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125 results on '"Utrecht University"'

1. Over het bepalen van de vorm van de aarde met behulp van slingers

Author

Goossens, Marius, van Galen, Petrus; Utrecht University, The Netherlands, Root (ed), Bart; Department of Space Engineering, Faculty of Aerospace Engineering, Delft University of Technology, The Netherlands, Goossens, Marius, van Galen, Petrus; Utrecht University, The Netherlands, and Root (ed), Bart; Department of Space Engineering, Faculty of Aerospace Engineering, Delft University of Technology, The Netherlands

Abstract

De dissertatie van Petrus van Galen van zijn promotieonderzoek aan de Universiteit Utrecht uit 1830 is een vergeten vondst in de geschiedenis van het zwaartekracht onderzoek naar de aarde. In de vertaling van het Latijn naar het Nederlands geeft deze dissertatie ons een inzicht in de wetenschappelijke ontdekkingen rond de tijd van zijn publicatie. Petrus van Galen geeft in zijn dissertatie een volledig beeld van alle slingermetingen die gedaan waren met betrekking tot het bepalen van de vorm van de aarde. Deze unieke metingen werden gedaan door verschillende ontdekkingsreizigers en wetenschappers, van Noord-Rusland tot in de Vuurland-archipel in het verre zuiden van Zuid-Amerika, allemaal om zo een beter beeld te krijgen van de afplatting van onze planeet. In zijn tweede hoofdstuk presenteert Van Galen in een wiskundige uiteenzetting hoe een slingermeting gecorrigeerd moet worden om zo nauwkeurig mogelijk de zwaartekracht te kunnen bepalen, hierbij verder bouwend aan de theorie van Christiaan Huygens. Hierbij selecteert hij ook de apparatuur en experimenten die precies genoeg zijn voor de bepaling van de vorm. In zijn laatste hoofdstuk werkt hij de wiskundige theorie uit hoe de vorm van de aarde bepaald kan worden door de verschillende zwaartekrachtmetingen. Hij gebruikt daarbij de net bedachte kleinste kwadratenmethode, om zo tot een waarde voor de afplatting te komen van 1/286.23. Deze waarde ligt dicht bij de huidige berekende waarde, een bijzondere prestatie zo'n tweehonderd jaar geleden. Dit boek presenteert zo een nieuw puzzelstukje in de fascinerende geschiedenis van de Nederlandse wetenschap. English summary Petrus van Galen's 1830 dissertation from his doctoral research at Utrecht University is a forgotten chapter in the history of earth gravity research. Translated from Latin into Dutch, this dissertation gives us an insight into the scientific discoveries around the time of his publication. In his dissertation, Petrus van Galen gives a complete picture o

Published
2024

2. Over het bepalen van de vorm van de aarde met behulp van slingers

Author

Goossens, Marius, van Galen, Petrus; Utrecht University, The Netherlands, Root (ed), Bart; Department of Space Engineering, Faculty of Aerospace Engineering, Delft University of Technology, The Netherlands, Goossens, Marius, van Galen, Petrus; Utrecht University, The Netherlands, and Root (ed), Bart; Department of Space Engineering, Faculty of Aerospace Engineering, Delft University of Technology, The Netherlands

Abstract

De dissertatie van Petrus van Galen van zijn promotieonderzoek aan de Universiteit Utrecht uit 1830 is een vergeten vondst in de geschiedenis van het zwaartekracht onderzoek naar de aarde. In de vertaling van het Latijn naar het Nederlands geeft deze dissertatie ons een inzicht in de wetenschappelijke ontdekkingen rond de tijd van zijn publicatie. Petrus van Galen geeft in zijn dissertatie een volledig beeld van alle slingermetingen die gedaan waren met betrekking tot het bepalen van de vorm van de aarde. Deze unieke metingen werden gedaan door verschillende ontdekkingsreizigers en wetenschappers, van Noord-Rusland tot in de Vuurland-archipel in het verre zuiden van Zuid-Amerika, allemaal om zo een beter beeld te krijgen van de afplatting van onze planeet. In zijn tweede hoofdstuk presenteert Van Galen in een wiskundige uiteenzetting hoe een slingermeting gecorrigeerd moet worden om zo nauwkeurig mogelijk de zwaartekracht te kunnen bepalen, hierbij verder bouwend aan de theorie van Christiaan Huygens. Hierbij selecteert hij ook de apparatuur en experimenten die precies genoeg zijn voor de bepaling van de vorm. In zijn laatste hoofdstuk werkt hij de wiskundige theorie uit hoe de vorm van de aarde bepaald kan worden door de verschillende zwaartekrachtmetingen. Hij gebruikt daarbij de net bedachte kleinste kwadratenmethode, om zo tot een waarde voor de afplatting te komen van 1/286.23. Deze waarde ligt dicht bij de huidige berekende waarde, een bijzondere prestatie zo'n tweehonderd jaar geleden. Dit boek presenteert zo een nieuw puzzelstukje in de fascinerende geschiedenis van de Nederlandse wetenschap. English summary Petrus van Galen's 1830 dissertation from his doctoral research at Utrecht University is a forgotten chapter in the history of earth gravity research. Translated from Latin into Dutch, this dissertation gives us an insight into the scientific discoveries around the time of his publication. In his dissertation, Petrus van Galen gives a complete picture o

Published
2024

3. Over het bepalen van de vorm van de aarde met behulp van slingers

Author

Goossens, Marius, van Galen, Petrus; Utrecht University, The Netherlands, Root (ed), Bart; Department of Space Engineering, Faculty of Aerospace Engineering, Delft University of Technology, The Netherlands, Goossens, Marius, van Galen, Petrus; Utrecht University, The Netherlands, and Root (ed), Bart; Department of Space Engineering, Faculty of Aerospace Engineering, Delft University of Technology, The Netherlands

Abstract

De dissertatie van Petrus van Galen van zijn promotieonderzoek aan de Universiteit Utrecht uit 1830 is een vergeten vondst in de geschiedenis van het zwaartekracht onderzoek naar de aarde. In de vertaling van het Latijn naar het Nederlands geeft deze dissertatie ons een inzicht in de wetenschappelijke ontdekkingen rond de tijd van zijn publicatie. Petrus van Galen geeft in zijn dissertatie een volledig beeld van alle slingermetingen die gedaan waren met betrekking tot het bepalen van de vorm van de aarde. Deze unieke metingen werden gedaan door verschillende ontdekkingsreizigers en wetenschappers, van Noord-Rusland tot in de Vuurland-archipel in het verre zuiden van Zuid-Amerika, allemaal om zo een beter beeld te krijgen van de afplatting van onze planeet. In zijn tweede hoofdstuk presenteert Van Galen in een wiskundige uiteenzetting hoe een slingermeting gecorrigeerd moet worden om zo nauwkeurig mogelijk de zwaartekracht te kunnen bepalen, hierbij verder bouwend aan de theorie van Christiaan Huygens. Hierbij selecteert hij ook de apparatuur en experimenten die precies genoeg zijn voor de bepaling van de vorm. In zijn laatste hoofdstuk werkt hij de wiskundige theorie uit hoe de vorm van de aarde bepaald kan worden door de verschillende zwaartekrachtmetingen. Hij gebruikt daarbij de net bedachte kleinste kwadratenmethode, om zo tot een waarde voor de afplatting te komen van 1/286.23. Deze waarde ligt dicht bij de huidige berekende waarde, een bijzondere prestatie zo'n tweehonderd jaar geleden. Dit boek presenteert zo een nieuw puzzelstukje in de fascinerende geschiedenis van de Nederlandse wetenschap. English summary Petrus van Galen's 1830 dissertation from his doctoral research at Utrecht University is a forgotten chapter in the history of earth gravity research. Translated from Latin into Dutch, this dissertation gives us an insight into the scientific discoveries around the time of his publication. In his dissertation, Petrus van Galen gives a complete picture o

Published
2024

8. Intra/ Sections:Post-Anthropocentric Concepts of Multiplicity

Author

Bachmann, Vera, Bengert, Martina, Chiaramonte, Xenia, Dulley, Iracema, González, Carmen, Hartmann, Nadine, Horst, Johanna-Charlotte, Işcen, Özgün Eylül, Jakka, Sarath, Kaiser, Birgit, Karrer, Michael, Landers, Elizabeth, Marino, Taynna, Meißner, Hanna, Simoni, Mariana, Steurer, Hannah, Wachter, Veronika von, Walther, Max, Welge, Jobst, Wild, Cornelia, Organized by Jenny Haase and Kathrin Thiele as part of the DFG research network ‘<a href='https://dispositiv-der-menge.de' target='_blank' rel='noopener'>Dispositiv der Menge</a>’ in cooperation with ICI Berlin, Universität Siegen, Martin-Luther-Universität Halle-Wittenberg, and Utrecht University, Bachmann, Vera, Bengert, Martina, Chiaramonte, Xenia, Dulley, Iracema, González, Carmen, Hartmann, Nadine, Horst, Johanna-Charlotte, Işcen, Özgün Eylül, Jakka, Sarath, Kaiser, Birgit, Karrer, Michael, Landers, Elizabeth, Marino, Taynna, Meißner, Hanna, Simoni, Mariana, Steurer, Hannah, Wachter, Veronika von, Walther, Max, Welge, Jobst, Wild, Cornelia, and Organized by Jenny Haase and Kathrin Thiele as part of the DFG research network ‘<a href='https://dispositiv-der-menge.de' target='_blank' rel='noopener'>Dispositiv der Menge</a>’ in cooperation with ICI Berlin, Universität Siegen, Martin-Luther-Universität Halle-Wittenberg, and Utrecht University

Abstract

The DFG-Network ‘Dispositiv der Menge’ (= crowd, mass, multitude) is based on the recognition that ‘the crowd’ has been constituted, classified, regulated, or dispersed throughout history in various, heterogenous, conflictual ways, which make it impossible to hold onto any understanding of the crowd as a clearly delimited and substantiated entity or to the forms in which it is represented as such. This workshop extends this approach by taking ‘the crowd’ itself as a multitude or multiplicity. It will address phenomena related to more fluctuating and in/determinate intra/sections of collectivities in order to transform the image of ‘the crowd’ from an in-divi-dual-ized One into a mani-fold multiplicity. Such a multiplicity in the singular plural is characterized by movement and motion, fragmentation and friction, ongoingness and inherent contestation. By focusing on this multiplicity, the workshop seeks to un-work a persistent conceptual anthropocentrism of the ways in which agentiality is conceptualized and imagined, instead searching for more dynamic relations with/in a variety of agencies (human, animal, plant, things, propositions) that can be seen as ‘intra-active’. Yet, while ‘the crowd’ will be approached from a critique of anthropomorphism, the turn towards ecological or relational co-existence cannot be a turn away from the violent asymmetrical relations of power and the continued flexibilization and hierarchical re- ordering of global social structures. The workshop sounds out conceptual and phenomenal resonances between what in Western academic discourses has of late become known as ‘New Materialism’ (in its different strands) and the long tradition of (but also always newly emerging) indigenous and decolonial epistemologies. The idea is to look for ways to concretize the potential for intra/sections in-between posthuman(ist) and indigenous/decolonial thought-practices, hoping for a dialogue between more Western-oriented approaches — e.g., actor-network th, Intra/ Sections: Post-Anthropocentric Concepts of Multiplicity, workshop, ICI Berlin, 24–25 March 2022

Published
2022

9. Introduction

Author

Organized by Jenny Haase and Kathrin Thiele as part of the DFG research network ‘<a href='https://dispositiv-der-menge.de' target='_blank' rel='noopener'>Dispositiv der Menge</a>’ in cooperation with ICI Berlin, Universität Siegen, Martin-Luther-Universität Halle-Wittenberg, and Utrecht University and Organized by Jenny Haase and Kathrin Thiele as part of the DFG research network ‘<a href='https://dispositiv-der-menge.de' target='_blank' rel='noopener'>Dispositiv der Menge</a>’ in cooperation with ICI Berlin, Universität Siegen, Martin-Luther-Universität Halle-Wittenberg, and Utrecht University

Abstract

Introduction to the workshop Intra/ Sections: Post-Anthropocentric Concepts of Multiplicity, ICI Berlin, 24–25 March 2022, video recording, mp4, 14:54

Published
2022

11. The Roles of Arithmetic Fluency and Executive Functioning in Mathematical Problem-Solving

Author

Utrecht University Library, Leerstoel Haan, Education and Learning: Cognitive and Motor Disabilities, Kaskens, Jarise, Goei, Sui Lin, Van Luit, Johannes E. H., Verhoeven, Ludo, Segers, Eliane, Utrecht University Library, Leerstoel Haan, Education and Learning: Cognitive and Motor Disabilities, Kaskens, Jarise, Goei, Sui Lin, Van Luit, Johannes E. H., Verhoeven, Ludo, and Segers, Eliane

Published
2022

13. The Roles of Arithmetic Fluency and Executive Functioning in Mathematical Problem-Solving

Author

Utrecht University Library, Leerstoel Haan, Education and Learning: Cognitive and Motor Disabilities, Kaskens, Jarise, Goei, Sui Lin, Van Luit, Johannes E. H., Verhoeven, Ludo, Segers, Eliane, Utrecht University Library, Leerstoel Haan, Education and Learning: Cognitive and Motor Disabilities, Kaskens, Jarise, Goei, Sui Lin, Van Luit, Johannes E. H., Verhoeven, Ludo, and Segers, Eliane

Published
2022

14. Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years

Author

National Institute of Mental Health (US), Karolinska Institute, Stockholm County Council, South-Eastern Norway Regional Health Authority, German Centre for Cardiovascular Research, Siemens Healthcare, University of Queensland, Eunice Kennedy Shriver National Institute of Child Health and Human Development (US), National Health and Medical Research Council (Australia), National Institute on Drug Abuse (US), Indiana State Department of Health, Parents of children with epilepsy, Epilepsy Therapy Project, Fight Against Childhood Epilepsy and Seizures, Epilepsy Foundation, American Epilepsy Society, Knut and Alice Wallenberg Foundation, European Commission, Dutch Research Council, Netherlands Organization for Scientific Research, Netherlands Brain Foundation, Utrecht University, European Research Council, National Center for Advancing Translational Sciences (US), National Institutes of Health (US), National Center for Research Resources (US), Fundación Marques de Valdecilla, Instituto de Salud Carlos III, Swedish Research Council, Kings College London, South London and Maudsley NHS Foundation Trust, NIHR Biomedical Research Centre (UK), National Institute for Health Research (UK), Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Antón, Alnæs, Dag, Alpert, Kathryn I., Andersson, Micael, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A., Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Sánchez-Juan, Pascual, Tordesillas-Gutiérrez, Diana, Ehrlich, Stefan, Bargalló, Núria, Weber, Bernd, Sarró, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Erk, Susanne, West, John D., Smoller, Jordan W., Sommer, Iris, Wen, Wei, Baumeister, Sarah, Hartman, Catharine A., Trollor, Julian N., Baur-Streubel, Ramona, Turner, Jessica A., Uhlmann, Anne, Espeseth, Thomas, van den Heuvel, Odile A., van den Meer, Dennis, van der Wee, Nic J. A., van Haren, Neeltje E. M., van't Ent, Dennis, van Erp, Theo G. M., Hatton, Sean N., Bonvino, Aurora, Veer, Ilya M., Veltman, Dick J., Fatouros-Bergman, Helena, Bertolino, Alessandro, Voineskos, Aristotle, Kanai, Ryota, Westlye, Lars T., Whalley, Heather, Wierenga, Lara M., Williams, Steven C. R., Heinz, Andreas, Wittfeld, Katharina, Wolf, Daniel H., Fisher, Simon E., Worker, Amanda, Wright, Margaret J., Yang, Kun, Yoncheva, Yulyia, Klein, Marieke, Boomsma, Dorret I., Zanetti, Marcus V., Ziegler, Georg C., Heslenfeld, Dirk J., Thompson, Paul M., Fouche, Jean-Paul, Frangou, Sophia, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Klyushnik, Tatyana P., Brouwer, Rachel M., Buitelaar, Jan K., Hibar, Derrek P., Franke, Barbara, Busatto, Geraldo F., Buckner, Randy L., Calhoun, Vincent, Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Castellanos, Francisco X., Cervenka, Simon, Koenders, Laura, Chaim-Avancini, Tiffany M., Frodl, Thomas, Hickie, Ian B., Ching, Christopher R. K., Chubar, Victoria, Clark, Vincent P., Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A., Dannlowski, Udo, Fuentes-Claramonte, Paola, Koops, Sanne, Ho, Beng-Choon, Dale, Anders M., Davey, Christopher, Geus, Eco J. C. de, de Haan, Lieuwe, Zubicaray, Greig I. de, den Braber, Anouk, Dickie, Erin W., Di Giorgio, Annabella, Hohmann, Sarah, Doan, Nhat Trung, Dørum, Erlend S., Hoekstra, Pieter J., Krämer, Bernd, Soriano-Mas, Carles, Glahn, David C., Kuntsi, Jonna, Gotlib, Ian H., Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E., Stein, Dan J., Lázaro, Luisa, Gur, Ruben C., Hahn, Tim, Lagopoulos, Jim, Harrison, Ben J., Völzke, Henry, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Strike, Lachlan T., Hulshoff Pol, Hilleke E., Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L., Jiang, Jiyang, Walter, Henrik, Lebedeva, Irina, Jönsson, Erik G., Joska, John A., Swagerman, Suzanne C., Kahn, René S., Kalnin, Andrew, Andreasen, Nancy C., Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W. J., Walton, Esther, Maingault, Sophie, Martin, Nicholas G., Tamnes, Christian K., Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, Andreassen, Ole A., McDonald, Brenna C., McIntosh, Andrew M., McMahon, Katie L., Wang, Lei, McPhilemy, Genevieve, Temmingh, Henk S., Meinert, Susanne, Menchón, José M., Medland, Sarah E., Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Asherson, Philip, Nakao, Tomohiro, Nordvik, Jan E., Wang, Yang, Thomopoulos, Sophia I., Nyberg, Lars, Oosterlaan, Jaap, Ortiz-Garcia de la Foz, Victor, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J., Banaschewski, Tobias, Potkin, Steven G., Tomyshev, Alexander S., Wassink, Thomas H., National Institute of Mental Health (US), Karolinska Institute, Stockholm County Council, South-Eastern Norway Regional Health Authority, German Centre for Cardiovascular Research, Siemens Healthcare, University of Queensland, Eunice Kennedy Shriver National Institute of Child Health and Human Development (US), National Health and Medical Research Council (Australia), National Institute on Drug Abuse (US), Indiana State Department of Health, Parents of children with epilepsy, Epilepsy Therapy Project, Fight Against Childhood Epilepsy and Seizures, Epilepsy Foundation, American Epilepsy Society, Knut and Alice Wallenberg Foundation, European Commission, Dutch Research Council, Netherlands Organization for Scientific Research, Netherlands Brain Foundation, Utrecht University, European Research Council, National Center for Advancing Translational Sciences (US), National Institutes of Health (US), National Center for Research Resources (US), Fundación Marques de Valdecilla, Instituto de Salud Carlos III, Swedish Research Council, Kings College London, South London and Maudsley NHS Foundation Trust, NIHR Biomedical Research Centre (UK), National Institute for Health Research (UK), Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Antón, Alnæs, Dag, Alpert, Kathryn I., Andersson, Micael, Radua, Joaquim, Reif, Andreas, Rinker, Daniel A., Roffman, Joshua L., Rosa, Pedro G. P., Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Sánchez-Juan, Pascual, Tordesillas-Gutiérrez, Diana, Ehrlich, Stefan, Bargalló, Núria, Weber, Bernd, Sarró, Salvador, Satterthwaite, Theodore D., Saykin, Andrew J., Serpa, Mauricio H., Schmaal, Lianne, Schnell, Knut, Schumann, Gunter, Sim, Kang, Erk, Susanne, West, John D., Smoller, Jordan W., Sommer, Iris, Wen, Wei, Baumeister, Sarah, Hartman, Catharine A., Trollor, Julian N., Baur-Streubel, Ramona, Turner, Jessica A., Uhlmann, Anne, Espeseth, Thomas, van den Heuvel, Odile A., van den Meer, Dennis, van der Wee, Nic J. A., van Haren, Neeltje E. M., van't Ent, Dennis, van Erp, Theo G. M., Hatton, Sean N., Bonvino, Aurora, Veer, Ilya M., Veltman, Dick J., Fatouros-Bergman, Helena, Bertolino, Alessandro, Voineskos, Aristotle, Kanai, Ryota, Westlye, Lars T., Whalley, Heather, Wierenga, Lara M., Williams, Steven C. R., Heinz, Andreas, Wittfeld, Katharina, Wolf, Daniel H., Fisher, Simon E., Worker, Amanda, Wright, Margaret J., Yang, Kun, Yoncheva, Yulyia, Klein, Marieke, Boomsma, Dorret I., Zanetti, Marcus V., Ziegler, Georg C., Heslenfeld, Dirk J., Thompson, Paul M., Fouche, Jean-Paul, Frangou, Sophia, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Klyushnik, Tatyana P., Brouwer, Rachel M., Buitelaar, Jan K., Hibar, Derrek P., Franke, Barbara, Busatto, Geraldo F., Buckner, Randy L., Calhoun, Vincent, Canales-Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Castellanos, Francisco X., Cervenka, Simon, Koenders, Laura, Chaim-Avancini, Tiffany M., Frodl, Thomas, Hickie, Ian B., Ching, Christopher R. K., Chubar, Victoria, Clark, Vincent P., Conrod, Patricia, Conzelmann, Annette, Crespo-Facorro, Benedicto, Crivello, Fabrice, Crone, Eveline A., Dannlowski, Udo, Fuentes-Claramonte, Paola, Koops, Sanne, Ho, Beng-Choon, Dale, Anders M., Davey, Christopher, Geus, Eco J. C. de, de Haan, Lieuwe, Zubicaray, Greig I. de, den Braber, Anouk, Dickie, Erin W., Di Giorgio, Annabella, Hohmann, Sarah, Doan, Nhat Trung, Dørum, Erlend S., Hoekstra, Pieter J., Krämer, Bernd, Soriano-Mas, Carles, Glahn, David C., Kuntsi, Jonna, Gotlib, Ian H., Grabe, Hans-Jörgen, Grimm, Oliver, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Gur, Rachel E., Stein, Dan J., Lázaro, Luisa, Gur, Ruben C., Hahn, Tim, Lagopoulos, Jim, Harrison, Ben J., Völzke, Henry, Holmes, Avram J., Hoogman, Martine, Hosten, Norbert, Howells, Fleur M., Strike, Lachlan T., Hulshoff Pol, Hilleke E., Huyser, Chaim, Jahanshad, Neda, James, Anthony, Jernigan, Terry L., Jiang, Jiyang, Walter, Henrik, Lebedeva, Irina, Jönsson, Erik G., Joska, John A., Swagerman, Suzanne C., Kahn, René S., Kalnin, Andrew, Andreasen, Nancy C., Lee, Won Hee, Lesch, Klaus-Peter, Lochner, Christine, Machielsen, Marise W. J., Walton, Esther, Maingault, Sophie, Martin, Nicholas G., Tamnes, Christian K., Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Mazoyer, Bernard, McDonald, Colm, Andreassen, Ole A., McDonald, Brenna C., McIntosh, Andrew M., McMahon, Katie L., Wang, Lei, McPhilemy, Genevieve, Temmingh, Henk S., Meinert, Susanne, Menchón, José M., Medland, Sarah E., Meyer-Lindenberg, Andreas, Naaijen, Jilly, Najt, Pablo, Asherson, Philip, Nakao, Tomohiro, Nordvik, Jan E., Wang, Yang, Thomopoulos, Sophia I., Nyberg, Lars, Oosterlaan, Jaap, Ortiz-Garcia de la Foz, Victor, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol-Clotet, Edith, Portella, Maria J., Banaschewski, Tobias, Potkin, Steven G., Tomyshev, Alexander S., and Wassink, Thomas H.

Abstract

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3–90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.

Published
2022

15. Towards motivated agents: an implemented blueprint of a computational motivation theory in minecraft

Author

Tromp, R.C., Harvard University, dr. Joscha Bach (Thesis Advisor), Utrecht University, prof. dr. Jan Broersen, Utrecht University, dr. Chris Janssen, Tromp, R.C., Harvard University, dr. Joscha Bach (Thesis Advisor), Utrecht University, prof. dr. Jan Broersen, and Utrecht University, dr. Chris Janssen

Abstract

If we want to understand why intelligent organisms move, we need to account for motivation. Artificial Intelligence provides a suitable approach for investigating motivation. Likewise, motivation is crucial for reaching Artificial General Intelligence. However, motives are still lacking in AI-models today. To investigate the general requirements of such a computational theory of motivation, multiple motivation theories are examined and compared. This is used to evaluate a promising computational theory of motivation that is under development for the MicroPsi cognitive architecture. To further develop and test the hypotheses of motivation theory it is implemented in an agent in the virtual world Minecraft. This provides a basis for research on motivated agents in virtual worlds.

Published
2019

16. Towards motivated agents: an implemented blueprint of a computational motivation theory in minecraft

Author

Tromp, R.C., Harvard University, dr. Joscha Bach (Thesis Advisor), Utrecht University, prof. dr. Jan Broersen, Utrecht University, dr. Chris Janssen, Tromp, R.C., Harvard University, dr. Joscha Bach (Thesis Advisor), Utrecht University, prof. dr. Jan Broersen, and Utrecht University, dr. Chris Janssen

Abstract

If we want to understand why intelligent organisms move, we need to account for motivation. Artificial Intelligence provides a suitable approach for investigating motivation. Likewise, motivation is crucial for reaching Artificial General Intelligence. However, motives are still lacking in AI-models today. To investigate the general requirements of such a computational theory of motivation, multiple motivation theories are examined and compared. This is used to evaluate a promising computational theory of motivation that is under development for the MicroPsi cognitive architecture. To further develop and test the hypotheses of motivation theory it is implemented in an agent in the virtual world Minecraft. This provides a basis for research on motivated agents in virtual worlds.

Published
2019

18. Dynamics of Identity Development in Adolescence: A Decade in Review

Author

Leerstoel Branje, Adolescent development: Characteristics and determinants, Leerstoel Thomaes, Social and personality development: A transactional approach, Utrecht University Library, Branje, Susan, De Moor, Elisabeth L., Spitzer, Jenna, Becht, Andrik I., Leerstoel Branje, Adolescent development: Characteristics and determinants, Leerstoel Thomaes, Social and personality development: A transactional approach, Utrecht University Library, Branje, Susan, De Moor, Elisabeth L., Spitzer, Jenna, and Becht, Andrik I.

Published
2021

20. Dynamics of Identity Development in Adolescence: A Decade in Review

Author

Leerstoel Branje, Adolescent development: Characteristics and determinants, Leerstoel Thomaes, Social and personality development: A transactional approach, Utrecht University Library, Branje, Susan, De Moor, Elisabeth L., Spitzer, Jenna, Becht, Andrik I., Leerstoel Branje, Adolescent development: Characteristics and determinants, Leerstoel Thomaes, Social and personality development: A transactional approach, Utrecht University Library, Branje, Susan, De Moor, Elisabeth L., Spitzer, Jenna, and Becht, Andrik I.

Published
2021

22. Dynamics of Identity Development in Adolescence: A Decade in Review

Author

Leerstoel Branje, Adolescent development: Characteristics and determinants, Leerstoel Thomaes, Social and personality development: A transactional approach, Utrecht University Library, Branje, Susan, De Moor, Elisabeth L., Spitzer, Jenna, Becht, Andrik I., Leerstoel Branje, Adolescent development: Characteristics and determinants, Leerstoel Thomaes, Social and personality development: A transactional approach, Utrecht University Library, Branje, Susan, De Moor, Elisabeth L., Spitzer, Jenna, and Becht, Andrik I.

Published
2021

23. L’ús de pràctiques autèntiques com a principi clau per al disseny de currículums de química

Author

Astrid Bulte; Utrecht University. Freudenthal Institute for Science and Mathematics Education (Netherlands), Gjalt Prins; Utrecht University. Freudenthal Institute for Science and Mathematics Education (Netherlands), Marijn Meijer; Utrecht University. Freudenthal Institute for Science and Mathematics Education (Netherlands), Albert Pilot; Utrecht University. Freudenthal Institute for Science and Mathematics Education (Netherlands), Hannah Sevian; University of Massachusetts Boston. Department of Chemistry (USA), Astrid Bulte; Utrecht University. Freudenthal Institute for Science and Mathematics Education (Netherlands), Gjalt Prins; Utrecht University. Freudenthal Institute for Science and Mathematics Education (Netherlands), Marijn Meijer; Utrecht University. Freudenthal Institute for Science and Mathematics Education (Netherlands), Albert Pilot; Utrecht University. Freudenthal Institute for Science and Mathematics Education (Netherlands), and Hannah Sevian; University of Massachusetts Boston. Department of Chemistry (USA)

Abstract

El contingut del currículum de química no s’ha modificat en els últims setanta anys. Com a resultat, els estudiants perceben que la química escolar no està ben relacionada amb les seves vides. Hem utilitzat pràctiques autèntiques com a contextos per seleccionar, especificar, reemplaçar i/o modificar continguts químics específics. En aquest article es descriu el procediment de recerca basat en el disseny que hem seguit per desenvolupar nous esbossos per a un currículum i per dissenyar un marc d’ensenyament juntament amb unitats curriculars exemplificadores. El marc i les unitats es van adaptar com a resultat de diversos cicles d’experimentació.paraules clau: Pràctiques autèntiques, context, procés de recerca basat en el disseny, unitats didàctiques exemplars., The content of the chemistry curriculum has not been changed in the past seventy years. As a result, students perceive that school chemistry is not well connected to their lived worlds. We used authentic practices as contexts to select, specify, replace and/or modify specific chemistry content. This paper describes the design-based research procedure we followed to develop new sketches for a curriculum and to design an instructional framework together with exemplary curriculum units. The framework and the units were adapted as a result of several cycles of experimentation.keywords: Authentic practices, context, design-based research procedure, exemplary curriculum units.

Published
2018

24. Quaternionic geometry in dimension 8

Author

Jorgen Ellegaard Andersen (Aarhus University) Christian Bar (Potsdam University) David Baraglia (University of Adelaide) Stefan Behrens (Utrecht University) Olivier Biquard (École Normale Supérieure) Indranil Biswas (Tata Institute of Fundamental Research) Philip Boalch (Université Paris-Sud) Fedor Bogomolov (Courant Institute of Mathematical Sciences, NYU) Steven Bradlow (University of Illinois Urbana-Champaign) Gil Cavalcanti (Utrecht University) Leonid Chekhov (Steklov Mathematical Institute of Russian Academy of Sciences and Laboratoire Poncelet) Brian Collier (University of Maryland) Tristan Collins (Harvard University) Diego Conti (Università di Milano Bicocca) Xenia de la Ossa (University of Oxford) Mykola Dedushenko (The California Institute of Technology) Simon Donaldson (Imperial and Simons Center, Stony Brook) Mathieu Dutour Sikiric (Ruder Boskovic) Giovanni Forni (University of Maryland) Marco Gualtieri (University of Toronto) Hang Fu (Courant Institute of Mathematical Sciences, NYU) Oscar Garcia-Prada (Institute of Mathematical Sciences) Paul Gauduchon (École Polytechnique) William Goldman (University of Maryland) Peter Gothen (University of Porto) Samuel Grushevsky (Stony Brook University) Sergei Gukov (The California Institute of Technology) Sebastian Hannes (Potsdam University) Tamas Hausel (Institute of Science and Technology Austria) Jochen Heinloth (University of Duisburg) Klaus Hulek (Leibniz University at Hannover) Jacques Hurtubise (McGill University) Lisa Jeffrey (University of Toronto) Ralph Klaasse (Utrecht University) Magdalena Larfors (Uppsala University) Thomas Bruun Madsen (Aarhus University) Marta Mazzocco (Loughborough University) Anton Mellit (Institute of Science and Technology Austria) Sergei Merkulov (University of Luxembourg) Shigefumi Mori (Kyoto University) James Mracek (University of Toronto) Ignasi Mundet i Riera (University of Barcelona) Du Pei (Aarhus University and The California Institute of Technology) Yuri Prokhorov, Jørgen Ellegaard Andersen, Andrew Dancer, Oscar García-Prada, Conti, D, Madsen, T, Salamon, S, Jorgen Ellegaard Andersen (Aarhus University) Christian Bar (Potsdam University) David Baraglia (University of Adelaide) Stefan Behrens (Utrecht University) Olivier Biquard (École Normale Supérieure) Indranil Biswas (Tata Institute of Fundamental Research) Philip Boalch (Université Paris-Sud) Fedor Bogomolov (Courant Institute of Mathematical Sciences, NYU) Steven Bradlow (University of Illinois Urbana-Champaign) Gil Cavalcanti (Utrecht University) Leonid Chekhov (Steklov Mathematical Institute of Russian Academy of Sciences and Laboratoire Poncelet) Brian Collier (University of Maryland) Tristan Collins (Harvard University) Diego Conti (Università di Milano Bicocca) Xenia de la Ossa (University of Oxford) Mykola Dedushenko (The California Institute of Technology) Simon Donaldson (Imperial and Simons Center, Stony Brook) Mathieu Dutour Sikiric (Ruder Boskovic) Giovanni Forni (University of Maryland) Marco Gualtieri (University of Toronto) Hang Fu (Courant Institute of Mathematical Sciences, NYU) Oscar Garcia-Prada (Institute of Mathematical Sciences) Paul Gauduchon (École Polytechnique) William Goldman (University of Maryland) Peter Gothen (University of Porto) Samuel Grushevsky (Stony Brook University) Sergei Gukov (The California Institute of Technology) Sebastian Hannes (Potsdam University) Tamas Hausel (Institute of Science and Technology Austria) Jochen Heinloth (University of Duisburg) Klaus Hulek (Leibniz University at Hannover) Jacques Hurtubise (McGill University) Lisa Jeffrey (University of Toronto) Ralph Klaasse (Utrecht University) Magdalena Larfors (Uppsala University) Thomas Bruun Madsen (Aarhus University) Marta Mazzocco (Loughborough University) Anton Mellit (Institute of Science and Technology Austria) Sergei Merkulov (University of Luxembourg) Shigefumi Mori (Kyoto University) James Mracek (University of Toronto) Ignasi Mundet i Riera (University of Barcelona) Du Pei (Aarhus University and The California Institute of Technology) Yuri Prokhorov, Jørgen Ellegaard Andersen, Andrew Dancer, Oscar García-Prada, Conti, D, Madsen, T, and Salamon, S

Abstract

We describe the 8-dimensional Wolf spaces as cohomogeneity one SU (3) -manifolds, and discover perturbations of the quaternion-kähler metric on the simply-connected 8-manifold G_2 /SO (4) that carry a closed fundamental 4-form but are not Einstein

Published
2018

25. Learning from patients about patient-centredness: A realist review: BEME Guide No. 60

Author

Huisartsopleiding, JC Overig onderzoek, Other research (not in main researchprogram), HAG Zorginnovatieonderzoek, Child Health, Infection & Immunity, Curr. Onderwijs Huisartsgeneeskunde, de Groot, Esther, Schönrock-Adema, Johanna, Utrecht, University, Damoiseaux, Roger, Van den Bogerd, Kristin, Diemers, Agnes, Grau Canét-Wittkampf, Christel, Jaarsma, Debbie, Mol, Saskia, Bombeke, Katrien, Huisartsopleiding, JC Overig onderzoek, Other research (not in main researchprogram), HAG Zorginnovatieonderzoek, Child Health, Infection & Immunity, Curr. Onderwijs Huisartsgeneeskunde, de Groot, Esther, Schönrock-Adema, Johanna, Utrecht, University, Damoiseaux, Roger, Van den Bogerd, Kristin, Diemers, Agnes, Grau Canét-Wittkampf, Christel, Jaarsma, Debbie, Mol, Saskia, and Bombeke, Katrien

Published
2020

26. Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development

Author

Utrecht University, European Commission, Netherlands Organization for Scientific Research, Brignani, Sara, Moreno-Bravo, Juan Antonio, Pasterkamp, R. Jeroen, Utrecht University, European Commission, Netherlands Organization for Scientific Research, Brignani, Sara, Moreno-Bravo, Juan Antonio, and Pasterkamp, R. Jeroen

Abstract

The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviors and show select disease vulnerability, including in Parkinson’s disease. Despite progress in identifying mDA neuron subtypes, how these neuronal subsets develop and organize into functional brain structures remains poorly understood. Here we generate and use an intersectional genetic platform, Pitx3-ITC, to dissect the mechanisms of substantia nigra (SN) development and implicate the guidance molecule Netrin-1 in the migration and positioning of mDA neuron subtypes in the SN. Unexpectedly, we show that Netrin-1, produced in the forebrain and provided to the midbrain through axon projections, instructs the migration of GABAergic neurons into the ventral SN. This migration is required to confine mDA neurons to the dorsal SN. These data demonstrate that neuron migration can be controlled by remotely produced and axon-derived secreted guidance cues, a principle that is likely to apply more generally.

Published
2020

27. Prolonged quiescence delays somatic stem cell‐like divisions in Caenorhabditis elegans and is controlled by insulin signaling

Author

National Institutes of Health (US), University of Aberdeen, Utrecht University, Ministerio de Economía y Competitividad (España), European Commission, European Research Council, Olmedo, María, Mata-Cabana, Alejandro, Rodríguez-Palero, María Jesús, García-Sánchez, Sabas, Fernández-Yáñez, Antonio, Merrow, Martha, Artal-Sanz, Marta, National Institutes of Health (US), University of Aberdeen, Utrecht University, Ministerio de Economía y Competitividad (España), European Commission, European Research Council, Olmedo, María, Mata-Cabana, Alejandro, Rodríguez-Palero, María Jesús, García-Sánchez, Sabas, Fernández-Yáñez, Antonio, Merrow, Martha, and Artal-Sanz, Marta

Abstract

Cells can enter quiescence in adverse conditions and resume proliferation when the environment becomes favorable. Prolonged quiescence comes with a cost, reducing the subsequent speed and potential to return to proliferation. Here, we show that a similar process happens during Caenorhabditis elegans development, providing an in vivo model to study proliferative capacity after quiescence. Hatching under starvation provokes the arrest of blast cell divisions that normally take place during the first larval stage (L1). We have used a novel method to precisely quantify each stage of postembryonic development to analyze the consequences of prolonged L1 quiescence. We report that prolonged L1 quiescence delays the reactivation of blast cell divisions in C. elegans, leading to a delay in the initiation of postembryonic development. The transcription factor DAF‐16/FOXO is necessary for rapid recovery after extended arrest, and this effect is independent from its role as a suppressor of cell proliferation. Instead, the activation of DAF‐16 by decreased insulin signaling reduces the rate of L1 aging, increasing proliferative potential. We also show that yolk provisioning affects the proliferative potential after L1 arrest modulating the rate of L1 aging, providing a possible mechanistic link between insulin signaling and the maintenance of proliferative potential. Furthermore, variable yolk provisioning in embryos is one of the sources of interindividual variability in recovery after quiescence of genetically identical animals. Our results support the relevance of L1 arrest as an in vivo model to study stem cell‐like aging and the mechanisms for maintenance of proliferation potential after quiescence.

Published
2020

28. Stalnaker on Externalism and Transparency

Author

ECAP 10: 10th European Conference of Analytic Philosophy (24-28/08/2020: Utrecht University, Utrecht, the Netherlands (online due the pandemic)), Bochner, Gregory, ECAP 10: 10th European Conference of Analytic Philosophy (24-28/08/2020: Utrecht University, Utrecht, the Netherlands (online due the pandemic)), and Bochner, Gregory

Abstract

info:eu-repo/semantics/nonPublished

Published
2020

29. Accuracy of telephone triage in primary care patients with chest discomfort: a cross-sectional study

Author

HAG Hart- Vaatziekten, UMC Utrecht Academie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Zorginnovatieonderzoek, Other research (not in main researchprogram), Huisartsopleiding, Child Health, Infection & Immunity, JC Overig onderzoek, General Practice & Nursing Science, Wouters, Loes Tcm, Rutten, Frans H, Erkelens, Daphne Ca, De Groot, Esther, Damoiseaux, Roger Amj, Utrecht, University, HAG Hart- Vaatziekten, UMC Utrecht Academie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Zorginnovatieonderzoek, Other research (not in main researchprogram), Huisartsopleiding, Child Health, Infection & Immunity, JC Overig onderzoek, General Practice & Nursing Science, Wouters, Loes Tcm, Rutten, Frans H, Erkelens, Daphne Ca, De Groot, Esther, Damoiseaux, Roger Amj, and Utrecht, University

Published
2020

30. Safety and feasibility of arterial wall targeting with robot-assisted high intensity focused ultrasound: a preclinical study

Author

Team Onderzoek, Zorgeenheid Vaatchirurgie Medisch, Pathologie Pathologen staf, Circulatory Health, Brain, Regenerative Medicine and Stem Cells, Team Medisch, Groen, M H A, Slieker, F J B, Vink, A, de Borst, G J, Simons, M V, Ebbini, E S, Utrecht, University, Hazenberg, C E V B, van Es, R, Team Onderzoek, Zorgeenheid Vaatchirurgie Medisch, Pathologie Pathologen staf, Circulatory Health, Brain, Regenerative Medicine and Stem Cells, Team Medisch, Groen, M H A, Slieker, F J B, Vink, A, de Borst, G J, Simons, M V, Ebbini, E S, Utrecht, University, Hazenberg, C E V B, and van Es, R

Published
2020

31. Fostering patient-centredness by following patients outside the clinical setting: an interview study

Author

Curr. Onderwijs Huisartsgeneeskunde, Onderwijssecretariaat, Other research (not in main researchprogram), JC Overig onderzoek, General Practice & Nursing Science, HAG Zorginnovatieonderzoek, Huisartsopleiding, Grau Canét-Wittkampf, Christel, Eijkelboom, Charlotte, Mol, Saskia, Utrecht, University, Hendriks, Iris, de Groot, Esther, Curr. Onderwijs Huisartsgeneeskunde, Onderwijssecretariaat, Other research (not in main researchprogram), JC Overig onderzoek, General Practice & Nursing Science, HAG Zorginnovatieonderzoek, Huisartsopleiding, Grau Canét-Wittkampf, Christel, Eijkelboom, Charlotte, Mol, Saskia, Utrecht, University, Hendriks, Iris, and de Groot, Esther

Published
2020

33. Non-dispensing pharmacists' actions and solutions of drug therapy problems among elderly polypharmacy patients in primary care

Author

Curr. Onderwijs Huisartsgeneeskunde, JC Overig onderzoek, Other research (not in main researchprogram), General Practice & Nursing Science, Divisieleiding, HAG Zorginnovatieonderzoek, Julius Centrum, Child Health, Cancer, Hazen, Ankie C. M., Utrecht, University, Poldervaart, Judith M., de Gier, Johan J., de Wit, Niek J., de Bont, Antoinette A., Bouvy, Marcel L., Curr. Onderwijs Huisartsgeneeskunde, JC Overig onderzoek, Other research (not in main researchprogram), General Practice & Nursing Science, Divisieleiding, HAG Zorginnovatieonderzoek, Julius Centrum, Child Health, Cancer, Hazen, Ankie C. M., Utrecht, University, Poldervaart, Judith M., de Gier, Johan J., de Wit, Niek J., de Bont, Antoinette A., and Bouvy, Marcel L.

Published
2019

34. Een prachtig vak

Author

HAG Infectieziekten, Infection & Immunity, Huisartsopleiding, Child Health, JC Overig onderzoek, Other research (not in main researchprogram), HAG Zorginnovatieonderzoek, Curr. Onderwijs Huisartsgeneeskunde, Opstelten, Wim, van der Horst, Henriëtte, Cals, Jochen, Damoiseaux, Roger, Utrecht, University, HAG Infectieziekten, Infection & Immunity, Huisartsopleiding, Child Health, JC Overig onderzoek, Other research (not in main researchprogram), HAG Zorginnovatieonderzoek, Curr. Onderwijs Huisartsgeneeskunde, Opstelten, Wim, van der Horst, Henriëtte, Cals, Jochen, Damoiseaux, Roger, and Utrecht, University

Published
2019

35. The Feasibility of Longitudinal Patient Contacts in a Large Medical School

Author

Curr. Onderwijs Huisartsgeneeskunde, Other research (not in main researchprogram), JC Overig onderzoek, Huisartsopleiding, General Practice & Nursing Science, HAG Zorginnovatieonderzoek, Mol Sl, Saskia, H Carrie, Chen, Steerneman, Anke, de Groot, Esther, Utrecht, University, Curr. Onderwijs Huisartsgeneeskunde, Other research (not in main researchprogram), JC Overig onderzoek, Huisartsopleiding, General Practice & Nursing Science, HAG Zorginnovatieonderzoek, Mol Sl, Saskia, H Carrie, Chen, Steerneman, Anke, de Groot, Esther, and Utrecht, University

Published
2019

36. Effects of non-dispensing pharmacists integrated in general practice on medication-related hospitalisations

Author

HAG Zorginnovatieonderzoek, Circulatory Health, Curr. Onderwijs Huisartsgeneeskunde, JC Overig onderzoek, Other research (not in main researchprogram), General Practice & Nursing Science, Child Health, Cancer, Sloeserwij, V M, Hazen, A C M, Utrecht, University, Leendertse, A J, Poldervaart, J M, de Bont, A A, de Gier, J J, Bouvy, M L, de Wit, N J, HAG Zorginnovatieonderzoek, Circulatory Health, Curr. Onderwijs Huisartsgeneeskunde, JC Overig onderzoek, Other research (not in main researchprogram), General Practice & Nursing Science, Child Health, Cancer, Sloeserwij, V M, Hazen, A C M, Utrecht, University, Leendertse, A J, Poldervaart, J M, de Bont, A A, de Gier, J J, Bouvy, M L, and de Wit, N J

Published
2019

37. 10Kin1day: A bottom-up neuroimaging initiative

Author

Utrecht University, Wellcome Trust, Medical Research Council (UK), Canadian Institutes of Health Research, European Research Council, European Commission, German Research Foundation, Science Foundation Ireland, Russian Foundation for Basic Research, Fundação para a Ciência e a Tecnologia (Portugal), Instituto de Salud Carlos III, National Institutes of Health (US), van den Heuvel, Martijn P., Scholtens, Lianne H., van der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J. N. L., Beyer, Frauke, McDonald, Colm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne, Menchón, José M., Merillat, Susan, Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Naumczyk, Patrycja, Mueller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Oranje, Bob, Ortiz-Garcia de la Foz, Victor, Peper, Jiska S., Pineda, Julian A., Rosa, Pedro G. P., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Serpa, Mauricio H., Ruigrok, Amber N., V, Sabisz, Agnieszka, Schell, Ulrich, Seedat, Soraya, Skouras, Stavros, Soriano-Mas, Carles, Sousa, Nuno, Szurowska, Edyta, van Erp, Theo G. M., Tomyshev, Alexander S., Tordesillas-Gutiérrez, Diana, Valk, Sofie L., van den Berg, Leonard H., Vollmar, Christian, van Haren, Neeltje E. M., van Leeuwen, Judith M. C., Villringer, Arno, Vinkers, Christiaan C. H., Waller, Lea, Walter, Henrik, Whalley, Heather, Witkowska, Marta, Booij, Linda, Witte, A. Veronica, Zanetti, Marcus V., Zhang, Rui, de Lange, Siemon C., Chaim-Avancini, Tiffany M., Braun, Kees P. J., Busatto, Geraldo F., Cahn, Wiepke, Cannon, Dara M., Chan, Sandra S. M., Chen, Eric Y. H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, Zwarte, Sonja M. C., Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Filippi, Massimo, Durston, Sarah, Díaz-Caneja, Covadonga M., Diaz-Zuluaga, Ana M., Emsley, Robin, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gasecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Kaleda, Vasiliy G., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jancke, Lutz, Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G. J. C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina, Lee, Edwin H. M., Lopez-Jaramillo, Carlos, Lett, Tristram A., Lewis, Simon J. G., Liem, Franziskus, Lombardo, Michael, V., Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, Martínez-Zalacaín, Ignacio, Utrecht University, Wellcome Trust, Medical Research Council (UK), Canadian Institutes of Health Research, European Research Council, European Commission, German Research Foundation, Science Foundation Ireland, Russian Foundation for Basic Research, Fundação para a Ciência e a Tecnologia (Portugal), Instituto de Salud Carlos III, National Institutes of Health (US), van den Heuvel, Martijn P., Scholtens, Lianne H., van der Burgh, Hannelore K., Agosta, Federica, Alloza, Clara, Arango, Celso, Auyeung, Bonnie, Baron-Cohen, Simon, Basaia, Silvia, Benders, Manon J. N. L., Beyer, Frauke, McDonald, Colm, McIntosh, Andrew M., McPhilemy, Genevieve, Meinert, Susanne, Menchón, José M., Merillat, Susan, Montag, Christian, Moreira, Pedro S., Morgado, Pedro, Mothersill, David O., Naumczyk, Patrycja, Mueller, Hans-Peter, Nabulsi, Leila, Najt, Pablo, Narkiewicz, Krzysztof, Oranje, Bob, Ortiz-Garcia de la Foz, Victor, Peper, Jiska S., Pineda, Julian A., Rosa, Pedro G. P., Rasser, Paul E., Redlich, Ronny, Repple, Jonathan, Reuter, Martin, Serpa, Mauricio H., Ruigrok, Amber N., V, Sabisz, Agnieszka, Schell, Ulrich, Seedat, Soraya, Skouras, Stavros, Soriano-Mas, Carles, Sousa, Nuno, Szurowska, Edyta, van Erp, Theo G. M., Tomyshev, Alexander S., Tordesillas-Gutiérrez, Diana, Valk, Sofie L., van den Berg, Leonard H., Vollmar, Christian, van Haren, Neeltje E. M., van Leeuwen, Judith M. C., Villringer, Arno, Vinkers, Christiaan C. H., Waller, Lea, Walter, Henrik, Whalley, Heather, Witkowska, Marta, Booij, Linda, Witte, A. Veronica, Zanetti, Marcus V., Zhang, Rui, de Lange, Siemon C., Chaim-Avancini, Tiffany M., Braun, Kees P. J., Busatto, Geraldo F., Cahn, Wiepke, Cannon, Dara M., Chan, Sandra S. M., Chen, Eric Y. H., Crespo-Facorro, Benedicto, Crone, Eveline A., Dannlowski, Udo, Zwarte, Sonja M. C., Dietsche, Bruno, Donohoe, Gary, Du Plessis, Stefan, Filippi, Massimo, Durston, Sarah, Díaz-Caneja, Covadonga M., Diaz-Zuluaga, Ana M., Emsley, Robin, Frodl, Thomas, Gorges, Martin, Graff, Beata, Grotegerd, Dominik, Gasecki, Dariusz, Hall, Julie M., Holleran, Laurena, Holt, Rosemary, Hopman, Helene J., Kaleda, Vasiliy G., Jansen, Andreas, Janssen, Joost, Jodzio, Krzysztof, Jancke, Lutz, Kassubek, Jan, Masouleh, Shahrzad Kharabian, Kircher, Tilo, Koevoets, Martijn G. J. C., Kostic, Vladimir S., Krug, Axel, Lawrie, Stephen M., Lebedeva, Irina, Lee, Edwin H. M., Lopez-Jaramillo, Carlos, Lett, Tristram A., Lewis, Simon J. G., Liem, Franziskus, Lombardo, Michael, V., Margulies, Daniel S., Markett, Sebastian, Marques, Paulo, and Martínez-Zalacaín, Ignacio

Abstract

We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain.

Published
2019

38. Interspecific hybridization and aneuploidy as adaptive mechanisms in saccharomyces yeasts

Author

Barrio, Eladio, Toft, Christina, Generalitat Valenciana, Utrecht University, Ministerio de Economía y Competitividad (España), European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Morard, Miguel, Barrio, Eladio, Toft, Christina, Generalitat Valenciana, Utrecht University, Ministerio de Economía y Competitividad (España), European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), and Morard, Miguel

Abstract

[EN]: With the explosion of genome sequencing technologies, mechanisms such as aneuploidy, polyploidy, and hybridization are emerging as being more frequent and relevant in genomes evolution than what was considered earlier. An interesting model to study such mechanisms are Saccharomyces yeasts as much data is available on its genome structure and evolution and they are easily manipulated in laboratory. Yeast from this genus have small and compact genomes that make them an interesting model for genomics studies on eukaryotic organisms. Moreover, hybrids between the different species of the genus are known and relevant for industrial processes. In this doctoral thesis, we aimed to investigate different aspects of the adaptive value of aneuploidy and interspecific hybridization in Saccharomyces. In the first chapter, we were interested in studying what genomic differences were underlying the different ethanol tolerance observed in S. cerevisiae strains. The most interesting genomic change we observed was a shared polysomy of chromosome III in the highest ethanol tolerant strains. We could determine that this correlation between ethanol tolerance and chromosome III copy number also appeared in different background and we confirmed it was an adaptive mechanism on ethanol stress. In the second chapter of this work, we asked how S. cerevisiae x S. kudriavzevii hybrids mate and how this mechanism would influence the genomic and adaptability outcome of these hybrids. We found that rare-mating was the most frequent but not the only mechanism use. As most of the hybrid were triploid and had a diploid heterozygous contribution of S. cerevisiae, this mating mechanism was the most probable. However, two hybrids were tetraploid. One had an extreme reduction of the S. kudriavzevii subgenome and heterozygous S. cerevisiae. This structure seemed more compatible with the outcome of artificial crossing in strain improvement programs. The last strain had a diploid homozygous contributi, [ES]: Las levaduras del género Saccharomyces son de reconocida importancia tanto por ser un modelo genético básico como por su uso biotecnológico. Tienen un genoma muy compacto. En sus aproximadas 12Mb tienen codificados 6000 genes. Además, muy pocos de estos genes contienen intrones. Esto convierte a estos organismos en unos modelos simples para el estudio genético y genómico. El género tiene 9 especies. La divergencia nucleotídica entre especies es interesante ya que puede cubrir la divergencia entre humanos y aves (S. cerevisiae vs S. kudriavzevii) como entre humanos y primates (S. cerevisiae vs S. paradoxus). De estas especies, S. cerevisiae es la más estudiada y usada biotecnológicamente. Sin embargo las otras especies tienen distintas propiedades fenotípicas que están levantando interés para la industria. Una de ellas es la capacidad de crecimiento a bajas temperaturas que se observa en Saccharomyces no cerevisiae. Estas diferencias fenotípicas y la divergencia entre especie convierten al género en un buen modelo para estudios genéticos y evolutivos. Los mecanismos que generan diversidad genómica son muy diversos. Si un genoma es heterocigoto tiene distintos alelos en el genoma y puede usar mecanismos como la pérdida de heterocigosidad para fijar uno u otro alelo en respuesta a estreses. Con el avance de las tecnologías de secuenciación del ADN y la explosión de estudios genómicos, la importancia de mecanismos de diversificación genómica como las aneuploidías, las polyploidías y la hibridación está quedando más clara. En Saccharomyces múltiples estudios están encontrando que variar el número de copias de ciertos cromosomas es un mecanismo muy frecuente en ambientes variables como son los ambientes industriales. Un hecho interesante es que en estos ambientes también se encontraron distintos híbridos interespecíficos del género. El ejemplo más famosos es el híbrido entre S. cerevisiae y S. eubayanus que es el responsable de la fermentación de cervezas de tipo la

Published
2019

39. Optimisation of telephone triage of callers with symptoms suggestive of acute cardiovascular disease in out-of-hours primary care: observational design of the Safety First study

Author

HAG Zorginnovatieonderzoek, Other research (not in main researchprogram), HAG Hart- Vaatziekten, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC Overig onderzoek, General Practice & Nursing Science, Huisartsopleiding, Infection & Immunity, Erkelens, Daphne Ca, Wouters, Loes Tcm, Utrecht, University, Damoiseaux, Roger Amj, De Groot, Esther, Hoes, Arno W, Rutten, Frans H, HAG Zorginnovatieonderzoek, Other research (not in main researchprogram), HAG Hart- Vaatziekten, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC Overig onderzoek, General Practice & Nursing Science, Huisartsopleiding, Infection & Immunity, Erkelens, Daphne Ca, Wouters, Loes Tcm, Utrecht, University, Damoiseaux, Roger Amj, De Groot, Esther, Hoes, Arno W, and Rutten, Frans H

Published
2019

45. Validity and reliability of a medical record review method identifying transitional patient safety incidents in merged primary and secondary care patients' records

Author

Infection & Immunity, JC onderzoeksprogramma Infectieziekten, JC Overig onderzoek, Other research (not in main researchprogram), General Practice & Nursing Science, Curr. Onderwijs Huisartsgeneeskunde, Verplegingswetenschap, JC onderzoeksprogramma Methodologie, Child Health, Cancer, Van Melle, Marije A., Utrecht, University, Poldervaart, Judith M., Verkerk, Otto Jan, Langelaan, Maaike, Van Stel, Henk F., De Wit, Niek J., Infection & Immunity, JC onderzoeksprogramma Infectieziekten, JC Overig onderzoek, Other research (not in main researchprogram), General Practice & Nursing Science, Curr. Onderwijs Huisartsgeneeskunde, Verplegingswetenschap, JC onderzoeksprogramma Methodologie, Child Health, Cancer, Van Melle, Marije A., Utrecht, University, Poldervaart, Judith M., Verkerk, Otto Jan, Langelaan, Maaike, Van Stel, Henk F., and De Wit, Niek J.

Published
2018

47. A Survey on Stability and Rigidity Results for Lie algebras

Author

Department of Mathematics, Utrecht University (Utrecht, The Netherlands) [research center], ERC Starting Grant No. 279729 [sponsor], Utrecht University (Utrecht, The Netherlands) [sponsor], FAPESP 2013/16753-8 and CNPq 304840/2013-0 (Brazil) [sponsor], Crainic, Marius, Struchiner, Ivan, Schatz, Florian, Department of Mathematics, Utrecht University (Utrecht, The Netherlands) [research center], ERC Starting Grant No. 279729 [sponsor], Utrecht University (Utrecht, The Netherlands) [sponsor], FAPESP 2013/16753-8 and CNPq 304840/2013-0 (Brazil) [sponsor], Crainic, Marius, Struchiner, Ivan, and Schatz, Florian

Abstract

We give simple and unified proofs of the known stability and rigidity results for Lie algebras, Lie subalgebras and Lie algebra homomorphisms. Moreover, we investigate when a Lie algebra homomorphism is stable under all automorphisms of the codomain (including outer automorphisms).

Published
2014

48. A Survey on Stability and Rigidity Results for Lie algebras

Author

Department of Mathematics, Utrecht University (Utrecht, The Netherlands) [research center], ERC Starting Grant No. 279729 [sponsor], Utrecht University (Utrecht, The Netherlands) [sponsor], FAPESP 2013/16753-8 and CNPq 304840/2013-0 (Brazil) [sponsor], Crainic, Marius, Struchiner, Ivan, Schatz, Florian, Department of Mathematics, Utrecht University (Utrecht, The Netherlands) [research center], ERC Starting Grant No. 279729 [sponsor], Utrecht University (Utrecht, The Netherlands) [sponsor], FAPESP 2013/16753-8 and CNPq 304840/2013-0 (Brazil) [sponsor], Crainic, Marius, Struchiner, Ivan, and Schatz, Florian

Abstract

We give simple and unified proofs of the known stability and rigidity results for Lie algebras, Lie subalgebras and Lie algebra homomorphisms. Moreover, we investigate when a Lie algebra homomorphism is stable under all automorphisms of the codomain (including outer automorphisms).

Published
2014

49. Deformations of coisotropic submanifolds for fibrewise entire Poisson structures

Author

Department of Mathematics, Utrecht University (Utrecht, The Netherlands) [research center], FCT through projects PTDC/MAT/098770/2008 and PTDC/MAT/099880/2008 [sponsor], MICINN RYC-2009-04065, MTM2009-08166-E, MTM2011-22612, ICMAT Severo Ochoa project SEV-2011-0087 (Spain) [sponsor], ERC Starting Grant no. 279729 [sponsor], Utrecht University (Utrecht, The Netherlands) [sponsor], Schatz, Florian, Zambon, Marco, Department of Mathematics, Utrecht University (Utrecht, The Netherlands) [research center], FCT through projects PTDC/MAT/098770/2008 and PTDC/MAT/099880/2008 [sponsor], MICINN RYC-2009-04065, MTM2009-08166-E, MTM2011-22612, ICMAT Severo Ochoa project SEV-2011-0087 (Spain) [sponsor], ERC Starting Grant no. 279729 [sponsor], Utrecht University (Utrecht, The Netherlands) [sponsor], Schatz, Florian, and Zambon, Marco

Abstract

We show that deformations of a coisotropic submanifold inside a fibrewise entire Poisson manifold are controlled by the L-infinity-algebra introduced by Oh-Park (for symplectic manifolds) and Cattaneo-Felder. In the symplectic case, we recover results previously obtained by Oh-Park. Moreover we consider the extended deformation problem and prove its obstructedness.

Published
2013

50. Deformations of coisotropic submanifolds for fibrewise entire Poisson structures

Author

Department of Mathematics, Utrecht University (Utrecht, The Netherlands) [research center], FCT through projects PTDC/MAT/098770/2008 and PTDC/MAT/099880/2008 [sponsor], MICINN RYC-2009-04065, MTM2009-08166-E, MTM2011-22612, ICMAT Severo Ochoa project SEV-2011-0087 (Spain) [sponsor], ERC Starting Grant no. 279729 [sponsor], Utrecht University (Utrecht, The Netherlands) [sponsor], Schatz, Florian, Zambon, Marco, Department of Mathematics, Utrecht University (Utrecht, The Netherlands) [research center], FCT through projects PTDC/MAT/098770/2008 and PTDC/MAT/099880/2008 [sponsor], MICINN RYC-2009-04065, MTM2009-08166-E, MTM2011-22612, ICMAT Severo Ochoa project SEV-2011-0087 (Spain) [sponsor], ERC Starting Grant no. 279729 [sponsor], Utrecht University (Utrecht, The Netherlands) [sponsor], Schatz, Florian, and Zambon, Marco

Abstract

We show that deformations of a coisotropic submanifold inside a fibrewise entire Poisson manifold are controlled by the L-infinity-algebra introduced by Oh-Park (for symplectic manifolds) and Cattaneo-Felder. In the symplectic case, we recover results previously obtained by Oh-Park. Moreover we consider the extended deformation problem and prove its obstructedness.

Published
2013

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