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AIM: Considering the unmet need for the counseling of cancer patients treated with immune checkpoint inhibitors (CKI) about influenza vaccination, an explorative study was planned to assess flu vaccine efficacy in this population. METHODS: INVIDIa was a retrospective, multicenter study, enrolling consecutive advanced cancer outpatients receiving CKI during the influenza season 2016-2017. RESULTS: Of 300 patients, 79 received flu vaccine. The incidence of influenza syndrome was 24.1% among vaccinated, versus 11.8% of controls; odds ratio: 2.4; 95% CI: 1.23-4.59; p = 0.009. The clinical ineffectiveness of vaccine was more pronounced among elderly: 37.8% among vaccinated patients, versus 6.1% of unvaccinated, odds ratio: 9.28; 95% CI: 2.77-31.14; p < 0.0001. CONCLUSION: Although influenza vaccine may be clinically ineffective in advanced cancer patients receiving CKI, it seems not to negatively impact the efficacy of anticancer therapy.

First, this paper examines the growth of cause marketing. Then, an overview is provided of cause marketing partnerships used to increase awareness of the breast cancer cause by nonprofit organizations in the U.S. and in Australia Next, this paper discusses Diffusion of Innovation Theory, and is the first to apply this theory to cause marketing, with an analysis done in the specific context of The Susan G. Komen Race for the Cure, the largest breast cancer nonprofit organisation in the world. The rationale for selecting this particular organisation had the purpose of determining Komen’s successful usage of partnerships, including cause marketing alliances, which can serve as an example for other nonprofit organisations. This paper provided new insights on the relationship of diffusion characteristics, cause marketing benefits and marketing strategies which can be of valuable assistance to nonprofit organisations to help achieve greater success in the future. In addition, recommendations are made for future research.

This paper is concerned with the role played by the ground Structural Coupling Test (SCT) and the update of the aeroservoelastic model in the qualification process of a modern combat aircraft. It represents the completion of Reference 1 after several improvements introduced in the Notch Filter (NF) design procedure, numerous ground test campaigns and the confirmation of flight trials. Most of modern combat aircraft are equipped with fly-by- wire and digital flight control systems (FCS). The problem of interaction between the dynamic response of the airframe and the FCS is usually solved through an appropriate set of notch filters, designed to attenuate the level of structure vibrations picked up by the FCS sensors. Fundamental part of the qualification of the notch filter set is the ground testing up activity, generally known as ground Structural Coupling Test., Presented at the Specialists' Meeting of the RTO Applied Vehicle Technology Panel (AVT) held in Ottawa, Canada, 18-20 Oct 1999. This article is from ADA388195 Structural Aspects of Flexible Aircraft Control (les Aspects structuraux du controle actif et flexible des aeronefs)

Results from structural coupling investigations are presented which include the design and verification of structural filters for a flight control system. The advantages of an integrated interdisciplinary flight control system (FCS) design on the basis of the coupled dynamic model of the structural dynamic model and the flight dynamic model of the aircraft are described. The design strategy of the Flight Control System development is improved through the integrated design optimisation procedure which includes the modelling of the coupled system of the flight dynamics, the structural dynamics, the actuators and sensors as well as the effects of the digital system. Different examples are demonstrated which document the advantages of the integrated, interdisciplinary design. Methods to avoid structural mode-flight interaction are described. Especially the design of filters to minimise interaction is outlined, which is based upon a model of the aircraft describing the coupled flight dynamic, flight control dynamics and structural dynamic behaviour and on ground and in flight structural coupling tests. The paper explains design procedures, design and clearance requirements, correlation between model predictions and structural coupling tests and model update for on ground and in flight., Presented at the Specialists' Meeting of the RTO Applied Vehicle Technology Panel (AVT) held in Ottawa, Canada, 18-20 Oct 1999. This article is from ADA388195 Structural Aspects of Flexible Aircraft Control (les Aspects structuraux du controle actif et flexible des aeronefs)