), Ikram, M. A. (M. Arfan), Irazola, V. E. (Vilma E.), Islam, M. (Muhammad), Ivkovic, V. (Vanja), Iwasaki, M. (Masanori), Jacobs, J. M. (Jeremy M.), Jafar, T. (Tazeen), Jamrozik, K. (Konrad), Janszky, I. (Imre), Jasienska, G. (Grazyna), Jelakovic, B. (Bojan), Jiang, C. Q. (Chao Qiang), Johansson, M. (Mattias), Jonas, J. B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Juresa, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kamaruddin, N. A. (Nor Azmi), Kasaeian, A. (Amir), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, U. (Ulrich), Boker, L. K. (Lital Keinan), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kemper, H. C. (Han C. G.), Kersting, M. (Mathilde), Key, T. (Timothy), Khader, Y. S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Khaw, K.-T. (Kay-Tee), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Klumbiene, J. (Jurate), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kristensen, P. L. (Peter Lund), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H. S. (Herculina S.), Kubinova, R. (Ruzena), Kuciene, R. (Renata), Kuh, D. (Diana), Kujala, U. M. (Urho M.), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Kumar, R. K. (R. Krishna), Kurjata, P. (Pawel), Kusuma, Y. S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Kyobutungi, C. (Catherine), Lachat, C. (Carl), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Laugsand, L. E. (Lars E.), Le, T. D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimaki, T. (Terho), Lekhraj, R. (Rampal), Leon-Munoz, L. M. (Luz M.), Levitt, N. S. (Naomi S.), Li, Y. (Yanping), Lilly, C. L. (Christa L.), Lim, W.-Y. (Wei-Yen), Fernanda Lima-Costa, M. (M.), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Lorbeer, R. (Roberto), Lotufo, P. A. (Paulo A.), Eugenio Lozano, J. (Jose), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Ma, J. (Jun), Machado-Coelho, G. L. (George L. L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D. J. (Dianna J.), Majer, M. (Marjeta), Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K. M. (Kodavanti Mallikharjuna), Malyutina, S. (Sofia), Manios, Y. (Yannis), Mann, J. I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martorell, R. (Reynaldo), Mathiesen, E. B. (Ellisiv B.), Matijasevich, A. (Alicia), Matsha, T. E. (Tandi E.), Mbanya, J. C. (Jean Claude N.), Posso, A. J. (Anselmo J. Mc Donald), McFarlane, S. R. (Shelly R.), McGarvey, S. T. (Stephen T.), McLachlan, S. (Stela), McLean, R. M. (Rachael M.), McNulty, B. A. (Breige A.), Khir, A. S. (Amir Sharifuddin Md), Mediene-Benchekor, S. (Sounnia), Medzioniene, J. (Jurate), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A. M. (Ana Maria B.), Menon, G. R. (Geetha R.), Meshram, I. I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Mikkel, K. (Kairit), Miller, J. C. (Jody C.), Francisco Miquel, J. (Juan), Jaime Miranda, J. (J.), Misigoj-Durakovic, M. (Marjeta), Mohamed, M. K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M. F. (Muhammad Fadhli Mohd), Moller, N. C. (Niels C.), Molnar, D. (Denes), Momenan, A. (Amirabbas), Monyeki, K. D. (Kotsedi Daniel K.), Moreira, L. B. (Leila B.), Morejon, A. (Alain), Moreno, L. A. (Luis A.), Morgan, K. (Karen), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M. E. (Mohammad Esmaeel), Motta, J. (Jorge), Muiesan, M. L. (Maria L.), Mueller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Musil, V. (Vera), Nagel, G. (Gabriele), Naidu, B. M. (Balkish M.), Nakamura, H. (Harunobu), Namsna, J. (Jana), Nang, E. E. (Ei Ei K.), Nangia, V. B. (Vinay B.), Narake, S. (Sameer), Maria Navarrete-Munoz, E. (Eva), Ndiaye, N. C. (Ndeye Coumba), Neal, W. A. (William A.), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N. D. (Nguyen D.), Nieto-Martinez, R. E. (Ramfis E.), Niiranen, T. J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Noboa, O. A. (Oscar A.), Noorbala, A. A. (Ahmad Ali), Norat, T. (Teresa), Noto, D. (Davide), Al Nsour, M. (Mohannad), O'Reilly, D. (Dermot), Oh, K. (Kyungwon), Olinto, M. T. (Maria Teresa A.), Oliveira, I. O. (Isabel O.), Omar, M. A. (Mohd Azahadi), Onat, A. (Altan), Ordunez, P. (Pedro), Osmond, C. (Clive), Ostojic, S. M. (Sergej M.), Otero, J. A. (Johanna A.), Overvad, K. (Kim), Owusu-Dabo, E. (Ellis), Paccaud, F. M. (Fred Michel), Padez, C. (Cristina), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palli, D. (Domenico), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Papandreou, D. (Dimitrios), Parnell, W. R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pecin, I. (Ivan), Pednekar, M. S. (Mangesh S.), Peer, N. (Nasheeta), Peeters, P. H. (Petra H.), Peixoto, S. V. (Sergio Viana), Pelletier, C. (Catherine), Peltonen, M. (Markku), Pereira, A. C. (Alexandre C.), Marina Perez, R. (Rosa), Peters, A. (Annette), Petkeviciene, J. (Janina), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, L. (Lorenza), Pitakaka, F. (Freda), Plans-Rubio, P. (Pedro), Polakowska, M. (Maria), Polasek, O. (Ozren), Porta, M. (Miquel), Portegies, M. L. (Marileen L. P.), Pourshams, A. (Akram), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J. F. (Jacqueline F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R. F. (Radwan F.), Qorbani, M. (Mostafa), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M. (Mahfuzar), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S. R. (Sudha Ramachandra), Ramos, E. (Elisabete), Rampal, S. (Sanjay), Rangel Reina, D. A. (Daniel A.), Rasmussen, F. (Finn), Redon, J. (Josep), Reganit, P. F. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), de Wit, T. F. (Tobias F. Rinke), Ritti-Dias, R. M. (Raphael M.), Robinson, S. M. (Sian M.), Robitaille, C. (Cynthia), Rodriguez-Artalejo, F. (Fernando), Rodriguez-Villamizar, L. A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rosengren, A. (Annika), Rubinstein, A. (Adolfo), Rui, O. (Ornelas), Sandra Ruiz-Betancourt, B. (Blanca), Russo Horimoto, A. R. (Andrea R. V.), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H. S. (Harshpal S.), Saidi, O. (Olfa), Sakarya, S. (Sibel), Salanave, B. (Benoit), Salazar Martinez, E. (Eduardo), Salmeron, D. (Diego), Salomaa, V. (Veikko), Salonen, J. T. (Jukka T.), Salvetti, M. (Massimo), Sanchez-Abanto, J. (Jose), Sans, S. (Susana), Santos, D. (Diana), Santos, I. S. (Ina S.), dos Santos, R. N. (Renata Nunes), Santos, R. (Rute), Saramies, J. L. (Jouko L.), Sardinha, L. B. (Luis B.), Margolis, G. S. (Giselle Sarganas), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S. C. (Savvas C.), Scazufca, M. (Marcia), Schargrodsky, H. (Herman), Schneider, I. J. (Ione J.), Schultsz, C. (Constance), Schutte, A. E. (Aletta E.), Sen, A. (Abhijit), Senbanjo, I. O. (Idowu O.), Sepanlou, S. G. (Sadaf G.), Sharma, S. K. (Sanjib K.), Shaw, J. E. (Jonathan E.), Shibuya, K. (Kenji), Shin, D. W. (Dong Wook), Shin, Y. (Youchan), Siantar, R. (Rosalynn), Sibai, A. M. (Abla M.), Santos Silva, D. A. (Diego Augusto), Simon, M. (Mary), Simons, J. (Judith), Simons, L. A. (Leon A.), Sjotrom, M. (Michael), Skovbjerg, S. (Sine), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smith, M. C. (Margaret C.), Snijder, M. B. (Marieke B.), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugene), Soderberg, S. (Stefan), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Song, Y. (Yi), Sorensen, T. I. (Thorkild I. A.), Jerome, C. S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J. A. (Jan A.), Starc, G. (Gregor), Stathopoulou, M. G. (Maria G.), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A. D. (Aryeh D.), Stergiou, G. S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stoeckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M. W. (Maria Wany), Sun, C.-A. (Chien-An), Sung, Y.-T. (Yn-Tz), Suriyawongpaisal, P. (Paibul), Sy, R. G. (Rody G.), Tai, E. S. (E. Shyong), Tammesoo, M.-L. (Mari-Liis), Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M. R. (Mohammed Rasoul), Tarqui-Mamani, C. B. (Carolina B.), Taylor, A. (Anne), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, B. H. (Betina H.), Tjonneland, A. (Anne), Tolonen, H. K. (Hanna K.), Topbas, M. (Murat), Topor-Madry, R. (Roman), Jose Tormo, M. (Maria), Torrent, M. (Maties), Traissac, P. (Pierre), Trichopoulos, D. (Dimitrios), Trichopoulou, A. (Antonia), Trinh, O. T. (Oanh T. H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M. K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Turley, M. L. (Maria L.), Tynelius, P. (Per), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Uusitalo, H. M. (Hannu M. T.), Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), van der Schouw, Y. T. (Yvonne T.), Van Herck, K. (Koen), van Rossem, L. (Lenie), van Valkengoed, I. G. (Irene G. M.), Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Verschuren, W. M. (W. M. Monique), Verstraeten, R. (Roosmarijn), Victora, C. G. (Cesar G.), Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J. K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Vrdoljak, A. (Ana), Vrijheid, M. (Martine), Wade, A. N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W. N. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. X. (Ya Xing), Wannamethee, S. G. (S. Goya), Wareham, N. (Nicholas), Wederkopp, N. (Niels), Weerasekera, D. (Deepa), Whincup, P. H. (Peter H.), Widhalm, K. (Kurt), Widyahening, I. S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A. H. (Alet H.), Wilks, R. J. (Rainford J.), Willeit, P. (Peter), Williams, E. A. (Emmanuel A.), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, T. Y. (Tien Yin), Wong-McClure, R. A. (Roy A.), Woo, J. (Jean), Wu, A. G. (Aleksander Giwercman), Wu, F. C. (Frederick C.), Wu, S. L. (Shou Ling), Xu, H. (Haiquan), Yan, W. (Weili), Yang, X. (Xiaoguang), Ye, X. (Xingwang), Yiallouros, P. K. (Panayiotis K.), Yoshihara, A. (Akihiro), Younger-Coleman, N. O. (Novie O.), Yusoff, A. F. (Ahmad F.), Zambon, S. (Sabina), Zdrojewski, T. (Tomasz), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingffeng), Zhu, D. (Dan), Zimmermann, E. (Esther), Zuniga Cisneros, J. (Julio), Zhou, B. (Bin), Bentham, J. (James), Di Cesare, M. (Mariachiara), Bixby, H. (Honor), Danaei, G. (Goodarz), Cowan, M. J. (Melanie J.), Paciorek, C. J. (Christopher J.), Singh, G. (Gitanjali), Hajifathalian, K. (Kaveh), Bennett, J. E. (James E.), Taddei, C. (Cristina), Bilano, V. (Ver), Carrillo-Larco, R. M. (Rodrigo M.), Djalalinia, S. (Shirin), Khatibzadeh, S. (Shahab), Lugero, C. (Charles), Peykari, N. (Niloofar), Zhang, W. Z. (Wan Zhu), Lu, Y. (Yuan), Stevens, G. A. (Gretchen A.), Riley, L. M. (Leanne M.), Bovet, P. (Pascal), Elliott, P. (Paul), Gu, D. (Dongfeng), Ikeda, N. (Nayu), Jackson, R. T. (Rod T.), Joffres, M. (Michel), Kengne, A. P. (Andre Pascal), Laatikainen, T. (Tiina), Lam, T. H. (Tai Hing), Laxmaiah, A. (Avula), Liu, J. (Jing), Miranda, J. J. (J. Jaime), Mondo, C. K. (Charles K.), Neuhauser, H. K. (Hannelore K.), Sundstrom, J. (Johan), Smeeth, L. (Liam), Soric, M. (Maroje), Woodward, M. (Mark), Ezzati, M. (Majid), Abarca-Gomez, L. (Leandra), Abdeen, Z. A. (Ziad A.), Rahim, H. A. (Hanan Abdul), Abu-Rmeileh, N. M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Afsana, K. (Kaosar), Aguilar-Salinas, C. A. (Carlos A.), Agyemang, C. (Charles), Ahmadvand, A. (Alireza), Ahrens, W. (Wolfgang), Al Raddadi, R. (Rajaa), Al Woyatan, R. (Rihab), Ali, M. M. (Mohamed M.), Alkerwi, A. (Ala'a), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L. B. (Lars Bo), Anderssen, S. A. (Sigmund A.), Angquist, L. (Lars), Anjana, R. M. (Ranjit Mohan), Ansong, D. (Daniel), Aounallah-Skhiri, H. (Hajer), Araujo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Aryal, K. (Krishna), Arveiler, D. (Dominique), Assah, F. K. (Felix K.), Assuncao, M. C. (Maria Cecilia F.), Avdicova, M. (Maria), Azevedo, A. (Ana), Azizi, F. (Fereidoun), Babu, B. V. (Bontha V.), Bahijri, S. (Suhad), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J. R. (Jose R.), Barbagallo, C. M. (Carlo M.), Barcelo, A. (Alberto), Barkat, A. (Amina), Barros, A. J. (Aluisio J. D.), Barros, M. V. (Mauro V.), Bata, I. (Iqbal), Batieha, A. M. (Anwar M.), Baur, L. A. (Louise A.), Beaglehole, R. (Robert), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benson, L. S. (Lowell S.), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S. K. (Santosh K.), Bi, Y. (Yufang), Bikbov, M. (Mukharram), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjokelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boeing, H. (Heiner), Boggia, J. G. (Jose G.), Boissonnet, C. P. (Carlos P.), Bongard, V. (Vanina), Braeckman, L. (Lutgart), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L. M. (Lizzy M.), Bruno, G. (Graziella), Bueno-de-Mesquita, H. B. (H. B. (as)), Bugge, A. (Anna), Burns, C. (Con), Bursztyn, M. (Michael), de Leon, A. C. (Antonio Cabrera), Cameron, C. (Christine), Can, G. (Gunay), Candido, A. P. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V. C. (Viviane C.), Carlsson, A. C. (Axel C.), Carvalho, M. J. (Maria J.), Casanueva, F. F. (Felipe F.), Casas, J.-P. (Juan-Pablo), Caserta, C. A. (Carmelo A.), Chamukuttan, S. (Snehalatha), Chan, A. W. (Angelique W.), Chan, Q. (Queenie), Chaturvedi, H. K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Dekkaki, I. C. (Imane Cherkaoui), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F. (Frank), Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Cyrus), Cooper, R. (Rachel), Coppinger, T. C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C. L. (Cora L.), Crujeiras, A. B. (Ana B.), Cruz, J. J. (Juan J.), D'Arrigo, G. (Graziella), d'Orsi, E. (Eleonora), Dallongeville, J. (Jean), Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T. M. (Thomas M.), Dauchet, L. (Luc), De Backer, G. (Guy), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Dehghan, A. (Abbas), Delisle, H. (Helene), Deschamps, V. (Valerie), Dhana, K. (Klodian), Di Castelnuovo, A. F. (Augusto F.), Dias-da-Costa, J. S. (Juvenal Soares), Diaz, A. (Alejandro), Dickerson, T. T. (Ty T.), Do, H. T. (Ha T. P.), Dobson, A. J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S. P. (Silvana P.), Doering, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Dulskiene, V. (Virginija), Dzakula, A. (Aleksandar), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Ellert, U. (Ute), Elosua, R. (Roberto), Erasmus, R. T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), Escobedo-de la Pena, J. (Jorge), Evans, A. (Alun), Faeh, D. (David), Fall, C. H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F. J. (Francisco J.), Ferguson, T. S. (Trevor S.), Fernandez-Berges, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J. D. (Joseph D.), Fischer, K. (Krista), Foeger, B. (Bernhard), Foo, L. H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fortmann, S. P. (Stephen P.), Fouad, H. M. (Heba M.), Francis, D. K. (Damian K.), Franco, M. d. (Maria do Carmo), Franco, O. H. (Oscar H.), Frontera, G. (Guillermo), Fuchs, F. D. (Flavio D.), Fuchs, S. C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gareta, D. (Dickman), Garnett, S. P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Gavrila, D. (Diana), Geleijnse, J. M. (Johanna M.), Ghasemian, A. (Anoosheh), Ghimire, A. (Anup), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Goldsmith, R. A. (Rebecca A.), Goncalves, H. (Helen), Gonzalez Gross, M. (Marcela), Gonzalez Rivas, J. P. (Juan P.), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dusan), Grajda, A. (Aneta), Gregor, R. D. (Ronald D.), Grodzicki, T. (Tomasz), Grontved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Guan, O. P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A. L. (Andre L.), Gulliford, M. C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Gunter, M. (Marc), Gupta, P. C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Hadaegh, F. (Farzad), Halkjaer, J. (Jytte), Hambleton, I. R. (Ian R.), Hardy, R. (Rebecca), Harikumar, R. (Rachakulla), Hata, J. (Jun), Hayes, A. J. (Alison J.), He, J. (Jiang), Hendriks, M. E. (Marleen Elisabeth), Henriques, A. (Ana), Hernandez Cadena, L. (Leticia), . (), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hihtaniemi, I. T. (Ilpo Tapani), Ho, S. Y. (Sai Yin), Ho, S. C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Dinc, G. H. (Gonul Horasan), Hormiga, C. M. (Claudia M.), Horta, B. L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T. T. (Thein Thein), Htet, A. S. (Aung Soe), Hu, Y. (Yonghua), Maria Huerta, J. (Jose), Husseini, A. S. (Abdullatif S.), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A. G. (Anna G.), Ibrahim, M. M. (M. Mohsen), Ikram, M. A. (M. Arfan), Irazola, V. E. (Vilma E.), Islam, M. (Muhammad), Ivkovic, V. (Vanja), Iwasaki, M. (Masanori), Jacobs, J. M. (Jeremy M.), Jafar, T. (Tazeen), Jamrozik, K. (Konrad), Janszky, I. (Imre), Jasienska, G. (Grazyna), Jelakovic, B. (Bojan), Jiang, C. Q. (Chao Qiang), Johansson, M. (Mattias), Jonas, J. B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Juresa, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kamaruddin, N. A. (Nor Azmi), Kasaeian, A. (Amir), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, U. (Ulrich), Boker, L. K. (Lital Keinan), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kemper, H. C. (Han C. G.), Kersting, M. (Mathilde), Key, T. (Timothy), Khader, Y. S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Khaw, K.-T. (Kay-Tee), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Klumbiene, J. (Jurate), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kristensen, P. L. (Peter Lund), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H. S. (Herculina S.), Kubinova, R. (Ruzena), Kuciene, R. (Renata), Kuh, D. (Diana), Kujala, U. M. (Urho M.), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Kumar, R. K. (R. Krishna), Kurjata, P. (Pawel), Kusuma, Y. S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Kyobutungi, C. (Catherine), Lachat, C. (Carl), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Laugsand, L. E. (Lars E.), Le, T. D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimaki, T. (Terho), Lekhraj, R. (Rampal), Leon-Munoz, L. M. (Luz M.), Levitt, N. S. (Naomi S.), Li, Y. (Yanping), Lilly, C. L. (Christa L.), Lim, W.-Y. (Wei-Yen), Fernanda Lima-Costa, M. (M.), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Lorbeer, R. (Roberto), Lotufo, P. A. (Paulo A.), Eugenio Lozano, J. (Jose), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Ma, J. (Jun), Machado-Coelho, G. L. (George L. L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D. J. (Dianna J.), Majer, M. (Marjeta), Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K. M. (Kodavanti Mallikharjuna), Malyutina, S. (Sofia), Manios, Y. (Yannis), Mann, J. I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martorell, R. (Reynaldo), Mathiesen, E. B. (Ellisiv B.), Matijasevich, A. (Alicia), Matsha, T. E. (Tandi E.), Mbanya, J. C. (Jean Claude N.), Posso, A. J. (Anselmo J. Mc Donald), McFarlane, S. R. (Shelly R.), McGarvey, S. T. (Stephen T.), McLachlan, S. (Stela), McLean, R. M. (Rachael M.), McNulty, B. A. (Breige A.), Khir, A. S. (Amir Sharifuddin Md), Mediene-Benchekor, S. (Sounnia), Medzioniene, J. (Jurate), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A. M. (Ana Maria B.), Menon, G. R. (Geetha R.), Meshram, I. I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Mikkel, K. (Kairit), Miller, J. C. (Jody C.), Francisco Miquel, J. (Juan), Jaime Miranda, J. (J.), Misigoj-Durakovic, M. (Marjeta), Mohamed, M. K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M. F. (Muhammad Fadhli Mohd), Moller, N. C. (Niels C.), Molnar, D. (Denes), Momenan, A. (Amirabbas), Monyeki, K. D. (Kotsedi Daniel K.), Moreira, L. B. (Leila B.), Morejon, A. (Alain), Moreno, L. A. (Luis A.), Morgan, K. (Karen), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M. E. (Mohammad Esmaeel), Motta, J. (Jorge), Muiesan, M. L. (Maria L.), Mueller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Musil, V. (Vera), Nagel, G. (Gabriele), Naidu, B. M. (Balkish M.), Nakamura, H. (Harunobu), Namsna, J. (Jana), Nang, E. E. (Ei Ei K.), Nangia, V. B. (Vinay B.), Narake, S. (Sameer), Maria Navarrete-Munoz, E. (Eva), Ndiaye, N. C. (Ndeye Coumba), Neal, W. A. (William A.), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N. D. (Nguyen D.), Nieto-Martinez, R. E. (Ramfis E.), Niiranen, T. J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Noboa, O. A. (Oscar A.), Noorbala, A. A. (Ahmad Ali), Norat, T. (Teresa), Noto, D. (Davide), Al Nsour, M. (Mohannad), O'Reilly, D. (Dermot), Oh, K. (Kyungwon), Olinto, M. T. (Maria Teresa A.), Oliveira, I. O. (Isabel O.), Omar, M. A. (Mohd Azahadi), Onat, A. (Altan), Ordunez, P. (Pedro), Osmond, C. (Clive), Ostojic, S. M. (Sergej M.), Otero, J. A. (Johanna A.), Overvad, K. (Kim), Owusu-Dabo, E. (Ellis), Paccaud, F. M. (Fred Michel), Padez, C. (Cristina), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palli, D. (Domenico), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Papandreou, D. (Dimitrios), Parnell, W. R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pecin, I. (Ivan), Pednekar, M. S. (Mangesh S.), Peer, N. (Nasheeta), Peeters, P. H. (Petra H.), Peixoto, S. V. (Sergio Viana), Pelletier, C. (Catherine), Peltonen, M. (Markku), Pereira, A. C. (Alexandre C.), Marina Perez, R. (Rosa), Peters, A. (Annette), Petkeviciene, J. (Janina), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, L. (Lorenza), Pitakaka, F. (Freda), Plans-Rubio, P. (Pedro), Polakowska, M. (Maria), Polasek, O. (Ozren), Porta, M. (Miquel), Portegies, M. L. (Marileen L. P.), Pourshams, A. (Akram), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J. F. (Jacqueline F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R. F. (Radwan F.), Qorbani, M. (Mostafa), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M. (Mahfuzar), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S. R. (Sudha Ramachandra), Ramos, E. (Elisabete), Rampal, S. (Sanjay), Rangel Reina, D. A. (Daniel A.), Rasmussen, F. (Finn), Redon, J. (Josep), Reganit, P. F. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), de Wit, T. F. (Tobias F. Rinke), Ritti-Dias, R. M. (Raphael M.), Robinson, S. M. (Sian M.), Robitaille, C. (Cynthia), Rodriguez-Artalejo, F. (Fernando), Rodriguez-Villamizar, L. A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rosengren, A. (Annika), Rubinstein, A. (Adolfo), Rui, O. (Ornelas), Sandra Ruiz-Betancourt, B. (Blanca), Russo Horimoto, A. R. (Andrea R. V.), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H. S. (Harshpal S.), Saidi, O. (Olfa), Sakarya, S. (Sibel), Salanave, B. (Benoit), Salazar Martinez, E. (Eduardo), Salmeron, D. (Diego), Salomaa, V. (Veikko), Salonen, J. T. (Jukka T.), Salvetti, M. (Massimo), Sanchez-Abanto, J. (Jose), Sans, S. (Susana), Santos, D. (Diana), Santos, I. S. (Ina S.), dos Santos, R. N. (Renata Nunes), Santos, R. (Rute), Saramies, J. L. (Jouko L.), Sardinha, L. B. (Luis B.), Margolis, G. S. (Giselle Sarganas), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S. C. (Savvas C.), Scazufca, M. (Marcia), Schargrodsky, H. (Herman), Schneider, I. J. (Ione J.), Schultsz, C. (Constance), Schutte, A. E. (Aletta E.), Sen, A. (Abhijit), Senbanjo, I. O. (Idowu O.), Sepanlou, S. G. (Sadaf G.), Sharma, S. K. (Sanjib K.), Shaw, J. E. (Jonathan E.), Shibuya, K. (Kenji), Shin, D. W. (Dong Wook), Shin, Y. (Youchan), Siantar, R. (Rosalynn), Sibai, A. M. (Abla M.), Santos Silva, D. A. (Diego Augusto), Simon, M. (Mary), Simons, J. (Judith), Simons, L. A. (Leon A.), Sjotrom, M. (Michael), Skovbjerg, S. (Sine), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smith, M. C. (Margaret C.), Snijder, M. B. (Marieke B.), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugene), Soderberg, S. (Stefan), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Song, Y. (Yi), Sorensen, T. I. (Thorkild I. A.), Jerome, C. S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J. A. (Jan A.), Starc, G. (Gregor), Stathopoulou, M. G. (Maria G.), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A. D. (Aryeh D.), Stergiou, G. S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stoeckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M. W. (Maria Wany), Sun, C.-A. (Chien-An), Sung, Y.-T. (Yn-Tz), Suriyawongpaisal, P. (Paibul), Sy, R. G. (Rody G.), Tai, E. S. (E. Shyong), Tammesoo, M.-L. (Mari-Liis), Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M. R. (Mohammed Rasoul), Tarqui-Mamani, C. B. (Carolina B.), Taylor, A. (Anne), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, B. H. (Betina H.), Tjonneland, A. (Anne), Tolonen, H. K. (Hanna K.), Topbas, M. (Murat), Topor-Madry, R. (Roman), Jose Tormo, M. (Maria), Torrent, M. (Maties), Traissac, P. (Pierre), Trichopoulos, D. (Dimitrios), Trichopoulou, A. (Antonia), Trinh, O. T. (Oanh T. H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M. K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Turley, M. L. (Maria L.), Tynelius, P. (Per), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Uusitalo, H. M. (Hannu M. T.), Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), van der Schouw, Y. T. (Yvonne T.), Van Herck, K. (Koen), van Rossem, L. (Lenie), van Valkengoed, I. G. (Irene G. M.), Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Verschuren, W. M. (W. M. Monique), Verstraeten, R. (Roosmarijn), Victora, C. G. (Cesar G.), Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J. K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Vrdoljak, A. (Ana), Vrijheid, M. (Martine), Wade, A. N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W. N. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. X. (Ya Xing), Wannamethee, S. G. (S. Goya), Wareham, N. (Nicholas), Wederkopp, N. (Niels), Weerasekera, D. (Deepa), Whincup, P. H. (Peter H.), Widhalm, K. (Kurt), Widyahening, I. S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A. H. (Alet H.), Wilks, R. J. (Rainford J.), Willeit, P. (Peter), Williams, E. A. (Emmanuel A.), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, T. Y. (Tien Yin), Wong-McClure, R. A. (Roy A.), Woo, J. (Jean), Wu, A. G. (Aleksander Giwercman), Wu, F. C. (Frederick C.), Wu, S. L. (Shou Ling), Xu, H. (Haiquan), Yan, W. (Weili), Yang, X. (Xiaoguang), Ye, X. (Xingwang), Yiallouros, P. K. (Panayiotis K.), Yoshihara, A. (Akihiro), Younger-Coleman, N. O. (Novie O.), Yusoff, A. F. (Ahmad F.), Zambon, S. (Sabina), Zdrojewski, T. (Tomasz), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingffeng), Zhu, D. (Dan), Zimmermann, E. (Esther), and Zuniga Cisneros, J. (Julio)
Abstract: Background: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods: For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of raised blood pressure for 200 countries. We calculated the contributions of changes in prevalence versus population growth and ageing to the increase in the number of adults with raised blood pressure. Findings: We pooled 1479 studies that had measured the blood pressures of 19.1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127.0 mm Hg (95% credible interval 125.7–128.3) in men and 122.3 mm Hg (121.0–123.6) in women; age-standardised mean diastolic blood pressure was 78.7 mm Hg (77.9–79.5) for men and 76.7 mm Hg (75.9–77.6) for women. Global age-standardised prevalence of raised blood pressure was 24.1% (21.4–27.1) in men and 20.1% (17.8–22.5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also decreased in women in central and eastern Europe, Latin America and the Caribbean, and, more recently, central Asia, Middle East, and north Africa, but the estimated trends in these super-regions had larger uncertainty than in high-income super-regions. By contrast, mean blood pressure might have increased in
Published: 2017

21. Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Weiderpass E, Arriola L, Molina-Montes E, Duell EJ, Santiuste C, Alonso de la Torre R, Barricarte Gurrea A, Stocks T, Johansson M, Ljungberg B, Wareham N, Khaw KT, Travis RC, Cross AJ, Murphy N, Riboli E, Scelo G.Int J Cancer. 2015 Oct 15;137(8):1953-66. [Epub 2015 Apr 28]. doi

Author: MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., Scelo, G., MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., and Scelo, G.
Published: 2017

22. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants

Author: Zhou, B, Bentham, J, Di Cesare, M, Bixby, H, Danaei, G, Cowan, MJ, Paciorek, CJ, Singh, G, Hajifathalian, K, Bennett, JE, Taddei, C, Bilano, V, Carrillo-Larco, RM, Djalalinia, S, Khatibzadeh, S, Lugero, C, Peykari, N, Zhang, WZ, Lu, Y, Stevens, GA, Riley, LM, Bovet, P, Elliott, P, Gu, D, Ikeda, N, Jackson, RT, Joffres, M, Kengne, AP, Laatikainen, T, Lam, TH, Laxmaiah, A, Liu, J, Miranda, JJ, Mondo, CK, Neuhauser, HK, Sundström, J, Smeeth, L, Soric, M, Woodward, M, Ezzati, M, Abarca-Gómez, L, Abdeen, ZA, Rahim, HA, Abu-Rmeileh, NM, Acosta-Cazares, B, Adams, R, Aekplakorn, W, Afsana, K, Aguilar-Salinas, CA, Agyemang, C, Ahmadvand, A, Ahrens, W, Al Raddadi, R, Al Woyatan, R, Ali, MM, Alkerwi, A, Aly, E, Amouyel, P, Amuzu, A, Andersen, LB, Anderssen, SA, Ängquist, L, Anjana, RM, Ansong, D, Aounallah-Skhiri, H, Araújo, J, Ariansen, I, Aris, T, Arlappa, N, Aryal, K, Arveiler, D, Assah, FK, Assun ao, MCF, Avdicová, M, Azevedo, A, Azizi, F, Babu, BV, Bahijri, S, Balakrishna, N, Bandosz, P, Banegas, JR, Barbagallo, CM, Barceló, A, Barkat, A, Barros, AJD, Barros, MV, Bata, I, Batieha, AM, Baur, LA, Beaglehole, R, Romdhane, HB, Benet, M, Benson, LS, Bernabe-Ortiz, A, Bernotiene, G, Bettiol, H, Bhagyalaxmi, A, Bharadwaj, S, Bhargava, SK, Bi, Y, Bikbov, M, Bjerregaard, P, Bjertness, E, Björkelund, C, Blokstra, A, Bo, S, Bobak, M, Boeing, H, Boggia, JG, Boissonnet, CP, Bongard, V, Braeckman, L, Brajkovich, I, Branca, F, Breckenkamp, J, Brenner, H, Brewster, LM, Bruno, G, Bueno-de-Mesquita, HB, Bugge, A, Burns, C, Bursztyn, M, de León, AC, Cacciottolo, J, Cameron, C, Can, G, Cândido, APC, Capuano, V, Cardoso, VC, Carlsson, AC, Carvalho, MJ, Casanueva, FF, Casas, J-P, Caserta, CA, Chamukuttan, S, Chan, AW, Chan, Q, Chaturvedi, HK, Chaturvedi, N, Chen, C-J, Chen, F, Chen, H, Chen, S, Chen, Z, Cheng, C-Y, Dekkaki, IC, Chetrit, A, Chiolero, A, Chiou, S-T, Chirita-Emandi, A, Cho, B, Cho, Y, Chudek, J, Cifkova, R, Claessens, F, Clays, E, Concin, H, Cooper, C, Cooper, R, Coppinger, TC, Costanzo, S, Cottel, D, Cowell, C, Craig, CL, Crujeiras, AB, Cruz, JJ, D Arrigo, G, d Orsi, E, Dallongeville, J, Damasceno, A, Dankner, R, Dantoft, TM, Dauchet, L, De Backer, G, De Bacquer, D, de Gaetano, G, De Henauw, S, De Smedt, D, Deepa, M, Dehghan, A, Delisle, H, Deschamps, V, Dhana, K, Di Castelnuovo, AF, Dias-da-Costa, JS, Diaz, A, Dickerson, TT, Do, HTP, Dobson, AJ, Donfrancesco, C, Donoso, SP, Döring, A, Doua, K, Drygas, W, Dulskiene, V, D akula, A, Dzerve, V, Dziankowska-Zaborszczyk, E, Eggertsen, R, Ekelund, U, El Ati, J, Ellert, U, Elosua, R, Erasmus, RT, Erem, C, Eriksen, L, Escobedo-de la Pe na, J, Evans, A, Faeh, D, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernández-Bergés, D, Ferrante, D, Ferrari, M, Ferreccio, C, Ferrieres, J, Finn, JD, Fischer, K, Föger, B, Foo, LH, Forslund, A-S, Forsner, M, Fortmann, SP, Fouad, HM, Francis, DK, do Carmo Franco, M, Franco, OH, Frontera, G, Fuchs, FD, Fuchs, SC, Fujita, Y, Furusawa, T, Gaciong, Z, Gareta, D, Garnett, SP, Gaspoz, J-M, Gasull, M, Gates, L, Gavrila, D, Geleijnse, JM, Ghasemian, A, Ghimire, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Goldsmith, RA, Gon alves, H, Gross, MG, González Rivas, JP, Gottrand, F, Graff-Iversen, S, Grafnetter, D, Grajda, A, Gregor, RD, Grodzicki, T, Grøntved, A, Gruden, G, Grujic, V, Guan, OP, Gudnason, V, Guerrero, R, Guessous, I, Guimaraes, AL, Gulliford, MC, Gunnlaugsdottir, J, Gunter, M, Gupta, PC, Gureje, O, Gurzkowska, B, Gutierrez, L, Gutzwiller, F, Hadaegh, F, Halkj r, J, Hambleton, IR, Hardy, R, Harikumar, R, Hata, J, Hayes, AJ, He, J, Hendriks, ME, Henriques, A, Cadena, LH, Herqutanto, Herrala, S, Heshmat, R, Hihtaniemi, IT, Ho, SY, Ho, SC, Hobbs, M, Hofman, A, Dinc, GH, Hormiga, CM, Horta, BL, Houti, L, Howitt, C, Htay, TT, Htet, AS, Hu, Y, Huerta, JM, Husseini, AS, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikram, MA, Irazola, VE, Islam, M, Ivkovic, V, Iwasaki, M, Jacobs, JM, Jafar, T, Jamrozik, K, Janszky, I, Jasienska, G, Jelakovic, B, Jiang, CQ, Johansson, M, Jonas, JB, J rgensen, T, Joshi, P, Juolevi, A, Jurak, G, Jure a, V, Kaaks, R, Kafatos, A, Kalter-Leibovici, O, Kamaruddin, NA, Kasaeian, A, Katz, J, Kauhanen, J, Kaur, P, Kavousi, M, Kazakbaeva, G, Keil, U, Boker, LK, Keinänen-Kiukaanniemi, S, Kelishadi, R, Kemper, HCG, Kersting, M, Key, T, Khader, YS, Khalili, D, Khang, Y-H, Khaw, K-T, Kiechl, S, Killewo, J, Kim, J, Klumbiene, J, Kolle, E, Kolsteren, P, Korrovits, P, Koskinen, S, Kouda, K, Koziel, S, Kristensen, PL, Krokstad, S, Kromhout, D, Kruger, HS, Kubinova, R, Kuciene, R, Kuh, D, Kujala, UM, Kula, K, Kulaga, Z, Krishna Kumar, R, Kurjata, P, Kusuma, YS, Kuulasmaa, K, Kyobutungi, C, Lachat, C, Landrove, O, Lanska, V, Lappas, G, Larijani, B, Laugsand, LE, Le Nguyen Bao, K, Le, TD, Leclercq, C, Lee, J, Lehtimäki, T, Lekhraj, R, León-Mu noz, LM, Levitt, NS, Li, Y, Lilly, CL, Lim, W-Y, Lima-Costa, MF, Lin, H-H, Lin, X, Linneberg, A, Lissner, L, Litwin, M, Lorbeer, R, Lotufo, PA, Lozano, JE, Luksiene, D, Lundqvist, A, Lunet, N, Lytsy, P, Ma, G, Ma, J, Machado-Coelho, GLL, Machi, S, Maggi, S, Magliano, DJ, Majer, M, Makdisse, M, Malekzadeh, R, Malhotra, R, Rao, KM, Malyutina, S, Manios, Y, Mann, JI, Manzato, E, Margozzini, P, Marques-Vidal, P, Marrugat, J, Martorell, R, Mathiesen, EB, Matijasevich, A, Matsha, TE, Mbanya, JCN, McDonald Posso, AJ, McFarlane, SR, McGarvey, ST, McLachlan, S, McLean, RM, McNulty, BA, MdKhir, AS, Mediene-Benchekor, S, Medzioniene, J, Meirhaeghe, A, Meisinger, C, Menezes, AMB, Menon, GR, Meshram, II, Metspalu, A, Mi, J, Mikkel, K, Miller, JC, Miquel, JF, Mi igoj-Durakovic, M, Mohamed, MK, Mohammad, K, Mohammadifard, N, Mohan, V, Mohd Yusoff, MF, M ller, NC, Molnár, D, Momenan, A, Monyeki, KDK, Moreira, LB, Morejon, A, Moreno, LA, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mota, J, Motlagh, ME, Motta, J, Muiesan, ML, Müller-Nurasyid, M, Murphy, N, Mursu, J, Musil, V, Nagel, G, Naidu, BM, Nakamura, H, Náme ná, J, Nang, EEK, Nangia, VB, Narake, S, Navarrete-Mu noz, EM, Ndiaye, NC, Neal, WA, Nenko, I, Nervi, F, Nguyen, ND, Nguyen, QN, Nieto-Martínez, RE, Niiranen, TJ, Ning, G, Ninomiya, T, Nishtar, S, Noale, M, Noboa, OA, Noorbala, AA, Norat, T, Noto, D, Al Nsour, M, O Reilly, D, Oh, K, Olinto, MTA, Oliveira, IO, Omar, MA, Onat, A, Ordunez, P, Osmond, C, Ostojic, SM, Otero, JA, Overvad, K, Owusu-Dabo, E, Paccaud, FM, Padez, C, Pahomova, E, Pajak, A, Palli, D, Palmieri, L, Panda-Jonas, S, Panza, F, Papandreou, D, Parnell, WR, Parsaeian, M, Pecin, I, Pednekar, MS, Peer, N, Peeters, PH, Peixoto, SV, Pelletier, C, Peltonen, M, Pereira, AC, Pérez, RM, Peters, A, Petkeviciene, J, Pham, ST, Pigeot, I, Pikhart, H, Pilav, A, Pilotto, L, Pitakaka, F, Plans-Rubió, P, Polakowska, M, Pola ek, O, Porta, M, Portegies, MLP, Pourshams, A, Pradeepa, R, Prashant, M, Price, JF, Puiu, M, Punab, M, Qasrawi, RF, Qorbani, M, Radic, I, Radisauskas, R, Rahman, M, Raitakari, O, Raj, M, Rao, SR, Ramachandran, A, Ramos, E, Rampal, S, Rangel Reina, DA, Rasmussen, F, Redon, J, Reganit, PFM, Ribeiro, R, Riboli, E, Rigo, F, Rinke de Wit, TF, Ritti-Dias, RM, Robinson, SM, Robitaille, C, Rodríguez-Artalejo, F, del Cristo Rodriguez-Perez, M, Rodríguez-Villamizar, LA, Rojas-Martinez, R, Rosengren, A, Rubinstein, A, Rui, O, Ruiz-Betancourt, BS, Russo Horimoto, ARV, Rutkowski, M, Sabanayagam, C, Sachdev, HS, Saidi, O, Sakarya, S, Salanave, B, Martinez, ES, Salmerón, D, Salomaa, V, Salonen, JT, Salvetti, M, Sánchez-Abanto, J, Sans, S, Santos, D, Santos, IS, dos Santos, RN, Santos, R, Saramies, JL, Sardinha, LB, Margolis, GS, Sarrafzadegan, N, Saum, K-U, Savva, SC, Scazufca, M, Schargrodsky, H, Schneider, IJ, Schultsz, C, Schutte, AE, Sen, A, Senbanjo, IO, Sepanlou, SG, Sharma, SK, Shaw, JE, Shibuya, K, Shin, DW, Shin, Y, Siantar, R, Sibai, AM, Santos Silva, DA, Simon, M, Simons, J, Simons, LA, Sjöström, M, Skovbjerg, S, Slowikowska-Hilczer, J, Slusarczyk, P, Smith, MC, Snijder, MB, So, H-K, Sobngwi, E, Söderberg, S, Solfrizzi, V, Sonestedt, E, Song, Y, S rensen, TIA, Jérome, CS, Soumare, A, Staessen, JA, Starc, G, Stathopoulou, MG, Stavreski, B, Steene-Johannessen, J, Stehle, P, Stein, AD, Stergiou, GS, Stessman, J, Stieber, J, Stöckl, D, Stocks, T, Stokwiszewski, J, Stronks, K, Strufaldi, MW, Sun, C-A, Sung, Y-T, Suriyawongpaisal, P, Sy, RG, Tai, ES, Tammesoo, M-L, Tamosiunas, A, Tang, L, Tang, X, Tanser, F, Tao, Y, Tarawneh, MR, Tarqui-Mamani, CB, Taylor, A, Theobald, H, Thijs, L, Thuesen, BH, Tjonneland, A, Tolonen, HK, Tolstrup, JS, Topbas, M, Topór-Madry, R, Tormo, MJ, Torrent, M, Traissac, P, Trichopoulos, D, Trichopoulou, A, Trinh, OTH, Trivedi, A, Tshepo, L, Tulloch-Reid, MK, Tuomainen, T-P, Tuomilehto, J, Turley, ML, Tynelius, P, Tzourio, C, Ueda, P, Ugel, E, Ulmer, H, Uusitalo, HMT, Valdivia, G, Valvi, D, van der Schouw, YT, Van Herck, K, van Rossem, L, van Valkengoed, IGM, Vanderschueren, D, Vanuzzo, D, Vatten, L, Vega, T, Velasquez-Melendez, G, Veronesi, G, Verschuren, WMM, Verstraeten, R, Victora, CG, Viet, L, Viikari-Juntura, E, Vineis, P, Vioque, J, Virtanen, JK, Visvikis-Siest, S, Viswanathan, B, Vollenweider, P, Voutilainen, S, Vrdoljak, A, Vrijheid, M, Wade, AN, Wagner, A, Walton, J, Wan Mohamud, WN, Wang, M-D, Wang, Q, Wang, YX, Wannamethee, SG, Wareham, N, Wederkopp, N, Weerasekera, D, Whincup, PH, Widhalm, K, Widyahening, IS, Wiecek, A, Wijga, AH, Wilks, RJ, Willeit, J, Willeit, P, Williams, EA, Wilsgaard, T, Wojtyniak, B, Wong, TY, Wong-McClure, RA, Woo, J, Wu, AG, Wu, FC, Wu, SL, Xu, H, Yan, W, Yang, X, Ye, X, Yiallouros, PK, Yoshihara, A, Younger-Coleman, NO, Yusoff, AF, Yusoff, MFM, Zambon, S, Zdrojewski, T, Zeng, Y, Zhao, D, Zhao, W, Zheng, Y, Zhu, D, Zimmermann, E, Cisneros, JZ, Zhou, B, Bentham, J, Di Cesare, M, Bixby, H, Danaei, G, Cowan, MJ, Paciorek, CJ, Singh, G, Hajifathalian, K, Bennett, JE, Taddei, C, Bilano, V, Carrillo-Larco, RM, Djalalinia, S, Khatibzadeh, S, Lugero, C, Peykari, N, Zhang, WZ, Lu, Y, Stevens, GA, Riley, LM, Bovet, P, Elliott, P, Gu, D, Ikeda, N, Jackson, RT, Joffres, M, Kengne, AP, Laatikainen, T, Lam, TH, Laxmaiah, A, Liu, J, Miranda, JJ, Mondo, CK, Neuhauser, HK, Sundström, J, Smeeth, L, Soric, M, Woodward, M, Ezzati, M, Abarca-Gómez, L, Abdeen, ZA, Rahim, HA, Abu-Rmeileh, NM, Acosta-Cazares, B, Adams, R, Aekplakorn, W, Afsana, K, Aguilar-Salinas, CA, Agyemang, C, Ahmadvand, A, Ahrens, W, Al Raddadi, R, Al Woyatan, R, Ali, MM, Alkerwi, A, Aly, E, Amouyel, P, Amuzu, A, Andersen, LB, Anderssen, SA, Ängquist, L, Anjana, RM, Ansong, D, Aounallah-Skhiri, H, Araújo, J, Ariansen, I, Aris, T, Arlappa, N, Aryal, K, Arveiler, D, Assah, FK, Assun ao, MCF, Avdicová, M, Azevedo, A, Azizi, F, Babu, BV, Bahijri, S, Balakrishna, N, Bandosz, P, Banegas, JR, Barbagallo, CM, Barceló, A, Barkat, A, Barros, AJD, Barros, MV, Bata, I, Batieha, AM, Baur, LA, Beaglehole, R, Romdhane, HB, Benet, M, Benson, LS, Bernabe-Ortiz, A, Bernotiene, G, Bettiol, H, Bhagyalaxmi, A, Bharadwaj, S, Bhargava, SK, Bi, Y, Bikbov, M, Bjerregaard, P, Bjertness, E, Björkelund, C, Blokstra, A, Bo, S, Bobak, M, Boeing, H, Boggia, JG, Boissonnet, CP, Bongard, V, Braeckman, L, Brajkovich, I, Branca, F, Breckenkamp, J, Brenner, H, Brewster, LM, Bruno, G, Bueno-de-Mesquita, HB, Bugge, A, Burns, C, Bursztyn, M, de León, AC, Cacciottolo, J, Cameron, C, Can, G, Cândido, APC, Capuano, V, Cardoso, VC, Carlsson, AC, Carvalho, MJ, Casanueva, FF, Casas, J-P, Caserta, CA, Chamukuttan, S, Chan, AW, Chan, Q, Chaturvedi, HK, Chaturvedi, N, Chen, C-J, Chen, F, Chen, H, Chen, S, Chen, Z, Cheng, C-Y, Dekkaki, IC, Chetrit, A, Chiolero, A, Chiou, S-T, Chirita-Emandi, A, Cho, B, Cho, Y, Chudek, J, Cifkova, R, Claessens, F, Clays, E, Concin, H, Cooper, C, Cooper, R, Coppinger, TC, Costanzo, S, Cottel, D, Cowell, C, Craig, CL, Crujeiras, AB, Cruz, JJ, D Arrigo, G, d Orsi, E, Dallongeville, J, Damasceno, A, Dankner, R, Dantoft, TM, Dauchet, L, De Backer, G, De Bacquer, D, de Gaetano, G, De Henauw, S, De Smedt, D, Deepa, M, Dehghan, A, Delisle, H, Deschamps, V, Dhana, K, Di Castelnuovo, AF, Dias-da-Costa, JS, Diaz, A, Dickerson, TT, Do, HTP, Dobson, AJ, Donfrancesco, C, Donoso, SP, Döring, A, Doua, K, Drygas, W, Dulskiene, V, D akula, A, Dzerve, V, Dziankowska-Zaborszczyk, E, Eggertsen, R, Ekelund, U, El Ati, J, Ellert, U, Elosua, R, Erasmus, RT, Erem, C, Eriksen, L, Escobedo-de la Pe na, J, Evans, A, Faeh, D, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernández-Bergés, D, Ferrante, D, Ferrari, M, Ferreccio, C, Ferrieres, J, Finn, JD, Fischer, K, Föger, B, Foo, LH, Forslund, A-S, Forsner, M, Fortmann, SP, Fouad, HM, Francis, DK, do Carmo Franco, M, Franco, OH, Frontera, G, Fuchs, FD, Fuchs, SC, Fujita, Y, Furusawa, T, Gaciong, Z, Gareta, D, Garnett, SP, Gaspoz, J-M, Gasull, M, Gates, L, Gavrila, D, Geleijnse, JM, Ghasemian, A, Ghimire, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Goldsmith, RA, Gon alves, H, Gross, MG, González Rivas, JP, Gottrand, F, Graff-Iversen, S, Grafnetter, D, Grajda, A, Gregor, RD, Grodzicki, T, Grøntved, A, Gruden, G, Grujic, V, Guan, OP, Gudnason, V, Guerrero, R, Guessous, I, Guimaraes, AL, Gulliford, MC, Gunnlaugsdottir, J, Gunter, M, Gupta, PC, Gureje, O, Gurzkowska, B, Gutierrez, L, Gutzwiller, F, Hadaegh, F, Halkj r, J, Hambleton, IR, Hardy, R, Harikumar, R, Hata, J, Hayes, AJ, He, J, Hendriks, ME, Henriques, A, Cadena, LH, Herqutanto, Herrala, S, Heshmat, R, Hihtaniemi, IT, Ho, SY, Ho, SC, Hobbs, M, Hofman, A, Dinc, GH, Hormiga, CM, Horta, BL, Houti, L, Howitt, C, Htay, TT, Htet, AS, Hu, Y, Huerta, JM, Husseini, AS, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikram, MA, Irazola, VE, Islam, M, Ivkovic, V, Iwasaki, M, Jacobs, JM, Jafar, T, Jamrozik, K, Janszky, I, Jasienska, G, Jelakovic, B, Jiang, CQ, Johansson, M, Jonas, JB, J rgensen, T, Joshi, P, Juolevi, A, Jurak, G, Jure a, V, Kaaks, R, Kafatos, A, Kalter-Leibovici, O, Kamaruddin, NA, Kasaeian, A, Katz, J, Kauhanen, J, Kaur, P, Kavousi, M, Kazakbaeva, G, Keil, U, Boker, LK, Keinänen-Kiukaanniemi, S, Kelishadi, R, Kemper, HCG, Kersting, M, Key, T, Khader, YS, Khalili, D, Khang, Y-H, Khaw, K-T, Kiechl, S, Killewo, J, Kim, J, Klumbiene, J, Kolle, E, Kolsteren, P, Korrovits, P, Koskinen, S, Kouda, K, Koziel, S, Kristensen, PL, Krokstad, S, Kromhout, D, Kruger, HS, Kubinova, R, Kuciene, R, Kuh, D, Kujala, UM, Kula, K, Kulaga, Z, Krishna Kumar, R, Kurjata, P, Kusuma, YS, Kuulasmaa, K, Kyobutungi, C, Lachat, C, Landrove, O, Lanska, V, Lappas, G, Larijani, B, Laugsand, LE, Le Nguyen Bao, K, Le, TD, Leclercq, C, Lee, J, Lehtimäki, T, Lekhraj, R, León-Mu noz, LM, Levitt, NS, Li, Y, Lilly, CL, Lim, W-Y, Lima-Costa, MF, Lin, H-H, Lin, X, Linneberg, A, Lissner, L, Litwin, M, Lorbeer, R, Lotufo, PA, Lozano, JE, Luksiene, D, Lundqvist, A, Lunet, N, Lytsy, P, Ma, G, Ma, J, Machado-Coelho, GLL, Machi, S, Maggi, S, Magliano, DJ, Majer, M, Makdisse, M, Malekzadeh, R, Malhotra, R, Rao, KM, Malyutina, S, Manios, Y, Mann, JI, Manzato, E, Margozzini, P, Marques-Vidal, P, Marrugat, J, Martorell, R, Mathiesen, EB, Matijasevich, A, Matsha, TE, Mbanya, JCN, McDonald Posso, AJ, McFarlane, SR, McGarvey, ST, McLachlan, S, McLean, RM, McNulty, BA, MdKhir, AS, Mediene-Benchekor, S, Medzioniene, J, Meirhaeghe, A, Meisinger, C, Menezes, AMB, Menon, GR, Meshram, II, Metspalu, A, Mi, J, Mikkel, K, Miller, JC, Miquel, JF, Mi igoj-Durakovic, M, Mohamed, MK, Mohammad, K, Mohammadifard, N, Mohan, V, Mohd Yusoff, MF, M ller, NC, Molnár, D, Momenan, A, Monyeki, KDK, Moreira, LB, Morejon, A, Moreno, LA, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mota, J, Motlagh, ME, Motta, J, Muiesan, ML, Müller-Nurasyid, M, Murphy, N, Mursu, J, Musil, V, Nagel, G, Naidu, BM, Nakamura, H, Náme ná, J, Nang, EEK, Nangia, VB, Narake, S, Navarrete-Mu noz, EM, Ndiaye, NC, Neal, WA, Nenko, I, Nervi, F, Nguyen, ND, Nguyen, QN, Nieto-Martínez, RE, Niiranen, TJ, Ning, G, Ninomiya, T, Nishtar, S, Noale, M, Noboa, OA, Noorbala, AA, Norat, T, Noto, D, Al Nsour, M, O Reilly, D, Oh, K, Olinto, MTA, Oliveira, IO, Omar, MA, Onat, A, Ordunez, P, Osmond, C, Ostojic, SM, Otero, JA, Overvad, K, Owusu-Dabo, E, Paccaud, FM, Padez, C, Pahomova, E, Pajak, A, Palli, D, Palmieri, L, Panda-Jonas, S, Panza, F, Papandreou, D, Parnell, WR, Parsaeian, M, Pecin, I, Pednekar, MS, Peer, N, Peeters, PH, Peixoto, SV, Pelletier, C, Peltonen, M, Pereira, AC, Pérez, RM, Peters, A, Petkeviciene, J, Pham, ST, Pigeot, I, Pikhart, H, Pilav, A, Pilotto, L, Pitakaka, F, Plans-Rubió, P, Polakowska, M, Pola ek, O, Porta, M, Portegies, MLP, Pourshams, A, Pradeepa, R, Prashant, M, Price, JF, Puiu, M, Punab, M, Qasrawi, RF, Qorbani, M, Radic, I, Radisauskas, R, Rahman, M, Raitakari, O, Raj, M, Rao, SR, Ramachandran, A, Ramos, E, Rampal, S, Rangel Reina, DA, Rasmussen, F, Redon, J, Reganit, PFM, Ribeiro, R, Riboli, E, Rigo, F, Rinke de Wit, TF, Ritti-Dias, RM, Robinson, SM, Robitaille, C, Rodríguez-Artalejo, F, del Cristo Rodriguez-Perez, M, Rodríguez-Villamizar, LA, Rojas-Martinez, R, Rosengren, A, Rubinstein, A, Rui, O, Ruiz-Betancourt, BS, Russo Horimoto, ARV, Rutkowski, M, Sabanayagam, C, Sachdev, HS, Saidi, O, Sakarya, S, Salanave, B, Martinez, ES, Salmerón, D, Salomaa, V, Salonen, JT, Salvetti, M, Sánchez-Abanto, J, Sans, S, Santos, D, Santos, IS, dos Santos, RN, Santos, R, Saramies, JL, Sardinha, LB, Margolis, GS, Sarrafzadegan, N, Saum, K-U, Savva, SC, Scazufca, M, Schargrodsky, H, Schneider, IJ, Schultsz, C, Schutte, AE, Sen, A, Senbanjo, IO, Sepanlou, SG, Sharma, SK, Shaw, JE, Shibuya, K, Shin, DW, Shin, Y, Siantar, R, Sibai, AM, Santos Silva, DA, Simon, M, Simons, J, Simons, LA, Sjöström, M, Skovbjerg, S, Slowikowska-Hilczer, J, Slusarczyk, P, Smith, MC, Snijder, MB, So, H-K, Sobngwi, E, Söderberg, S, Solfrizzi, V, Sonestedt, E, Song, Y, S rensen, TIA, Jérome, CS, Soumare, A, Staessen, JA, Starc, G, Stathopoulou, MG, Stavreski, B, Steene-Johannessen, J, Stehle, P, Stein, AD, Stergiou, GS, Stessman, J, Stieber, J, Stöckl, D, Stocks, T, Stokwiszewski, J, Stronks, K, Strufaldi, MW, Sun, C-A, Sung, Y-T, Suriyawongpaisal, P, Sy, RG, Tai, ES, Tammesoo, M-L, Tamosiunas, A, Tang, L, Tang, X, Tanser, F, Tao, Y, Tarawneh, MR, Tarqui-Mamani, CB, Taylor, A, Theobald, H, Thijs, L, Thuesen, BH, Tjonneland, A, Tolonen, HK, Tolstrup, JS, Topbas, M, Topór-Madry, R, Tormo, MJ, Torrent, M, Traissac, P, Trichopoulos, D, Trichopoulou, A, Trinh, OTH, Trivedi, A, Tshepo, L, Tulloch-Reid, MK, Tuomainen, T-P, Tuomilehto, J, Turley, ML, Tynelius, P, Tzourio, C, Ueda, P, Ugel, E, Ulmer, H, Uusitalo, HMT, Valdivia, G, Valvi, D, van der Schouw, YT, Van Herck, K, van Rossem, L, van Valkengoed, IGM, Vanderschueren, D, Vanuzzo, D, Vatten, L, Vega, T, Velasquez-Melendez, G, Veronesi, G, Verschuren, WMM, Verstraeten, R, Victora, CG, Viet, L, Viikari-Juntura, E, Vineis, P, Vioque, J, Virtanen, JK, Visvikis-Siest, S, Viswanathan, B, Vollenweider, P, Voutilainen, S, Vrdoljak, A, Vrijheid, M, Wade, AN, Wagner, A, Walton, J, Wan Mohamud, WN, Wang, M-D, Wang, Q, Wang, YX, Wannamethee, SG, Wareham, N, Wederkopp, N, Weerasekera, D, Whincup, PH, Widhalm, K, Widyahening, IS, Wiecek, A, Wijga, AH, Wilks, RJ, Willeit, J, Willeit, P, Williams, EA, Wilsgaard, T, Wojtyniak, B, Wong, TY, Wong-McClure, RA, Woo, J, Wu, AG, Wu, FC, Wu, SL, Xu, H, Yan, W, Yang, X, Ye, X, Yiallouros, PK, Yoshihara, A, Younger-Coleman, NO, Yusoff, AF, Yusoff, MFM, Zambon, S, Zdrojewski, T, Zeng, Y, Zhao, D, Zhao, W, Zheng, Y, Zhu, D, Zimmermann, E, and Cisneros, JZ
Abstract: Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of raised blood pressure for 200 countries. We calculated the contributions of changes in prevalence versus population growth and ageing to the increase in the number of adults with raised blood pressure. Findings We pooled 1479 studies that had measured the blood pressures of 19·1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127·0 mm Hg (95% credible interval 125·7–128·3) in men and 122·3 mm Hg (121·0–123·6) in women; age-standardised mean diastolic blood pressure was 78·7 mm Hg (77·9–79·5) for men and 76·7 mm Hg (75·9–77·6) for women. Global age-standardised prevalence of raised blood pressure was 24·1% (21·4–27·1) in men and 20·1% (17·8–22·5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also decreased in women in central and eastern Europe, Latin America and the Caribbean, and, more recently, central Asia, Middle East, and north Africa, but the estimated trends in these super-regions had larger uncertainty than in high-income super-regions. By contrast, mean blood pressure might have increased in east and so
Published: 2017

23. Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21

Author: Zhang, M. Wang, Z. Obazee, O. Jia, J. Childs, E.J. Hoskins, J. Figlioli, G. Mocci, E. Collins, I. Chung, C.C. Hautman, C. Arslan, A.A. Beane-Freeman, L. Bracci, P.M. Buring, J. Duell, E.J. Gallinger, S. Giles, G.G. Goodman, G.E. Goodman, P.J. Kamineni, A. Kolonel, L.N. Kulke, M.H. Malats, N. Olson, S.H. Sesso, H.D. Visvanathan, K. White, E. Zheng, W. Abnet, C.C. Albanes, D. Andreotti, G. Brais, L. Bas Bueno-de-Mesquita, H. Basso, D. Berndt, S.I. Boutron-Ruault, M.-C. Bijlsma, M.F. Brenner, H. Burdette, L. Campa, D. Caporaso, N.E. Capurso, G. Cavestro, G.M. Cotterchio, M. Costello, E. Elena, J. Boggi, U. Michael Gaziano, J. Gazouli, M. Giovannucci, E.L. Goggins, M. Gross, M. Haiman, C.A. Hassan, M. Helzlsouer, K.J. Hu, N. Hunter, D.J. Iskierka-Jazdzewska, E. Jenab, M. Kaaks, R. Key, T.J. Khaw, K.-T. Klein, E.A. Kogevinas, M. Krogh, V. Kupcinskas, J. Kurtz, R.C. Landi, M.T. Landi, S. Marchand, L.L. Mambrini, A. Mannisto, S. Milne, R.L. Neale, R.E. Oberg, A.L. Panico, S. Patel, A.V. Peeters, P.H.M. Peters, U. Pezzilli, R. Porta, M. Purdue, M. Ramón Quiros, J. Riboli, E. Rothman, N. Scarpa, A. Scelo, G. Shu, X.-O. Silverman, D.T. Soucek, P. Strobel, O. Sund, M. Malecka-Panas, E. Taylor, P.R. Tavano, F. Travis, R.C. Thornquist, M. Tjønneland, A. Tobias, G.S. Trichopoulos, D. Vashist, Y. Vodicka, P. Wactawski-Wende, J. Wentzensen, N. Yu, H. Yu, K. Zeleniuch-Jacquotte, A. Kooperberg, C. Risch, H.A. Jacobs, E.J. Li, D. Fuchs, C. Hoover, R. Hartge, P. Chanock, S.J. Petersen, G.M. Stolzenberg-Solomon, R.S. Wolpin, B.M. Kraft, P. Klein, A.P. Canzian, F. Amundadottir, L.T. and Zhang, M. Wang, Z. Obazee, O. Jia, J. Childs, E.J. Hoskins, J. Figlioli, G. Mocci, E. Collins, I. Chung, C.C. Hautman, C. Arslan, A.A. Beane-Freeman, L. Bracci, P.M. Buring, J. Duell, E.J. Gallinger, S. Giles, G.G. Goodman, G.E. Goodman, P.J. Kamineni, A. Kolonel, L.N. Kulke, M.H. Malats, N. Olson, S.H. Sesso, H.D. Visvanathan, K. White, E. Zheng, W. Abnet, C.C. Albanes, D. Andreotti, G. Brais, L. Bas Bueno-de-Mesquita, H. Basso, D. Berndt, S.I. Boutron-Ruault, M.-C. Bijlsma, M.F. Brenner, H. Burdette, L. Campa, D. Caporaso, N.E. Capurso, G. Cavestro, G.M. Cotterchio, M. Costello, E. Elena, J. Boggi, U. Michael Gaziano, J. Gazouli, M. Giovannucci, E.L. Goggins, M. Gross, M. Haiman, C.A. Hassan, M. Helzlsouer, K.J. Hu, N. Hunter, D.J. Iskierka-Jazdzewska, E. Jenab, M. Kaaks, R. Key, T.J. Khaw, K.-T. Klein, E.A. Kogevinas, M. Krogh, V. Kupcinskas, J. Kurtz, R.C. Landi, M.T. Landi, S. Marchand, L.L. Mambrini, A. Mannisto, S. Milne, R.L. Neale, R.E. Oberg, A.L. Panico, S. Patel, A.V. Peeters, P.H.M. Peters, U. Pezzilli, R. Porta, M. Purdue, M. Ramón Quiros, J. Riboli, E. Rothman, N. Scarpa, A. Scelo, G. Shu, X.-O. Silverman, D.T. Soucek, P. Strobel, O. Sund, M. Malecka-Panas, E. Taylor, P.R. Tavano, F. Travis, R.C. Thornquist, M. Tjønneland, A. Tobias, G.S. Trichopoulos, D. Vashist, Y. Vodicka, P. Wactawski-Wende, J. Wentzensen, N. Yu, H. Yu, K. Zeleniuch-Jacquotte, A. Kooperberg, C. Risch, H.A. Jacobs, E.J. Li, D. Fuchs, C. Hoover, R. Hartge, P. Chanock, S.J. Petersen, G.M. Stolzenberg-Solomon, R.S. Wolpin, B.M. Kraft, P. Klein, A.P. Canzian, F. Amundadottir, L.T.
Abstract: Genome-wide association studies (GWAS) have identified common pancreatic cancer susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify new susceptibility variants, we performed imputation based on 1000 Genomes (1000G) Project data and association analysis using 5,107 case and 8,845 control subjects from 27 cohort and case-control studies that participated in the PanScan I-III GWAS. This analysis, in combination with a two-staged replication in an additional 6,076 case and 7,555 control subjects from the PANcreatic Disease ReseArch (PANDoRA) and Pancreatic Cancer Case-Control (PanC4) Consortia uncovered 3 new pancreatic cancer risk signals marked by single nucleotide polymorphisms (SNPs) rs2816938 at chromosome 1q32.1 (per allele odds ratio (OR) = 1.20, P = 4.88x10-15), rs10094872 at 8q24.21 (OR = 1.15, P = 3.22x10-9) and rs35226131 at 5p15.33 (OR = 0.71, P = 1.70x10-8). These SNPs represent independent risk variants at previously identified pancreatic cancer risk loci on chr1q32.1 (NR5A2), chr8q24.21 (MYC) and chr5p15.33 (CLPTM1L-TERT) as per analyses conditioned on previously reported susceptibility variants. We assessed expression of candidate genes at the three risk loci in histologically normal (n = 10) and tumor (n = 8) derived pancreatic tissue samples and observed a marked reduction of NR5A2 expression (chr1q32.1) in the tumors (fold change -7.6, P = 5.7x10-8). This finding was validated in a second set of paired (n = 20) histologically normal and tumor derived pancreatic tissue samples (average fold change for three NR5A2 isoforms -31.3 to -95.7, P = 7.5x10-4-2.0x10-3). Our study has identified new susceptibility variants independently conferring pancreatic cancer risk that merit functional follow-up to identify target genes and explain the underlying biology.
Published: 2016

24. Prenatal maternal physical activity and stem cells in umbilical cord blood

Author: Onoyama, S. Qiu, L. Pang Low, H. Chang, C.I. Strohsnitter, W.C. Norwitz, E.R. Lopresti, M. Edmiston, K. Lee, I.M. Trichopoulos, D. Lagiou, P. Hsieh, C.-C. and Onoyama, S. Qiu, L. Pang Low, H. Chang, C.I. Strohsnitter, W.C. Norwitz, E.R. Lopresti, M. Edmiston, K. Lee, I.M. Trichopoulos, D. Lagiou, P. Hsieh, C.-C.
Abstract: Purpose: Early life processes, through influence on fetal stem cells, affect postnatal and adult health outcomes. This study examines the effects of physical activity before and during pregnancy on stem cell counts in umbilical cord blood. Methods: We isolated mononuclear cells from umbilical cord blood samples from 373 singleton full-term pregnancies and quantified hematopoietic (CD34+, CD34+ CD38j, and CD34+ c-kit+), endothelial (CD34+CD133+, CD34+CD133+VEGFR2+, CD34+VEGFR2+, and CD133+VEGFR2+), and putative breast (EpCAM+, EpCAM+CD49f +, EpCAM+CD49f +CD117+, CD49f +CD24+, CD24+CD29+, and CD24+CD29+CD49f +) stem/progenitor cell subpopulations by flow cytometry. Information on physical activities before and during pregnancy was obtained from questionnaires. Weekly energy expenditure was estimated based on metabolic equivalent task values. Results: Prepregnancy vigorous exercise was associated positively with levels of endothelial CD34+CD133+, CD34+CD133+VEGFR2+, CD34+VEGFR2+, and CD133+VEGFR2+ progenitor cell populations (P = 0.02, P = 0.01, P = 0.001, and P = 0.003, respectively); positive associations were observed in samples from the first births and those from the second or later births. Prepregnancy moderate and light exercises and light exercise during the first trimester were not significantly associated with any stem/ progenitor cell population. Light exercise during the second trimester was positively associated with CD34+VEGFR2+ endothelial progenitor cells (P = 0.03). In addition, levels of EpCAM+CD49f + and CD49f +CD24+ breast stem cells were significantly lower among pregnant women who engaged in vigorous/moderate exercise during pregnancy (P = 0.05 and P = 0.02, respectively). Conclusions: Vigorous exercise before pregnancy increases the number of endothelial progenitor cells in umbilical cord blood and thus could potentially enhance endothelial function and improve cardiovascular fitness in the offspring. Findings of lower levels of putative breast s
Published: 2016

25. A century of trends in adult human height

Author: Bentham, J. (James), Di Cesare, M. (Mariachiara), Stevens, G.A. (Gretchen A.), Zhou, B. (Bin), Bixby, H. (Honor), Cowan, M. (Melanie), Fortunato, L. (Léa), Bennett, J.E. (James E.), Danaei, G. (Goodarz), Hajifathalian, K. (Kaveh), Lu, Y. (Yuan), Riley, L.M. (Leanne M.), Laxmaiah, A. (Avula), Kontis, V. (Vasilis), Paciorek, C.J. (Christopher J.), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Hamid, Z.A. (Zargar Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Agyemang, C.O. (Charles), Ahmadvand, A. (Alireza), Ahrens, W. (W.), Al-Hazzaa, H.M. (Hazzaa M.), Al-Othman, A.R. (Amani Rashed), Raddadi, R.A. (Rajaa Al), Ali, M.M. (Mohamed M.), Alkerwi, A. (Ala’a), Alvarez-Pedrerol, M. (Mar), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Babu, B.V. (Bontha V.), Bahijri, S. (Suhad), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Barros, M.V. (Mauro V.), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batista, R.L. (Rosangela L.), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Romdhane, H.B. (Habiba Ben), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bhatti, Z. (Zaid), Bhutta, Z.A. (Zulfiqar A), Bi, H. (Hongsheng), Bi, Y. (Yufang), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boddy, L.M. (Lynne M.), Boehm, B.O. (Bernhard), Boeing, H. (Heiner), Boissonnet, C.P. (Carlos P.), Bongard, V. (Vanina), Bovet, P. (Pascal), Braeckman, L. (Lutgart), Bragt, M.C.E. (Marjolijn C. E.), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bueno-de-Mesquita, H.B. (H. Bas), Bugge, A. (Anna), Burns, C. (Con), De León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Cama, T. (Tilema), Cameron, C. (Christine), Camolas, J. (José), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carlsson, A.C. (Axel C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Chamukuttan, S. (Snehalatha), Chan, A.W.M. (Angelique), Chan, Q. (Queenie), Chaturvedi, H.K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, B. (Belong), Cho, Y. (Yumi), Christensen, K. (Kaare), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Coppinger, T.C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C.L. (Cora L.), Crujeiras, A.B. (Ana B.), D’Arrigo, G. (Graziella), d’Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Damsgaard, C.T. (Camilla T.), Dankner, R. (Rachel), Dauchet, L. (Luc), De Backer, G. (Guy), De Bacquer, D. (Dirk), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Delpeuch, F. (Francis), Deschamps, V. (Valérie), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Dias-da-Costa, J.S. (Juvenal Soares), Diaz, A. (Alejandro), Djalalinia, S. (Shirin), Do, H.T.P. (Ha T. P.), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S.P. (Silvana P.), Döring, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Dzerve, V. (Vilnis), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Elliott, P. (Paul), Engle-Stone, R. (Reina), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), Escobedo-de la Peña, J. (Jorge), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J.D. (Joseph D.), Fischer, K. (Krista), Flores, E.M. (Eric Monterubio), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fortmann, S.P. (Stephen), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Fuchs, F.D. (Flavio D.), Fuchs, S.C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gafencu, M. (Mihai), Gareta, D. (Dickman), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Goldsmith, R.A. (Rebecca A.), Gonçalves, H. (Helen), Gross, M., González Rivas, J.P. (Juan P.), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Grajda, A. (Aneta), Grammatikopoulou, M.G. (Maria G.), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Gu, D. (Dongfeng), Gualdi-Russo, E. (Emanuela), Guan, O.P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gulliford, M.C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Gunter, M. (Marc), Guo, X. (Xiuhua), Guo, Y. (Yin), Gupta, P.C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Halkjær, J., Hambleton, I.R. (Ian R.), Hardy, R., Kumar, R.H. (Rachakulla Hari), Hata, J. (Jun), Hayes, A.J. (Alison J.), He, J. (Jiang), Hendriks, M.E. (Marleen), Cadena, L.H. (Leticia Hernandez), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yonghua), Husseini, A. (Abdullatif), Huu, C.N. (Chinh Nguyen), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (Mohsen M.), Ikeda, N. (Nayu), Ikram, M.A. (Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Ivkovic, V. (Vanja), Iwasaki, M. (Masanori), Jackson, R.T. (Rod T.), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jamrozik, K., Janszky, I. (Imre), Jasienska, G. (Grazyna), Jelakovic, B. (Bojan), Jiang, C.Q. (Chao Qiang), Joffres, M. (Michel), Johansson, M. (Mattias), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Jureša, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kapantais, E. (Efthymios), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keil, M. (Mark), Boker, L.K. (Lital Keinan), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kemper, H.C.G., Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Key, T. (Tim), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Khaw, K.-T. (Kay-Tee), Khouw, I.M.S.L. (Ilse M. S. L.), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Klimont, J. (Jeannette), Klumbiene, J. (Jurate), Koirala, B. (Bhawesh), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kratzer, W. (Wolfgang), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H.S. (Herculina S.), Kubinova, R., Kujala, U.M. (Urho), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Krishna Kumar, R., Kurjata, P. (Pawel), Kusuma, Y.S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Kyobutungi, C. (Catherine), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Laugsand, L.E. (Lars E.), Bao, K.L.N. (Khanh Le Nguyen), Le, T.D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J.J.M. (Jeannette), Lee, J. (Jeonghee), Lehtimäki, T. (Terho), Lekhraj, R. (Rampal), León-Muñoz, L.M. (Luz M.), Li, Y. (Yanping), Lilly, C.L. (Christa L.), Lim, W.-Y. (Wei-Yen), Fernanda Lima-Costa, M., Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Liu, J. (Jing), Lorbeer, R. (Roberto), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Ma, J. (Jun), Machado-Coelho, G.L.L. (George L. L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D.J., Maire, B. (Bernard), Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K.M. (Kodavanti Mallikharjuna), Malyutina, S., Manios, Y., Mann, J.I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Markey, O. (Oonagh), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martin-Prevel, Y. (Yves), Martorell, R. (Reynaldo), Masoodi, S.R. (Shariq R.), Mathiesen, E.B. (Ellisiv), Matsha, T.E. (Tandi E.), Mazur, A. (Artur), Mbanya, J.C.N. (Jean Claude N.), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McKee, M. (Martin), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McNulty, B.A. (Breige A.), Yusof, S.M. (Safiah Md), Mediene-Benchekor, S. (Sounnia), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A.M.B. (Ana Maria B.), Mensink, G.B.M. (Gert B. M.), Meshram, I.I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Michaelsen, K.F., Mikkel, K. (Kairit), Miller, J.C. (Jody C.), Miquel, J.F. (Juan Francisco), Jaime Miranda, J., Mišigoj-Durakovic, M. (Marjeta), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Molbo, D. (Drude), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Mondo, C.K. (Charles K.), Monterrubio, E.A. (Eric A.), Monyeki, K.D.K. (Kotsedi Daniel K.), Moreira, L.B. (Leila B.), Morejon, A. (Alain), Moreno, L.A. (Luis A.), Morgan, K. (Karen), Mortensen, E.L. (Erik Lykke), Moschonis, G., Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Mu, T.T. (Thet Thet), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Murtagh, E.M. (Elaine M.), Musa, K.I. (Kamarul Imran), Musil, V. (Vera), Nagel, G. (Gabriele), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, M. (Monika), Nankap, M. (Martin), Narake, S. (Sameer), Navarrete-Muñoz, E.M., Neal, W.A. (William A.), Nenko, I. (Ilona), Neovius, M. (Martin), Nervi, F. (Flavio), Neuhauser, H.K. (Hannelore K.), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Norat, T. (Teresa), Noto, D. (Davide), Nsour, M.A. (Mohannad Al), O’Reilly, D. (Dermot), Oh, K. (Kyungwon), Olayan, I.H. (Iman H.), Olinto, M.T.A. (Maria Teresa Anselmo), Oltarzewski, M. (Maciej), Omar, M.A. (Mohd A.), Onat, A. (Altan), Ordunez, P. (Pedro), Ortiz, A.P. (Ana P.), Osler, M. (Merete), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Otero, J.A. (Johanna A.), Overvad, K. (Kim), Owusu-Dabo, E. (Ellis), Paccaud, F.M. (Fred Michel), Padez, C. (Cristina), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palli, D. (Domenico), Palloni, A. (Alberto), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pecin, I. (Ivan), Pednekar, M.S. (Mangesh S.), Peeters, P.H.M., Peixoto, S.V. (Sergio Viana), Peltonen, M. (Markku), Pereira, A. (A.), Pérez, C.M. (Cynthia M.), Peters, A., Petkeviciene, J. (Janina), Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, A. (Alberto), Pistelli, F. (Francesco), Pitakaka, F. (Freda), Piwonska, A. (Aleksandra), Plans-Rubió, P. (Pedro), Poh, B.K. (Bee Koon), Porta, M., Portegies, M.L.P. (Marileen), Poulimeneas, D. (Dimitrios), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J.F. (Jackie F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R.F. (Radwan F.), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M.-M. (Mah-mudur), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramke, J. (Jacqueline), Ramos, R. (Rafel), Rampal, S. (Sanjay), Rasmussen, F. (Finn), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), Rinke de Wit, T.F. (Tobias), Ritti-Dias, R.M. (Raphael M.), Rivera, J.A. (Juan A.), Robinson, S.M. (Siân), Robitaille, C. (Cynthia), Rodríguez Artalejo, F. (Fernando), Del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rojroong-Wasinkul, N. (Nipa), Romaguera, D. (Dora), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Rouse, I. (Ian), Rubinstein, A. (Adolfo), Rühli, F.J. (Frank J.), Rui, O. (Ornelas), Ruiz-Betancourt, B.S. (Blanca Sandra), Russo Horimoto, A.R.V. (Andrea R. V.), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Saidi, O. (Olfa), Salanave, B. (Benoit), Martinez, E.S. (Eduardo Salazar), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sandjaja, Sans, S. (Susana), Santos, D.A. (Diana A.), Santos, O. (Osvaldo), Dos Santos, R.N. (Renata Nunes), Santos, R. (Rute), Saramies, J. (Jouko), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Scazufca, M. (Marcia), Rosario, A.S. (Angelika Schaffrath), Schargrodsky, H. (Herman), Schienkiewitz, A. (Anja), Schmidt, I.M. (Ida Maria), Schneider, I.J.C. (Ione J C), Schultsz, C. (Constance), Schutte, A.E. (Aletta E.), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Senbanjo, I.O. (Idowu O.), Sepanlou, S.G. (Sadaf G), Shalnova, S.A. (Svetlana A.), Sharma, S.K. (Sanjib K.), Shaw, J.E., Shibuya, K. (Kenji), Shin, D.W. (Dong Wook), Shin, Y. (Youchan), Shiri, R. (Rahman), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, A.M. (Antonio M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Smith, M.C. (Margaret C.), Snijder, M.B. (Marieke), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugène), Söderberg, S. (Stefan), Soekatri, M.Y.E. (Moesijanti Y. E.), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Song, Y. (Yi), Sørensen, T.I.A. (Thorkild), Soric, M. (Maroje), Jérome, C.S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J.A. (Jan), Starc, G. (Gregor), Stathopoulou, M.G. (Maria G.), Staub, K. (Kaspar), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stergiou, G.S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stöckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stratton, G. (Gareth), Stronks, K. (Karien), Strufaldi, M.W. (Maria Wany), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Sung, Y.-T. (Yn-Tz), Sunyer, J. (Jordi), Suriyawongpaisal, P. (Paibul), Swinburn, B.A. (Boyd A.), Sy, R.G. (Rody G.), Szponar, L. (Lucjan), Shyong Tai, E., Tammesoo, M.L., Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M.R. (Mohammed Rasoul), Tarp, J. (Jakob), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Tchibindat, F. (Félicité), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, L. (Leif), Tjønneland, A. (Anne), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne S.), Topbas, M. (Murat), Topór-Madry, R. (Roman), Torrent, M. (Maties), Toselli, S. (Stefania), Traissac, P. (Pierre), Trichopoulou, A. (Antonia), Trichopoulos, D. (Dimitrios), Trinh, O.T.H. (Oanh T. H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Turley, M.L. (Maria L.), Tynelius, P. (Per), Tzotzas, T. (Themistoklis), Tzourio, C. (Christophe), Ueda, P. (Peter), Ukoli, F.A.M. (Flora A. M.), Ulmer, H. (Hanno), Unal, B. (Belgin), Uusitalo, H.M.T. (Hannu M. T.), Valdivia, G. (Gonzalo), Vale, S. (Susana), Valvi, D. (Damaskini), Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Rossem, L. (Lenie) van, Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Monique Verschuren, W.M., Verstraeten, R. (Roosmarijn), Victora, C.G. (Cesar G.), Viegi, G., Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrdoljak, A. (Ana), Vrijheid, M. (Martine), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. (Ying), Goya Wannamethee, S., Wareham, N.J. (Nick), Weerasekera, D. (Deepa), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A.H. (Alet), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, J.E. (Jyh Eiin), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C.W. (Frederick C.), Wu, J. (Jianfeng), Wu, S.L. (Shou Ling), Xu, H. (Haiquan), Xu, L. (Liang), Yamborisut, U. (Uruwan), Yan, W. (Weili), Yang, X. (Xiaoguang), Yardim, N. (Nazan), Ye, X. (Xingwang), Yiallouros, P.K. (P.), Yoshihara, A. (Akihiro), You, Q.S. (Qi Sheng), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad F.), Zainuddin, A.A. (Ahmad A.), Zambon, S. (Sabina), Zdrojewski, T. (T.), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingfeng), Zhou, M. (Ming), Zhu, D. (Dan), Zimmermann, E., Cisneros, J.Z. (Julio Zuñiga), Bentham, J. (James), Di Cesare, M. (Mariachiara), Stevens, G.A. (Gretchen A.), Zhou, B. (Bin), Bixby, H. (Honor), Cowan, M. (Melanie), Fortunato, L. (Léa), Bennett, J.E. (James E.), Danaei, G. (Goodarz), Hajifathalian, K. (Kaveh), Lu, Y. (Yuan), Riley, L.M. (Leanne M.), Laxmaiah, A. (Avula), Kontis, V. (Vasilis), Paciorek, C.J. (Christopher J.), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Hamid, Z.A. (Zargar Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Agyemang, C.O. (Charles), Ahmadvand, A. (Alireza), Ahrens, W. (W.), Al-Hazzaa, H.M. (Hazzaa M.), Al-Othman, A.R. (Amani Rashed), Raddadi, R.A. (Rajaa Al), Ali, M.M. (Mohamed M.), Alkerwi, A. (Ala’a), Alvarez-Pedrerol, M. (Mar), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Babu, B.V. (Bontha V.), Bahijri, S. (Suhad), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Barros, M.V. (Mauro V.), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batista, R.L. (Rosangela L.), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Romdhane, H.B. (Habiba Ben), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bhatti, Z. (Zaid), Bhutta, Z.A. (Zulfiqar A), Bi, H. (Hongsheng), Bi, Y. (Yufang), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boddy, L.M. (Lynne M.), Boehm, B.O. (Bernhard), Boeing, H. (Heiner), Boissonnet, C.P. (Carlos P.), Bongard, V. (Vanina), Bovet, P. (Pascal), Braeckman, L. (Lutgart), Bragt, M.C.E. (Marjolijn C. E.), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bueno-de-Mesquita, H.B. (H. Bas), Bugge, A. (Anna), Burns, C. (Con), De León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Cama, T. (Tilema), Cameron, C. (Christine), Camolas, J. (José), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carlsson, A.C. (Axel C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Chamukuttan, S. (Snehalatha), Chan, A.W.M. (Angelique), Chan, Q. (Queenie), Chaturvedi, H.K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, B. (Belong), Cho, Y. (Yumi), Christensen, K. (Kaare), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Coppinger, T.C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C.L. (Cora L.), Crujeiras, A.B. (Ana B.), D’Arrigo, G. (Graziella), d’Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Damsgaard, C.T. (Camilla T.), Dankner, R. (Rachel), Dauchet, L. (Luc), De Backer, G. (Guy), De Bacquer, D. (Dirk), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Delpeuch, F. (Francis), Deschamps, V. (Valérie), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Dias-da-Costa, J.S. (Juvenal Soares), Diaz, A. (Alejandro), Djalalinia, S. (Shirin), Do, H.T.P. (Ha T. P.), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S.P. (Silvana P.), Döring, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Dzerve, V. (Vilnis), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Elliott, P. (Paul), Engle-Stone, R. (Reina), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), Escobedo-de la Peña, J. (Jorge), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J.D. (Joseph D.), Fischer, K. (Krista), Flores, E.M. (Eric Monterubio), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fortmann, S.P. (Stephen), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Fuchs, F.D. (Flavio D.), Fuchs, S.C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gafencu, M. (Mihai), Gareta, D. (Dickman), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Goldsmith, R.A. (Rebecca A.), Gonçalves, H. (Helen), Gross, M., González Rivas, J.P. (Juan P.), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Grajda, A. (Aneta), Grammatikopoulou, M.G. (Maria G.), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Gu, D. (Dongfeng), Gualdi-Russo, E. (Emanuela), Guan, O.P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gulliford, M.C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Gunter, M. (Marc), Guo, X. (Xiuhua), Guo, Y. (Yin), Gupta, P.C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Halkjær, J., Hambleton, I.R. (Ian R.), Hardy, R., Kumar, R.H. (Rachakulla Hari), Hata, J. (Jun), Hayes, A.J. (Alison J.), He, J. (Jiang), Hendriks, M.E. (Marleen), Cadena, L.H. (Leticia Hernandez), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yonghua), Husseini, A. (Abdullatif), Huu, C.N. (Chinh Nguyen), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (Mohsen M.), Ikeda, N. (Nayu), Ikram, M.A. (Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Ivkovic, V. (Vanja), Iwasaki, M. (Masanori), Jackson, R.T. (Rod T.), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jamrozik, K., Janszky, I. (Imre), Jasienska, G. (Grazyna), Jelakovic, B. (Bojan), Jiang, C.Q. (Chao Qiang), Joffres, M. (Michel), Johansson, M. (Mattias), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Jureša, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kapantais, E. (Efthymios), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keil, M. (Mark), Boker, L.K. (Lital Keinan), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kemper, H.C.G., Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Key, T. (Tim), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Khaw, K.-T. (Kay-Tee), Khouw, I.M.S.L. (Ilse M. S. L.), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Klimont, J. (Jeannette), Klumbiene, J. (Jurate), Koirala, B. (Bhawesh), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kratzer, W. (Wolfgang), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H.S. (Herculina S.), Kubinova, R., Kujala, U.M. (Urho), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Krishna Kumar, R., Kurjata, P. (Pawel), Kusuma, Y.S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Kyobutungi, C. (Catherine), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Laugsand, L.E. (Lars E.), Bao, K.L.N. (Khanh Le Nguyen), Le, T.D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J.J.M. (Jeannette), Lee, J. (Jeonghee), Lehtimäki, T. (Terho), Lekhraj, R. (Rampal), León-Muñoz, L.M. (Luz M.), Li, Y. (Yanping), Lilly, C.L. (Christa L.), Lim, W.-Y. (Wei-Yen), Fernanda Lima-Costa, M., Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Liu, J. (Jing), Lorbeer, R. (Roberto), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Ma, J. (Jun), Machado-Coelho, G.L.L. (George L. L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D.J., Maire, B. (Bernard), Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K.M. (Kodavanti Mallikharjuna), Malyutina, S., Manios, Y., Mann, J.I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Markey, O. (Oonagh), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martin-Prevel, Y. (Yves), Martorell, R. (Reynaldo), Masoodi, S.R. (Shariq R.), Mathiesen, E.B. (Ellisiv), Matsha, T.E. (Tandi E.), Mazur, A. (Artur), Mbanya, J.C.N. (Jean Claude N.), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McKee, M. (Martin), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McNulty, B.A. (Breige A.), Yusof, S.M. (Safiah Md), Mediene-Benchekor, S. (Sounnia), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A.M.B. (Ana Maria B.), Mensink, G.B.M. (Gert B. M.), Meshram, I.I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Michaelsen, K.F., Mikkel, K. (Kairit), Miller, J.C. (Jody C.), Miquel, J.F. (Juan Francisco), Jaime Miranda, J., Mišigoj-Durakovic, M. (Marjeta), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Molbo, D. (Drude), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Mondo, C.K. (Charles K.), Monterrubio, E.A. (Eric A.), Monyeki, K.D.K. (Kotsedi Daniel K.), Moreira, L.B. (Leila B.), Morejon, A. (Alain), Moreno, L.A. (Luis A.), Morgan, K. (Karen), Mortensen, E.L. (Erik Lykke), Moschonis, G., Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Mu, T.T. (Thet Thet), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Murtagh, E.M. (Elaine M.), Musa, K.I. (Kamarul Imran), Musil, V. (Vera), Nagel, G. (Gabriele), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, M. (Monika), Nankap, M. (Martin), Narake, S. (Sameer), Navarrete-Muñoz, E.M., Neal, W.A. (William A.), Nenko, I. (Ilona), Neovius, M. (Martin), Nervi, F. (Flavio), Neuhauser, H.K. (Hannelore K.), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Norat, T. (Teresa), Noto, D. (Davide), Nsour, M.A. (Mohannad Al), O’Reilly, D. (Dermot), Oh, K. (Kyungwon), Olayan, I.H. (Iman H.), Olinto, M.T.A. (Maria Teresa Anselmo), Oltarzewski, M. (Maciej), Omar, M.A. (Mohd A.), Onat, A. (Altan), Ordunez, P. (Pedro), Ortiz, A.P. (Ana P.), Osler, M. (Merete), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Otero, J.A. (Johanna A.), Overvad, K. (Kim), Owusu-Dabo, E. (Ellis), Paccaud, F.M. (Fred Michel), Padez, C. (Cristina), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palli, D. (Domenico), Palloni, A. (Alberto), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pecin, I. (Ivan), Pednekar, M.S. (Mangesh S.), Peeters, P.H.M., Peixoto, S.V. (Sergio Viana), Peltonen, M. (Markku), Pereira, A. (A.), Pérez, C.M. (Cynthia M.), Peters, A., Petkeviciene, J. (Janina), Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, A. (Alberto), Pistelli, F. (Francesco), Pitakaka, F. (Freda), Piwonska, A. (Aleksandra), Plans-Rubió, P. (Pedro), Poh, B.K. (Bee Koon), Porta, M., Portegies, M.L.P. (Marileen), Poulimeneas, D. (Dimitrios), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J.F. (Jackie F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R.F. (Radwan F.), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M.-M. (Mah-mudur), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramke, J. (Jacqueline), Ramos, R. (Rafel), Rampal, S. (Sanjay), Rasmussen, F. (Finn), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), Rinke de Wit, T.F. (Tobias), Ritti-Dias, R.M. (Raphael M.), Rivera, J.A. (Juan A.), Robinson, S.M. (Siân), Robitaille, C. (Cynthia), Rodríguez Artalejo, F. (Fernando), Del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rojroong-Wasinkul, N. (Nipa), Romaguera, D. (Dora), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Rouse, I. (Ian), Rubinstein, A. (Adolfo), Rühli, F.J. (Frank J.), Rui, O. (Ornelas), Ruiz-Betancourt, B.S. (Blanca Sandra), Russo Horimoto, A.R.V. (Andrea R. V.), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Saidi, O. (Olfa), Salanave, B. (Benoit), Martinez, E.S. (Eduardo Salazar), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sandjaja, Sans, S. (Susana), Santos, D.A. (Diana A.), Santos, O. (Osvaldo), Dos Santos, R.N. (Renata Nunes), Santos, R. (Rute), Saramies, J. (Jouko), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Scazufca, M. (Marcia), Rosario, A.S. (Angelika Schaffrath), Schargrodsky, H. (Herman), Schienkiewitz, A. (Anja), Schmidt, I.M. (Ida Maria), Schneider, I.J.C. (Ione J C), Schultsz, C. (Constance), Schutte, A.E. (Aletta E.), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Senbanjo, I.O. (Idowu O.), Sepanlou, S.G. (Sadaf G), Shalnova, S.A. (Svetlana A.), Sharma, S.K. (Sanjib K.), Shaw, J.E., Shibuya, K. (Kenji), Shin, D.W. (Dong Wook), Shin, Y. (Youchan), Shiri, R. (Rahman), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, A.M. (Antonio M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Smith, M.C. (Margaret C.), Snijder, M.B. (Marieke), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugène), Söderberg, S. (Stefan), Soekatri, M.Y.E. (Moesijanti Y. E.), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Song, Y. (Yi), Sørensen, T.I.A. (Thorkild), Soric, M. (Maroje), Jérome, C.S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J.A. (Jan), Starc, G. (Gregor), Stathopoulou, M.G. (Maria G.), Staub, K. (Kaspar), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stergiou, G.S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stöckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stratton, G. (Gareth), Stronks, K. (Karien), Strufaldi, M.W. (Maria Wany), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Sung, Y.-T. (Yn-Tz), Sunyer, J. (Jordi), Suriyawongpaisal, P. (Paibul), Swinburn, B.A. (Boyd A.), Sy, R.G. (Rody G.), Szponar, L. (Lucjan), Shyong Tai, E., Tammesoo, M.L., Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M.R. (Mohammed Rasoul), Tarp, J. (Jakob), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Tchibindat, F. (Félicité), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, L. (Leif), Tjønneland, A. (Anne), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne S.), Topbas, M. (Murat), Topór-Madry, R. (Roman), Torrent, M. (Maties), Toselli, S. (Stefania), Traissac, P. (Pierre), Trichopoulou, A. (Antonia), Trichopoulos, D. (Dimitrios), Trinh, O.T.H. (Oanh T. H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Turley, M.L. (Maria L.), Tynelius, P. (Per), Tzotzas, T. (Themistoklis), Tzourio, C. (Christophe), Ueda, P. (Peter), Ukoli, F.A.M. (Flora A. M.), Ulmer, H. (Hanno), Unal, B. (Belgin), Uusitalo, H.M.T. (Hannu M. T.), Valdivia, G. (Gonzalo), Vale, S. (Susana), Valvi, D. (Damaskini), Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Rossem, L. (Lenie) van, Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Monique Verschuren, W.M., Verstraeten, R. (Roosmarijn), Victora, C.G. (Cesar G.), Viegi, G., Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrdoljak, A. (Ana), Vrijheid, M. (Martine), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. (Ying), Goya Wannamethee, S., Wareham, N.J. (Nick), Weerasekera, D. (Deepa), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A.H. (Alet), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, J.E. (Jyh Eiin), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C.W. (Frederick C.), Wu, J. (Jianfeng), Wu, S.L. (Shou Ling), Xu, H. (Haiquan), Xu, L. (Liang), Yamborisut, U. (Uruwan), Yan, W. (Weili), Yang, X. (Xiaoguang), Yardim, N. (Nazan), Ye, X. (Xingwang), Yiallouros, P.K. (P.), Yoshihara, A. (Akihiro), You, Q.S. (Qi Sheng), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad F.), Zainuddin, A.A. (Ahmad A.), Zambon, S. (Sabina), Zdrojewski, T. (T.), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingfeng), Zhou, M. (Ming), Zhu, D. (Dan), Zimmermann, E., and Cisneros, J.Z. (Julio Zuñiga)
Abstract: Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5-22.7) and 16.5 cm (13.3- 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8- 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
Published: 2016
Full Text: View/download PDF

26. Trends in adult body-mass index in 200 countries from 1975 to 2014: A pooled analysis of 1698 population-based measurement studies with 19.2 million participants

Author: Di Cesare, M. (Mariachiara), Bentham, J. (James), Stevens, G.A. (Gretchen A.), Zhou, B. (Bin), Danaei, G. (Goodarz), Lu, Y. (Yuan), Bixby, H. (Honor), Cowan, M.J. (Melanie J.), Riley, L.M. (Leanne M.), Hajifathalian, K. (Kaveh), Fortunato, L. (Léa), Taddei, C. (Cristina), Bennett, J.E. (James E.), Ikeda, N. (Nayu), Khang, Y.-H. (Young-Ho), Kyobutungi, C. (Catherine), Laxmaiah, A. (Avula), Li, Y. (Yanping), Lin, H.-H. (Hsien-Ho), Miranda, J.J. (J. Jaime), Mostafa, A. (Aya), Turley, M.L. (Maria L.), Paciorek, C.J. (Christopher J.), Gunter, M. (Marc), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Hamid, Z.A. (Zargar Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Ahmadvand, A. (Alireza), Ahrens, W. (W.), Ali, M.M. (Mohamed M.), Alkerwi, A. (Ala'a), Alvarez-Pedrerol, M. (Mar), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Andrade, D.S. (Dolores S.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Babu, B.V. (Bontha V.), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Barros, M.V. (Mauro V.), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batista, R.L. (Rosangela L.), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Romdhane, H.B. (Habiba Ben), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bhatti, Z. (Zaid), Bhutta, Z.A. (Zulfiqar A), Bi, H. (HongSheng), Bi, Y. (Yufang), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blake, M. (Margaret), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boddy, L.M. (Lynne M.), Boehm, B.O. (Bernhard), Boeing, H. (Heiner), Boissonnet, C.P. (Carlos P.), Bongard, V. (Vanina), Bovet, P. (Pascal), Braeckman, L. (Lutgart), Bragt, M.C.E. (Marjolijn C.E.), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bueno-De-Mesquita, H.B., Bugge, A. (Anna), Burns, C. (Con), De León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Cama, T. (Tilema), Cameron, C. (Christine), Camolas, J. (José), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Castetbon, K., Chamukuttan, S. (Snehalatha), Chan, A.W. (Angelique W.), Chan, Q. (Queenie), Chaturvedi, H.K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, Y. (Yumi), Christensen, K. (Kaare), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Coppinger, T.C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C.L. (Cora L.), Crujeiras, A.B. (Ana B.), D'Arrigo, G. (Graziella), D'Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Damsgaard, C.T. (Camilla T.), Dankner, R. (Rachel), Dauchet, L. (Luc), De Backer, G. (Guy), De Bacquer, D. (Dirk), De Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Delpeuch, F. (Francis), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Dias-Da-Costa, J.S. (Juvenal Soares), Diaz, A. (Alejandro), Djalalinia, S. (Shirin), Do, H.T.P. (Ha T.P.), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Döring, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Elliott, P. (Paul), Engle-Stone, R. (Reina), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), De La Peña, J.E. (Jorge Escobedo), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J.D. (Joseph D.), Fischer, K. (Krista), Flores, E.M. (Eric Monterubio), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Fortmann, S.P. (Stephen), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Fuchs, F.D. (Flavio D.), Fuchs, S.C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gafencu, M. (Mihai), Gareta, D. (Dickman), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Goldsmith, R.A. (Rebecca A.), Gross, M., Rivas, J.P.G. (Juan P. González), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Grajda, A. (Aneta), Grammatikopoulou, M.G. (Maria G.), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Gu, D. (Dongfeng), Guan, O.P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gulliford, M.C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Guo, X.H. (Xiu H.), Guo, Y. (Yin), Gupta, P.C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Halkjær, J., Hardy, R., Kumar, R.H. (Rachakulla Hari), Hayes, A.J. (Alison J.), He, J. (Jiang), Hendriks, M.E. (Marleen), Cadena, L.H. (Leticia Hernandez), Heshmat, R. (Ramin), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yonghua), Hussieni, A.S. (Abdullatif S.), Huu, C.N. (Chinh Nguyen), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (M. Mohsen), Ikram, M.A. (Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Iwasaki, M. (Masanori), Jackson, R.T. (Rod T.), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jamrozik, K., Jasienska, G. (Grazyna), Jiang, C.Q. (Chao Qiang), Joffres, M. (Michel), Johansson, M. (Mattias), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Jureša, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kapantais, E. (Efthymios), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keil, M. (Mark), Boker, L.K. (Lital Keinan), Kelishadi, R. (Roya), Kemper, H.H.C.G. (Han H.C.G.), Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Key, T. (Timothy), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khaw, K.-T. (Kay-Tee), Khouw, I.M.S.L. (Ilse M.S.L.), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Kiyohara, Y. (Yutaka), Klimont, J. (Jeannette), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kratzer, W. (Wolfgang), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H.S. (Herculina S.), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Kumar, R.K. (R. Krishna), Kusuma, Y.S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Laugsand, L.E. (Lars E.), Le Nguyen Bao, K. (Khanh), Le, T.D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimäki, T. (Terho), Lekhraj, R. (Rampal), León-Munoz, L.M. (Luz M.), Lim, W.-Y. (Wei-Yen), Lima-Costa, M.F. (M. Fernanda), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Liu, J. (Jing), Lorbeer, R. (Roberto), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D.J., Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K.M. (Kodavanti Mallikharjuna), Manios, Y., Mann, J.I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Markey, O. (Oonagh), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martin-Prevel, Y. (Yves), Martorell, R. (Reynaldo), Masoodi, S.R. (Shariq R.), Matsha, T.E. (Tandi E.), Mazur, A. (Artur), Mbanya, J.C.N. (Jean Claude N.), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McKee, M. (Martin), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McNulty, B.A. (Breige A.), Md Yusof, S. (Safiah), Mediene-Benchekor, S. (Sounnia), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Mendes, L.L. (Larissa L.), Menezes, A.M.B. (Ana Maria B.), Mensink, G.B.M. (Gert B.M.), Meshram, I.I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Michaelsen, K.F., Mikkel, K. (Kairit), Miller, J.C. (Jody C.), Miquel, J.F. (Juan Francisco), Mišigoj-Duraković, M. (Marjeta), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Molbo, D. (Drude), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Mondo, C.K. (Charles K.), Monterrubio, E.A. (Eric A.), Monyeki, K.D.K. (Kotsedi Daniel K.), Moreira, L.B. (Leila B.), Morejon, A. (Alain), Moreno, L.A. (Luis A.), Morgan, K. (Karen), Mortensen, E.L. (Erik Lykke), Moschonis, G., Mossakowska, M. (Malgorzata), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Mu, T.T. (Thet Thet), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Murtagh, E.M. (Elaine M.), Musa, K.I. (Kamarul Imran), Musil, V. (Vera), Nagel, G. (Gabriele), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, M. (Monika), Nankap, M. (Martin), Narake, S. (Sameer), Navarrete-Muñoz, E.M., Nenko, I. (Ilona), Neovius, M. (Martin), Nervi, F. (Flavio), Neuhauser, H.K. (Hannelore K.), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Norat, T. (Teresa), Noto, D. (Davide), Al Nsour, M. (Mohannad), O'Reilly, D. (Dermot), Ochoa-Avilés, A.M. (Angélica M.), Oh, K. (Kyungwon), Olayan, I.H. (Iman H.), Olinto, M.T.A. (Maria Teresa Anselmo), Oltarzewski, M. (Maciej), Omar, M.A. (Mohd A.), Onat, A. (Altan), Ordunez, P. (Pedro), Ortiz, A.P. (Ana P.), Osler, M. (Merete), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Otero, J.A. (Johanna A.), Overvad, K. (Kim), Paccaud, F.M. (Fred Michel), Padez, C. (Cristina), Pajak, A. (Andrzej), Palli, D. (Domenico), Palloni, A. (Alberto), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pednekar, M.S. (Mangesh S.), Peeters, P.H.M., Peixoto, S.V. (Sergio Viana), Pereira, A. (A.), Pérez, C.M. (Cynthia M.), Peters, A., Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, A. (Alberto), Pistelli, F. (Francesco), Pitakaka, F. (Freda), Piwonska, A. (Aleksandra), Piwonski, J. (Jerzy), Plans-Rubió, P. (Pedro), Poh, B.K. (Bee Koon), Porta, M., Portegies, M.L.P. (Marileen), Poulimeneas, D. (Dimitrios), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J.F. (Jackie F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R.F. (Radwan F.), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M. (Mahmudur), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramke, J. (Jacqueline), Ramos, R. (Rafel), Rampal, S. (Sanjay), Rasmussen, F. (Finn), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), De Wit, T.F.R. (Tobias Floris Rinke), Ritti-Dias, R.M. (Raphael M.), Rivera, J.A. (Juan A.), Robinson, S.M. (Siân), Robitaille, C. (Cynthia), Rodríguez Artalejo, F. (Fernando), Del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rojroongwasinkul, N. (Nipa), Romaguera, D. (Dora), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Rouse, I. (Ian), Rubinstein, A. (Adolfo), Rühli, F.J. (Frank J.), Rui, O. (Ornelas), Ruiz-Betancourt, B.S. (Blanca Sandra), Horimoto, A.R.V.R. (Andrea R.V. Russo), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Saidi, O. (Olfa), Salanave, B. (Benoit), Martinez, E.S. (Eduardo Salazar), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sandjaja, Sans, S. (Susana), Santos, D.A. (Diana A.), Santos, O. (Osvaldo), Dos Santos, R.N. (Renata Nunes), Santos, R. (Rute), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Scazufca, M. (Marcia), Rosario, A.S. (Angelika Schaffrath), Schargrodsky, H. (Herman), Schienkiewitz, A. (Anja), Schmidt, I.M. (Ida Maria), Schneider, I.J.C. (Ione J C), Schultsz, C. (Constance), Schutte, A.E. (Aletta E.), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Senbanjo, I.O. (Idowu O.), Sepanlou, S.G. (Sadaf G), Shalnova, S.A. (Svetlana A.), Shaw, J.E., Shibuya, K. (Kenji), Shin, Y. (Youchan), Shiri, R. (Rahman), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, A.M. (Antonio M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon A.), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Smith, M.C. (Margaret C.), Snijder, M.B. (Marieke), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugène), Söderberg, S. (Stefan), Soekatri, M.Y.E. (Moesijanti Y.E.), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Sørensen, T.I.A. (Thorkild), Sorić, M. (Maroje), Jérome, C.S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J.A. (Jan), Starc, G. (Gregor), Stathopoulou, M.G. (Maria G.), Staub, K. (Kaspar), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stergiou, G.S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stöckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stratton, G. (Gareth), Strufaldi, M.W. (Maria Wany), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Sung, Y.-T. (Yn-Tz), Sunyer, J. (Jordi), Suriyawongpaisal, P. (Paibul), Swinburn, B.A. (Boyd A.), Sy, R.G. (Rody G.), Szponar, L. (Lucjan), Tai, E.S. (E. Shyong), Tammesoo, M.L., Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M. (Mohammed), Tarp, J. (Jakob), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Tchibindat, F. (Félicité), Thijs, L. (Lutgarde), Thuesen, L. (Leif), Tjønneland, A. (Anne), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne S.), Topbas, M. (Murat), Topór-Madry, R. (Roman), Torrent, M. (Maties), Traissac, P. (Pierre), Trichopoulou, A. (Antonia), Trichopoulos, D. (Dimitrios), Trinh, O.T.H. (Oanh T.H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tynelius, P. (Per), Tzotzas, T. (Themistoklis), Tzourio, C. (Christophe), Ueda, P. (Peter), Ukoli, F.A.M. (Flora A.M.), Ulmer, H. (Hanno), Unal, B. (Belgin), Valdivia, G. (Gonzalo), Vale, S. (Susana), Valvi, D. (Damaskini), Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Monique Verschuren, W.M., Viegi, G., Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrijheid, M. (Martine), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. (Ying), Wannamethee, S.G. (Goya), Wareham, N.J. (Nick), Weerasekera, D. (Deepa), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Wojtyniak, B. (Bogdan), Wong, J.E. (Jyh Eiin), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C. (Frederick C.), Wu, J. (JianFeng), Wu, S.L. (Shou Ling), Xu, H. (Haiquan), Xu, L. (Liang), Yamborisut, U. (Uruwan), Yan, W. (Weili), Yang, X. (Xiaoguang), Yardim, N. (Nazan), Ye, X. (Xingwang), Yiallouros, P.K. (P.), Yoshihara, A. (Akihiro), You, Q.S. (Qi Sheng), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad F.), Zainuddin, A.A. (Ahmad A.), Zambon, S. (Sabina), Zdrojewski, T. (T.), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingfeng), Zhou, M. (Ming), Zhu, D. (Dan), Zimmermann, E., Cisneros, J.Z. (Julio Zuñiga), Di Cesare, M. (Mariachiara), Bentham, J. (James), Stevens, G.A. (Gretchen A.), Zhou, B. (Bin), Danaei, G. (Goodarz), Lu, Y. (Yuan), Bixby, H. (Honor), Cowan, M.J. (Melanie J.), Riley, L.M. (Leanne M.), Hajifathalian, K. (Kaveh), Fortunato, L. (Léa), Taddei, C. (Cristina), Bennett, J.E. (James E.), Ikeda, N. (Nayu), Khang, Y.-H. (Young-Ho), Kyobutungi, C. (Catherine), Laxmaiah, A. (Avula), Li, Y. (Yanping), Lin, H.-H. (Hsien-Ho), Miranda, J.J. (J. Jaime), Mostafa, A. (Aya), Turley, M.L. (Maria L.), Paciorek, C.J. (Christopher J.), Gunter, M. (Marc), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Hamid, Z.A. (Zargar Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Ahmadvand, A. (Alireza), Ahrens, W. (W.), Ali, M.M. (Mohamed M.), Alkerwi, A. (Ala'a), Alvarez-Pedrerol, M. (Mar), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Andrade, D.S. (Dolores S.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Babu, B.V. (Bontha V.), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Barros, M.V. (Mauro V.), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batista, R.L. (Rosangela L.), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Romdhane, H.B. (Habiba Ben), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bhatti, Z. (Zaid), Bhutta, Z.A. (Zulfiqar A), Bi, H. (HongSheng), Bi, Y. (Yufang), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blake, M. (Margaret), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boddy, L.M. (Lynne M.), Boehm, B.O. (Bernhard), Boeing, H. (Heiner), Boissonnet, C.P. (Carlos P.), Bongard, V. (Vanina), Bovet, P. (Pascal), Braeckman, L. (Lutgart), Bragt, M.C.E. (Marjolijn C.E.), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bueno-De-Mesquita, H.B., Bugge, A. (Anna), Burns, C. (Con), De León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Cama, T. (Tilema), Cameron, C. (Christine), Camolas, J. (José), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Castetbon, K., Chamukuttan, S. (Snehalatha), Chan, A.W. (Angelique W.), Chan, Q. (Queenie), Chaturvedi, H.K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, Y. (Yumi), Christensen, K. (Kaare), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Coppinger, T.C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C.L. (Cora L.), Crujeiras, A.B. (Ana B.), D'Arrigo, G. (Graziella), D'Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Damsgaard, C.T. (Camilla T.), Dankner, R. (Rachel), Dauchet, L. (Luc), De Backer, G. (Guy), De Bacquer, D. (Dirk), De Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Delpeuch, F. (Francis), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Dias-Da-Costa, J.S. (Juvenal Soares), Diaz, A. (Alejandro), Djalalinia, S. (Shirin), Do, H.T.P. (Ha T.P.), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Döring, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Elliott, P. (Paul), Engle-Stone, R. (Reina), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), De La Peña, J.E. (Jorge Escobedo), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J.D. (Joseph D.), Fischer, K. (Krista), Flores, E.M. (Eric Monterubio), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Fortmann, S.P. (Stephen), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Fuchs, F.D. (Flavio D.), Fuchs, S.C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gafencu, M. (Mihai), Gareta, D. (Dickman), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Goldsmith, R.A. (Rebecca A.), Gross, M., Rivas, J.P.G. (Juan P. González), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Grajda, A. (Aneta), Grammatikopoulou, M.G. (Maria G.), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Gu, D. (Dongfeng), Guan, O.P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gulliford, M.C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Guo, X.H. (Xiu H.), Guo, Y. (Yin), Gupta, P.C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Halkjær, J., Hardy, R., Kumar, R.H. (Rachakulla Hari), Hayes, A.J. (Alison J.), He, J. (Jiang), Hendriks, M.E. (Marleen), Cadena, L.H. (Leticia Hernandez), Heshmat, R. (Ramin), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yonghua), Hussieni, A.S. (Abdullatif S.), Huu, C.N. (Chinh Nguyen), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (M. Mohsen), Ikram, M.A. (Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Iwasaki, M. (Masanori), Jackson, R.T. (Rod T.), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jamrozik, K., Jasienska, G. (Grazyna), Jiang, C.Q. (Chao Qiang), Joffres, M. (Michel), Johansson, M. (Mattias), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Jureša, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kapantais, E. (Efthymios), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keil, M. (Mark), Boker, L.K. (Lital Keinan), Kelishadi, R. (Roya), Kemper, H.H.C.G. (Han H.C.G.), Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Key, T. (Timothy), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khaw, K.-T. (Kay-Tee), Khouw, I.M.S.L. (Ilse M.S.L.), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Kiyohara, Y. (Yutaka), Klimont, J. (Jeannette), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kratzer, W. (Wolfgang), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H.S. (Herculina S.), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Kumar, R.K. (R. Krishna), Kusuma, Y.S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Laugsand, L.E. (Lars E.), Le Nguyen Bao, K. (Khanh), Le, T.D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimäki, T. (Terho), Lekhraj, R. (Rampal), León-Munoz, L.M. (Luz M.), Lim, W.-Y. (Wei-Yen), Lima-Costa, M.F. (M. Fernanda), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Liu, J. (Jing), Lorbeer, R. (Roberto), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D.J., Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K.M. (Kodavanti Mallikharjuna), Manios, Y., Mann, J.I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Markey, O. (Oonagh), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martin-Prevel, Y. (Yves), Martorell, R. (Reynaldo), Masoodi, S.R. (Shariq R.), Matsha, T.E. (Tandi E.), Mazur, A. (Artur), Mbanya, J.C.N. (Jean Claude N.), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McKee, M. (Martin), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McNulty, B.A. (Breige A.), Md Yusof, S. (Safiah), Mediene-Benchekor, S. (Sounnia), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Mendes, L.L. (Larissa L.), Menezes, A.M.B. (Ana Maria B.), Mensink, G.B.M. (Gert B.M.), Meshram, I.I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Michaelsen, K.F., Mikkel, K. (Kairit), Miller, J.C. (Jody C.), Miquel, J.F. (Juan Francisco), Mišigoj-Duraković, M. (Marjeta), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Molbo, D. (Drude), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Mondo, C.K. (Charles K.), Monterrubio, E.A. (Eric A.), Monyeki, K.D.K. (Kotsedi Daniel K.), Moreira, L.B. (Leila B.), Morejon, A. (Alain), Moreno, L.A. (Luis A.), Morgan, K. (Karen), Mortensen, E.L. (Erik Lykke), Moschonis, G., Mossakowska, M. (Malgorzata), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Mu, T.T. (Thet Thet), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Murtagh, E.M. (Elaine M.), Musa, K.I. (Kamarul Imran), Musil, V. (Vera), Nagel, G. (Gabriele), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, M. (Monika), Nankap, M. (Martin), Narake, S. (Sameer), Navarrete-Muñoz, E.M., Nenko, I. (Ilona), Neovius, M. (Martin), Nervi, F. (Flavio), Neuhauser, H.K. (Hannelore K.), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Norat, T. (Teresa), Noto, D. (Davide), Al Nsour, M. (Mohannad), O'Reilly, D. (Dermot), Ochoa-Avilés, A.M. (Angélica M.), Oh, K. (Kyungwon), Olayan, I.H. (Iman H.), Olinto, M.T.A. (Maria Teresa Anselmo), Oltarzewski, M. (Maciej), Omar, M.A. (Mohd A.), Onat, A. (Altan), Ordunez, P. (Pedro), Ortiz, A.P. (Ana P.), Osler, M. (Merete), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Otero, J.A. (Johanna A.), Overvad, K. (Kim), Paccaud, F.M. (Fred Michel), Padez, C. (Cristina), Pajak, A. (Andrzej), Palli, D. (Domenico), Palloni, A. (Alberto), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pednekar, M.S. (Mangesh S.), Peeters, P.H.M., Peixoto, S.V. (Sergio Viana), Pereira, A. (A.), Pérez, C.M. (Cynthia M.), Peters, A., Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, A. (Alberto), Pistelli, F. (Francesco), Pitakaka, F. (Freda), Piwonska, A. (Aleksandra), Piwonski, J. (Jerzy), Plans-Rubió, P. (Pedro), Poh, B.K. (Bee Koon), Porta, M., Portegies, M.L.P. (Marileen), Poulimeneas, D. (Dimitrios), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J.F. (Jackie F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R.F. (Radwan F.), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M. (Mahmudur), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramke, J. (Jacqueline), Ramos, R. (Rafel), Rampal, S. (Sanjay), Rasmussen, F. (Finn), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), De Wit, T.F.R. (Tobias Floris Rinke), Ritti-Dias, R.M. (Raphael M.), Rivera, J.A. (Juan A.), Robinson, S.M. (Siân), Robitaille, C. (Cynthia), Rodríguez Artalejo, F. (Fernando), Del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rojroongwasinkul, N. (Nipa), Romaguera, D. (Dora), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Rouse, I. (Ian), Rubinstein, A. (Adolfo), Rühli, F.J. (Frank J.), Rui, O. (Ornelas), Ruiz-Betancourt, B.S. (Blanca Sandra), Horimoto, A.R.V.R. (Andrea R.V. Russo), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Saidi, O. (Olfa), Salanave, B. (Benoit), Martinez, E.S. (Eduardo Salazar), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sandjaja, Sans, S. (Susana), Santos, D.A. (Diana A.), Santos, O. (Osvaldo), Dos Santos, R.N. (Renata Nunes), Santos, R. (Rute), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Scazufca, M. (Marcia), Rosario, A.S. (Angelika Schaffrath), Schargrodsky, H. (Herman), Schienkiewitz, A. (Anja), Schmidt, I.M. (Ida Maria), Schneider, I.J.C. (Ione J C), Schultsz, C. (Constance), Schutte, A.E. (Aletta E.), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Senbanjo, I.O. (Idowu O.), Sepanlou, S.G. (Sadaf G), Shalnova, S.A. (Svetlana A.), Shaw, J.E., Shibuya, K. (Kenji), Shin, Y. (Youchan), Shiri, R. (Rahman), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, A.M. (Antonio M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon A.), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Smith, M.C. (Margaret C.), Snijder, M.B. (Marieke), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugène), Söderberg, S. (Stefan), Soekatri, M.Y.E. (Moesijanti Y.E.), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Sørensen, T.I.A. (Thorkild), Sorić, M. (Maroje), Jérome, C.S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J.A. (Jan), Starc, G. (Gregor), Stathopoulou, M.G. (Maria G.), Staub, K. (Kaspar), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stergiou, G.S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stöckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stratton, G. (Gareth), Strufaldi, M.W. (Maria Wany), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Sung, Y.-T. (Yn-Tz), Sunyer, J. (Jordi), Suriyawongpaisal, P. (Paibul), Swinburn, B.A. (Boyd A.), Sy, R.G. (Rody G.), Szponar, L. (Lucjan), Tai, E.S. (E. Shyong), Tammesoo, M.L., Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M. (Mohammed), Tarp, J. (Jakob), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Tchibindat, F. (Félicité), Thijs, L. (Lutgarde), Thuesen, L. (Leif), Tjønneland, A. (Anne), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne S.), Topbas, M. (Murat), Topór-Madry, R. (Roman), Torrent, M. (Maties), Traissac, P. (Pierre), Trichopoulou, A. (Antonia), Trichopoulos, D. (Dimitrios), Trinh, O.T.H. (Oanh T.H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tynelius, P. (Per), Tzotzas, T. (Themistoklis), Tzourio, C. (Christophe), Ueda, P. (Peter), Ukoli, F.A.M. (Flora A.M.), Ulmer, H. (Hanno), Unal, B. (Belgin), Valdivia, G. (Gonzalo), Vale, S. (Susana), Valvi, D. (Damaskini), Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Monique Verschuren, W.M., Viegi, G., Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrijheid, M. (Martine), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. (Ying), Wannamethee, S.G. (Goya), Wareham, N.J. (Nick), Weerasekera, D. (Deepa), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Wojtyniak, B. (Bogdan), Wong, J.E. (Jyh Eiin), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C. (Frederick C.), Wu, J. (JianFeng), Wu, S.L. (Shou Ling), Xu, H. (Haiquan), Xu, L. (Liang), Yamborisut, U. (Uruwan), Yan, W. (Weili), Yang, X. (Xiaoguang), Yardim, N. (Nazan), Ye, X. (Xingwang), Yiallouros, P.K. (P.), Yoshihara, A. (Akihiro), You, Q.S. (Qi Sheng), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad F.), Zainuddin, A.A. (Ahmad A.), Zambon, S. (Sabina), Zdrojewski, T. (T.), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingfeng), Zhou, M. (Ming), Zhu, D. (Dan), Zimmermann, E., and Cisneros, J.Z. (Julio Zuñiga)
Abstract: Copyright
Published: 2016
Full Text: View/download PDF

27. A century of trends in adult human height.

Author: NCD Risk Factor Collaboration (NCD-RisC), Bentham, J., Cesare, M.D., Stevens, G.A., Zhou, B., Bixby, H., Cowan, M., Fortunato, L., Bennett, J.E., Danaei, G., Hajifathalian, K., Lu, Y., Riley, L.M., Laxmaiah, A., Kontis, V., Paciorek, C.J., Riboli, E., Ezzati, M., Abdeen, Z.A., Hamid, Z.A., Abu-Rmeileh, N.M., Acosta-Cazares, B., Adams, R., Aekplakorn, W., Aguilar-Salinas, C.A., Agyemang, C., Ahmadvand, A., Ahrens, W., Al-Hazzaa, H.M., Al-Othman, A.R., Raddadi, R.A., Ali, M.M., Alkerwi, A., Alvarez-Pedrerol, M., Aly, E., Amouyel, P., Amuzu, A., Andersen, L.B., Anderssen, S.A., Anjana, R.M., Aounallah-Skhiri, H., Ariansen, I., Aris, T., Arlappa, N., Arveiler, D., Assah, F.K., Avdicová, M., Azizi, F., Babu, B.V., Bahijri, S., Balakrishna, N., Bandosz, P., Banegas, J.R., Barbagallo, C.M., Barceló, A., Barkat, A., Barros, M.V., Bata, I., Batieha, A.M., Batista, R.L., Baur, L.A., Beaglehole, R., Romdhane, H.B., Benet, M., Bernabe-Ortiz, A., Bernotiene, G., Bettiol, H., Bhagyalaxmi, A., Bharadwaj, S., Bhargava, S.K., Bhatti, Z., Bhutta, Z.A., Bi, H., Bi, Y., Bjerregaard, P., Bjertness, E., Bjertness, M.B., Björkelund, C., Blokstra, A., Bo, S., Bobak, M., Boddy, L.M., Boehm, B.O., Boeing, H., Boissonnet, C.P., Bongard, V., Bovet, P., Braeckman, L., Bragt, M.C., Brajkovich, I., Branca, F., Breckenkamp, J., Brenner, H., Brewster, L.M., Brian, G.R., Bruno, G., Bueno-de-Mesquita, H.A., Bugge, A., Burns, C., León, A.C., Cacciottolo, J., Cama, T., Cameron, C., Camolas, J., Can, G., Cândido, A.P., Capuano, V., Cardoso, V.C., Carlsson, A.C., Carvalho, M.J., Casanueva, F.F., Casas, J.P., Caserta, C.A., Chamukuttan, S., Chan, A.W., Chan, Q., Chaturvedi, H.K., Chaturvedi, N., Chen, C.J., Chen, F., Chen, H., Chen, S., Chen, Z., Cheng, C.Y., Chetrit, A., Chiolero, A., Chiou, S.T., Chirita-Emandi, A., Cho, B., Cho, Y., Christensen, K., Chudek, J., Cifkova, R., Claessens, F., Clays, E., Concin, H., Cooper, C., Cooper, R., Coppinger, T.C., Costanzo, S., Cottel, D., Cowell, C., Craig, C.L., Crujeiras, A.B., D'Arrigo, G., d'Orsi, E., Dallongeville, J., Damasceno, A., Damsgaard, C.T., Dankner, R., Dauchet, L., Backer, G.D., Bacquer, D.D., Gaetano, Gd, Henauw, S.D., Smedt, D.D., Deepa, M., Deev, A.D., Dehghan, A., Delisle, H., Delpeuch, F., Deschamps, V., Dhana, K., Castelnuovo, A.F., Dias-da-Costa, J.S., Diaz, A., Djalalinia, S., Do, H.T., Dobson, A.J., Donfrancesco, C., Donoso, S.P., Döring, A., Doua, K., Drygas, W., Dzerve, V., Egbagbe, E., Eggertsen, R., Ekelund, U., Ati, J.E., Elliott, P., Engle-Stone, R., Erasmus, R.T., Erem, C., Eriksen, L., Peña, J.E., Evans, A., Faeh, D., Fall, C.H., Farzadfar, F., Felix-Redondo, F.J., Ferguson, T.S., Fernández-Bergés, D., Ferrante, D., Ferrari, M., Ferreccio, C., Ferrieres, J., Finn, J.D., Fischer, K., Flores, E.M., Föger, B., Foo, L.H., Forslund, A.S., Forsner, M., Fortmann, S.P., Fouad, H.M., Francis, D.K., Franco, M.do C., Franco, O.H., Frontera, G., Fuchs, F.D., Fuchs, S.C., Fujita, Y., Furusawa, T., Gaciong, Z., Gafencu, M., Gareta, D., Garnett, S.P., Gaspoz, J.M., Gasull, M., Gates, L., Geleijnse, J.M., Ghasemian, A., Giampaoli, S., Gianfagna, F., Giovannelli, J., Giwercman, A., Goldsmith, R.A., Gonçalves, H., Gross, M.G., Rivas, J.P., Gorbea, M.B., Gottrand, F., Graff-Iversen, S., Grafnetter, D., Grajda, A., Grammatikopoulou, M.G., Gregor, R.D., Grodzicki, T., Grøntved, A., Gruden, G., Grujic, V., Gu, D., Gualdi-Russo, E., Guan, O.P., Gudnason, V., Guerrero, R., Guessous, I., Guimaraes, A.L., Gulliford, M.C., Gunnlaugsdottir, J., Gunter, M., Guo, X., Guo, Y., Gupta, P.C., Gureje, O., Gurzkowska, B., Gutierrez, L., Gutzwiller, F., Halkjær, J., Hambleton, I.R., Hardy, R., Kumar, R.H., Hata, J., Hayes, A.J., He, J., Hendriks, M.E., Cadena, L.H., Herrala, S., Heshmat, R., Hihtaniemi, I.T., Ho, S.Y., Ho, S.C., Hobbs, M., Hofman, A., Hormiga, C.M., Horta, B.L., Houti, L., Howitt, C., Htay, T.T., Htet, A.S., Htike, M.M., Hu, Y., Husseini, A., Huu, C.N., Huybrechts, I., Hwalla, N., Iacoviello, L., Iannone, A.G., Ibrahim, M.M., Ikeda, N., Ikram, M.A., Irazola, V.E., Islam, M., Ivkovic, V., Iwasaki, M., Jackson, R.T., Jacobs, J.M., Jafar, T., Jamil, K.M., Jamrozik, K., Janszky, I., Jasienska, G., Jelakovic, B., Jiang, C.Q., Joffres, M., Johansson, M., Jonas, J.B., Jørgensen, T., Joshi, P., Juolevi, A., Jurak, G., Jureša, V., Kaaks, R., Kafatos, A., Kalter-Leibovici, O., Kapantais, E., Kasaeian, A., Katz, J., Kaur, P., Kavousi, M., Keil, U., Boker, L.K., Keinänen-Kiukaanniemi, S., Kelishadi, R., Kemper, H.C., Kengne, A.P., Kersting, M., Key, T., Khader, Y.S., Khalili, D., Khang, Y.H., Khaw, K.T., Khouw, I.M., Kiechl, S., Killewo, J., Kim, J., Klimont, J., Klumbiene, J., Koirala, B., Kolle, E., Kolsteren, P., Korrovits, P., Koskinen, S., Kouda, K., Koziel, S., Kratzer, W., Krokstad, S., Kromhout, D., Kruger, H.S., Kubinova, R., Kujala, U.M., Kula, K., Kulaga, Z., Kumar, R.K., Kurjata, P., Kusuma, Y.S., Kuulasmaa, K., Kyobutungi, C., Laamiri, F.Z., Laatikainen, T., Lachat, C., Laid, Y., Lam, T.H., Landrove, O., Lanska, V., Lappas, G., Larijani, B., Laugsand, L.E., Bao, K.le N., Le, T.D., Leclercq, C., Lee, J., Lehtimäki, T., Lekhraj, R., León-Muñoz, L.M., Li, Y., Lilly, C.L., Lim, W.Y., Lima-Costa, M.F., Lin, H.H., Lin, X., Linneberg, A., Lissner, L., Litwin, M., Liu, J., Lorbeer, R., Lotufo, P.A., Lozano, J.E., Luksiene, D., Lundqvist, A., Lunet, N., Lytsy, P., Ma, G., Ma, J., Machado-Coelho, G.L., Machi, S., Maggi, S., Ano, D.J., Maire, B., Makdisse, M., Malekzadeh, R., Malhotra, R., Rao, K.M., Malyutina, S., Manios, Y., Mann, J.I., Manzato, E., Margozzini, P., Markey, O., Marques-Vidal, P., Marrugat, J., Martin-Prevel, Y., Martorell, R., Masoodi, S.R., Mathiesen, E.B., Matsha, T.E., Mazur, A., Mbanya, J.C., McFarlane, S.R., McGarvey, S.T., McKee, M., McLachlan, S., McLean, R.M., McNulty, B.A., Yusof, S.M., Mediene-Benchekor, S., Meirhaeghe, A., Meisinger, C., Menezes, A.M., Mensink, G.B., Meshram, I.I., Metspalu, A., Mi, J., Michaelsen, K.F., Mikkel, K., Miller, J.C., Miquel, J.F., Miranda, J.J., Mišigoj-Durakovic, M., Mohamed, M.K., Mohammad, K., Mohammadifard, N., Mohan, V., Yusoff, M.F., Molbo, D., Møller, N.C., Molnár, D., Mondo, C.K., Monterrubio, E.A., Monyeki, K.D., Moreira, L.B., Morejon, A., Moreno, L.A., Morgan, K., Mortensen, E.L., Moschonis, G., Mossakowska, M., Mostafa, A., Mota, J., Motlagh, M.E., Motta, J., Mu, T.T., Muiesan, M.L., Müller-Nurasyid, M., Murphy, N., Mursu, J., Murtagh, E.M., Musa, K.I., Musil, V., Nagel, G., Nakamura, H., Jana, N., Nang, E.E., Nangia, V.B., Nankap, M., Narake, S., Navarrete Muñoz, E.M., Neal, W.A., Nenko, I., Neovius, M., Nervi, F., Neuhauser, H.K., Nguyen, N.D., Nguyen, Q.N., Nieto Martínez, R.E., Ning, G., Ninomiya, T., Nishtar, S., Noale, M., Norat, T., Noto, D., Nsour, M.A., O'Reilly, D., Oh, K., Olayan, I.H., Olinto, M.T., Oltarzewski, M., Omar, M.A., Onat, A., Ordunez, P., Ortiz, A.P., Osler, M., Osmond, C., Ostojic, S.M., Otero, J.A., Overvad, K., Owusu-Dabo, E., Paccaud, F.M., Padez, C., Pahomova, E., Pajak, A., Palli, D., Palloni, A., Palmieri, L., Panda-Jonas, S., Panza, F., Parnell, W.R., Parsaeian, M., Pecin, I., Pednekar, M.S., Peeters, P.H., Peixoto, S.V., Peltonen, M., Pereira, A.C., Pérez, C.M., Peters, A., Petkeviciene, J., Peykari, N., Pham, S.T., Pigeot, I., Pikhart, H., Pilav, A., Pilotto, L., Pistelli, F., Pitakaka, F., Piwonska, A., Plans-Rubió, P., Poh, B.K., Porta, M., Portegies, M.L., Poulimeneas, D., Pradeepa, R., Prashant, M., Price, J.F., Puiu, M., Tartu, M.P., Qasrawi, R.F., Qorbani, M., Bao, T.Q., Radic, I., Radisauskas, R., Rahman, M., Raitakari, O., Raj, M., Rao, S.R., Ramachandran, A., Ramke, J., Ramos, R., Rampal, S., Rasmussen, F., Redon, J., Reganit, P.F., Ribeiro, R., Rigo, F., Wit, T.F., Ritti-Dias, R.M., Rivera, J.A., Robinson, S.M., Robitaille, C., Rodríguez-Artalejo, F., Rodriguez-Perez, M.del C., Rodríguez-Villamizar, L.A., Rojas-Martinez, R., Rojroongwasinkul, N., Romaguera, D., Ronkainen, K., Rosengren, A., Rouse, I., Rubinstein, A., Rühli, F.J., Rui, O., Ruiz-Betancourt, B.S., Horimoto, A.R., Rutkowski, M., Sabanayagam, C., Sachdev, H.S., Saidi, O., Salanave, B., Sandjaja, S., Martinez, E.S., Salomaa, V., Salonen, J.T., Salvetti, M., Sánchez-Abanto, J., Sans, S., Santos, D.A., Santos, O., Santos, R.N., Santos, R., Saramies, J.L., Sardinha, L.B., Sarrafzadegan, N., Saum, K.U., Savva, S.C., Scazufca, M., Rosario, A.S., Schargrodsky, H., Schienkiewitz, A., Schmidt, I.M., Schneider, I.J., Schultsz, C., Schutte, A.E., Sein, A.A., Sen, A., Senbanjo, I.O., Sepanlou, S.G., Shalnova, S.A., Sharma, S.K., Shaw, J.E., Shibuya, K., Shin, D.W., Shin, Y., Shiri, R., Siantar, R., Sibai, A.M., Silva, A.M., Silva, D.A., Simon, M., Simons, J., Simons, L.A., Sjostrom, M., Slowikowska-Hilczer, J., Slusarczyk, P., Smeeth, L., Smith, M.C., Snijder, M.B., So, H.K., Sobngwi, E., Söderberg, S., Soekatri, M.Y., Solfrizzi, V., Sonestedt, E., Song, Y., Sørensen, T.Ia., Soric, M., Jérome, C.S., Soumare, A., Staessen, J.A., Starc, G., Stathopoulou, M.G., Staub, K., Stavreski, B., Steene-Johannessen, J., Stehle, P., Stein, A.D., Stergiou, G.S., Stieber, J., Stöckl, D., Stocks, T., Stokwiszewski, J., Stratton, G., Stronks, K., Strufaldi, M.W., Sun, C.A., Sundström, J., Sung, Y.T., Sunyer, J., Suriyawongpaisal, P., Swinburn, B.A., Sy, R.G., Szponar, L., Tai, E.S., Tammesoo, M.L., Tamosiunas, A., Tang, L., Tang, X., Tanser, F., Tao, Y., Tarawneh, M.R., Tarp, J., Tarqui-Mamani, C.B., Taylor, A., Tchibindat, F., Theobald, H., Thijs, L., Thuesen, B.H., Tjonneland, A., Tolonen, H.K., Tolstrup, J.S., Topbas, M., Topór-Madry, R., Torrent, M., Toselli, S., Traissac, P., Trichopoulou, A., Trichopoulos, D., Trinh, O.T., Trivedi, A., Tshepo, L., Tulloch-Reid, M.K., Tuomainen, T.P., Tuomilehto, J., Turley, M.L., Tynelius, P., Tzotzas, T., Tzourio, C., Ueda, P., Ukoli, F.A., Ulmer, H., Unal, B., Uusitalo, H.M., Valdivia, G., Vale, S., Valvi, D., Schouw, Y.T., Herck, K.V., Minh, H.V., Rossem, Lv, Valkengoed, I.G., Vanderschueren, D., Vanuzzo, D., Vatten, L., Vega, T., Velasquez-Melendez, G., Veronesi, G., Verschuren, W.M., Verstraeten, R., Victora, C.G., Viegi, G., Viet, L., Viikari-Juntura, E., Vineis, P., Vioque, J., Virtanen, J.K., Visvikis-Siest, S., Viswanathan, B., Vollenweider, P., Voutilainen, S., Vrdoljak, A., Vrijheid, M., Wade, A.N., Wagner, A., Walton, J., Mohamud, W.N., Wang, M.D., Wang, Q., Wang, Y.X., Wannamethee, S.G., Wareham, N., Weerasekera, D., Whincup, P.H., Widhalm, K., Widyahening, I.S., Wiecek, A., Wijga, A.H., Wilks, R.J., Willeit, J., Wilsgaard, T., Wojtyniak, B., Wong, J.E., Wong, T.Y., Woo, J., Woodward, M., Wu, F.C., Wu, J., Wu, S.L., Xu, H., Xu, L., Yamborisut, U., Yan, W., Yang, X., Yardim, N., Ye, X., Yiallouros, P.K., Yoshihara, A., You, Q.S., Younger-Coleman, N.O., Yusoff, A.F., Zainuddin, A.A., Zambon, S., Zdrojewski, T., Zeng, Y., Zhao, D., Zhao, W., Zheng, Y., Zhou, M., Zhu, D., Zimmermann, E., Cisneros, J.Z., NCD Risk Factor Collaboration (NCD-RisC), Bentham, J., Cesare, M.D., Stevens, G.A., Zhou, B., Bixby, H., Cowan, M., Fortunato, L., Bennett, J.E., Danaei, G., Hajifathalian, K., Lu, Y., Riley, L.M., Laxmaiah, A., Kontis, V., Paciorek, C.J., Riboli, E., Ezzati, M., Abdeen, Z.A., Hamid, Z.A., Abu-Rmeileh, N.M., Acosta-Cazares, B., Adams, R., Aekplakorn, W., Aguilar-Salinas, C.A., Agyemang, C., Ahmadvand, A., Ahrens, W., Al-Hazzaa, H.M., Al-Othman, A.R., Raddadi, R.A., Ali, M.M., Alkerwi, A., Alvarez-Pedrerol, M., Aly, E., Amouyel, P., Amuzu, A., Andersen, L.B., Anderssen, S.A., Anjana, R.M., Aounallah-Skhiri, H., Ariansen, I., Aris, T., Arlappa, N., Arveiler, D., Assah, F.K., Avdicová, M., Azizi, F., Babu, B.V., Bahijri, S., Balakrishna, N., Bandosz, P., Banegas, J.R., Barbagallo, C.M., Barceló, A., Barkat, A., Barros, M.V., Bata, I., Batieha, A.M., Batista, R.L., Baur, L.A., Beaglehole, R., Romdhane, H.B., Benet, M., Bernabe-Ortiz, A., Bernotiene, G., Bettiol, H., Bhagyalaxmi, A., Bharadwaj, S., Bhargava, S.K., Bhatti, Z., Bhutta, Z.A., Bi, H., Bi, Y., Bjerregaard, P., Bjertness, E., Bjertness, M.B., Björkelund, C., Blokstra, A., Bo, S., Bobak, M., Boddy, L.M., Boehm, B.O., Boeing, H., Boissonnet, C.P., Bongard, V., Bovet, P., Braeckman, L., Bragt, M.C., Brajkovich, I., Branca, F., Breckenkamp, J., Brenner, H., Brewster, L.M., Brian, G.R., Bruno, G., Bueno-de-Mesquita, H.A., Bugge, A., Burns, C., León, A.C., Cacciottolo, J., Cama, T., Cameron, C., Camolas, J., Can, G., Cândido, A.P., Capuano, V., Cardoso, V.C., Carlsson, A.C., Carvalho, M.J., Casanueva, F.F., Casas, J.P., Caserta, C.A., Chamukuttan, S., Chan, A.W., Chan, Q., Chaturvedi, H.K., Chaturvedi, N., Chen, C.J., Chen, F., Chen, H., Chen, S., Chen, Z., Cheng, C.Y., Chetrit, A., Chiolero, A., Chiou, S.T., Chirita-Emandi, A., Cho, B., Cho, Y., Christensen, K., Chudek, J., Cifkova, R., Claessens, F., Clays, E., Concin, H., Cooper, C., Cooper, R., Coppinger, T.C., Costanzo, S., Cottel, D., Cowell, C., Craig, C.L., Crujeiras, A.B., D'Arrigo, G., d'Orsi, E., Dallongeville, J., Damasceno, A., Damsgaard, C.T., Dankner, R., Dauchet, L., Backer, G.D., Bacquer, D.D., Gaetano, Gd, Henauw, S.D., Smedt, D.D., Deepa, M., Deev, A.D., Dehghan, A., Delisle, H., Delpeuch, F., Deschamps, V., Dhana, K., Castelnuovo, A.F., Dias-da-Costa, J.S., Diaz, A., Djalalinia, S., Do, H.T., Dobson, A.J., Donfrancesco, C., Donoso, S.P., Döring, A., Doua, K., Drygas, W., Dzerve, V., Egbagbe, E., Eggertsen, R., Ekelund, U., Ati, J.E., Elliott, P., Engle-Stone, R., Erasmus, R.T., Erem, C., Eriksen, L., Peña, J.E., Evans, A., Faeh, D., Fall, C.H., Farzadfar, F., Felix-Redondo, F.J., Ferguson, T.S., Fernández-Bergés, D., Ferrante, D., Ferrari, M., Ferreccio, C., Ferrieres, J., Finn, J.D., Fischer, K., Flores, E.M., Föger, B., Foo, L.H., Forslund, A.S., Forsner, M., Fortmann, S.P., Fouad, H.M., Francis, D.K., Franco, M.do C., Franco, O.H., Frontera, G., Fuchs, F.D., Fuchs, S.C., Fujita, Y., Furusawa, T., Gaciong, Z., Gafencu, M., Gareta, D., Garnett, S.P., Gaspoz, J.M., Gasull, M., Gates, L., Geleijnse, J.M., Ghasemian, A., Giampaoli, S., Gianfagna, F., Giovannelli, J., Giwercman, A., Goldsmith, R.A., Gonçalves, H., Gross, M.G., Rivas, J.P., Gorbea, M.B., Gottrand, F., Graff-Iversen, S., Grafnetter, D., Grajda, A., Grammatikopoulou, M.G., Gregor, R.D., Grodzicki, T., Grøntved, A., Gruden, G., Grujic, V., Gu, D., Gualdi-Russo, E., Guan, O.P., Gudnason, V., Guerrero, R., Guessous, I., Guimaraes, A.L., Gulliford, M.C., Gunnlaugsdottir, J., Gunter, M., Guo, X., Guo, Y., Gupta, P.C., Gureje, O., Gurzkowska, B., Gutierrez, L., Gutzwiller, F., Halkjær, J., Hambleton, I.R., Hardy, R., Kumar, R.H., Hata, J., Hayes, A.J., He, J., Hendriks, M.E., Cadena, L.H., Herrala, S., Heshmat, R., Hihtaniemi, I.T., Ho, S.Y., Ho, S.C., Hobbs, M., Hofman, A., Hormiga, C.M., Horta, B.L., Houti, L., Howitt, C., Htay, T.T., Htet, A.S., Htike, M.M., Hu, Y., Husseini, A., Huu, C.N., Huybrechts, I., Hwalla, N., Iacoviello, L., Iannone, A.G., Ibrahim, M.M., Ikeda, N., Ikram, M.A., Irazola, V.E., Islam, M., Ivkovic, V., Iwasaki, M., Jackson, R.T., Jacobs, J.M., Jafar, T., Jamil, K.M., Jamrozik, K., Janszky, I., Jasienska, G., Jelakovic, B., Jiang, C.Q., Joffres, M., Johansson, M., Jonas, J.B., Jørgensen, T., Joshi, P., Juolevi, A., Jurak, G., Jureša, V., Kaaks, R., Kafatos, A., Kalter-Leibovici, O., Kapantais, E., Kasaeian, A., Katz, J., Kaur, P., Kavousi, M., Keil, U., Boker, L.K., Keinänen-Kiukaanniemi, S., Kelishadi, R., Kemper, H.C., Kengne, A.P., Kersting, M., Key, T., Khader, Y.S., Khalili, D., Khang, Y.H., Khaw, K.T., Khouw, I.M., Kiechl, S., Killewo, J., Kim, J., Klimont, J., Klumbiene, J., Koirala, B., Kolle, E., Kolsteren, P., Korrovits, P., Koskinen, S., Kouda, K., Koziel, S., Kratzer, W., Krokstad, S., Kromhout, D., Kruger, H.S., Kubinova, R., Kujala, U.M., Kula, K., Kulaga, Z., Kumar, R.K., Kurjata, P., Kusuma, Y.S., Kuulasmaa, K., Kyobutungi, C., Laamiri, F.Z., Laatikainen, T., Lachat, C., Laid, Y., Lam, T.H., Landrove, O., Lanska, V., Lappas, G., Larijani, B., Laugsand, L.E., Bao, K.le N., Le, T.D., Leclercq, C., Lee, J., Lehtimäki, T., Lekhraj, R., León-Muñoz, L.M., Li, Y., Lilly, C.L., Lim, W.Y., Lima-Costa, M.F., Lin, H.H., Lin, X., Linneberg, A., Lissner, L., Litwin, M., Liu, J., Lorbeer, R., Lotufo, P.A., Lozano, J.E., Luksiene, D., Lundqvist, A., Lunet, N., Lytsy, P., Ma, G., Ma, J., Machado-Coelho, G.L., Machi, S., Maggi, S., Ano, D.J., Maire, B., Makdisse, M., Malekzadeh, R., Malhotra, R., Rao, K.M., Malyutina, S., Manios, Y., Mann, J.I., Manzato, E., Margozzini, P., Markey, O., Marques-Vidal, P., Marrugat, J., Martin-Prevel, Y., Martorell, R., Masoodi, S.R., Mathiesen, E.B., Matsha, T.E., Mazur, A., Mbanya, J.C., McFarlane, S.R., McGarvey, S.T., McKee, M., McLachlan, S., McLean, R.M., McNulty, B.A., Yusof, S.M., Mediene-Benchekor, S., Meirhaeghe, A., Meisinger, C., Menezes, A.M., Mensink, G.B., Meshram, I.I., Metspalu, A., Mi, J., Michaelsen, K.F., Mikkel, K., Miller, J.C., Miquel, J.F., Miranda, J.J., Mišigoj-Durakovic, M., Mohamed, M.K., Mohammad, K., Mohammadifard, N., Mohan, V., Yusoff, M.F., Molbo, D., Møller, N.C., Molnár, D., Mondo, C.K., Monterrubio, E.A., Monyeki, K.D., Moreira, L.B., Morejon, A., Moreno, L.A., Morgan, K., Mortensen, E.L., Moschonis, G., Mossakowska, M., Mostafa, A., Mota, J., Motlagh, M.E., Motta, J., Mu, T.T., Muiesan, M.L., Müller-Nurasyid, M., Murphy, N., Mursu, J., Murtagh, E.M., Musa, K.I., Musil, V., Nagel, G., Nakamura, H., Jana, N., Nang, E.E., Nangia, V.B., Nankap, M., Narake, S., Navarrete Muñoz, E.M., Neal, W.A., Nenko, I., Neovius, M., Nervi, F., Neuhauser, H.K., Nguyen, N.D., Nguyen, Q.N., Nieto Martínez, R.E., Ning, G., Ninomiya, T., Nishtar, S., Noale, M., Norat, T., Noto, D., Nsour, M.A., O'Reilly, D., Oh, K., Olayan, I.H., Olinto, M.T., Oltarzewski, M., Omar, M.A., Onat, A., Ordunez, P., Ortiz, A.P., Osler, M., Osmond, C., Ostojic, S.M., Otero, J.A., Overvad, K., Owusu-Dabo, E., Paccaud, F.M., Padez, C., Pahomova, E., Pajak, A., Palli, D., Palloni, A., Palmieri, L., Panda-Jonas, S., Panza, F., Parnell, W.R., Parsaeian, M., Pecin, I., Pednekar, M.S., Peeters, P.H., Peixoto, S.V., Peltonen, M., Pereira, A.C., Pérez, C.M., Peters, A., Petkeviciene, J., Peykari, N., Pham, S.T., Pigeot, I., Pikhart, H., Pilav, A., Pilotto, L., Pistelli, F., Pitakaka, F., Piwonska, A., Plans-Rubió, P., Poh, B.K., Porta, M., Portegies, M.L., Poulimeneas, D., Pradeepa, R., Prashant, M., Price, J.F., Puiu, M., Tartu, M.P., Qasrawi, R.F., Qorbani, M., Bao, T.Q., Radic, I., Radisauskas, R., Rahman, M., Raitakari, O., Raj, M., Rao, S.R., Ramachandran, A., Ramke, J., Ramos, R., Rampal, S., Rasmussen, F., Redon, J., Reganit, P.F., Ribeiro, R., Rigo, F., Wit, T.F., Ritti-Dias, R.M., Rivera, J.A., Robinson, S.M., Robitaille, C., Rodríguez-Artalejo, F., Rodriguez-Perez, M.del C., Rodríguez-Villamizar, L.A., Rojas-Martinez, R., Rojroongwasinkul, N., Romaguera, D., Ronkainen, K., Rosengren, A., Rouse, I., Rubinstein, A., Rühli, F.J., Rui, O., Ruiz-Betancourt, B.S., Horimoto, A.R., Rutkowski, M., Sabanayagam, C., Sachdev, H.S., Saidi, O., Salanave, B., Sandjaja, S., Martinez, E.S., Salomaa, V., Salonen, J.T., Salvetti, M., Sánchez-Abanto, J., Sans, S., Santos, D.A., Santos, O., Santos, R.N., Santos, R., Saramies, J.L., Sardinha, L.B., Sarrafzadegan, N., Saum, K.U., Savva, S.C., Scazufca, M., Rosario, A.S., Schargrodsky, H., Schienkiewitz, A., Schmidt, I.M., Schneider, I.J., Schultsz, C., Schutte, A.E., Sein, A.A., Sen, A., Senbanjo, I.O., Sepanlou, S.G., Shalnova, S.A., Sharma, S.K., Shaw, J.E., Shibuya, K., Shin, D.W., Shin, Y., Shiri, R., Siantar, R., Sibai, A.M., Silva, A.M., Silva, D.A., Simon, M., Simons, J., Simons, L.A., Sjostrom, M., Slowikowska-Hilczer, J., Slusarczyk, P., Smeeth, L., Smith, M.C., Snijder, M.B., So, H.K., Sobngwi, E., Söderberg, S., Soekatri, M.Y., Solfrizzi, V., Sonestedt, E., Song, Y., Sørensen, T.Ia., Soric, M., Jérome, C.S., Soumare, A., Staessen, J.A., Starc, G., Stathopoulou, M.G., Staub, K., Stavreski, B., Steene-Johannessen, J., Stehle, P., Stein, A.D., Stergiou, G.S., Stieber, J., Stöckl, D., Stocks, T., Stokwiszewski, J., Stratton, G., Stronks, K., Strufaldi, M.W., Sun, C.A., Sundström, J., Sung, Y.T., Sunyer, J., Suriyawongpaisal, P., Swinburn, B.A., Sy, R.G., Szponar, L., Tai, E.S., Tammesoo, M.L., Tamosiunas, A., Tang, L., Tang, X., Tanser, F., Tao, Y., Tarawneh, M.R., Tarp, J., Tarqui-Mamani, C.B., Taylor, A., Tchibindat, F., Theobald, H., Thijs, L., Thuesen, B.H., Tjonneland, A., Tolonen, H.K., Tolstrup, J.S., Topbas, M., Topór-Madry, R., Torrent, M., Toselli, S., Traissac, P., Trichopoulou, A., Trichopoulos, D., Trinh, O.T., Trivedi, A., Tshepo, L., Tulloch-Reid, M.K., Tuomainen, T.P., Tuomilehto, J., Turley, M.L., Tynelius, P., Tzotzas, T., Tzourio, C., Ueda, P., Ukoli, F.A., Ulmer, H., Unal, B., Uusitalo, H.M., Valdivia, G., Vale, S., Valvi, D., Schouw, Y.T., Herck, K.V., Minh, H.V., Rossem, Lv, Valkengoed, I.G., Vanderschueren, D., Vanuzzo, D., Vatten, L., Vega, T., Velasquez-Melendez, G., Veronesi, G., Verschuren, W.M., Verstraeten, R., Victora, C.G., Viegi, G., Viet, L., Viikari-Juntura, E., Vineis, P., Vioque, J., Virtanen, J.K., Visvikis-Siest, S., Viswanathan, B., Vollenweider, P., Voutilainen, S., Vrdoljak, A., Vrijheid, M., Wade, A.N., Wagner, A., Walton, J., Mohamud, W.N., Wang, M.D., Wang, Q., Wang, Y.X., Wannamethee, S.G., Wareham, N., Weerasekera, D., Whincup, P.H., Widhalm, K., Widyahening, I.S., Wiecek, A., Wijga, A.H., Wilks, R.J., Willeit, J., Wilsgaard, T., Wojtyniak, B., Wong, J.E., Wong, T.Y., Woo, J., Woodward, M., Wu, F.C., Wu, J., Wu, S.L., Xu, H., Xu, L., Yamborisut, U., Yan, W., Yang, X., Yardim, N., Ye, X., Yiallouros, P.K., Yoshihara, A., You, Q.S., Younger-Coleman, N.O., Yusoff, A.F., Zainuddin, A.A., Zambon, S., Zdrojewski, T., Zeng, Y., Zhao, D., Zhao, W., Zheng, Y., Zhou, M., Zhu, D., Zimmermann, E., and Cisneros, J.Z.
Abstract: Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5-22.7) and 16.5 cm (13.3-19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8-144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
Published: 2016

28. A Nested Case-Control Study of Metabolically Defined Body Size Phenotypes and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Murphy, N., Cross, A.J., Abubakar, M., Jenab, M., Aleksandrova, K., Boutron-Ruault, M.C., Dossus, L., Racine, A., Kuhn, T., Katzke, V.A., Tjonneland, A., Petersen, K.E., Overvad, K., Quiros, J.R., Jakszyn, P., Molina-Montes, E., Dorronsoro, M., Huerta, J.M., Barricarte, A., Khaw, K.T., Wareham, N., Travis, R.C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Masala, G., Krogh, V., Tumino, R., Vineis, P., Panico, S., Bueno-de-Mesquita, H.B., Siersema, P.D., Peeters, P.H., Ohlsson, B., Ericson, U., Palmqvist, R., Nystrom, H., Weiderpass, E., Skeie, G., Freisling, H., Kong, S.Y., Tsilidis, K., Muller, D.C., Riboli, E., Gunter, M.J., Murphy, N., Cross, A.J., Abubakar, M., Jenab, M., Aleksandrova, K., Boutron-Ruault, M.C., Dossus, L., Racine, A., Kuhn, T., Katzke, V.A., Tjonneland, A., Petersen, K.E., Overvad, K., Quiros, J.R., Jakszyn, P., Molina-Montes, E., Dorronsoro, M., Huerta, J.M., Barricarte, A., Khaw, K.T., Wareham, N., Travis, R.C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Masala, G., Krogh, V., Tumino, R., Vineis, P., Panico, S., Bueno-de-Mesquita, H.B., Siersema, P.D., Peeters, P.H., Ohlsson, B., Ericson, U., Palmqvist, R., Nystrom, H., Weiderpass, E., Skeie, G., Freisling, H., Kong, S.Y., Tsilidis, K., Muller, D.C., Riboli, E., and Gunter, M.J.
Abstract: Contains fulltext : 165685.pdf (publisher's version ) (Open Access), BACKGROUND: Obesity is positively associated with colorectal cancer. Recently, body size subtypes categorised by the prevalence of hyperinsulinaemia have been defined, and metabolically healthy overweight/obese individuals (without hyperinsulinaemia) have been suggested to be at lower risk of cardiovascular disease than their metabolically unhealthy (hyperinsulinaemic) overweight/obese counterparts. Whether similarly variable relationships exist for metabolically defined body size phenotypes and colorectal cancer risk is unknown. METHODS AND FINDINGS: The association of metabolically defined body size phenotypes with colorectal cancer was investigated in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolic health/body size phenotypes were defined according to hyperinsulinaemia status using serum concentrations of C-peptide, a marker of insulin secretion. A total of 737 incident colorectal cancer cases and 737 matched controls were divided into tertiles based on the distribution of C-peptide concentration amongst the control population, and participants were classified as metabolically healthy if below the first tertile of C-peptide and metabolically unhealthy if above the first tertile. These metabolic health definitions were then combined with body mass index (BMI) measurements to create four metabolic health/body size phenotype categories: (1) metabolically healthy/normal weight (BMI < 25 kg/m2), (2) metabolically healthy/overweight (BMI >/= 25 kg/m2), (3) metabolically unhealthy/normal weight (BMI < 25 kg/m2), and (4) metabolically unhealthy/overweight (BMI >/= 25 kg/m2). Additionally, in separate models, waist circumference measurements (using the International Diabetes Federation cut-points [>/=80 cm for women and >/=94 cm for men]) were used (instead of BMI) to create the four metabolic health/body size phenotype categories. Statistical tests used in the analysis were all two-sided, and a p
Published: 2016

29. Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21

Author: Zhang, M, Wang, Z, Obazee, O, Jia, J, Childs, EJ, Hoskins, J, Figlioli, G, Mocci, E, Collins, I, Chung, CC, Hautman, C, Arslan, AA, Beane-Freeman, L, Bracci, PM, Buring, J, Duell, EJ, Gallinger, S, Giles, GG, Goodman, GE, Goodman, PJ, Kamineni, A, Kolonel, LN, Kulke, MH, Malats, N, Olson, SH, Sesso, HD, Visvanathan, K, White, E, Zheng, W, Abnet, CC, Albanes, D, Andreotti, G, Brais, L, Bueno-de-Mesquita, HB, Basso, D, Berndt, SI, Boutron-Ruault, M-C, Bijlsma, MF, Brenner, H, Burdette, L, Campa, D, Caporaso, NE, Capurso, G, Cavestro, GM, Cotterchio, M, Costello, E, Elena, J, Boggi, U, Gaziano, JM, Gazouli, M, Giovannucci, EL, Goggins, M, Gross, M, Haiman, CA, Hassan, M, Helzlsouer, KJ, Hu, N, Hunter, DJ, Iskierka-Jazdzewska, E, Jenab, M, Kaaks, R, Key, TJ, Khaw, K-T, Klein, EA, Kogevinas, M, Krogh, V, Kupcinskas, J, Kurtz, RC, Landi, MT, Landi, S, Le Marchand, L, Mambrini, A, Mannisto, S, Milne, RL, Neale, RE, Oberg, AL, Panico, S, Patel, AV, Peeters, PHM, Peters, U, Pezzilli, R, Porta, M, Purdue, M, Ramon Quiros, J, Riboli, E, Rothman, N, Scarpa, A, Scelo, G, Shu, X-O, Silverman, DT, Soucek, P, Strobel, O, Sund, M, Malecka-Panas, E, Taylor, PR, Tavano, F, Travis, RC, Thornquist, M, Tjonneland, A, Tobias, GS, Trichopoulos, D, Vashist, Y, Vodicka, P, Wactawski-Wende, J, Wentzensen, N, Yu, H, Yu, K, Zeleniuch-Jacquotte, A, Kooperberg, C, Risch, HA, Jacobs, EJ, Li, D, Fuchs, C, Hoover, R, Hartge, P, Chanock, SJ, Petersen, GM, Stolzenberg-Solomon, RS, Wolpin, BM, Kraft, P, Klein, AP, Canzian, F, Amundadottir, LT, Zhang, M, Wang, Z, Obazee, O, Jia, J, Childs, EJ, Hoskins, J, Figlioli, G, Mocci, E, Collins, I, Chung, CC, Hautman, C, Arslan, AA, Beane-Freeman, L, Bracci, PM, Buring, J, Duell, EJ, Gallinger, S, Giles, GG, Goodman, GE, Goodman, PJ, Kamineni, A, Kolonel, LN, Kulke, MH, Malats, N, Olson, SH, Sesso, HD, Visvanathan, K, White, E, Zheng, W, Abnet, CC, Albanes, D, Andreotti, G, Brais, L, Bueno-de-Mesquita, HB, Basso, D, Berndt, SI, Boutron-Ruault, M-C, Bijlsma, MF, Brenner, H, Burdette, L, Campa, D, Caporaso, NE, Capurso, G, Cavestro, GM, Cotterchio, M, Costello, E, Elena, J, Boggi, U, Gaziano, JM, Gazouli, M, Giovannucci, EL, Goggins, M, Gross, M, Haiman, CA, Hassan, M, Helzlsouer, KJ, Hu, N, Hunter, DJ, Iskierka-Jazdzewska, E, Jenab, M, Kaaks, R, Key, TJ, Khaw, K-T, Klein, EA, Kogevinas, M, Krogh, V, Kupcinskas, J, Kurtz, RC, Landi, MT, Landi, S, Le Marchand, L, Mambrini, A, Mannisto, S, Milne, RL, Neale, RE, Oberg, AL, Panico, S, Patel, AV, Peeters, PHM, Peters, U, Pezzilli, R, Porta, M, Purdue, M, Ramon Quiros, J, Riboli, E, Rothman, N, Scarpa, A, Scelo, G, Shu, X-O, Silverman, DT, Soucek, P, Strobel, O, Sund, M, Malecka-Panas, E, Taylor, PR, Tavano, F, Travis, RC, Thornquist, M, Tjonneland, A, Tobias, GS, Trichopoulos, D, Vashist, Y, Vodicka, P, Wactawski-Wende, J, Wentzensen, N, Yu, H, Yu, K, Zeleniuch-Jacquotte, A, Kooperberg, C, Risch, HA, Jacobs, EJ, Li, D, Fuchs, C, Hoover, R, Hartge, P, Chanock, SJ, Petersen, GM, Stolzenberg-Solomon, RS, Wolpin, BM, Kraft, P, Klein, AP, Canzian, F, and Amundadottir, LT
Abstract: Genome-wide association studies (GWAS) have identified common pancreatic cancer susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify new susceptibility variants, we performed imputation based on 1000 Genomes (1000G) Project data and association analysis using 5,107 case and 8,845 control subjects from 27 cohort and case-control studies that participated in the PanScan I-III GWAS. This analysis, in combination with a two-staged replication in an additional 6,076 case and 7,555 control subjects from the PANcreatic Disease ReseArch (PANDoRA) and Pancreatic Cancer Case-Control (PanC4) Consortia uncovered 3 new pancreatic cancer risk signals marked by single nucleotide polymorphisms (SNPs) rs2816938 at chromosome 1q32.1 (per allele odds ratio (OR) = 1.20, P = 4.88x10 -15), rs10094872 at 8q24.21 (OR = 1.15, P = 3.22x10 -9) and rs35226131 at 5p15.33 (OR = 0.71, P = 1.70x10 -8). These SNPs represent independent risk variants at previously identified pancreatic cancer risk loci on chr1q32.1 ( NR5A2), chr8q24.21 ( MYC) and chr5p15.33 ( CLPTM1L- TERT) as per analyses conditioned on previously reported susceptibility variants. We assessed expression of candidate genes at the three risk loci in histologically normal ( n = 10) and tumor ( n = 8) derived pancreatic tissue samples and observed a marked reduction of NR5A2 expression (chr1q32.1) in the tumors (fold change -7.6, P = 5.7x10 -8). This finding was validated in a second set of paired ( n = 20) histologically normal and tumor derived pancreatic tissue samples (average fold change for three NR5A2 isoforms -31.3 to -95.7, P = 7.5x10 -4-2.0x10 -3). Our study has identified new susceptibility variants independently conferring pancreatic cancer risk that merit functional follow-up to identify target genes and explain the underlying biology.
Published: 2016

30. Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation

Author: Gusev, A, Shi, H, Kichaev, G, Pomerantz, M, Li, F, Long, HW, Ingles, SA, Kittles, RA, Strom, SS, Rybicki, BA, Nemesure, B, Isaacs, WB, Zheng, W, Pettaway, CA, Yeboah, ED, Tettey, Y, Biritwum, RB, Adjei, AA, Tay, E, Truelove, A, Niwa, S, Chokkalingam, AP, John, EM, Murphy, AB, Signorello, LB, Carpten, J, Leske, MC, Wu, S-Y, Hennis, AJM, Neslund-Dudas, C, Hsing, AW, Chu, L, Goodman, PJ, Klein, EA, Witte, JS, Casey, G, Kaggwa, S, Cook, MB, Stram, DO, Blot, WJ, Eeles, RA, Easton, D, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Muir, K, Giles, GG, Southey, MC, Fitzgerald, LM, Gronberg, H, Wiklund, F, Aly, M, Henderson, BE, Schleutker, J, Wahlfors, T, Tammela, TLJ, Nordestgaard, BG, Key, TJ, Travis, RC, Neal, DE, Donovan, JL, Hamdy, FC, Pharoah, P, Pashayan, N, Khaw, K-T, Stanford, JL, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Maier, C, Vogel, W, Luedeke, M, Herkommer, K, Kibel, AS, Cybulski, C, Wokolorczyk, D, Kluzniak, W, Cannon-Albright, L, Teerlink, C, Brenner, H, Dieffenbach, AK, Arndt, V, Park, JY, Sellers, TA, Lin, H-Y, Slavov, C, Kaneva, R, Mitev, V, Batra, J, Spurdle, A, Clements, JA, Teixeira, MR, Pandha, H, Michael, A, Paulo, P, Maia, S, Kierzek, A, Conti, DV, Albanes, D, Berg, C, Berndt, SI, Campa, D, Crawford, ED, Diver, WR, Gapstur, SM, Gaziano, JM, Giovannucci, E, Hoover, R, Hunter, DJ, Johansson, M, Kraft, P, Le Marchand, L, Lindstrom, S, Navarro, C, Overvad, K, Riboli, E, Siddiq, A, Stevens, VL, Trichopoulos, D, Vineis, P, Yeager, M, Trynka, G, Raychaudhuri, S, Schumacher, FR, Price, AL, Freedman, ML, Haiman, CA, Pasaniuc, B, Cook, M, Guy, M, Govindasami, K, Leongamornlert, D, Sawyer, EJ, Wilkinson, R, Saunders, EJ, Tymrakiewicz, M, Dadaev, T, Morgan, A, Fisher, C, Hazel, S, Livni, N, Lophatananon, A, Pedersen, J, Hopper, JL, Adolfson, J, Stattin, P, Johansson, J-E, Cavalli-Bjoerkman, C, Karlsson, A, Broms, M, Auvinen, A, Kujala, P, Maeaettaenen, L, Murtola, T, Taari, K, Weischer, M, Nielsen, SF, Klarskov, P, Roder, A, Iversen, P, Wallinder, H, Gustafsson, S, Cox, A, Brown, P, George, A, Marsden, G, Lane, A, Davis, M, Tillmans, L, Riska, S, Wang, L, Rinckleb, A, Lubiski, J, Stegmaier, C, Pow-Sang, J, Park, H, Radlein, S, Rincon, M, Haley, J, Zachariah, B, Kachakova, D, Popov, E, Mitkova, A, Vlahova, A, Dikov, T, Christova, S, Heathcote, P, Wood, G, Malone, G, Saunders, P, Eckert, A, Yeadon, T, Kerr, K, Collins, A, Turner, M, Srinivasan, S, Kedda, M-A, Alexander, K, Omara, T, Wu, H, Henrique, R, Pinto, P, Santos, J, Barros-Silva, J, Gusev, A, Shi, H, Kichaev, G, Pomerantz, M, Li, F, Long, HW, Ingles, SA, Kittles, RA, Strom, SS, Rybicki, BA, Nemesure, B, Isaacs, WB, Zheng, W, Pettaway, CA, Yeboah, ED, Tettey, Y, Biritwum, RB, Adjei, AA, Tay, E, Truelove, A, Niwa, S, Chokkalingam, AP, John, EM, Murphy, AB, Signorello, LB, Carpten, J, Leske, MC, Wu, S-Y, Hennis, AJM, Neslund-Dudas, C, Hsing, AW, Chu, L, Goodman, PJ, Klein, EA, Witte, JS, Casey, G, Kaggwa, S, Cook, MB, Stram, DO, Blot, WJ, Eeles, RA, Easton, D, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Muir, K, Giles, GG, Southey, MC, Fitzgerald, LM, Gronberg, H, Wiklund, F, Aly, M, Henderson, BE, Schleutker, J, Wahlfors, T, Tammela, TLJ, Nordestgaard, BG, Key, TJ, Travis, RC, Neal, DE, Donovan, JL, Hamdy, FC, Pharoah, P, Pashayan, N, Khaw, K-T, Stanford, JL, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Maier, C, Vogel, W, Luedeke, M, Herkommer, K, Kibel, AS, Cybulski, C, Wokolorczyk, D, Kluzniak, W, Cannon-Albright, L, Teerlink, C, Brenner, H, Dieffenbach, AK, Arndt, V, Park, JY, Sellers, TA, Lin, H-Y, Slavov, C, Kaneva, R, Mitev, V, Batra, J, Spurdle, A, Clements, JA, Teixeira, MR, Pandha, H, Michael, A, Paulo, P, Maia, S, Kierzek, A, Conti, DV, Albanes, D, Berg, C, Berndt, SI, Campa, D, Crawford, ED, Diver, WR, Gapstur, SM, Gaziano, JM, Giovannucci, E, Hoover, R, Hunter, DJ, Johansson, M, Kraft, P, Le Marchand, L, Lindstrom, S, Navarro, C, Overvad, K, Riboli, E, Siddiq, A, Stevens, VL, Trichopoulos, D, Vineis, P, Yeager, M, Trynka, G, Raychaudhuri, S, Schumacher, FR, Price, AL, Freedman, ML, Haiman, CA, Pasaniuc, B, Cook, M, Guy, M, Govindasami, K, Leongamornlert, D, Sawyer, EJ, Wilkinson, R, Saunders, EJ, Tymrakiewicz, M, Dadaev, T, Morgan, A, Fisher, C, Hazel, S, Livni, N, Lophatananon, A, Pedersen, J, Hopper, JL, Adolfson, J, Stattin, P, Johansson, J-E, Cavalli-Bjoerkman, C, Karlsson, A, Broms, M, Auvinen, A, Kujala, P, Maeaettaenen, L, Murtola, T, Taari, K, Weischer, M, Nielsen, SF, Klarskov, P, Roder, A, Iversen, P, Wallinder, H, Gustafsson, S, Cox, A, Brown, P, George, A, Marsden, G, Lane, A, Davis, M, Tillmans, L, Riska, S, Wang, L, Rinckleb, A, Lubiski, J, Stegmaier, C, Pow-Sang, J, Park, H, Radlein, S, Rincon, M, Haley, J, Zachariah, B, Kachakova, D, Popov, E, Mitkova, A, Vlahova, A, Dikov, T, Christova, S, Heathcote, P, Wood, G, Malone, G, Saunders, P, Eckert, A, Yeadon, T, Kerr, K, Collins, A, Turner, M, Srinivasan, S, Kedda, M-A, Alexander, K, Omara, T, Wu, H, Henrique, R, Pinto, P, Santos, J, and Barros-Silva, J
Abstract: Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.
Published: 2016

31. A Nested Case-Control Study of Metabolically Defined Body Size Phenotypes and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Murphy, N., Cross, A.J., Abubakar, M., Jenab, M., Aleksandrova, K., Boutron-Ruault, M.C., Dossus, L., Racine, A., Kuhn, T., Katzke, V.A., Tjonneland, A., Petersen, K.E., Overvad, K., Quiros, J.R., Jakszyn, P., Molina-Montes, E., Dorronsoro, M., Huerta, J.M., Barricarte, A., Khaw, K.T., Wareham, N., Travis, R.C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Masala, G., Krogh, V., Tumino, R., Vineis, P., Panico, S., Bueno-de-Mesquita, H.B., Siersema, P.D., Peeters, P.H., Ohlsson, B., Ericson, U., Palmqvist, R., Nystrom, H., Weiderpass, E., Skeie, G., Freisling, H., Kong, S.Y., Tsilidis, K., Muller, D.C., Riboli, E., Gunter, M.J., Murphy, N., Cross, A.J., Abubakar, M., Jenab, M., Aleksandrova, K., Boutron-Ruault, M.C., Dossus, L., Racine, A., Kuhn, T., Katzke, V.A., Tjonneland, A., Petersen, K.E., Overvad, K., Quiros, J.R., Jakszyn, P., Molina-Montes, E., Dorronsoro, M., Huerta, J.M., Barricarte, A., Khaw, K.T., Wareham, N., Travis, R.C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Masala, G., Krogh, V., Tumino, R., Vineis, P., Panico, S., Bueno-de-Mesquita, H.B., Siersema, P.D., Peeters, P.H., Ohlsson, B., Ericson, U., Palmqvist, R., Nystrom, H., Weiderpass, E., Skeie, G., Freisling, H., Kong, S.Y., Tsilidis, K., Muller, D.C., Riboli, E., and Gunter, M.J.
Abstract: Contains fulltext : 165685.pdf (publisher's version ) (Open Access), BACKGROUND: Obesity is positively associated with colorectal cancer. Recently, body size subtypes categorised by the prevalence of hyperinsulinaemia have been defined, and metabolically healthy overweight/obese individuals (without hyperinsulinaemia) have been suggested to be at lower risk of cardiovascular disease than their metabolically unhealthy (hyperinsulinaemic) overweight/obese counterparts. Whether similarly variable relationships exist for metabolically defined body size phenotypes and colorectal cancer risk is unknown. METHODS AND FINDINGS: The association of metabolically defined body size phenotypes with colorectal cancer was investigated in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolic health/body size phenotypes were defined according to hyperinsulinaemia status using serum concentrations of C-peptide, a marker of insulin secretion. A total of 737 incident colorectal cancer cases and 737 matched controls were divided into tertiles based on the distribution of C-peptide concentration amongst the control population, and participants were classified as metabolically healthy if below the first tertile of C-peptide and metabolically unhealthy if above the first tertile. These metabolic health definitions were then combined with body mass index (BMI) measurements to create four metabolic health/body size phenotype categories: (1) metabolically healthy/normal weight (BMI < 25 kg/m2), (2) metabolically healthy/overweight (BMI >/= 25 kg/m2), (3) metabolically unhealthy/normal weight (BMI < 25 kg/m2), and (4) metabolically unhealthy/overweight (BMI >/= 25 kg/m2). Additionally, in separate models, waist circumference measurements (using the International Diabetes Federation cut-points [>/=80 cm for women and >/=94 cm for men]) were used (instead of BMI) to create the four metabolic health/body size phenotype categories. Statistical tests used in the analysis were all two-sided, and a p
Published: 2016

32. A Nested Case-Control Study of Metabolically Defined Body Size Phenotypes and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Murphy, N., Cross, A.J., Abubakar, M., Jenab, M., Aleksandrova, K., Boutron-Ruault, M.C., Dossus, L., Racine, A., Kuhn, T., Katzke, V.A., Tjonneland, A., Petersen, K.E., Overvad, K., Quiros, J.R., Jakszyn, P., Molina-Montes, E., Dorronsoro, M., Huerta, J.M., Barricarte, A., Khaw, K.T., Wareham, N., Travis, R.C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Masala, G., Krogh, V., Tumino, R., Vineis, P., Panico, S., Bueno-de-Mesquita, H.B., Siersema, P.D., Peeters, P.H., Ohlsson, B., Ericson, U., Palmqvist, R., Nystrom, H., Weiderpass, E., Skeie, G., Freisling, H., Kong, S.Y., Tsilidis, K., Muller, D.C., Riboli, E., Gunter, M.J., Murphy, N., Cross, A.J., Abubakar, M., Jenab, M., Aleksandrova, K., Boutron-Ruault, M.C., Dossus, L., Racine, A., Kuhn, T., Katzke, V.A., Tjonneland, A., Petersen, K.E., Overvad, K., Quiros, J.R., Jakszyn, P., Molina-Montes, E., Dorronsoro, M., Huerta, J.M., Barricarte, A., Khaw, K.T., Wareham, N., Travis, R.C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Masala, G., Krogh, V., Tumino, R., Vineis, P., Panico, S., Bueno-de-Mesquita, H.B., Siersema, P.D., Peeters, P.H., Ohlsson, B., Ericson, U., Palmqvist, R., Nystrom, H., Weiderpass, E., Skeie, G., Freisling, H., Kong, S.Y., Tsilidis, K., Muller, D.C., Riboli, E., and Gunter, M.J.
Abstract: Contains fulltext : 165685.pdf (publisher's version ) (Open Access), BACKGROUND: Obesity is positively associated with colorectal cancer. Recently, body size subtypes categorised by the prevalence of hyperinsulinaemia have been defined, and metabolically healthy overweight/obese individuals (without hyperinsulinaemia) have been suggested to be at lower risk of cardiovascular disease than their metabolically unhealthy (hyperinsulinaemic) overweight/obese counterparts. Whether similarly variable relationships exist for metabolically defined body size phenotypes and colorectal cancer risk is unknown. METHODS AND FINDINGS: The association of metabolically defined body size phenotypes with colorectal cancer was investigated in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolic health/body size phenotypes were defined according to hyperinsulinaemia status using serum concentrations of C-peptide, a marker of insulin secretion. A total of 737 incident colorectal cancer cases and 737 matched controls were divided into tertiles based on the distribution of C-peptide concentration amongst the control population, and participants were classified as metabolically healthy if below the first tertile of C-peptide and metabolically unhealthy if above the first tertile. These metabolic health definitions were then combined with body mass index (BMI) measurements to create four metabolic health/body size phenotype categories: (1) metabolically healthy/normal weight (BMI < 25 kg/m2), (2) metabolically healthy/overweight (BMI >/= 25 kg/m2), (3) metabolically unhealthy/normal weight (BMI < 25 kg/m2), and (4) metabolically unhealthy/overweight (BMI >/= 25 kg/m2). Additionally, in separate models, waist circumference measurements (using the International Diabetes Federation cut-points [>/=80 cm for women and >/=94 cm for men]) were used (instead of BMI) to create the four metabolic health/body size phenotype categories. Statistical tests used in the analysis were all two-sided, and a p
Published: 2016

33. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants

Author: di Cesare, M, Bentham, J, Stevens, GA, Zhou, B, Danaei, G, Lu, Y (Yi), Bixby, H, Cowan, MJ, Riley, LM, Hajifathalian, K, Fortunato, L, Taddei, C, Bennett, JE, Ikeda, N, Khang, YH, Kyobutungi, C, Laxmaiah, A, Li, YP, Lin, HH, Miranda, JJ, Mostafa, A, Turley, ML, Paciorek, CJ, Gunter, M, Ezzati, M, Abdeen, ZA, Hamid, ZA, Abu-Rmeileh, NM, Acosta-Cazares, B, Adams, R, Aekplakorn, W, Aguilar-Salinas, CA, Ahmadvand, A, Ahrens, W, Ali, MM, Alkerwi, A, Alvarez-Pedrerol, M, Aly, E, Amouyel, P, Amuzu, A, Andersen, LB, Anderssen, SA, Andrade, DS, Anjana, RM, Aounallah-Skhiri, H, Ariansen, I, Aris, T, Arlappa, N, Arveiler, D, Assah, FK, Avdicova, M, Azizi, F, Babu, BV, Balakrishna, N, Bandosz, P, Banegas, JR, Barbagallo, CM, Barcelo, A, Barkat, A, Barros, MV, Bata, I, Batieha, AM, Batista, RL, Baur, LA, Beaglehole, R, Ben Romdhane, H, Benet, M, Bernabe-Ortiz, A, Bernotiene, G, Bettiol, H, Bhagyalaxmi, A, Bharadwaj, S, Bhargava, SK, Bhatti, Z, Bhutta, ZA, Bi, HS, Bi, YF, Bjerregaard, P, Bjertness, E, Bjertness, MB, Bjorkelund, C, Blake, M, Blokstra, A, Bo, S, Bobak, M, Boddy, LM, Boehm, BO, Boeing, H, Boissonnet, CP, Bongard, V, Bovet, P, Braeckman, L, Bragt, MCE, Brajkovich, I, Branca, F, Breckenkamp, J, Brenner, H, Brewster, LM, Brian, GR, Bruno, G, Bueno-de-Mesquita, HB, Bugge, A, Burns, C, de Leon, AC, Cacciottolo, J, Cama, T, Cameron, C, Camolas, J, Can, G, Candido, APC, Capuano, V, Cardoso, VC, Carvalho, MJ, Casanueva, FF, Casas, JP, Caserta, CA, Castetbon, K, Chamukuttan, S, Chan, AW, Chan, Q, Chaturvedi, HK, Chaturvedi, N, Chen, CJ, Chen, FF, Chen, HS, Chen, SH, Chen, ZM, Cheng, CY (Ching-Yu), Chetrit, A, Chiolero, A, Chiou, ST, Chirita-Emandi, A, Cho, Y, Christensen, K, Chudek, J, Cifkova, R, Claessens, F, Clays, E, Concin, H, Cooper, C, Cooper, R, Coppinger, TC, Costanzo, S, Cottel, D, Cowell, C, Craig, CL, Crujeiras, AB, D'Arrigo, G, d'Orsi, E, Dallongeville, J, Damasceno, A, Damsgaard, CT, Danaei, GG, Dankner, R, Dauchet, L, de Backer, G, De Bacquer, D, de Gaetano, G, de Henauw, S, De Smedt, D, Deepa, M, Deev, AD, Dehghan, Abbas, Delisle, H, Delpeuch, F, Dhana, K, di Castelnuovo, AF, Dias-Da-Costa, JS, Diaz, A, Djalalinia, S, Do, HTP, Dobson, AJ, Donfrancesco, C, Doring, A, Doua, K, Drygas, W, Egbagbe, EE, Eggertsen, R, Ekelund, U, El Ati, J, Elliott, P, Engle-Stone, R, Erasmus, RT, Erem, C, Eriksen, L, Escobedo-de la Pena, J, Evans, A, Faeh, D, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernandez-Berges, D, Ferrante, D, Ferrari, M, Ferreccio, C, Ferrieres, J, Finn, JD, Fischer, K, Flores, EM, Foger, B, Foo, LH, Forslund, AS, Fortmann, SP, Fouad, HM, Francis, DK, Franco, MD, Franco Duran, OH, Frontera, G, Fuchs, FD, Fuchs, SC, Fujita, Y, Furusawa, T, Gaciong, Z, Gafencu, M, Gareta, D, Garnett, SP, Gaspoz, JM, Gasull, M, Gates, L, Geleijnse, JM, Ghasemian, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Giwercman, A, Goldsmith, RA, Gross, MG, Rivas, JPG, Gorbea, MB, Gottrand, F, Iversen, SG, Grafnetter, D, Grajda, A, Grammatikopoulou, MG, Gregor, RD, Grodzicki, T, Grontved, A, Gruden, G, Grujic, V, Gu, DF, Guan, OP, Gudnason, V, Guerrero, R, Guessous, I, Guimaraes, AL, Gulliford, MC, Gunnlaugsdottir, J, Guo, XH, Guo, Y, Gupta, PC, Gureje, O, Gurzkowska, B, Gutierrez, L, Gutzwiller, F, Halkjaer, J, Hardy, R, Kumar, RH, Hayes, AJ, He, J, Hendriks, ME, Cadena, LH, Heshmat, R, Hihtaniemi, IT, Ho, SY, Ho, SC, Hobbs, M, Hofman, Bert, Hormiga, CM, Horta, BL, Houti, L, Htay, TT, Htet, AS, Htike, MMT, Hu, YH, Hussieni, AS, Huu, CN, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikram, Arfan, Irazola, VE, Islam, M, Iwasaki, M, Jackson, RT, Jacobs, JM, Jafar, T, Jamil, KM, Jamrozik, K, Jasienska, G, Jiang, CQ, Joffres, M, Johansson, M, Jonas, JB, Jorgensen, T, Joshi, P, Juolevi, A, Jurak, G, Juresa, V, Kaaks, R, Kafatos, A, Kalter-Leibovici, O, Kapantais, E, Kasaeian, A, Katz, J, Kaur, P, Kavousi, Maryam, Keil, U, Boker, LK, Kelishadi, R, Kemper, H, Kengne, AP, Kersting, M, Key, T, Khader, YS, Khalili, D, Khaw, KTH, Khouw, I, Kiechl, S, Killewo, J, Kim, J, Kiyohara, Y, Klimont, J, Kolle, E, Kolsteren, P, Korrovits, P, Koskinen, S, Kouda, K, Koziel, S, Kratzer, W, Krokstad, S, Kromhout, D, Kruger, HS, Kula, K, Kulaga, Z, Kumar, RK, Kusuma, YS, Kuulasmaa, K, Laamiri, FZ, Laatikainen, T, Lachat, C, Laid, Y, Lam, TH, Landrove, O, Lanska, V, Lappas, G, Laugsand, L E, Bao, KLN, Le, TD, Leclercq, C, Lee, J, Lee, JJ, Lehtimaki, T, Lekhraj, R, Leon-Munoz, LM, Lim, WY, Lima-Costa, MF, Lin, X, Linneberg, A, Lissner, L, Litwin, M, Liu, J (Jingjing), Lorbeer, R, Lotufo, PA, Lozano, JE, Luksiene, D, Lundqvist, A, Lunet, N, Lytsy, P, Ma, GS, Machi, S, Maggi, S, Magliano, DJ, Makdisse, M, Malekzadeh, R, Malhotra, R (Rahul), Rao, KM, Manios, Y, Mann, JI, Manzato, E, Margozzini, P, Markey, O, Marques-Vidal, P, Marrugat, J, Martin-Prevel, Y, Martorell, R, Masoodi, SR, Matsha, TE, Mazur, A, Mbanya, JCN, McFarlane, SR, McGarvey, ST, McKee, M, McLachlan, S, McLean, RM, McNulty, BA, Yusof, SM, Mediene-Benchekor, S, Meirhaeghe, A, Meisinger, C, Mendes, LL, Menezes, AMB, Mensink, GBM, Meshram, II, Metspalu, A, Mi, J, Michaelsen, KF, Mikkel, K, Miller, JC, Miquel, JF, Misigoj-Durakovic, M, Mohamed, MK, Mohammad, K, Mohammadifard, N, Mohan, V, Yusoff, MFM, Molbo, D, Moller, NC, Molnar, D, Mondo, CK, Monterrubio, EA, Monyeki, KDK, Moreira, LB, Morejon, A, Moreno, LA, Morgan, K, Mortensen, EL, Moschonis, G, Mossakowska, M, Mota, J, Motlagh, ME, Motta, J, Mu, TT, Muiesan, ML, Muller-Nurasyid, M, Murphy, N, Mursu, J, Murtagh, EM, Musa, KI, Musil, V, Nagel, G, Nakamura, H, Namesna, J, Nang, EEK, Nangia, VB, Nankap, M, Narake, S, Navarrete-Munoz, EM, Nenko, I, Neovius, M, Nervi, F, Neuhauser, HK, Nguyen, ND, Nguyen, QN, Nieto-Martinez, RE, Ning, G, Ninomiya, T, Nishtar, S, Noale, M, Norat, T, Noto, D, Al Nsour, M, O'Reilly, D, Ochoa-Aviles, AM, Oh, K, Olayan, IH, Olinto, MTA, Oltarzewski, M, Omar, MA, Onat, A, Ordunez, P, Ortiz, AP, Osler, M, Osmond, C, Ostojic, SM, Otero, JA, Overvad, K, Paccaud, FM, Padez, C, Pajak, A, Palli, D, Palloni, A, Palmieri, L, Panda-Jonas, S, Panza, F, Parnell, WR, Parsaeian, M, Pednekar, MS, Peeters, PH, Peixoto, SV, Pereira, AC, Perez, CM (Cynthia), Peters, A, Peykari, N, Pham, ST, Pigeot, I, Pikhart, H, Pilav, A, Pilotto, L, Pistelli, F, Pitakaka, F, Piwonska, A, Piwonski, J, Plans-Rubio, P, Poh, BK, Porta, M, Portegies, Marileen, Poulimeneas, D, Pradeepa, R, Prashant, M, Price, JF, Puiu, M, Punab, M, Qasrawi, RF, Qorbani, M, Bao, TQ, Radic, I, Radisauskas, R, Rahman, M, Raitakari, O, Raj, M, Rao, SR, Ramachandran, A, Ramke, J, Ramos, R, Rampal, S, Rasmussen, F, Redon, J, Reganit, PFM, Ribeiro, R, Riboli, E, Rigo, F, de Wit, TFR, Ritti-Dias, RM, Rivera, JA, Robinson, SM, Robitaille, C, Rodriguez-Artalejo, F, Rodriguez-Perez, MD, Rodriguez-Villamizar, LA, Rojas-Martinez, R, Rojroongwasinkul, N, Romaguera, D, Ronkainen, K, Rosengren, A, Rouse, I, Rubinstein, A, Ruhli, FJ, Rui, O, Ruiz-Betancourt, BS, Horimoto, A, Rutkowski, M, Sabanayagam, C, Sachdev, HS, Saidi, O, Salanave, B, Martinez, ES, Salomaa, V, Salonen, JT, Salvetti, M, Sanchez-Abanto, J, Sandjaja, Sans, S, Santos, DA, Santos, O, dos Santos, RN, dos Santos, R, Sardinha, LB, Sarrafzadegan, N, Saum, KU, Savva, SC, Scazufca, M, Rosario, AS, Schargrodsky, H, Schienkiewitz, A, Schmidt, IM, Schneider, IJ, Schultsz, C, Schutte, A, Sein, AA, Senbanjo, IO, Sepanlou, SG, Shalnova, SA, Shaw, JE, Shibuya, K, Shin, YC, Shiri, R, Siantar, R, Sibai, AM, Silva, AM, Silva, DAS, Simon, M, Simons, J, Simons, LA, Sjostrom, M, Slowikowska-Hilczer, J, Slusarczyk, P, Smeeth, L, Smith, MC, Snijder, MB, So, HK, Sobngwi, E, Soderberg, S, Soekatri, MYE, Solfrizzi, V, Sonestedt, E, Sorensen, TIA, Soric, M, Jerome, CS, Soumare, A, Staessen, JA, Starc, G, Stathopoulou, MG, Staub, K, Stavreski, B, Steene-Johannessen, J, Stehle, P, Stein, AD, Stergiou, GS, Stessman, J, Stieber, J, Stockl, D, Stocks, T, Stokwiszewski, J, Stratton, G, Strufaldi, MW, Sun, CA, Sundstrom, J, Sung, YT, Sunyer, J, Suriyawongpaisal, P, Swinburn, BA, Sy, RG, Szponar, L, Tai, ES, Tammesoo, ML, Tamosiunas, A, Tang, L, Tang, X, Tanser, F, Tao, Y, Tarp, J, Tarqui-Mamani, CB, Taylor, A, Tchibindat, F, Thijs, L, Thuesen, B H, Tjonneland, A, Tolonen, HK, Tolstrup, JS, Topbas, M, Topor-Madry, R, Torrent, M, Traissac, P, Trichopoulou, A, Trichopoulos, D, Trinh, OTH, Trivedi, A, Tshepo, L, Tulloch-Reid, MK, Tuomainen, TP, Tuomilehto, J, Tynelius, P, Tzotzas, T, Tzourio, C, Ueda, P, Ukoli, FAM, Ulmer, H, Unal, B, Valdivia, G, Vale, S, Valvi, D, van der Schouw, YT, Van Herck, K, Minh, HV, van Valkengoed, IGM, Vanderschueren, D, Vanuzzo, D, Vatten, L, Vega, T, Velasquez-Melendez, G, Veronesi, G, Verschuren, WMM, Viegi, G, Viet, L, Viikari-Juntura, E, Vineis, P, Vioque, J, Virtanen, JK, Visvikis-Siest, S, Viswanathan, B, Vollenweider, P, Voutilainen, S, Vrijheid, M, Wade, AN, Wagner, A, Walton, J, Mohamud, WNW, Wang, MD, Wang, Q, Wang, YX, Wannamethee, SG, Wareham, N, Weerasekera, D, Whincup, PH, Widhalm, K, Widyahening, IS, Wiecek, A, Wilks, RJ, Willeit, J, Wojtyniak, B, Wong, JE, Wong, TY, Woo, J, Woodward, M, Wu, FC, Wu, JF, Wu, SL, Xu, HQ, Xu, L, Yamborisut, U, Yan, WL, Yang, XG, Yardim, N, Ye, XW, Yiallouros, PK, Yoshihara, A, You, QS, Younger-Coleman, NO, Yusoff, AF, Zainuddin, AA, Zambon, S, Zdrojewski, T, Zeng, Yaping, Zhao, D (Dan), Zhao, WH, Zheng, YF, Zhou, MG, Zhu, D, Zimmermann, E, Cisneros, JZ, di Cesare, M, Bentham, J, Stevens, GA, Zhou, B, Danaei, G, Lu, Y (Yi), Bixby, H, Cowan, MJ, Riley, LM, Hajifathalian, K, Fortunato, L, Taddei, C, Bennett, JE, Ikeda, N, Khang, YH, Kyobutungi, C, Laxmaiah, A, Li, YP, Lin, HH, Miranda, JJ, Mostafa, A, Turley, ML, Paciorek, CJ, Gunter, M, Ezzati, M, Abdeen, ZA, Hamid, ZA, Abu-Rmeileh, NM, Acosta-Cazares, B, Adams, R, Aekplakorn, W, Aguilar-Salinas, CA, Ahmadvand, A, Ahrens, W, Ali, MM, Alkerwi, A, Alvarez-Pedrerol, M, Aly, E, Amouyel, P, Amuzu, A, Andersen, LB, Anderssen, SA, Andrade, DS, Anjana, RM, Aounallah-Skhiri, H, Ariansen, I, Aris, T, Arlappa, N, Arveiler, D, Assah, FK, Avdicova, M, Azizi, F, Babu, BV, Balakrishna, N, Bandosz, P, Banegas, JR, Barbagallo, CM, Barcelo, A, Barkat, A, Barros, MV, Bata, I, Batieha, AM, Batista, RL, Baur, LA, Beaglehole, R, Ben Romdhane, H, Benet, M, Bernabe-Ortiz, A, Bernotiene, G, Bettiol, H, Bhagyalaxmi, A, Bharadwaj, S, Bhargava, SK, Bhatti, Z, Bhutta, ZA, Bi, HS, Bi, YF, Bjerregaard, P, Bjertness, E, Bjertness, MB, Bjorkelund, C, Blake, M, Blokstra, A, Bo, S, Bobak, M, Boddy, LM, Boehm, BO, Boeing, H, Boissonnet, CP, Bongard, V, Bovet, P, Braeckman, L, Bragt, MCE, Brajkovich, I, Branca, F, Breckenkamp, J, Brenner, H, Brewster, LM, Brian, GR, Bruno, G, Bueno-de-Mesquita, HB, Bugge, A, Burns, C, de Leon, AC, Cacciottolo, J, Cama, T, Cameron, C, Camolas, J, Can, G, Candido, APC, Capuano, V, Cardoso, VC, Carvalho, MJ, Casanueva, FF, Casas, JP, Caserta, CA, Castetbon, K, Chamukuttan, S, Chan, AW, Chan, Q, Chaturvedi, HK, Chaturvedi, N, Chen, CJ, Chen, FF, Chen, HS, Chen, SH, Chen, ZM, Cheng, CY (Ching-Yu), Chetrit, A, Chiolero, A, Chiou, ST, Chirita-Emandi, A, Cho, Y, Christensen, K, Chudek, J, Cifkova, R, Claessens, F, Clays, E, Concin, H, Cooper, C, Cooper, R, Coppinger, TC, Costanzo, S, Cottel, D, Cowell, C, Craig, CL, Crujeiras, AB, D'Arrigo, G, d'Orsi, E, Dallongeville, J, Damasceno, A, Damsgaard, CT, Danaei, GG, Dankner, R, Dauchet, L, de Backer, G, De Bacquer, D, de Gaetano, G, de Henauw, S, De Smedt, D, Deepa, M, Deev, AD, Dehghan, Abbas, Delisle, H, Delpeuch, F, Dhana, K, di Castelnuovo, AF, Dias-Da-Costa, JS, Diaz, A, Djalalinia, S, Do, HTP, Dobson, AJ, Donfrancesco, C, Doring, A, Doua, K, Drygas, W, Egbagbe, EE, Eggertsen, R, Ekelund, U, El Ati, J, Elliott, P, Engle-Stone, R, Erasmus, RT, Erem, C, Eriksen, L, Escobedo-de la Pena, J, Evans, A, Faeh, D, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernandez-Berges, D, Ferrante, D, Ferrari, M, Ferreccio, C, Ferrieres, J, Finn, JD, Fischer, K, Flores, EM, Foger, B, Foo, LH, Forslund, AS, Fortmann, SP, Fouad, HM, Francis, DK, Franco, MD, Franco Duran, OH, Frontera, G, Fuchs, FD, Fuchs, SC, Fujita, Y, Furusawa, T, Gaciong, Z, Gafencu, M, Gareta, D, Garnett, SP, Gaspoz, JM, Gasull, M, Gates, L, Geleijnse, JM, Ghasemian, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Giwercman, A, Goldsmith, RA, Gross, MG, Rivas, JPG, Gorbea, MB, Gottrand, F, Iversen, SG, Grafnetter, D, Grajda, A, Grammatikopoulou, MG, Gregor, RD, Grodzicki, T, Grontved, A, Gruden, G, Grujic, V, Gu, DF, Guan, OP, Gudnason, V, Guerrero, R, Guessous, I, Guimaraes, AL, Gulliford, MC, Gunnlaugsdottir, J, Guo, XH, Guo, Y, Gupta, PC, Gureje, O, Gurzkowska, B, Gutierrez, L, Gutzwiller, F, Halkjaer, J, Hardy, R, Kumar, RH, Hayes, AJ, He, J, Hendriks, ME, Cadena, LH, Heshmat, R, Hihtaniemi, IT, Ho, SY, Ho, SC, Hobbs, M, Hofman, Bert, Hormiga, CM, Horta, BL, Houti, L, Htay, TT, Htet, AS, Htike, MMT, Hu, YH, Hussieni, AS, Huu, CN, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikram, Arfan, Irazola, VE, Islam, M, Iwasaki, M, Jackson, RT, Jacobs, JM, Jafar, T, Jamil, KM, Jamrozik, K, Jasienska, G, Jiang, CQ, Joffres, M, Johansson, M, Jonas, JB, Jorgensen, T, Joshi, P, Juolevi, A, Jurak, G, Juresa, V, Kaaks, R, Kafatos, A, Kalter-Leibovici, O, Kapantais, E, Kasaeian, A, Katz, J, Kaur, P, Kavousi, Maryam, Keil, U, Boker, LK, Kelishadi, R, Kemper, H, Kengne, AP, Kersting, M, Key, T, Khader, YS, Khalili, D, Khaw, KTH, Khouw, I, Kiechl, S, Killewo, J, Kim, J, Kiyohara, Y, Klimont, J, Kolle, E, Kolsteren, P, Korrovits, P, Koskinen, S, Kouda, K, Koziel, S, Kratzer, W, Krokstad, S, Kromhout, D, Kruger, HS, Kula, K, Kulaga, Z, Kumar, RK, Kusuma, YS, Kuulasmaa, K, Laamiri, FZ, Laatikainen, T, Lachat, C, Laid, Y, Lam, TH, Landrove, O, Lanska, V, Lappas, G, Laugsand, L E, Bao, KLN, Le, TD, Leclercq, C, Lee, J, Lee, JJ, Lehtimaki, T, Lekhraj, R, Leon-Munoz, LM, Lim, WY, Lima-Costa, MF, Lin, X, Linneberg, A, Lissner, L, Litwin, M, Liu, J (Jingjing), Lorbeer, R, Lotufo, PA, Lozano, JE, Luksiene, D, Lundqvist, A, Lunet, N, Lytsy, P, Ma, GS, Machi, S, Maggi, S, Magliano, DJ, Makdisse, M, Malekzadeh, R, Malhotra, R (Rahul), Rao, KM, Manios, Y, Mann, JI, Manzato, E, Margozzini, P, Markey, O, Marques-Vidal, P, Marrugat, J, Martin-Prevel, Y, Martorell, R, Masoodi, SR, Matsha, TE, Mazur, A, Mbanya, JCN, McFarlane, SR, McGarvey, ST, McKee, M, McLachlan, S, McLean, RM, McNulty, BA, Yusof, SM, Mediene-Benchekor, S, Meirhaeghe, A, Meisinger, C, Mendes, LL, Menezes, AMB, Mensink, GBM, Meshram, II, Metspalu, A, Mi, J, Michaelsen, KF, Mikkel, K, Miller, JC, Miquel, JF, Misigoj-Durakovic, M, Mohamed, MK, Mohammad, K, Mohammadifard, N, Mohan, V, Yusoff, MFM, Molbo, D, Moller, NC, Molnar, D, Mondo, CK, Monterrubio, EA, Monyeki, KDK, Moreira, LB, Morejon, A, Moreno, LA, Morgan, K, Mortensen, EL, Moschonis, G, Mossakowska, M, Mota, J, Motlagh, ME, Motta, J, Mu, TT, Muiesan, ML, Muller-Nurasyid, M, Murphy, N, Mursu, J, Murtagh, EM, Musa, KI, Musil, V, Nagel, G, Nakamura, H, Namesna, J, Nang, EEK, Nangia, VB, Nankap, M, Narake, S, Navarrete-Munoz, EM, Nenko, I, Neovius, M, Nervi, F, Neuhauser, HK, Nguyen, ND, Nguyen, QN, Nieto-Martinez, RE, Ning, G, Ninomiya, T, Nishtar, S, Noale, M, Norat, T, Noto, D, Al Nsour, M, O'Reilly, D, Ochoa-Aviles, AM, Oh, K, Olayan, IH, Olinto, MTA, Oltarzewski, M, Omar, MA, Onat, A, Ordunez, P, Ortiz, AP, Osler, M, Osmond, C, Ostojic, SM, Otero, JA, Overvad, K, Paccaud, FM, Padez, C, Pajak, A, Palli, D, Palloni, A, Palmieri, L, Panda-Jonas, S, Panza, F, Parnell, WR, Parsaeian, M, Pednekar, MS, Peeters, PH, Peixoto, SV, Pereira, AC, Perez, CM (Cynthia), Peters, A, Peykari, N, Pham, ST, Pigeot, I, Pikhart, H, Pilav, A, Pilotto, L, Pistelli, F, Pitakaka, F, Piwonska, A, Piwonski, J, Plans-Rubio, P, Poh, BK, Porta, M, Portegies, Marileen, Poulimeneas, D, Pradeepa, R, Prashant, M, Price, JF, Puiu, M, Punab, M, Qasrawi, RF, Qorbani, M, Bao, TQ, Radic, I, Radisauskas, R, Rahman, M, Raitakari, O, Raj, M, Rao, SR, Ramachandran, A, Ramke, J, Ramos, R, Rampal, S, Rasmussen, F, Redon, J, Reganit, PFM, Ribeiro, R, Riboli, E, Rigo, F, de Wit, TFR, Ritti-Dias, RM, Rivera, JA, Robinson, SM, Robitaille, C, Rodriguez-Artalejo, F, Rodriguez-Perez, MD, Rodriguez-Villamizar, LA, Rojas-Martinez, R, Rojroongwasinkul, N, Romaguera, D, Ronkainen, K, Rosengren, A, Rouse, I, Rubinstein, A, Ruhli, FJ, Rui, O, Ruiz-Betancourt, BS, Horimoto, A, Rutkowski, M, Sabanayagam, C, Sachdev, HS, Saidi, O, Salanave, B, Martinez, ES, Salomaa, V, Salonen, JT, Salvetti, M, Sanchez-Abanto, J, Sandjaja, Sans, S, Santos, DA, Santos, O, dos Santos, RN, dos Santos, R, Sardinha, LB, Sarrafzadegan, N, Saum, KU, Savva, SC, Scazufca, M, Rosario, AS, Schargrodsky, H, Schienkiewitz, A, Schmidt, IM, Schneider, IJ, Schultsz, C, Schutte, A, Sein, AA, Senbanjo, IO, Sepanlou, SG, Shalnova, SA, Shaw, JE, Shibuya, K, Shin, YC, Shiri, R, Siantar, R, Sibai, AM, Silva, AM, Silva, DAS, Simon, M, Simons, J, Simons, LA, Sjostrom, M, Slowikowska-Hilczer, J, Slusarczyk, P, Smeeth, L, Smith, MC, Snijder, MB, So, HK, Sobngwi, E, Soderberg, S, Soekatri, MYE, Solfrizzi, V, Sonestedt, E, Sorensen, TIA, Soric, M, Jerome, CS, Soumare, A, Staessen, JA, Starc, G, Stathopoulou, MG, Staub, K, Stavreski, B, Steene-Johannessen, J, Stehle, P, Stein, AD, Stergiou, GS, Stessman, J, Stieber, J, Stockl, D, Stocks, T, Stokwiszewski, J, Stratton, G, Strufaldi, MW, Sun, CA, Sundstrom, J, Sung, YT, Sunyer, J, Suriyawongpaisal, P, Swinburn, BA, Sy, RG, Szponar, L, Tai, ES, Tammesoo, ML, Tamosiunas, A, Tang, L, Tang, X, Tanser, F, Tao, Y, Tarp, J, Tarqui-Mamani, CB, Taylor, A, Tchibindat, F, Thijs, L, Thuesen, B H, Tjonneland, A, Tolonen, HK, Tolstrup, JS, Topbas, M, Topor-Madry, R, Torrent, M, Traissac, P, Trichopoulou, A, Trichopoulos, D, Trinh, OTH, Trivedi, A, Tshepo, L, Tulloch-Reid, MK, Tuomainen, TP, Tuomilehto, J, Tynelius, P, Tzotzas, T, Tzourio, C, Ueda, P, Ukoli, FAM, Ulmer, H, Unal, B, Valdivia, G, Vale, S, Valvi, D, van der Schouw, YT, Van Herck, K, Minh, HV, van Valkengoed, IGM, Vanderschueren, D, Vanuzzo, D, Vatten, L, Vega, T, Velasquez-Melendez, G, Veronesi, G, Verschuren, WMM, Viegi, G, Viet, L, Viikari-Juntura, E, Vineis, P, Vioque, J, Virtanen, JK, Visvikis-Siest, S, Viswanathan, B, Vollenweider, P, Voutilainen, S, Vrijheid, M, Wade, AN, Wagner, A, Walton, J, Mohamud, WNW, Wang, MD, Wang, Q, Wang, YX, Wannamethee, SG, Wareham, N, Weerasekera, D, Whincup, PH, Widhalm, K, Widyahening, IS, Wiecek, A, Wilks, RJ, Willeit, J, Wojtyniak, B, Wong, JE, Wong, TY, Woo, J, Woodward, M, Wu, FC, Wu, JF, Wu, SL, Xu, HQ, Xu, L, Yamborisut, U, Yan, WL, Yang, XG, Yardim, N, Ye, XW, Yiallouros, PK, Yoshihara, A, You, QS, Younger-Coleman, NO, Yusoff, AF, Zainuddin, AA, Zambon, S, Zdrojewski, T, Zeng, Yaping, Zhao, D (Dan), Zhao, WH, Zheng, YF, Zhou, MG, Zhu, D, Zimmermann, E, and Cisneros, JZ
Published: 2016

34. Diabetes and Onset of Natural Menopause: Results From the European Prospective Investigation Into Cancer and Nutrition

Author: Brand, J.S. Onland-Moret, N.C. Eijkemans, M.J.C. Tjønneland, A. Roswall, N. Overvad, K. Fagherazzi, G. Clavel-Chapelon, F. Dossus, L. Lukanova, A. Grote, V. Bergmann, M.M. Boeing, H. Trichopoulou, A. Tzivoglou, M. Trichopoulos, D. Grioni, S. Mattiello, A. Masala, G. Tumino, R. Vineis, P. Bueno-De-Mesquita, H.B. Weiderpass, E. Redondo, M.L. Sánchez, M.J. Huerta Castaño, J.M. Arriola, L. Ardanaz, E. Duell, E.J. Rolandsson, O. Franks, P.W. Butt, S. Nilsson, P. Khaw, K.T. Wareham, N. Travis, R. Romieu, I. Gunter, M.J. Riboli, E. Van Der Schouw, Y.T. and Brand, J.S. Onland-Moret, N.C. Eijkemans, M.J.C. Tjønneland, A. Roswall, N. Overvad, K. Fagherazzi, G. Clavel-Chapelon, F. Dossus, L. Lukanova, A. Grote, V. Bergmann, M.M. Boeing, H. Trichopoulou, A. Tzivoglou, M. Trichopoulos, D. Grioni, S. Mattiello, A. Masala, G. Tumino, R. Vineis, P. Bueno-De-Mesquita, H.B. Weiderpass, E. Redondo, M.L. Sánchez, M.J. Huerta Castaño, J.M. Arriola, L. Ardanaz, E. Duell, E.J. Rolandsson, O. Franks, P.W. Butt, S. Nilsson, P. Khaw, K.T. Wareham, N. Travis, R. Romieu, I. Gunter, M.J. Riboli, E. Van Der Schouw, Y.T.
Published: 2015

35. Size at birth and risk of breast cancer: update from a prospective population-based study

Author: Sandvei, M.S. Lagiou, P. Romundstad, P.R. Trichopoulos, D. Vatten, L.J. and Sandvei, M.S. Lagiou, P. Romundstad, P.R. Trichopoulos, D. Vatten, L.J.
Abstract: Birth size variables (birth weight, birth length and head circumference) have been reported to be positively associated with adult breast cancer risk, whereas a possible association of placental weight has not been adequately studied. It has also been suggested that maternal height may modify the association of birth size with adult breast cancer risk, but this has not been studied in detail. We updated a long-term follow-up of 22,931 Norwegian women (average of 51 years of follow up during which 870 women were diagnosed with breast cancer) and assessed placental weight in relation to breast cancer risk, in addition to providing updated analyses on breast cancer risk in relation to birth weight, birth length and head circumference. Placental weight was not associated with risk for breast cancer in adulthood, but there was a positive association of breast cancer risk with birth length (HR 1.13, 95 % CI 1.05–1.21, per 2 cm increment), though not with birth weight (HR 1.02, 95 % CI 0.95–1.10 per 0.5 kg increment). For birth length, the graded increase in risk was particularly strong among women whose mothers were relatively tall (p for trend, 0.001), compared to the trend among women whose mothers were relatively short (p for trend, 0.221). The results showed a robust and positive association of birth length with breast cancer risk, and may be especially strong in women whose mothers were relatively tall. We found no association of placental weight with risk for breast cancer. © 2015, Springer Science+Business Media Dordrecht.
Published: 2015

36. Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies

Author: Gapstur, S. M. Patel, A. V. Banks, E. Dal Maso, L. and Talamini, R. Chetrit, A. Hirsh-Yechezkel, G. Lubin, F. and Sadetzki, S. Beral, V. Bull, D. Cairns, B. Crossley, B. and Gaitskell, K. Goodill, A. Green, J. Hermon, C. Key, T. Moser, K. Reeves, G. Sitas, F. Collins, R. Peto, R. Gonzalez, C. A. Lee, N. Marchbanks, P. Ory, H. W. and Peterson, H. B. Wingo, P. A. Martin, N. Silpisornkosol, S. and Theetranont, C. Boosiri, B. Chutivongse, S. Jimakorn, P. and Virutamasen, P. Wongsrichanalai, C. Goodman, M. T. and Lidegaard, O. Kjaer, S. K. Morch, L. S. Tjonneland, A. and Byers, T. Rohan, T. Mosgaard, B. Vessey, M. Yeates, D. and Freudenheim, J. L. Titus, L. J. Chang-Claude, J. Kaaks, R. Anderson, K. E. Lazovich, D. Robien, K. Hampton, J. and Newcomb, P. A. Rossing, M. A. Thomas, D. B. Weiss, N. S. and Lokkegaard, E. Riboli, E. Clavel-Chapelon, F. Cramer, D. and Hankinson, S. E. Tamimi, R. M. Tworoger, S. S. and Franceschi, S. La Vecchia, C. Negri, E. Adami, H. O. and Magnusson, C. Riman, T. Weiderpass, E. Wolk, A. and Schouten, L. J. van den Brandt, P. A. Chantarakul, N. and Koetsawang, S. Rachawat, D. Palli, D. Black, A. Brinton, L. A. Freedman, D. M. Hartge, P. Hsing, A. W. Jnr, J. V. Lacey Lissowska, J. Hoover, R. N. Schairer, C. Babb, C. and Urban, M. Graff-Iversen, S. Selmer, R. Bain, C. J. and Green, A. C. Purdie, D. M. Siskind, V. Webb, P. M. and Moysich, K. McCann, S. E. Hannaford, P. Kay, C. Binns, C. W. Lee, A. H. Zhang, M. Ness, R. B. Nasca, P. and Coogan, P. F. Palmer, J. R. Rosenberg, L. Whittemore, A. and Katsouyanni, K. Trichopoulou, A. Trichopoulos, D. Tzonou, A. and Dabancens, A. Martinez, L. Molina, R. Salas, O. and Lurie, G. Carney, M. E. Wilkens, L. R. Hartman, L. and Manjer, J. Olsson, H. Kumle, M. Grisso, J. A. Morgan, M. and Wheeler, J. E. Edwards, R. P. Kelley, J. L. Modugno, F. and Onland-Moret, N. C. Peeters, P. H. M. Casagrande, J. and Pike, M. C. Wu, A. H. Canfell, K. Miller, A. B. Gram, I. T. Lund, E. McGowan, L. Shu, X. O. Zheng, W. Farley and Gapstur, S. M. Patel, A. V. Banks, E. Dal Maso, L. and Talamini, R. Chetrit, A. Hirsh-Yechezkel, G. Lubin, F. and Sadetzki, S. Beral, V. Bull, D. Cairns, B. Crossley, B. and Gaitskell, K. Goodill, A. Green, J. Hermon, C. Key, T. Moser, K. Reeves, G. Sitas, F. Collins, R. Peto, R. Gonzalez, C. A. Lee, N. Marchbanks, P. Ory, H. W. and Peterson, H. B. Wingo, P. A. Martin, N. Silpisornkosol, S. and Theetranont, C. Boosiri, B. Chutivongse, S. Jimakorn, P. and Virutamasen, P. Wongsrichanalai, C. Goodman, M. T. and Lidegaard, O. Kjaer, S. K. Morch, L. S. Tjonneland, A. and Byers, T. Rohan, T. Mosgaard, B. Vessey, M. Yeates, D. and Freudenheim, J. L. Titus, L. J. Chang-Claude, J. Kaaks, R. Anderson, K. E. Lazovich, D. Robien, K. Hampton, J. and Newcomb, P. A. Rossing, M. A. Thomas, D. B. Weiss, N. S. and Lokkegaard, E. Riboli, E. Clavel-Chapelon, F. Cramer, D. and Hankinson, S. E. Tamimi, R. M. Tworoger, S. S. and Franceschi, S. La Vecchia, C. Negri, E. Adami, H. O. and Magnusson, C. Riman, T. Weiderpass, E. Wolk, A. and Schouten, L. J. van den Brandt, P. A. Chantarakul, N. and Koetsawang, S. Rachawat, D. Palli, D. Black, A. Brinton, L. A. Freedman, D. M. Hartge, P. Hsing, A. W. Jnr, J. V. Lacey Lissowska, J. Hoover, R. N. Schairer, C. Babb, C. and Urban, M. Graff-Iversen, S. Selmer, R. Bain, C. J. and Green, A. C. Purdie, D. M. Siskind, V. Webb, P. M. and Moysich, K. McCann, S. E. Hannaford, P. Kay, C. Binns, C. W. Lee, A. H. Zhang, M. Ness, R. B. Nasca, P. and Coogan, P. F. Palmer, J. R. Rosenberg, L. Whittemore, A. and Katsouyanni, K. Trichopoulou, A. Trichopoulos, D. Tzonou, A. and Dabancens, A. Martinez, L. Molina, R. Salas, O. and Lurie, G. Carney, M. E. Wilkens, L. R. Hartman, L. and Manjer, J. Olsson, H. Kumle, M. Grisso, J. A. Morgan, M. and Wheeler, J. E. Edwards, R. P. Kelley, J. L. Modugno, F. and Onland-Moret, N. C. Peeters, P. H. M. Casagrande, J. and Pike, M. C. Wu, A. H. Canfell, K. Miller, A. B. Gram, I. T. Lund, E. McGowan, L. Shu, X. O. Zheng, W. Farley
Abstract: Background Half the epidemiological studies with information about menopausal hormone therapy and ovarian cancer risk remain unpublished, and some retrospective studies could have been biased by selective participation or recall. We aimed to assess with minimal bias the effects of hormone therapy on ovarian cancer risk. Methods Individual participant datasets from 52 epidemiological studies were analysed centrally. The principal analyses involved the prospective studies (with last hormone therapy use extrapolated forwards for up to 4 years). Sensitivity analyses included the retrospective studies. Adjusted Poisson regressions yielded relative risks (RRs) versus never-use. Findings During prospective follow-up, 12 110 postmenopausal women, 55% (6601) of whom had used hormone therapy, developed ovarian cancer. Among women last recorded as current users, risk was increased even with <5 years of use (RR 1.43, 95% CI 1.31-1.56; p<0.0001). Combining current-or-recent use (any duration, but stopped <5 years before diagnosis) resulted in an RR of 1.37 (95% CI 1.29-1.46; p<0.0001); this risk was similar in European and American prospective studies and for oestrogen-only and oestrogen-progestagen preparations, but differed across the four main tumour types (heterogeneity p<0.0001), being definitely increased only for the two most common types, serous (RR 1.53, 95% CI 1.40-1.66; p<0.0001) and endometrioid (1.42, 1.20-1.67; p<0.0001). Risk declined the longer ago use had ceased, although about 10 years after stopping long-duration hormone therapy use there was still an excess of serous or endometrioid tumours (RR 1.25, 95% CI 1.07-1.46, p=0.005). Interpretation The increased risk may well be largely or wholly causal; if it is, women who use hormone therapy for 5 years from around age 50 years have about one extra ovarian cancer per 1000 users and, if its prognosis is typical, about one extra ovarian cancer death per 1700 users.
Published: 2015

37. Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study

Author: Bamia, C. Lagiou, P. Jenab, M. Trichopoulou, A. Fedirko, V. Aleksandrova, K. Pischon, T. Overvad, K. Olsen, A. Tjønneland, A. Boutron-Ruault, M.-C. Fagherazzi, G. Racine, A. Kuhn, T. Boeing, H. Floegel, A. Benetou, V. Palli, D. Grioni, S. Panico, S. Tumino, R. Vineis, P. Bueno-De-Mesquita, H.B. Dik, V.K. Bhoo-Pathy, N. Uiterwaal, C.S.P.M. Weiderpass, E. Lund, E. Quirós, J.R. Zamora-Ros, R. Molina-Montes, E. Chirlaque, M.-D. Ardanaz, E. Dorronsoro, M. Lindkvist, B. Wallström, P. Nilsson, L.M. Sund, M. Khaw, K.-T. Wareham, N. Bradbury, K.E. Travis, R.C. Ferrari, P. Duarte-Salles, T. Stepien, M. Gunter, M. Murphy, N. Riboli, E. Trichopoulos, D. and Bamia, C. Lagiou, P. Jenab, M. Trichopoulou, A. Fedirko, V. Aleksandrova, K. Pischon, T. Overvad, K. Olsen, A. Tjønneland, A. Boutron-Ruault, M.-C. Fagherazzi, G. Racine, A. Kuhn, T. Boeing, H. Floegel, A. Benetou, V. Palli, D. Grioni, S. Panico, S. Tumino, R. Vineis, P. Bueno-De-Mesquita, H.B. Dik, V.K. Bhoo-Pathy, N. Uiterwaal, C.S.P.M. Weiderpass, E. Lund, E. Quirós, J.R. Zamora-Ros, R. Molina-Montes, E. Chirlaque, M.-D. Ardanaz, E. Dorronsoro, M. Lindkvist, B. Wallström, P. Nilsson, L.M. Sund, M. Khaw, K.-T. Wareham, N. Bradbury, K.E. Travis, R.C. Ferrari, P. Duarte-Salles, T. Stepien, M. Gunter, M. Murphy, N. Riboli, E. Trichopoulos, D.
Abstract: Inverse associations of coffee and/or tea in relation to hepatocellular carcinoma (HCC) risk have been consistently identified in studies conducted mostly in Asia where consumption patterns of such beverages differ from Europe. In the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 201 HCC cases among 486,799 men/women, after a median follow-up of 11 years. We calculated adjusted hazard ratios (HRs) for HCC incidence in relation to quintiles/categories of coffee/tea intakes. We found that increased coffee and tea intakes were consistently associated with lower HCC risk. The inverse associations were substantial, monotonic and statistically significant. Coffee consumers in the highest compared to the lowest quintile had lower HCC risk by 72% [HR: 0.28; 95% confidence intervals (CIs): 0.16-0.50, p-trend < 0.001]. The corresponding association of tea with HCC risk was 0.41 (95% CI: 0.22-0.78, p-trend50.003). There was no compelling evidence of heterogeneity of these associations across strata of important HCC risk factors, including hepatitis B or hepatitis C status (available in a nested case-control study). The inverse, monotonic associations of coffee intake with HCC were apparent for caffeinated (p-trend50.009), but not decaffeinated (p-trend50.45) coffee for which, however, data were available for a fraction of subjects. Results from this multicentre, European cohort study strengthen the existing evidence regarding the inverse association between coffee/tea and HCC risk. Given the apparent lack of heterogeneity of these associations by HCC risk factors and that coffee/tea are universal exposures, our results could have important implications for high HCC risk subjects. © 2014 UICC.
Published: 2015

38. Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women: The European prospective investigation into cancer and nutrition study (EPIC)

Author: Ekelund, U. Ward, H.A. Norat, T. Luan, J. May, A.M. Weiderpass, E. Sharp, S.J. Overvad, K. Østergaard, J.N. Tjønneland, A. Johnsen, N.F. Mesrine, S. Fournier, A. Fagherazzi, G. Trichopoulou, A. Lagiou, P. Trichopoulos, D. Li, K. Kaaks, R. Ferrari, P. Licaj, I. Jenab, M. Bergmann, M. Boeing, H. Palli, D. Sieri, S. Panico, S. Tumino, R. Vineis, P. Peeters, P.H. Monnikhof, E. Bueno-De-Mesquita, H.B. Quirós, J.R. Agudo, A. Sánchez, M.-J. Huerta, J.M. Ardanaz, E. Arriola, L. Hedblad, B. Wirfält, E. Sund, M. Johansson, M. Key, T.J. Travis, R.C. Khaw, K.-T. Brage, S. Wareham, N.J. Riboli, E. and Ekelund, U. Ward, H.A. Norat, T. Luan, J. May, A.M. Weiderpass, E. Sharp, S.J. Overvad, K. Østergaard, J.N. Tjønneland, A. Johnsen, N.F. Mesrine, S. Fournier, A. Fagherazzi, G. Trichopoulou, A. Lagiou, P. Trichopoulos, D. Li, K. Kaaks, R. Ferrari, P. Licaj, I. Jenab, M. Bergmann, M. Boeing, H. Palli, D. Sieri, S. Panico, S. Tumino, R. Vineis, P. Peeters, P.H. Monnikhof, E. Bueno-De-Mesquita, H.B. Quirós, J.R. Agudo, A. Sánchez, M.-J. Huerta, J.M. Ardanaz, E. Arriola, L. Hedblad, B. Wirfält, E. Sund, M. Johansson, M. Key, T.J. Travis, R.C. Khaw, K.-T. Brage, S. Wareham, N.J. Riboli, E.
Abstract: Background: The higher risk of death resulting from excess adiposity may be attenuated by physical activity (PA). However, the theoretical number of deaths reduced by eliminating physical inactivity compared with overall and abdominal obesity remains unclear. Objective: We examined whether overall and abdominal adiposity modified the association between PA and all-cause mortality and estimated the population attributable fraction (PAF) and the years of life gained for these exposures. Design: This was a cohort study in 334,161 European men and women. The mean follow-up time was 12.4 y, corresponding to 4,154,915 person-years. Height, weight, and waist circumference (WC) were measured in the clinic. PA was assessed with a validated self-report instrument. The combined associations between PA, BMI, and WC with mortality were examined with Cox proportional hazards models, stratified by center and age group, and adjusted for sex, education, smoking, and alcohol intake. Centerspecific PAF associated with inactivity, body mass index (BMI; in kg/m2) (>30), and WC (≥102 cm for men, ≥88 cm for women) were calculated and combined in random-effects meta-analysis. Life-tables analyses were used to estimate gains in life expectancy for the exposures. Results: Significant interactions (PA × BMI and PA × WC) were observed, so HRs were estimated within BMI and WC strata. The hazards of all-cause mortality were reduced by 16-30% in moderately inactive individuals compared with those categorized as inactive in different strata of BMI and WC. Avoiding all inactivity would theoretically reduce all-cause mortality by 7.35% (95% CI: 5.88%, 8.83%). Corresponding estimates for avoiding obesity (BMI >30) were 3.66% (95% CI: 2.30%, 5.01%). The estimates for avoiding high WC were similar to those for physical inactivity. Conclusion: The greatest reductions in mortality risk were observed between the 2 lowest activity groups across levels of general and abdominal adiposity, which
Published: 2015

39. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort

Author: Hughes, D.J. Fedirko, V. Jenab, M. Schomburg, L. Méplan, C. Freisling, H. Bueno-De-Mesquita, H.B. Hybsier, S. Becker, N.-P. Czuban, M. Tjønneland, A. Outzen, M. Boutron-Ruault, M.-C. Racine, A. Bastide, N. Kühn, T. Kaaks, R. Trichopoulos, D. Trichopoulou, A. Lagiou, P. Panico, S. Peeters, P.H. Weiderpass, E. Skeie, G. Dagrun, E. Chirlaque, M.-D. Sánchez, M.-J. Ardanaz, E. Ljuslinder, I. Wennberg, M. Bradbury, K.E. Vineis, P. Naccarati, A. Palli, D. Boeing, H. Overvad, K. Dorronsoro, M. Jakszyn, P. Cross, A.J. Quirós, J.R. Stepien, M. Kong, S.Y. Duarte-Salles, T. Riboli, E. Hesketh, J.E. and Hughes, D.J. Fedirko, V. Jenab, M. Schomburg, L. Méplan, C. Freisling, H. Bueno-De-Mesquita, H.B. Hybsier, S. Becker, N.-P. Czuban, M. Tjønneland, A. Outzen, M. Boutron-Ruault, M.-C. Racine, A. Bastide, N. Kühn, T. Kaaks, R. Trichopoulos, D. Trichopoulou, A. Lagiou, P. Panico, S. Peeters, P.H. Weiderpass, E. Skeie, G. Dagrun, E. Chirlaque, M.-D. Sánchez, M.-J. Ardanaz, E. Ljuslinder, I. Wennberg, M. Bradbury, K.E. Vineis, P. Naccarati, A. Palli, D. Boeing, H. Overvad, K. Dorronsoro, M. Jakszyn, P. Cross, A.J. Quirós, J.R. Stepien, M. Kong, S.Y. Duarte-Salles, T. Riboli, E. Hesketh, J.E.
Published: 2015

40. An epidemiologic risk prediction model for ovarian cancer in Europe: the EPIC study

Author: Li, K. Huesing, A. Fortner, R. T. Tjonneland, A. Hansen, L. Dossus, L. Chang-Claude, J. Bergmann, M. Steffen, A. and Bamia, C. Trichopoulos, D. Trichopoulou, A. Palli, D. and Mattiello, A. Agnoli, C. Tumino, R. Onland-Moret, N. C. and Peeters, P. H. Bueno-de-Mesquita, H. B(as) Gram, I. T. and Weiderpass, E. Sanchez-Cantalejo, E. Chirlaque, M-D Duell, E. J. Ardanaz, E. Idahl, A. Lundin, E. Khaw, K-T and Travis, R. C. Merritt, M. A. Gunter, M. J. Riboli, E. and Ferrari, P. Terry, K. Cramer, D. Kaaks, R. and Li, K. Huesing, A. Fortner, R. T. Tjonneland, A. Hansen, L. Dossus, L. Chang-Claude, J. Bergmann, M. Steffen, A. and Bamia, C. Trichopoulos, D. Trichopoulou, A. Palli, D. and Mattiello, A. Agnoli, C. Tumino, R. Onland-Moret, N. C. and Peeters, P. H. Bueno-de-Mesquita, H. B(as) Gram, I. T. and Weiderpass, E. Sanchez-Cantalejo, E. Chirlaque, M-D Duell, E. J. Ardanaz, E. Idahl, A. Lundin, E. Khaw, K-T and Travis, R. C. Merritt, M. A. Gunter, M. J. Riboli, E. and Ferrari, P. Terry, K. Cramer, D. Kaaks, R.
Abstract: Background: Ovarian cancer has a high case-fatality ratio, largely due to late diagnosis. Epidemiologic risk prediction models could help identify women at increased risk who may benefit from targeted prevention measures, such as screening or chemopreventive agents. Methods: We built an ovarian cancer risk prediction model with epidemiologic risk factors from 202 206 women in the European Prospective Investigation into Cancer and Nutrition study. Results: Older age at menopause, longer duration of hormone replacement therapy, and higher body mass index were included as increasing ovarian cancer risk, whereas unilateral ovariectomy, longer duration of oral contraceptive use, and higher number of full-term pregnancies were decreasing risk. The discriminatory power (overall concordance index) of this model, as examined with five-fold cross-validation, was 0.64 (95% confidence interval (CI): 0.57, 0.70). The ratio of the expected to observed number of ovarian cancer cases occurring in the first 5 years of follow-up was 0.90 (293 out of 324, 95% CI: 0.81-1.01), in general there was no evidence for miscalibration. Conclusion: Our ovarian cancer risk model containing only epidemiological data showed modest discriminatory power for a Western European population. Future studies should consider adding informative biomarkers to possibly improve the predictive ability of the model.
Published: 2015

41. Fruit and vegetable consumption in relation to hepatocellular carcinoma in a multi-centre, European cohort study

Author: Bamia, C. Lagiou, P. Jenab, M. Aleksandrova, K. Fedirko, V. Trichopoulos, D. Overvad, K. Tjonneland, A. Olsen, A. and Clavel-Chapelon, F. Boutron-Ruault, M-C Kvaskoff, M. and Katzke, V. A. Kuehn, T. Boeing, H. Noethlings, U. Palli, D. Sieri, S. Panico, S. Tumino, R. Naccarati, A. and Bueno-de-Mesquita, H. B(As) Peeters, P. H. M. Weiderpass, E. and Skeie, G. Quiros, J. R. Agudo, A. Chirlaque, M-D and Sanchez, M-J Ardanaz, E. Dorronsoro, M. Ericson, U. and Nilsson, L. M. Wennberg, M. Khaw, K-T Wareham, N. Key, T. J. Travis, R. C. Ferrari, P. Stepien, M. and Duarte-Salles, T. Norat, T. Murphy, N. Riboli, E. and Trichopoulou, A. and Bamia, C. Lagiou, P. Jenab, M. Aleksandrova, K. Fedirko, V. Trichopoulos, D. Overvad, K. Tjonneland, A. Olsen, A. and Clavel-Chapelon, F. Boutron-Ruault, M-C Kvaskoff, M. and Katzke, V. A. Kuehn, T. Boeing, H. Noethlings, U. Palli, D. Sieri, S. Panico, S. Tumino, R. Naccarati, A. and Bueno-de-Mesquita, H. B(As) Peeters, P. H. M. Weiderpass, E. and Skeie, G. Quiros, J. R. Agudo, A. Chirlaque, M-D and Sanchez, M-J Ardanaz, E. Dorronsoro, M. Ericson, U. and Nilsson, L. M. Wennberg, M. Khaw, K-T Wareham, N. Key, T. J. Travis, R. C. Ferrari, P. Stepien, M. and Duarte-Salles, T. Norat, T. Murphy, N. Riboli, E. and Trichopoulou, A.
Abstract: Background: Vegetable and/or fruit intakes in association with hepatocellular carcinoma (HCC) risk have been investigated in case-control studies conducted in specific European countries and cohort studies conducted in Asia, with inconclusive results. No multi-centre European cohort has investigated the indicated associations. Methods: In 486 799 men/women from the European Prospective Investigation into Cancer and nutrition, we identified 201 HCC cases after 11 years median follow-up. We calculated adjusted hazard ratios (HRs) for HCC incidence for sex-specific quintiles and per 100 g d(-1) increments of vegetable/fruit intakes. Results: Higher vegetable intake was associated with a statistically significant, monotonic reduction of HCC risk: HR (100 g d(-1) increment): 0.83; 95% CI: 0.71-0.98. This association was consistent in sensitivity analyses with no apparent heterogeneity across strata of HCC risk factors. Fruit intake was not associated with HCC incidence: HR (100 g d(-1) increment): 1.01; 95% CI: 0.92-1.11. Conclusions: Vegetable, but not fruit, intake is associated with lower HCC risk with no evidence for heterogeneity of this association in strata of important HCC risk factors. Mechanistic studies should clarify pathways underlying this association. Given that HCC prognosis is poor and that vegetables are practically universally accessible, our results may be important, especially for those at high risk for the disease.
Published: 2015

42. Relation of dietary glycemic load with ischemic and hemorrhagic stroke: a cohort study in Greece and a meta-analysis

Author: Rossi, M. Turati, F. Lagiou, P. Trichopoulos, D. La Vecchia, C. Trichopoulou, A. and Rossi, M. Turati, F. Lagiou, P. Trichopoulos, D. La Vecchia, C. Trichopoulou, A.
Abstract: Purpose: High glycemic load (GL) has been associated with excess stroke risk. Data suggest a different role of diet in the etiology of ischemic and hemorrhagic stroke. Methods: We analyzed data from 19,824 participants of the Greek cohort of the population-based European Prospective Investigation into Cancer and nutrition (EPIC), who were free of cardiovascular diseases, cancer, and diabetes at baseline and had not developed diabetes. Diet was assessed at enrollment through a validated, interviewer-administered semi-quantitative food frequency questionnaire. The average daily GL was derived using standard tables. We also conducted a meta-analysis on GL and stroke (overall, ischemic and hemorrhagic), using random-effects models. Results: In the Greek EPIC cohort, 304 incident stroke cases were identified (67 ischemic, 49 hemorrhagic). Using Cox proportional hazards regression models adjusted for potential confounders, the hazard ratios for the highest versus the lowest GL tertiles were 1.07 [95 % confidence interval (CI) 0.74–1.54] for overall stroke, 1.55 (95 % CI 0.72–3.36) for ischemic and 0.48 (95 % CI 0.18–1.25) for hemorrhagic stroke (p-heterogeneity <0.01). The meta-analysis, including a total of 3,088 incident cases and 247 deaths from stroke (1,469 cases and 126 deaths ischemic; 576 cases and 94 deaths hemorrhagic), estimated pooled relative risks for the highest versus the lowest GL levels of 1.23 (95 % CI 1.07–1.41) for overall, 1.35 (95 % CI 1.06–1.72) for ischemic, and 1.09 (95 % CI 0.81–1.47) for hemorrhagic stroke (p-heterogeneity = 0.275). Conclusions: This study indicates that GL is an important determinant of the more common ischemic—though not of the hemorrhagic—stroke. © 2014, Springer-Verlag Berlin Heidelberg.
Published: 2015

43. Expression of estrogen receptors in non-malignant mammary tissue modifies the association between insulin-like growth factor 1 and breast cancer risk

Author: Samoli, E. Lagiou, A. Zourna, P. Barbouni, A. Georgila, C. Tsikkinis, A. Vassilarou, D. Minaki, P. Sfikas, C. and Spanos, E. Trichopoulos, D. Lagiou, P. and Samoli, E. Lagiou, A. Zourna, P. Barbouni, A. Georgila, C. Tsikkinis, A. Vassilarou, D. Minaki, P. Sfikas, C. and Spanos, E. Trichopoulos, D. Lagiou, P.
Abstract: Background: Several studies have reported that the insulin-like growth factor 1 (IGF-1) is positively associated with estrogen receptor-positive [ER(+)] breast cancer risk, whereas there is little or no association with respect to ER(-) breast cancer. All comparisons of ER(+) breast cancer cases, however, have been made versus healthy controls, for whom there is no information about the ER expression in their mammary gland. Patients and methods: In the context of a case-control investigation conducted in Athens, Greece, we studied 102 women with incident ER alpha(+) breast cancer and compared their IGF-1 blood levels with those of 178 ER alpha(+) and 83 ER alpha(-) women with benign breast disease (BBD) who underwent biopsies in the context of their standard medical care. Data were analysed using multiple logistic regression and controlling for potential confounding variables. Results: ER alpha(+) breast cancer patients had higher IGF-1 levels compared with women with BBD [odds ratio (OR) 1.36, 95% confidence interval (CI): 0.95-1.94, per 1 standard deviation (SD) increase in IGF-1 levels]. When ER alpha status of women with BBD was taken into account, the difference in IGF-1 levels between ER alpha(+) breast cancer patients and women with BBD was clearly driven by the comparison with BBD women who were ER alpha(+) (OR = 1.95, 95% CI: 1.31-2.89 per 1 SD increase in IGF-1 levels), whereas there was essentially no association with IGF-1 levels when ER alpha(+) breast cancer patients were compared with ER alpha(-) BBD women. These contrasts were particularly evident among post/peri-menopausal women. Conclusion(s): We found evidence in support of an interaction of IGF-1 with the expression of ER alpha in the non-malignant mammary tissue in the context of breast cancer pathogenesis. This is in line with previous evidence suggesting that IGF-1 increases the risk of ER(+) breast cancer.
Published: 2015

44. Glycemic load and coronary heart disease in a Mediterranean population: The EPIC Greek cohort study

Author: Turati, F. Dilis, V. Rossi, M. Lagiou, P. Benetou, V. Katsoulis, M. Naska, A. Trichopoulos, D. La Vecchia, C. Trichopoulou, A. and Turati, F. Dilis, V. Rossi, M. Lagiou, P. Benetou, V. Katsoulis, M. Naska, A. Trichopoulos, D. La Vecchia, C. Trichopoulou, A.
Abstract: Background and aims: High glycemic load (GL) has been associated with increased coronary heart disease (CHD) risk. We evaluated whether preference of low-GL foods conveys incremental benefits with respect to CHD, especially to people adhering to the traditional Mediterranean diet (MD). Methods and results: We analyzed data from the Greek European Prospective Investigation into Cancer and Nutrition, including 20,275 participants free of cardiovascular diseases, cancer, or diabetes at baseline and without incident diabetes. Subjects completed a validated, semi-quantitative food frequency questionnaire at enrollment. We calculated a 10-point MD adherence score and the dietary GL, and estimated hazard ratios (HRs) for CHD incidence and mortality through Cox proportional hazard regression. After a median follow-up of 10.4 years, 417 participants developed CHD, and 162 died from the disease. A significant positive association of GL with CHD incidence emerged (HR for the highest versus the lowest tertile=1.41, 95% confidence interval, CI: 1.05-1.90). HRs for CHD mortality exceeded unity but were not statistically significant. The association with GL was stronger among subjects with higher body mass index. High adherence to MD with low/moderate GL was associated with lower risk of CHD incidence (HR = 0.61, CI: 0.39-0.95) and mortality (HR = 0.47, 95% CI: 0.23-96). Conclusion: High dietary GL increases the risk of CHD. Compared to a high GL diet with suboptimal adherence to the traditional Mediterranean pattern, a low/moderate GL diet that also conforms to the traditional MD principles could lead to a 40% reduced risk for CHD, and over 50% reduced risk for death from CHD. © 2014 Elsevier B.V..
Published: 2015

45. Dietary Folate Intake and Breast Cancer Risk: European Prospective Investigation Into Cancer and Nutrition

Author: de Batlle, J. Ferrari, P. Chajes, V. Park, J. Y. and Slimani, N. McKenzie, F. Overvad, K. Roswall, N. and Tjonneland, A. Boutron-Ruault, M. C. Clavel-Chapelon, F. and Fagherazzi, G. Katzke, V. Kaaks, R. Bergmann, M. M. and Trichopoulou, A. Lagiou, P. Trichopoulos, D. Palli, D. and Sieri, S. Panico, S. Tumino, R. Vineis, P. and Bueno-de-Mesquita, H. B. Peeters, P. H. Hjartaker, A. and Engeset, D. Weiderpass, E. Sanchez, S. Travier, N. and Sanchez, M. J. Amiano, P. Chirlaque, M. D. Barricarte Gurrea, A. Khaw, K. T. Key, T. J. Bradbury, K. E. and Ericson, U. Sonestedt, E. Van Guelpen, B. Schneede, J. and Riboli, E. Romieu, I. and de Batlle, J. Ferrari, P. Chajes, V. Park, J. Y. and Slimani, N. McKenzie, F. Overvad, K. Roswall, N. and Tjonneland, A. Boutron-Ruault, M. C. Clavel-Chapelon, F. and Fagherazzi, G. Katzke, V. Kaaks, R. Bergmann, M. M. and Trichopoulou, A. Lagiou, P. Trichopoulos, D. Palli, D. and Sieri, S. Panico, S. Tumino, R. Vineis, P. and Bueno-de-Mesquita, H. B. Peeters, P. H. Hjartaker, A. and Engeset, D. Weiderpass, E. Sanchez, S. Travier, N. and Sanchez, M. J. Amiano, P. Chirlaque, M. D. Barricarte Gurrea, A. Khaw, K. T. Key, T. J. Bradbury, K. E. and Ericson, U. Sonestedt, E. Van Guelpen, B. Schneede, J. and Riboli, E. Romieu, I.
Abstract: There is limited evidence on the association between dietary folate intake and the risk of breast cancer (BC) by hormone receptor expression in the tumors. We investigated the relationship between dietary folate and BC risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 367993 women age 35 to 70 years were recruited in 10 European countries. During a median follow-up of 11.5 years, 11575 women with BC were identified. Dietary folate intake was estimated from country-specific dietary questionnaires. Cox proportional hazards regression models were used to quantify the association between dietary variables and BC risk. BC tumors were classified by receptor status. Subgroup analyses were performed by menopausal status and alcohol intake. Intake of other B vitamins was considered. All statistical tests were two-sided. A borderline inverse association was observed between dietary folate and BC risk (hazard ratio comparing top vs bottom quintile [HRQ5-Q1] = 0.92, 95% CI = 0.83 to 1.01, P (trend) = .037). In premenopausal women, we observed a statistically significant trend towards lower risk in estrogen receptor-negative BC (HRQ5-Q1 = 0.66, 95% CI = 0.45 to 0.96, P (trend) = .042) and progesterone receptor-negative BC (HRQ5-Q1 = 0.70, 95% CI = 0.51 to 0.97, P (trend) = .021). No associations were found in postmenopausal women. A 14% reduction in BC risk was observed when comparing the highest with the lowest dietary folate tertiles in women having a high (> 12 alcoholic drinks/week) alcohol intake (HRT3-T1 = 0.86, 95% CI = 0.75 to 0.98, P (interaction) = .035). Higher dietary folate intake may be associated with a lower risk of sex hormone receptor-negative BC in premenopausal women.
Published: 2015

46. Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort

Author: Ose, J. Fortner, R. T. Schock, H. Peeters, P. H. and Onland-Moret, N. C. Bueno-de-Mesquita, H. B. Weiderpass, E. and Gram, I. T. Overvad, K. Tjonneland, A. Dossus, L. and Fournier, A. Baglietto, L. Trichopoulou, A. Benetou, V. and Trichopoulos, D. Boeing, H. Masala, G. Krogh, V. and Matiello, A. Tumino, R. Popovic, M. Obon-Santacana, M. and Larranaga, N. Ardanaz, E. Sanchez, M-J Menendez, V. and Chirlaque, M-D Travis, R. C. Khaw, K-T Braendstedt, J. and Idahl, A. Lundin, E. Rinaldi, S. Kuhn, E. Romieu, I. and Gunter, M. J. Merritt, M. A. Riboli, E. Kaaks, R. and Ose, J. Fortner, R. T. Schock, H. Peeters, P. H. and Onland-Moret, N. C. Bueno-de-Mesquita, H. B. Weiderpass, E. and Gram, I. T. Overvad, K. Tjonneland, A. Dossus, L. and Fournier, A. Baglietto, L. Trichopoulou, A. Benetou, V. and Trichopoulos, D. Boeing, H. Masala, G. Krogh, V. and Matiello, A. Tumino, R. Popovic, M. Obon-Santacana, M. and Larranaga, N. Ardanaz, E. Sanchez, M-J Menendez, V. and Chirlaque, M-D Travis, R. C. Khaw, K-T Braendstedt, J. and Idahl, A. Lundin, E. Rinaldi, S. Kuhn, E. Romieu, I. and Gunter, M. J. Merritt, M. A. Riboli, E. Kaaks, R.
Abstract: Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n = 565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.
Published: 2015

47. Effect of preeclampsia on umbilical cord blood stem cells in relation to breast cancer susceptibility in the offspring

Author: Qiu, L. Onoyama, S. Low, H.P. Chang, C.-I. Strohsnitter, W.C. Norwitz, E.R. Lopresti, M. Edmiston, K. Lambe, M. Trichopoulos, D. Lagiou, P. Hsieh, C.-C. and Qiu, L. Onoyama, S. Low, H.P. Chang, C.-I. Strohsnitter, W.C. Norwitz, E.R. Lopresti, M. Edmiston, K. Lambe, M. Trichopoulos, D. Lagiou, P. Hsieh, C.-C.
Abstract: Women born from a preeclamptic (PE) pregnancy are associated with a lower risk of breast cancer. Prenatal and early-life exposures are hypothesized to influence breast cancer susceptibility through their effect on stem cells. We examined stem cell populations in umbilical cord blood from PE pregnancies and compared with those from pregnancies without this condition. We isolated mononuclear cells from 58 PE and 197 normotensive (non-PE) umbilical cord blood samples and examined the different stem cell populations. Hematopoietic (CD34(+) and CD34(+)CD38(-)), endothelial (CD34(+)CD133(+), CD34(+)VEGFR2(+), CD133(+)VEGFR2(+) and CD34(+)CD133(+)VEGFR2(+)), and putative breast (EpCAM(+), EpCAM(+)CD49f(+), EpCAM(+)CD49f(+)CD117(+), CD49f(+)CD24(+), CD24(+)CD29(+) and CD24(+)CD29(+)CD49f(+)) stem/progenitor cell subpopulations were quantified by flow cytometry and compared between PE and non-PE samples. Hematopoietic CD34(+) cell counts were significantly lowered in PE compared with non-PE samples (P = 0.039, Kruskal-Wallis test). Levels of CD34(+)CD133(+) endothelial progenitor cells were also lower in PE samples (P = 0.032, multiple regression analysis). EpCAM(+) and EpCAM(+)CD49f(+) putative breast stem cell levels were significantly lowered in PE subjects (multiple regression analysis: P = 0.038 and 0.007, respectively). Stratifying by newborn gender, EpCAM(+) and EpCAM(+)CD49f(+) stem cells were significantly lowered in PE samples of female, but not male, newborns. Umbilical cord blood samples from pregnancies complicated by preeclampsia thus had significantly lower levels of hematopoietic, endothelial, and putative breast stem cells than non-PE controls. With a lowered breast cancer risk for offspring of a PE pregnancy, our findings provide support to the hypothesis that susceptibility to breast oncogenesis may be affected by conditions and processes during the prenatal period. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissio
Published: 2015

48. Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk

Author: Nimptsch, K. Aleksandrova, K. Boeing, H. Janke, J. Lee, Y.-A. Jenab, M. Bueno-De-Mesquita, H.B. Jansen, E.H.J.M. Tsilidis, K.K. Trichopoulou, A. Weiderpass, E. Wu, C. Overvad, K. Tjønneland, A. Boutron-Ruault, M.-C. Dossus, L. Racine, A. Kaaks, R. Canzian, F. Lagiou, P. Trichopoulos, D. Palli, D. Agnoli, C. Tumino, R. Vineis, P. Panico, S. Johansson, A. Van Guelpen, B. Khaw, K.-T. Wareham, N. Peeters, P.H. Quirós, J.R. García, A.V. Molina-Montes, E. Dorronsoro, M. Chirlaque, M.-D. Gurrea, A.B. Key, T.J. Duarte-Salles, T. Stepien, M. Gunter, M.J. Riboli, E. Pischon, T. and Nimptsch, K. Aleksandrova, K. Boeing, H. Janke, J. Lee, Y.-A. Jenab, M. Bueno-De-Mesquita, H.B. Jansen, E.H.J.M. Tsilidis, K.K. Trichopoulou, A. Weiderpass, E. Wu, C. Overvad, K. Tjønneland, A. Boutron-Ruault, M.-C. Dossus, L. Racine, A. Kaaks, R. Canzian, F. Lagiou, P. Trichopoulos, D. Palli, D. Agnoli, C. Tumino, R. Vineis, P. Panico, S. Johansson, A. Van Guelpen, B. Khaw, K.-T. Wareham, N. Peeters, P.H. Quirós, J.R. García, A.V. Molina-Montes, E. Dorronsoro, M. Chirlaque, M.-D. Gurrea, A.B. Key, T.J. Duarte-Salles, T. Stepien, M. Gunter, M.J. Riboli, E. Pischon, T.
Abstract: High blood concentrations of C-reactive protein (CRP) have been associated with elevated risk of colorectal cancer in several prospective studies including the European Prospective Investigation into Cancer and Nutrition (EPIC), but it is unknown whether these observations reflect a causal relationship. We aimed to investigate whether CRP genetic variants associated with lifelong higher CRP concentrations translate into higher colorectal cancer risk. We conducted a prospective nested case-control study within EPIC including 727 cases diagnosed between 1992 and 2003 and 727 matched controls selected according to an incidence-density sampling protocol. Baseline CRP concentrations were measured in plasma samples by a high sensitivity assay. Tagging single nucleotide polymorphisms (SNPs) in the CRP gene (rs1205, rs1800947, rs1130864, rs2808630, rs3093077) were identified via HapMap. The causal effect of CRP on colorectal cancer risk was examined in a Mendelian Randomization approach utilizing multiple CRP genetic variants as instrumental variables. The SNPs rs1205, rs1800947, rs1130864 and rs3093077 were significantly associated with CRP concentrations and were incorporated in a CRP allele score which was associated with 13% higher CRP concentrations per allele count (95% confidence interval 8-19%). Using the CRPscore as instrumental variable, genetically twofold higher CRP concentrations were associated with higher risk of colorectal cancer (odds ratio 1.74, 95% confidence interval 1.06-2.85). Similar observations were made using alternative definitions of instrumental variables. Our findings give support to the hypothesis that elevated circulating CRP may play a direct role in the etiology of colorectal cancer. © 2014 UICC.
Published: 2015

49. Diabetes and onset of natural menopause: results from the European Prospective Investigation into Cancer and Nutrition

Author: Brand, J. S. Onland-Moret, N. C. Eijkemans, M. J. C. and Tjonneland, A. Roswall, N. Overvad, K. Fagherazzi, G. and Clavel-Chapelon, F. Dossus, L. Lukanova, A. Grote, V. and Bergmann, M. M. Boeing, H. Trichopoulou, A. Tzivoglou, M. and Trichopoulos, D. Grioni, S. Mattiello, A. Masala, G. and Tumino, R. Vineis, P. Bueno-De-Mesquita, H. B. Weiderpass, E. Redondo, M. L. Sanchez, M. J. Huerta Castano, J. M. and Arriola, L. Ardanaz, E. Duell, E. J. Rolandsson, O. and Franks, P. W. Butt, S. Nilsson, P. Khaw, K. T. Wareham, N. Travis, R. Romieu, I. Gunter, M. J. Riboli, E. and van der Schouw, Y. T. and Brand, J. S. Onland-Moret, N. C. Eijkemans, M. J. C. and Tjonneland, A. Roswall, N. Overvad, K. Fagherazzi, G. and Clavel-Chapelon, F. Dossus, L. Lukanova, A. Grote, V. and Bergmann, M. M. Boeing, H. Trichopoulou, A. Tzivoglou, M. and Trichopoulos, D. Grioni, S. Mattiello, A. Masala, G. and Tumino, R. Vineis, P. Bueno-De-Mesquita, H. B. Weiderpass, E. Redondo, M. L. Sanchez, M. J. Huerta Castano, J. M. and Arriola, L. Ardanaz, E. Duell, E. J. Rolandsson, O. and Franks, P. W. Butt, S. Nilsson, P. Khaw, K. T. Wareham, N. Travis, R. Romieu, I. Gunter, M. J. Riboli, E. and van der Schouw, Y. T.
Abstract: STUDY QUESTION: Do women who have diabetes before menopause have their menopause at an earlier age compared with women without diabetes? SUMMARY ANSWER: Although there was no overall association between diabetes and age at menopause, our study suggests that early-onset diabetes may accelerate menopause. WHAT IS KNOWN ALREADY: Today, more women of childbearing age are being diagnosed with diabetes, but little is known about the impact of diabetes on reproductive health. STUDY DESIGN, SIZE, DURATION: We investigated the impact of diabetes on age at natural menopause (ANM) in 258 898 women from the European Prospective Investigation into Cancer and Nutrition (EPIC), enrolled between 1992 and 2000. PARTICIPANTS/MATERIALS, SETTING, METHODS: Determinant and outcome information was obtained through questionnaires. Time-dependent Cox regression analyses were used to estimate the associations of diabetes and age at diabetes diagnosis with ANM, stratified by center and adjusted for age, smoking, reproductive and diabetes risk factors and with age from birth to menopause or censoring as the underlying time scale. MAIN RESULTS AND THE ROLE OF CHANCE: Overall, no association between diabetes and ANM was found (hazard ratio (HR) = 0.94; 95% confidence interval (CI) 0.89-1.01). However, women with diabetes before the age of 20 years had an earlier menopause (10-20 years: HR = 1.43; 95% CI 1.02-2.01, <10 years: HR = 1.59; 95% CI 1.03-2.43) compared with non-diabetic women, whereas women with diabetes at age 50 years and older had a later menopause (HR = 0.81; 95% CI 0.70-0.95). None of the other age groups were associated with ANM. LIMITATIONS, REASONS FOR CAUTION: Strengths of the study include the large sample size and the broad set of potential confounders measured. However, results may have been underestimated due to survival bias. We cannot be sure about the sequence of the events in women with a late age at diabetes, as both events then occur in a short period. We could no
Published: 2015

50. Dietary folate intake and breast cancer risk : European prospective investigation into cancer and nutrition

Author: de Batlle, J., Ferrari, P., Chajes, V., Park, J. Y., Slimani, N., McKenzie, F., Overvad, K., Roswall, N., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, G., Katzke, V., Kaaks, R., Bergmann, M. M., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Peeters, P. H., Hjartåker, A., Engeset, D., Weiderpass, E., Sánchez, S., Travier, N., Sanchez, M. J., Amiano, P., Chirlaque, M. D., Barricarte Gurrea, A., Khaw, K. T., Key, T. J., Bradbury, K. E., Ericson, U., Sonestedt, E., Van Guelpen, Bethany, Schneede, Jörn, Riboli, E., Romieu, I., de Batlle, J., Ferrari, P., Chajes, V., Park, J. Y., Slimani, N., McKenzie, F., Overvad, K., Roswall, N., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, G., Katzke, V., Kaaks, R., Bergmann, M. M., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Peeters, P. H., Hjartåker, A., Engeset, D., Weiderpass, E., Sánchez, S., Travier, N., Sanchez, M. J., Amiano, P., Chirlaque, M. D., Barricarte Gurrea, A., Khaw, K. T., Key, T. J., Bradbury, K. E., Ericson, U., Sonestedt, E., Van Guelpen, Bethany, Schneede, Jörn, Riboli, E., and Romieu, I.
Abstract: There is limited evidence on the association between dietary folate intake and the risk of breast cancer (BC) by hormone receptor expression in the tumors. We investigated the relationship between dietary folate and BC risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 367993 women age 35 to 70 years were recruited in 10 European countries. During a median follow-up of 11.5 years, 11575 women with BC were identified. Dietary folate intake was estimated from country-specific dietary questionnaires. Cox proportional hazards regression models were used to quantify the association between dietary variables and BC risk. BC tumors were classified by receptor status. Subgroup analyses were performed by menopausal status and alcohol intake. Intake of other B vitamins was considered. All statistical tests were two-sided. A borderline inverse association was observed between dietary folate and BC risk (hazard ratio comparing top vs bottom quintile [HRQ5-Q1] = 0.92, 95% CI = 0.83 to 1.01, P (trend) = .037). In premenopausal women, we observed a statistically significant trend towards lower risk in estrogen receptor-negative BC (HRQ5-Q1 = 0.66, 95% CI = 0.45 to 0.96, P (trend) = .042) and progesterone receptor-negative BC (HRQ5-Q1 = 0.70, 95% CI = 0.51 to 0.97, P (trend) = .021). No associations were found in postmenopausal women. A 14% reduction in BC risk was observed when comparing the highest with the lowest dietary folate tertiles in women having a high (> 12 alcoholic drinks/week) alcohol intake (HRT3-T1 = 0.86, 95% CI = 0.75 to 0.98, P (interaction) = .035). Higher dietary folate intake may be associated with a lower risk of sex hormone receptor-negative BC in premenopausal women.
Published: 2015
Full Text: View/download PDF

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Publication Year Range

Publication Type

Journal

Database

Publisher

760 results on '"Trichopoulos D"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources