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PURPOSE: To describe the design and rationale of the phase 3 TENAYA (ClinicalTrials.gov identifier, NCT03823287) and LUCERNE (ClinicalTrials.gov identifier, NCT03823300) trials that aimed to assess efficacy, safety, and durability of faricimab, the first bispecific antibody for intraocular use, which independently binds and neutralizes both angiopoietin-2 and vascular endothelial growth factor-A (VEGF-A) versus aflibercept in patients with neovascular age-related macular degeneration (nAMD). DESIGN: Identical, global, double-masked, randomized, controlled, phase 3 clinical trials. PARTICIPANTS: Adults with treatment-naïve nAMD. METHODS: These trials were designed to evaluate patients randomized to receive faricimab 6.0 mg up to every 16 weeks after 4 initial every-4-week doses or aflibercept 2.0 mg every 8 weeks after 3 initial every-4-week doses. The initial doses in the faricimab arm were followed by individualized fixed treatment intervals up to week 60, based on disease activity assessment at weeks 20 and 24, guided by central subfield thickness, best-corrected visual acuity (BCVA), and investigator assessment. The primary efficacy end point was BCVA change from baseline averaged over weeks 40, 44, and 48. Secondary end points included the proportion of patients receiving every-8-week, every-12-week, and every-16-week faricimab and anatomic outcomes. Safety outcomes included incidence and severity of ocular and nonocular adverse events. From week 60, faricimab-treated patients followed a personalized treatment interval (PTI), a novel protocol-driven treat-and-extend regimen with interval adjustment from every 8 weeks to every 16 weeks based on individualized treatment response measured by anatomic criteria, functional criteria, and investigator assessment of patients' disease activity. MAIN OUTCOME MEASURES: Rationale for trial design and PTI approach. RESULTS: The TENAYA and LUCERNE trials were the first registrational trials in nAMD to test fixed dosing regime

By the end of 2018, 42 years after the landing of the two Viking seismometers on Mars, InSight will deploy onto Mars' surface the SEIS (Seismic Experiment for Internal Structure) instrument; a six-axes seismometer equipped with both a long-period three-axes Very Broad Band (VBB) instrument and a three-axes short-period (SP) instrument. These six sensors will cover a broad range of the seismic bandwidth, from 0.01 Hz to 50 Hz, with possible extension to longer periods. Data will be transmitted in the form of three continuous VBB components at 2 sample per second (sps), an estimation of the short period energy content from the SP at 1 sps and a continuous compound VBB/SP vertical axis at 10 sps. The continuous streams will be augmented by requested event data with sample rates from 20 to 100 sps. SEIS will improve upon the existing resolution of Viking's Mars seismic monitoring by a factor of ∼ 2500 at 1 Hz and ∼ 200 000 at 0.1 Hz. An additional major improvement is that, contrary to Viking, the seismometers will be deployed via a robotic arm directly onto Mars' surface and will be protected against temperature and wind by highly efficient thermal and wind shielding. Based on existing knowledge of Mars, it is reasonable to infer a moment magnitude detection threshold of M w ∼ 3 at 40 ∘ epicentral distance and a potential to detect several tens of quakes and about five impacts per year. In this paper, we first describe the science goals of the experiment and the rationale used to define its requirements. We then provide a detailed description of the hardware, from the sensors to the deployment system and associated performance, including transfer functions of the seismic sensors and temperature sensors. We conclude by describing the experiment ground segment, including data processing services, outreach and education networks and provide a description of the format to be used for future data distribution.Electronic supplementary materialTh

By the end of 2018, 42 years after the landing of the two Viking seismometers on Mars, InSight will deploy onto Mars' surface the SEIS (Seismic Experiment for Internal Structure) instrument; a six-axes seismometer equipped with both a long-period three-axes Very Broad Band (VBB) instrument and a three-axes short-period (SP) instrument. These six sensors will cover a broad range of the seismic bandwidth, from 0.01 Hz to 50 Hz, with possible extension to longer periods. Data will be transmitted in the form of three continuous VBB components at 2 sample per second (sps), an estimation of the short period energy content from the SP at 1 sps and a continuous compound VBB/SP vertical axis at 10 sps. The continuous streams will be augmented by requested event data with sample rates from 20 to 100 sps. SEIS will improve upon the existing resolution of Viking's Mars seismic monitoring by a factor of ∼2500 at 1 Hz and ∼200000 at 0.1 Hz. An additional major improvement is that, contrary to Viking, the seismometers will be deployed via a robotic arm directly onto Mars' surface and will be protected against temperature and wind by highly efficient thermal and wind shielding. Based on existing knowledge of Mars, it is reasonable to infer a moment magnitude detection threshold of Mw∼3 at 40∘ epicentral distance and a potential to detect several tens of quakes and about five impacts per year. In this paper, we first describe the science goals of the experiment and the rationale used to define its requirements. We then provide a detailed description of the hardware, from the sensors to the deployment system and associated performance, including transfer functions of the seismic sensors and temperature sensors. We conclude by describing the experiment ground segment, including data processing services, outreach and education networks and provide a description of the format to be used for future data distribution.Electronic supplementary materialThe onlin

In this paper we analyze hypersingular integral equations of the Peierls type specified on the whole real axis. The method of "approximate approximations" [Maz'ya, Proceedings of the Eighth Conference on the Mathematics of Finite Elements and Applications, VIII, MAFELAP 1993, Brunel University, 1994, pp. 107-104] is employed in order to produce numerical solutions of high accuracy, and the results are applied to problems in the theory of dislocations. The critical Peierls stress is evaluated for different configurations of dislocations and for different types of the interatomic force law.

This document contains papers and panel position papers that would have presented or distributed at the August 1990 Symposium which was canceled. Panel discussions on (1) Curriculum Trends in Software Engineering; (2) Lessons Learned in Software Engineering taught with Ada; (3) The Future of Ada. Papers presented such as, Implementation of Artificial Systems in Ada; A Design Methodology for Object Based Languages; Program Development and Ada; STANFINS redesign Subsystem II: Developing a Large MIS Application Using Ada; The Place of Ada in an Undergraduate Software Engineering Curriculum; Using Short Laboratory Exercises to Develop Ada Awareness.

Gas gun impact experiments and computational simulations were performed to investigate a technique for increasing flyer plate velocities. Stainless steel impactors, PMMA and aluminum buffers, and stainless steel flyers were used. Charged contact pins were used to measure impactor and flyer velocities. The velocities of the flyers were on the order of 1.5 times the impactor velocities, in agreement with computational results. (Author)

The free-surface velocity of a shock-loaded 3.73-mm-thick tantalum disk has been measured with a capacitor gauge. Stress reverberations were produced in the tantalum disk by impacting it with a 2.65-mm-thick alpha titanium disk at a velocity of 0.111 km/s in a gas gun. An initial shock compressive stress slightly larger than the measured 2.1-GPa Hugoniot elastic limit was produced in the tantalum. The shape of the free-surface-velocity profile suggested that spall fracture did not occur in the specimen disk at this stress level. This result was verified by examining the recovered and sectioned disk. (Author)

The patent relates to positron-emitting probes that have certain features that facilitate the use of positrons for nondestructive testing of fatigued metals. The features include the use of an unfatigued substrate for supporting the positron-emitting material, electric and/or magnetic fields to concentrate the positrons on the test item, and a thin scintillator window for use with those radioactive materials that emit a positron without emitting a time-correlated gamma photon., Supersedes AD-D001 263.

Fiber-reinforced resin-matrix composites reportedly suffer significant degradation in their mechanical properties when they are exposed to hot, moist environments for extended periods. Moisture weakens the fiber-matrix bond as well as the matrix shear strength. Despite the importance of measuring moisture content and its effects on composite material properties, not enough data are available on suitable nondestructive techniques for detecting and measuring moisture diffusion in resin-matrix composite materials. This paper addresses the problem of measuring the moisture content of such materials, using the positron lifetime technique. (AN)

Military aircraft missions are all multidimensional in nature. This means that every mission can be divided into usually one overall goal or purpose (i.e., destroy the target, deliver the supplies, rescue the survivors, etc.), with several subgoals (safety, minimize susceptibility, timeliness, etc.). Since missions are multidimensional, the operator effort in the form of mental and physical action (performance) becomes multidimensional. The multidimentional nature of skilled aircrew performance, in turn, reguires that several criteria, all of which are relevant for a particular activity, be defined and used [ Ref• 1 ]. The unique situation of an aircrew flying an aircraft for a specific mission and the necessary determination of subcriteria for evaluating accomplishment of that mission requires further research of an analytical and empirical nature. The relationship among altitute, airspreed, operator activity, and the hundreds of other system variables that comprise the total system must be compared to mission success in quantifiable terms. This study is an effort to improve acquisition of training performance information in affortable ways on behalf of the Hellenic Air Force (HAF) . Thus, it is divided in: (1) The principles of human performance, (2) Definition of the criteria and their measurement, (3) Systematic definition of performance measure appropriate to combat- training needs, (4) Definition of a cost effective measurement system usable in combat-crew training environments to acquire and process needed training information. The method that was used was a search of the available materials found in the NPS library. Most of the data found was based on DSAF studies.

The infrared (4000-55/cm) and Raman (3200-75/cm) spectra of 1,1'- dibromo-, 1,1'-diiodo-, and 1,1'-dichloroferrocene are reported. An attempt is made to give a complete vibrational assignment for all fundamental vibrations of these molecules. The results of these assignments are compared to those of 1,1'- dimethylferrocene and of monosubstituted benzenes. The assigned frequencies were tested by utilizing the inequality rule of Whiffen and Steele.

Fifty-four representative soil samples from all over the world were selected for heavy mineral analysis from those provided by the Naval Weapons Center, China Lake, California. Data thus obtained, in conjunction with mineralogical, chemical, and abrasion investigation data from the literature, is presented in support of a discussion of the relationship between the mineralogical and chemical content to abrasion/corrosion potential of environmental dust. Crushed quartz is the most representative material for dust abrasion testing, but not for total dust damage potential prediction. It is quartz (not laterite) together with the phenomena of 'Differential A Aeration Cell' corrosion/erosion-corrosion and possible thermochemical contributions, that is believed to be responsible for the extensive damage to military ordnance due to dust contamination experienced in Southeast Asia.

Military aircraft missions are all multidimensional in nature. This means that every mission can be divided into usually one overall goal or purpose (i.e., destroy the target, deliver the supplies, rescue the survivors, etc.), with several subgoals (safety, minimize susceptibility, timeliness, etc.). Since missions are multidimensional, the operator effort in the form of mental and physical action (performance) becomes multidimensional. The multidimentional nature of skilled aircrew performance, in turn, reguires that several criteria, all of which are relevant for a particular activity, be defined and used [ Ref• 1 ]. The unique situation of an aircrew flying an aircraft for a specific mission and the necessary determination of subcriteria for evaluating accomplishment of that mission requires further research of an analytical and empirical nature. The relationship among altitute, airspreed, operator activity, and the hundreds of other system variables that comprise the total system must be compared to mission success in quantifiable terms. This study is an effort to improve acquisition of training performance information in affortable ways on behalf of the Hellenic Air Force (HAF) . Thus, it is divided in: (1) The principles of human performance, (2) Definition of the criteria and their measurement, (3) Systematic definition of performance measure appropriate to combat- training needs, (4) Definition of a cost effective measurement system usable in combat-crew training environments to acquire and process needed training information. The method that was used was a search of the available materials found in the NPS library. Most of the data found was based on DSAF studies., http://archive.org/details/criteriforcombat1094519219, Captain, Hellenic Air Force, Approved for public release; distribution is unlimited.