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We analyze quasi-two-body charmless $B$ decays $B_{(s)} \to P_1 V \to P_1 P_2 P_3$ with $V$ representing a vector resonant, and $P_{1,2,3}$ as a light pseudo-scalar meson, pion, kaon or $\eta^{(\prime)}$. The intermediate processes $B_{(s)} \to P_1 V $ are calculated in the factorization-assisted topological-amplitude approach and the vector resonant effects are described by the Breit-Wigner propagator, which successively decay to $P_1 P_2$ via strong interaction. Taking into account of all vector resonances in ground state, $\rho, K^*, \omega, \phi$, we present the related branching fractions, and calculate the virtual effects for $B_{(s)} \to \pi, K (\rho ,\omega \to) KK$. We also predict direct $\it{CP}$ asymmetries of three body B decay modes with $\rho, K^*$ resonances as intermediate states. Our predicted branching fractions of decay modes dominated by the color-favored tree diagram or the color-favored penguin diagram are consistent with the perturbative QCD approach's predictions as well as QCD factorization approach. While for those nonperturbative contribution dominated decay modes, the branching ratios in this work are in better agreement with current experimental data than the PQCD predictions and the QCD factorization results due to their shortage of the nonperturbative contributions or $1/m_b$ power corrections. Many of the decays channels, especially for direct $\it{CP}$ asymmetries, are waiting for the future experiments., Comment: 28 pages, 2 figures

Xue-Lian Pang,* Qiao-Xin Li,* Zhi-Ping Ma, Yi Shi, Yu-Qing Ma, Xin-Xia Li, Wen-Li Cui, Wei Zhang Department of Pathology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of China *These authors contributed equally to this work Abstract: The KRAS gene mutation is involved in several types of tumors. However, the potential role of the KRAS mutation in human primary and paired metastatic colorectal cancer (CRC) among different nationalities is poorly understood. In the present study, we assessed the relationship between KRAS mutation status and overall survival (OS) and disease-free survival (DFS) in 230 patients with primary and paired metastatic CRC. The KRAS mutation rate in primary CRC tissue was 43.0% (99/230), which was higher than in paired metastatic CRC, which was 31.9% (23/72; P<0.001). Clinicopathologically, the KRAS gene mutation rate was higher in tumors that had infiltrated more deeply (T3, T4) and in lymph node (LN) metastases (N1/N2) (P=0.029 and P=0.010, respectively). The KRAS gene status did not differ between the Han and Uyghur nationalities in both primary and metastatic CRC. In 72 paired cases, the KRAS mutation rate in primary CRC was significantly higher than in metastatic CRC (P<0.001) and in metastatic CRC that had infiltrated more deeply (T3, T4) (P=0.034). In the metastatic cases, the KRAS gene mutation rate was higher in patients aged over 65 years (P=0.035). Specifically, KRAS mutation was correlated with a poorer OS and DFS (P=0.004 and P=0.029, respectively). In our study, 35 patients with wild-type KRAS who received cetuximab targeted therapy had a better DFS than patients with mutant KRAS (P=0.029). The results of the current study demonstrate that the KRAS status is significantly associated with infiltrating LN metastases and the TNM stage in primary CRC. In addition, the results show that the KRAS mutation is significantly more common in primary tumors than in paired met

Objectives Presence of non-alcoholic fatty liver disease (NAFLD) can predict risks for diabetes, cardiovascular disease and advanced liver disease in the general population. We aimed to establish a non-invasive score for prediction of NAFLD in Han Chinese, the largest ethnic group in the world, and detect whether ethnicity influences the accuracy of such a score. Methods Liver fat content (LFAT) was measured by quantitative ultrasound in 3548 subjects in the Shanghai Changfeng Community and a Chinese score was created using multivariate logistic regression analyses. This new score was internally validated in Chinese and externally in Finns. Its diagnostic performance was compared to the NAFLD liver fat score, fatty liver index (FLI) and hepatic steatosis index (HSI) developed in Finns, Italians and Koreans. We also analyzed how obesity related to LFAT measured by H-1-MRS in 79 Finns and 118 Chinese with type 2 diabetes (T2D). Results The metabolic syndrome and T2D, fasting serum insulin, body mass index (BMI) and AST/ALT ratio were independent predictors of NAFLD in Chinese. The AUROC in the Chinese validation cohort was 0.76 (0.73-0.78) and in Finns 0.73 (0.68-0.78) (p Conclusion The predictors of NAFLD in Han Chinese are as in Europids but the Chinese have more LFAT for any given degree of obesity than Europids. Ethnicity needs to be considered when NAFLD is predicted using risk scores.

by Xin-xia Tian., Thesis (Ph.D.)--Chinese University of Hong Kong, 1999., Includes bibliographical references (p. 195-212)., Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web., Mode of access: World Wide Web., s in English and Chinese., http://library.cuhk.edu.hk/record=b6073200, Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Regression analysis has been used to investigate the correlation between blasting damage depth and peak particle velocity (PPV) using on site measurements from high rock slopes at the Xiluodo and Baihetan hydroelectric projects (China). Results showed there was a power function relationship, and the correlation coefficient exceeded 80%. 3D numerical simulation of blasting excavation was used to verify the relationship, and results agreed well with those of site experiments. A new damage-vibration couple control approach of high rock slopes is proposed which uses an equivalent blasting vibration control standard (EBVCS). The mathematical description of EBVCS was determined with the stress attention law, and the rationale was verified with the experimental and numerical data. The damage-vibration couple control approach was used during the excavation of the Wudongde limestone high rock slope. Results suggested that the PPV in the radial direction is most suitable for the control approach. The appropriate position of EBVCS was at the inside of the berm. The detonation distance could affect the correctness of damage-vibration couple approach significantly, and the ideal position is the nearest berm., Regression analysis has been used to investigate the correlation between blasting damage depth and peak particle velocity (PPV) using on site measurements from high rock slopes at the Xiluodo and Baihetan hydroelectric projects (China). Results showed there was a power function relationship, and the correlation coefficient exceeded 80%. 3D numerical simulation of blasting excavation was used to verify the relationship, and results agreed well with those of site experiments. A new damage-vibration couple control approach of high rock slopes is proposed which uses an equivalent blasting vibration control standard (EBVCS). The mathematical description of EBVCS was determined with the stress attention law, and the rationale was verified with the experimental and numerical data. The damage-vibration couple control approach was used during the excavation of the Wudongde limestone high rock slope. Results suggested that the PPV in the radial direction is most suitable for the control approach. The appropriate position of EBVCS was at the inside of the berm. The detonation distance could affect the correctness of damage-vibration couple approach significantly, and the ideal position is the nearest berm.