1. HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort
- Author
-
McKinnon, L.R. (Lyle), Nagelkerke, N.J.D. (Nico), Kaul, R. (Rupert), Shaw, S.Y. (Souradet), Capina, R. (Rupert), Luo, M. (Ma), Kariri, A. (Anthony), Apidi, W. (Winnie), Kimani, M. (Makobu), Wachihi, C. (Charles), Jaoko, W. (Walter), Anzala, A.O. (Omu), Kimani, J. (Joshua), Ball, T.B. (Blake), Plummer, F.A. (Francis), McKinnon, L.R. (Lyle), Nagelkerke, N.J.D. (Nico), Kaul, R. (Rupert), Shaw, S.Y. (Souradet), Capina, R. (Rupert), Luo, M. (Ma), Kariri, A. (Anthony), Apidi, W. (Winnie), Kimani, M. (Makobu), Wachihi, C. (Charles), Jaoko, W. (Walter), Anzala, A.O. (Omu), Kimani, J. (Joshua), Ball, T.B. (Blake), and Plummer, F.A. (Francis)
- Abstract
HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective female sex worker cohort (1985-2004) that Clade D (n = 54) is associated with a more rapid CD4 decline than clade A1 (n = 150, 20.6% vs 13.4% decline per year, 1.53-fold increase, p = 0.015). This was independent of "protective" HLA and country of origin (p = 0.053), which in turn were also independent predictors of the rate of CD4 decline (p = 0.026 and 0.005, respectively). These data confirm that clade D is more pathogenic than clade A1. The precise reason for this difference is currently unclear, and requires further study. This is first study to demonstrate difference in HIV-1 disease progression between clades while controlling for protective HLA alleles.
- Published
- 2012
- Full Text
- View/download PDF