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Your search keyword '"Unsöld, Bernhard"' showing total 5 results
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5 results on '"Unsöld, Bernhard"'

1. Loss of CASK Accelerates Heart Failure Development.

Author

Mustroph, Julian, Mustroph, Julian, Sag, Can M, Bähr, Felix, Schmidtmann, Anna-Lena, Gupta, Shamindra N, Dietz, Alexander, Islam, MM Towhidul, Lücht, Charlotte, Beuthner, Bo Eric, Pabel, Steffen, Baier, Maria J, El-Armouche, Ali, Sossalla, Samuel, Anderson, Mark E, Möllmann, Julia, Lehrke, Michael, Marx, Nikolaus, Mohler, Peter J, Bers, Donald M, Unsöld, Bernhard, He, Tao, Dewenter, Matthias, Backs, Johannes, Maier, Lars S, Wagner, Stefan, Mustroph, Julian, Mustroph, Julian, Sag, Can M, Bähr, Felix, Schmidtmann, Anna-Lena, Gupta, Shamindra N, Dietz, Alexander, Islam, MM Towhidul, Lücht, Charlotte, Beuthner, Bo Eric, Pabel, Steffen, Baier, Maria J, El-Armouche, Ali, Sossalla, Samuel, Anderson, Mark E, Möllmann, Julia, Lehrke, Michael, Marx, Nikolaus, Mohler, Peter J, Bers, Donald M, Unsöld, Bernhard, He, Tao, Dewenter, Matthias, Backs, Johannes, Maier, Lars S, and Wagner, Stefan

Abstract

[Figure: see text].

Published
2021

2. Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator

Author

Chang Liao, Mei-Ling, de Boer, Teun P, Mutoh, Hiroki, Raad, Nour, Richter, Claudia, Wagner, Eva, Downie, Bryan R, Unsöld, Bernhard, Arooj, Iqra, Streckfuss-Bömeke, Katrin, Döker, Stephan, Luther, Stefan, Guan, Kaomei, Wagner, Stefan, Lehnart, Stephan E, Maier, Lars S, Stühmer, Walter, Wettwer, Erich, van Veen, Toon, Morlock, Michael M, Knöpfel, Thomas, Zimmermann, Wolfram-Hubertus, Chang Liao, Mei-Ling, de Boer, Teun P, Mutoh, Hiroki, Raad, Nour, Richter, Claudia, Wagner, Eva, Downie, Bryan R, Unsöld, Bernhard, Arooj, Iqra, Streckfuss-Bömeke, Katrin, Döker, Stephan, Luther, Stefan, Guan, Kaomei, Wagner, Stefan, Lehnart, Stephan E, Maier, Lars S, Stühmer, Walter, Wettwer, Erich, van Veen, Toon, Morlock, Michael M, Knöpfel, Thomas, and Zimmermann, Wolfram-Hubertus

Published
2015

3. Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator

Author

Chang Liao, Mei-Ling, de Boer, Teun P, Mutoh, Hiroki, Raad, Nour, Richter, Claudia, Wagner, Eva, Downie, Bryan R, Unsöld, Bernhard, Arooj, Iqra, Streckfuss-Bömeke, Katrin, Döker, Stephan, Luther, Stefan, Guan, Kaomei, Wagner, Stefan, Lehnart, Stephan E, Maier, Lars S, Stühmer, Walter, Wettwer, Erich, van Veen, Toon, Morlock, Michael M, Knöpfel, Thomas, Zimmermann, Wolfram-Hubertus, Chang Liao, Mei-Ling, de Boer, Teun P, Mutoh, Hiroki, Raad, Nour, Richter, Claudia, Wagner, Eva, Downie, Bryan R, Unsöld, Bernhard, Arooj, Iqra, Streckfuss-Bömeke, Katrin, Döker, Stephan, Luther, Stefan, Guan, Kaomei, Wagner, Stefan, Lehnart, Stephan E, Maier, Lars S, Stühmer, Walter, Wettwer, Erich, van Veen, Toon, Morlock, Michael M, Knöpfel, Thomas, and Zimmermann, Wolfram-Hubertus

Published
2015

4. Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator

Author

Medische Fysiologie, Circulatory Health, Chang Liao, Mei-Ling, de Boer, Teun P, Mutoh, Hiroki, Raad, Nour, Richter, Claudia, Wagner, Eva, Downie, Bryan R, Unsöld, Bernhard, Arooj, Iqra, Streckfuss-Bömeke, Katrin, Döker, Stephan, Luther, Stefan, Guan, Kaomei, Wagner, Stefan, Lehnart, Stephan E, Maier, Lars S, Stühmer, Walter, Wettwer, Erich, van Veen, Toon, Morlock, Michael M, Knöpfel, Thomas, Zimmermann, Wolfram-Hubertus, Medische Fysiologie, Circulatory Health, Chang Liao, Mei-Ling, de Boer, Teun P, Mutoh, Hiroki, Raad, Nour, Richter, Claudia, Wagner, Eva, Downie, Bryan R, Unsöld, Bernhard, Arooj, Iqra, Streckfuss-Bömeke, Katrin, Döker, Stephan, Luther, Stefan, Guan, Kaomei, Wagner, Stefan, Lehnart, Stephan E, Maier, Lars S, Stühmer, Walter, Wettwer, Erich, van Veen, Toon, Morlock, Michael M, Knöpfel, Thomas, and Zimmermann, Wolfram-Hubertus

Published
2015

5. Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction

Author

UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - (SLuc) Service de médecine interne générale, Unsöld, Bernhard, Kaul, Axel, Sbroggiò, Mauro, Schubert, Carola, Regitz-Zagrosek, Vera, Brancaccio, Mara, Damilano, Federico, Hirsch, Emilio, Van Bilsen, Marc, Munts, Chantal, Sipido, Karin, Bito, Virginie, Detre, Elke, Wagner, Nana Maria, Schäfer, Katrin, Seidler, Tim, Vogt, Johannes, Neef, Stefan, Bleckmann, Annalen, Maier, Lars S, Balligand, Jean-Luc, Bouzin, Caroline, Ventura-Clapier, Renée, Garnier, Anne, Eschenhagen, Thomas, El-Armouche, Ali, Knöll, Ralph, Tarone, Guido, Hasenfuß, Gerd, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - (SLuc) Service de médecine interne générale, Unsöld, Bernhard, Kaul, Axel, Sbroggiò, Mauro, Schubert, Carola, Regitz-Zagrosek, Vera, Brancaccio, Mara, Damilano, Federico, Hirsch, Emilio, Van Bilsen, Marc, Munts, Chantal, Sipido, Karin, Bito, Virginie, Detre, Elke, Wagner, Nana Maria, Schäfer, Katrin, Seidler, Tim, Vogt, Johannes, Neef, Stefan, Bleckmann, Annalen, Maier, Lars S, Balligand, Jean-Luc, Bouzin, Caroline, Ventura-Clapier, Renée, Garnier, Anne, Eschenhagen, Thomas, El-Armouche, Ali, Knöll, Ralph, Tarone, Guido, and Hasenfuß, Gerd

Abstract

AIMS: Melusin is a muscle-specific chaperone protein whose expression is required for a compensatory hypertrophy response to pressure overload. Here, we evaluated the consequences of melusin overexpression in the setting of myocardial infarction (MI) using a comprehensive multicentre approach. METHODS AND RESULTS: Mice overexpressing melusin in the heart (TG) and wild-type controls (WT) were subjected to permanent LAD ligation and both the acute response (Day 3) and subsequent remodelling (2 weeks) were examined. Mortality in wild-type mice was significant between Days 3 and 7, primarily due to cardiac rupture, but melusin's overexpression strongly reduced mortality (43.2% in wild-type vs. 27.3% in melusin-TG, P = 0.005). At Day 3 after MI, a time point preceding the mortality peak, TG hearts had increased heat shock protein 70 expression, increased ERK1/2 signalling, reduced cardiomyocyte hyper-contractility and inflammatory cell infiltrates, and increased matricellular protein expression in the infarcted area. At 2 weeks after MI, melusin overexpression conferred a favourable adaptive remodelling characterized by reduced left ventricle dilatation and better preserved contractility in the presence of a comparable degree of hypertrophy. Adaptive remodelling in melusin TG mice was characterized by reduced apoptosis and fibrosis as well as increased cardiomyocyte contractility. CONCLUSIONS: Consistent with its function as a chaperone protein, melusin overexpression exerts a dual protective action following MI reducing an array of maladaptive processes. In the early phase after MI, reduced inflammation and myocyte remodelling protect against cardiac rupture. Chronically, reduced myocyte loss and matrix remodelling, with preserved myocyte contractility, confer adaptive LV remodelling.

Published
2014

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