Search

We discuss applications of the study of the new and barely explored class of changing-look (CL) narrow-line Seyfert 1 (NLS1) galaxies and comment on their detection with the space mission SVOM (Space Variable Objects Monitor). We highlight the case of NGC 1566, which is outstanding in many respects, for instance as one of the nearest known CL AGN undergoing exceptional outbursts. Its NLS1 nature is discussed, and we take it as a nearby prototype for systems that could be discovered and studied in the near future, including with SVOM. Finally, we briefly examine the broader implications and applications of CL events in NLS1 galaxies and show that such systems, once discovered in larger numbers, will greatly advance our understanding of the physics of the environment of rapidly growing supermassive black holes. This White Paper is part of a sequence of publications which explore aspects of our understanding of (CL) NLS1 galaxy physics with future missions., Comment: 14 pages, 4 figures. Accepted for publication in the Universe Special Issue "A Multimessenger View of Supermassive Black Holes and the Quasar Main Sequence"

INTRODUCTION: Many patients with cognitive and neuropsychiatric symptoms face diagnostic delay and misdiagnosis. We investigated whether cerebrospinal fluid (CSF) neurofilament light (NfL) and total-tau (t-tau) could assist in the clinical scenario of differentiating neurodegenerative (ND) from psychiatric disorders (PSY), and rapidly progressive disorders. METHODS: Biomarkers were examined in patients from specialist services (ND and PSY) and a national Creutzfeldt-Jakob registry (Creutzfeldt-Jakob disease [CJD] and rapidly progressive dementias/atypically rapid variants of common ND, RapidND). RESULTS: A total of 498 participants were included: 197 ND, 67 PSY, 161 CJD, 48 RapidND, and 20 controls. NfL was elevated in ND compared to PSY and controls, with highest levels in CJD and RapidND. NfL distinguished ND from PSY with 95%/78% positive/negative predictive value, 92%/87% sensitivity/specificity, 91% accuracy. NfL outperformed t-tau in most real-life clinical diagnostic dilemma scenarios, except distinguishing CJD from RapidND. DISCUSSION: We demonstrated strong generalizable evidence for the diagnostic utility of CSF NfL in differentiating ND from psychiatric disorders, with high accuracy.

Habitability of an exoplanet is believed to be profoundly affected by activities of the host stars, although the related coronal mass ejections (CMEs) are still rarely detected in solar-like and late-type stars. We here report an observational study on flares of two M-dwarfs triggered by the high-cadence survey performed by the Ground Wide-angle Camera system. In both events, the fast, time-resolved spectroscopy enables us to identify symmetric broad H$\alpha$ emission with not only a nearly zero bulk velocity, but also a large projected maximum velocity as high as $\sim700-800\ \mathrm{km\ s^{-1}}$. This broadening could be resulted from either Stark (pressure) effect or a flaring-associated CME at stellar limb. In the context of the CME scenario, the CME mass is estimated to be $\sim4\times10^{18}$ g and $2\times10^{19}$ g. In addition, our spectral analysis reveals a temporal variation of the line center of the narrow H$\alpha$ emission in both events. The variation amplitudes are at tens of $\mathrm{km\ s^{-1}}$, which could be ascribed to the chromospheric evaporation in one event, and to a binary scenario in the other one. With the total flaring energy determined from our photometric monitor, we show a reinforced trend in which larger the flaring energy, higher the CME mass is., Comment: 15 pages, 10 figures and 3 tables. Accepted by ApJ. arXiv admin note: text overlap with arXiv:2106.04774

[Formula presented] Introduction Central nervous system relapse (secondary central nervous system lymphoma -SCNS) is an uncommon but devastating complication of aggressive B-cell lymphoma. Patients (Pts) with CNS-IPI 4-6 are at greatest risk (10.2% at 2 years). Intravenous high-dose methotrexate (HD-MTX) is widely used to mitigate SCNS risk but data supporting this practice are limited. Methods We performed a multicentre, retrospective study at 21 sites in Australia, Asia, North America and Europe. Chart or registry review was performed for consecutively diagnosed pts with diffuse large B-cell lymphoma (DLBCL) and CNS-IPI 4-6, high grade B-cell lymphoma (HGBL) with rearrangements of MYC+BCL2 and/or BCL6 and primary breast/testicular DLBCL irrespective of CNS-IPI. Pts were diagnosed between 2000-2020, 18-80 years at diagnosis, and treated with curative intent anti-CD20 based chemo-immunotherapy. Pts with CNS involvement at diagnosis were excluded. HD-MTX was defined as at least one cycle of intravenous MTX at any dose. Time to SCNS was calculated from date of diagnosis (all-pts), and from the end of frontline systemic lymphoma therapy, defined as 6x21 days from diagnosis (complete response (CR-pts)), until SCNS, systemic relapse, death, or censoring, whichever came first. Cumulative risk of SCNS was computed using the Aalen-Johansen estimator treating death and systemic relapses as competing events. Adjusted cumulative risks were obtained by using an inverse probability of treatment weighting approach. The average treatment effect was computed as the difference in adjusted 5-year risk of SCNS. Results - 2300 and 1455 pts were included in the all-pts and CR-pts analyses, respectively. Baseline demographics and details of therapy are summarised in Table 1. Except for a predominance of males, pts <=60 years and pts with ECOG 0-1 in the HD-MTX vs no HD-MTX groups, the demographics and treatments were well balanced. At a median follow up of 5.9 years (range 0.0-19.1) and

[Formula presented] Introduction Central nervous system relapse (secondary central nervous system lymphoma -SCNS) is an uncommon but devastating complication of aggressive B-cell lymphoma. Patients (Pts) with CNS-IPI 4-6 are at greatest risk (10.2% at 2 years). Intravenous high-dose methotrexate (HD-MTX) is widely used to mitigate SCNS risk but data supporting this practice are limited. Methods We performed a multicentre, retrospective study at 21 sites in Australia, Asia, North America and Europe. Chart or registry review was performed for consecutively diagnosed pts with diffuse large B-cell lymphoma (DLBCL) and CNS-IPI 4-6, high grade B-cell lymphoma (HGBL) with rearrangements of MYC+BCL2 and/or BCL6 and primary breast/testicular DLBCL irrespective of CNS-IPI. Pts were diagnosed between 2000-2020, 18-80 years at diagnosis, and treated with curative intent anti-CD20 based chemo-immunotherapy. Pts with CNS involvement at diagnosis were excluded. HD-MTX was defined as at least one cycle of intravenous MTX at any dose. Time to SCNS was calculated from date of diagnosis (all-pts), and from the end of frontline systemic lymphoma therapy, defined as 6x21 days from diagnosis (complete response (CR-pts)), until SCNS, systemic relapse, death, or censoring, whichever came first. Cumulative risk of SCNS was computed using the Aalen-Johansen estimator treating death and systemic relapses as competing events. Adjusted cumulative risks were obtained by using an inverse probability of treatment weighting approach. The average treatment effect was computed as the difference in adjusted 5-year risk of SCNS. Results - 2300 and 1455 pts were included in the all-pts and CR-pts analyses, respectively. Baseline demographics and details of therapy are summarised in Table 1. Except for a predominance of males, pts <=60 years and pts with ECOG 0-1 in the HD-MTX vs no HD-MTX groups, the demographics and treatments were well balanced. At a median follow up of 5.9 years (range 0.0-19.1) and

Multi-wavelength simultaneous observations are essential to the constraints on the origin of fast radio bursts (FRBs). However, it is a significant observational challenge due to the nature of FRBs as transients with a radio millisecond duration, which occur randomly in the sky regardless of time and position. Here, we report the search for short-time fast optical bursts in the GWAC archived data associated with FRB 20181130B, which were detected by the Five Hundred Meter Spherical Radio Telescope (FAST) and recently reported. No new credible sources were detected in all single GWAC images with an exposure time of 10 s, including image with coverage of the expected arrival time in optical wavelength by taking the high dispersion measurements into account. Our results provide a limiting magnitude of 15.43$\pm0.04$ mag in R band, corresponding to a flux density of 1.66 Jy or 8.35 mag in AB system by assuming that the duration of the optical band is similar to that of the radio band of about 10 ms. This limiting magnitude makes the spectral index of $\alpha<0.367$ from optical to radio wavelength. The possible existence of longer duration optical emission was also investigated with an upper limits of 0.33 Jy (10.10 mag), 1.74 mJy (15.80 mag) and 0.16 mJy (18.39 mag) for the duration of 50 ms, 10 s and 6060 s, respectively. This undetected scenario could be partially attributed to the shallow detection capability, as well as the high inferred distance of FRB 20181130B and the low fluence in radio wavelength. The future detectability of optical flashes associated with nearby and bright FRBs are also discussed in this paper., Comment: Accepted by ApJ

The flare-associated stellar coronal mass ejection (CME) in solar-like and late type stars is quite essential for the habitability of an exoplanet. In this paper, we report detection of flare-associated CMEs in two M-dwarfs, thanks to the high cadence survey carried out by the Ground Wide-angle Camera system and the fast photometric and spectroscopic follow-ups. The flare energy in $R-$band is determined to be $1.6\times10^{35}\ \mathrm{erg}$ and $8.1\times10^{33}\ \mathrm{erg}$ based on the modeling of their light curves. The time-resolved spectroscopyic observations start at about 20 and 40 minutes after the trigger in both cases. The large projected maximum velocity of $\sim500-700\ \mathrm{km\ s^{-1}}$ suggests that the high velocity wing of their H$\alpha$ emission lines are most likely resulted from a CME event in both stars, after excluding the possibility of chromospheric evaporation and coronal rain. The masses of the CMEs are estimated to be $1.5-4.5\times10^{19}\ \mathrm{g}$ and $7.1\times10^{18}\ \mathrm{g}$., Comment: 15 pages, 10 figures and 5 tables, accepted by ApJ

Research in schizophrenia (SZ) emphasizes the need for new therapeutic approaches based on antioxidant/anti-inflammatory compounds and psycho-social therapy. A hallmark of SZ is a dysfunction of parvalbumin-expressing fast-spiking interneurons (PVI), which are essential for neuronal synchrony during sensory/cognitive processing. Oxidative stress and inflammation during early brain development, as observed in SZ, affect PVI maturation. We compared the efficacy of N-acetyl-cysteine (NAC) and/or environmental enrichment (EE) provided during juvenile and/or adolescent periods in rescuing PVI impairments induced by an additional oxidative insult during childhood in a transgenic mouse model with gluthation deficit (Gclm KO), relevant for SZ. We tested whether this rescue was promoted by the inhibition of MMP9/RAGE mechanism, both in the mouse model and in early psychosis (EP) patients, enrolled in a double-blind, randomized, placebo-controlled clinical trial of NAC supplementation for 6 months. We show that a sequential combination of NAC+EE applied after an early-life oxidative insult recovers integrity and function of PVI network in adult Gclm KO, via the inhibition of MMP9/RAGE. Six-month NAC treatment in EP patients reduces plasma sRAGE in association with increased prefrontal GABA, improvement of cognition and clinical symptoms, suggesting similar neuroprotective mechanisms. The sequential combination of NAC+EE reverses long-lasting effects of an early oxidative insult on PVI/perineuronal net (PNN) through the inhibition of MMP9/RAGE mechanism. In analogy, patients vulnerable to early-life insults could benefit from a combined pharmacological and psycho-social therapy.

IMPORTANCE: Proton magnetic resonance spectroscopy (1H-MRS) studies indicate that altered brain glutamatergic function may be associated with the pathophysiology of schizophrenia and the response to antipsychotic treatment. However, the association of altered glutamatergic function with clinical and demographic factors is unclear. OBJECTIVE: To assess the associations of age, symptom severity, level of functioning, and antipsychotic treatment with brain glutamatergic metabolites. DATA SOURCES: The MEDLINE database was searched to identify journal articles published between January 1, 1980, and June 3, 2020, using the following search terms: MRS or magnetic resonance spectroscopy and (1) schizophrenia or (2) psychosis or (3) UHR or (4) ARMS or (5) ultra-high risk or (6) clinical high risk or (7) genetic high risk or (8) prodrome* or (9) schizoaffective. Authors of 114 1H-MRS studies measuring glutamate (Glu) levels in patients with schizophrenia were contacted between January 2014 and June 2020 and asked to provide individual participant data. STUDY SELECTION: In total, 45 1H-MRS studies contributed data. DATA EXTRACTION AND SYNTHESIS: Associations of Glu, Glu plus glutamine (Glx), or total creatine plus phosphocreatine levels with age, antipsychotic medication dose, symptom severity, and functioning were assessed using linear mixed models, with study as a random factor. MAIN OUTCOMES AND MEASURES: Glu, Glx, and Cr values in the medial frontal cortex (MFC) and medial temporal lobe (MTL). RESULTS: In total, 42 studies were included, with data for 1251 patients with schizophrenia (mean [SD] age, 30.3 [10.4] years) and 1197 healthy volunteers (mean [SD] age, 27.5 [8.8] years). The MFC Glu (F1,1211.9 = 4.311, P = .04) and Glx (F1,1079.2 = 5.287, P = .02) levels were lower in patients than in healthy volunteers, and although creatine levels appeared lower in patients, the difference was not significant (F1,1395.9 = 3.622, P = .06). In both patients and volunteers, the MFC

Multi-wavelength simultaneous observations are essential to the constraints on the origin of fast radio bursts (FRBs). However, it is a significant observational challenge due to the nature of FRBs as transients with a radio millisecond duration, which occur randomly in the sky regardless of time and position. Here, we report the search for short-time fast optical bursts in the GWAC archived data associated with FRB 20181130B, which were detected by the Five Hundred Meter Spherical Radio Telescope (FAST) and recently reported. No new credible sources were detected in all single GWAC images with an exposure time of 10 s, including image with coverage of the expected arrival time in optical wavelength by taking the high dispersion measurements into account. Our results provide a limiting magnitude of 15.43$\pm0.04$ mag in R band, corresponding to a flux density of 1.66 Jy or 8.35 mag in AB system by assuming that the duration of the optical band is similar to that of the radio band of about 10 ms. This limiting magnitude makes the spectral index of $\alpha<0.367$ from optical to radio wavelength. The possible existence of longer duration optical emission was also investigated with an upper limits of 0.33 Jy (10.10 mag), 1.74 mJy (15.80 mag) and 0.16 mJy (18.39 mag) for the duration of 50 ms, 10 s and 6060 s, respectively. This undetected scenario could be partially attributed to the shallow detection capability, as well as the high inferred distance of FRB 20181130B and the low fluence in radio wavelength. The future detectability of optical flashes associated with nearby and bright FRBs are also discussed in this paper., Comment: Accepted by ApJ

The flare-associated stellar coronal mass ejection (CME) in solar-like and late type stars is quite essential for the habitability of an exoplanet. In this paper, we report detection of flare-associated CMEs in two M-dwarfs, thanks to the high cadence survey carried out by the Ground Wide-angle Camera system and the fast photometric and spectroscopic follow-ups. The flare energy in $R-$band is determined to be $1.6\times10^{35}\ \mathrm{erg}$ and $8.1\times10^{33}\ \mathrm{erg}$ based on the modeling of their light curves. The time-resolved spectroscopyic observations start at about 20 and 40 minutes after the trigger in both cases. The large projected maximum velocity of $\sim500-700\ \mathrm{km\ s^{-1}}$ suggests that the high velocity wing of their H$\alpha$ emission lines are most likely resulted from a CME event in both stars, after excluding the possibility of chromospheric evaporation and coronal rain. The masses of the CMEs are estimated to be $1.5-4.5\times10^{19}\ \mathrm{g}$ and $7.1\times10^{18}\ \mathrm{g}$., Comment: 15 pages, 10 figures and 5 tables, accepted by ApJ

The observation of the transient sky through a multitude of astrophysical messengers hasled to several scientific breakthroughs these last two decades thanks to the fast evolution ofthe observational techniques and strategies employed by the astronomers. Now, it requiresto be able to coordinate multi-wavelength and multi-messenger follow-up campaign withinstruments both in space and on ground jointly capable of scanning a large fraction of thesky with a high imaging cadency and duty cycle. In the optical domain, the key challengeof the wide field of view telescopes covering tens to hundreds of square degrees is to dealwith the detection, the identification and the classification of hundreds to thousands of opticaltransient (OT) candidates every night in a reasonable amount of time. In the last decade, newautomated tools based on machine learning approaches have been developed to perform thosetasks with a low computing time and a high classification efficiency. In this paper, we presentan efficient classification method using Convolutional Neural Networks (CNN) to discard anybogus falsely detected in astrophysical images in the optical domain. We designed this toolto improve the performances of the OT detection pipeline of the Ground Wide field AngleCameras (GWAC) telescopes, a network of robotic telescopes aiming at monitoring the opticaltransient sky down to R=16 with a 15 seconds imaging cadency. We applied our trainedCNN classifier on a sample of 1472 GWAC OT candidates detected by the real-time detectionpipeline. It yields a good classification performance with 94% of well classified event and afalse positive rate of 4%., Comment: 12 pages, 8 figures, 5 tables

Various mechanisms involved in schizophrenia pathophysiology, such as dopamine dysregulation, glutamate/NMDA receptor dysfunction, neuroinflammation or redox imbalance, all appear to converge towards an oxidative stress "hub" affecting parvalbumine interneurones (PVI) and their perineuronal nets (PNN) (Lancet Psychiatry. 2015;2:258-70); (Nat Rev Neurosci. 2016;17:125-34). We aim to investigate underlying mechanisms linking oxidative stress with neuroinflammatory and their long-lasting harmful consequences. In a transgenic mouse of redox dysregulation carrying a permanent deficit of glutathione synthesis (gclm-/-), the anterior cingulate cortex presented early in the development increased oxidative stress which was prevented by the antioxidant N-acetylcysteine (Eur J Neurosci. 2000;12:3721-8). This oxidative stress induced microglia activation and redox-sensitive matrix metalloproteinase 9 (MMP9) stimulation, leading to the receptor for advanced glycation end-products (RAGE) shedding into soluble and nuclear forms, and subsequently to nuclear factor-kB (NF-kB) activation and secretion of various cytokines. Blocking MMP9 activation prevented this sequence of alterations and rescued the normal maturation of PVI/PNN, even if performed after an additional insult that exacerbated the long term PVI/PNN impairments. MMP9 inhibition thus appears to be able to interrupt the vicious circle that maintains the long-lasting deleterious effects of the reciprocal interaction between oxidative stress and neuroinflammation, impacting on PVI/PNN integrity. Translation of these experimental findings to first episode patients revealed an increase in plasma soluble RAGE relative to healthy controls. This increase was associated with low prefrontal GABA levels, potentially predicting a central inhibitory/excitatory imbalance linked to RAGE shedding. This study paves the way for mechanistically related biomarkers needed for early intervention and MMP9/RAGE pathway modulation may lead to pr

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

In this paper, we report the detection and follow-ups of a super stellar flare GWAC\,181229A with an amplitude of $\Delta R\sim$9.5 mag on a M9 type star by $\text{SVOM/GWAC}$ and the dedicated follow-up telescopes. The estimated bolometric energy $E_{bol}$ is $(5.56-9.25)\times10^{34}$ ergs, which places the event to be one of the most powerful flares on ultracool stars. The magnetic strength is inferred to be (3.6-4.7) kG. Thanks to the sampling with a cadence of 15 seconds, a new component near the peak time with a very steep decay is detected in the $R$-band light curve, followed by the two-component flare template given by Davenport et al. (2014). An effective temperature of $5340\pm40$ K is measured by a blackbody shape fitting to the spectrum at the shallower phase during the flare. The filling factors of the flare are estimated to be $\sim$30\% and 19\% at the peak time and at 54 min after the first detection. The detection of the particular event with large amplitude, huge-emitted energy and a new component demonstrates that a high cadence sky monitoring cooperating with fast follow-up observations is very essential for understanding the violent magnetic activity., Comment: 14 pages, 12 figures, 4 tables, accepted by ApJ

The observation of the transient sky through a multitude of astrophysical messengers hasled to several scientific breakthroughs these last two decades thanks to the fast evolution ofthe observational techniques and strategies employed by the astronomers. Now, it requiresto be able to coordinate multi-wavelength and multi-messenger follow-up campaign withinstruments both in space and on ground jointly capable of scanning a large fraction of thesky with a high imaging cadency and duty cycle. In the optical domain, the key challengeof the wide field of view telescopes covering tens to hundreds of square degrees is to dealwith the detection, the identification and the classification of hundreds to thousands of opticaltransient (OT) candidates every night in a reasonable amount of time. In the last decade, newautomated tools based on machine learning approaches have been developed to perform thosetasks with a low computing time and a high classification efficiency. In this paper, we presentan efficient classification method using Convolutional Neural Networks (CNN) to discard anybogus falsely detected in astrophysical images in the optical domain. We designed this toolto improve the performances of the OT detection pipeline of the Ground Wide field AngleCameras (GWAC) telescopes, a network of robotic telescopes aiming at monitoring the opticaltransient sky down to R=16 with a 15 seconds imaging cadency. We applied our trainedCNN classifier on a sample of 1472 GWAC OT candidates detected by the real-time detectionpipeline. It yields a good classification performance with 94% of well classified event and afalse positive rate of 4%., Comment: 12 pages, 8 figures, 5 tables

Ascochyta blight (AB) is one of the major biotic stresses known to limit the chickpea production worldwide. To dissect the complex mechanisms of AB resistance in chickpea, three approaches, namely, transcriptome, small RNA and degradome sequencing were used. The transcriptome sequencing of 20 samples including two resistant genotypes, two susceptible genotypes and one introgression line under control and stress conditions at two time points (3rd and 7th day post inoculation) identified a total of 6767 differentially expressed genes (DEGs). These DEGs were mainly related to pathogenesis‐related proteins, disease resistance genes like NBS‐LRR, cell wall biosynthesis and various secondary metabolite synthesis genes. The small RNA sequencing of the samples resulted in the identification of 651 miRNAs which included 478 known and 173 novel miRNAs. A total of 297 miRNAs were differentially expressed between different genotypes, conditions and time points. Using degradome sequencing and in silico approaches, 2131 targets were predicted for 629 miRNAs. The combined analysis of both small RNA and transcriptome datasets identified 12 miRNA‐mRNA interaction pairs that exhibited contrasting expression in resistant and susceptible genotypes and also, a subset of genes that might be post‐transcriptionally silenced during AB infection. The comprehensive integrated analysis in the study provides better insights into the transcriptome dynamics and regulatory network components associated with AB stress in chickpea and, also offers candidate genes for chickpea improvement.

Mantle cell lymphoma (MCL) is an uncommon and typically aggressive form of lymphoma. Although often initially chemosensitive, relapse is common. Several induction and conditioning regimens are used in transplant-eligible patients, and the optimal approach remains unknown. We performed an international, retrospective study of transplant-eligible patients to assess impact of induction chemoimmunotherapy and conditioning regimens on clinical outcomes. We identified 228 patients meeting inclusion criteria. Baseline characteristics were similar among the induction groups except for some variation in age. The type of induction chemoimmunotherapy received did not influence overall response rates (ORRs) (0.43), progression-free survival (PFS) (P >.67), or overall survival (OS) (P >.35) on multivariate analysis (PFS and OS). Delivery of autologous stem cell transplant (ASCT) was associated with favorable PFS and OS (0.01) on univariate analysis only; this benefit was not seen on multivariate analysis-PFS (0.36) and OS (0.21). Compared with busulfan and melphalan (BuMel), the use of the carmustine, etoposide, cytarabine, melphalan (BEAM)-conditioning regimen was associated with inferior PFS (HR = 2.0 [95% CI 1.1-3.6], 0.02) but not OS (HR = 1.1 [95% CI 0.5-2.3], 0.81) on univariate analysis only. Within the limits of a retrospective study and modest power for some comparisons, type of induction therapy did not influence ORR, PFS, or OS for transplant-eligible patients with MCL. International efforts are required to perform randomized clinical trials evaluating chemoimmunotherapy induction regimens.Copyright © 2019 John Wiley & Sons, Ltd.

We report our photometric and spectroscopic follow-up observations of the superoutbursts of three dwarf novae (GWAC\,180415A, GWAC\,181017A and GWAC\,181211A) identified independently by the Ground Wide-angle Cameras system, one of the ground-based instruments of the China-France SVOM mission. Based on a combination of our photometry and that taken from the AAVSO, our period analysis of the superhumps enables us to determine the mass ratios to be 0.0967-0.1163, 0.1879-0.1883 and 0.0981-0.1173 for GWAC\,180415A, GWAC\,181017A and GWAC\,181211A, respectively. GWAC\,180415A can be firmly identified as a WZ sge-type dwarf novae due to its long duration ($\sim2$ weeks) multiple rebrightenings with amplitudes of 3-4 magnitudes, the early superhump associated with a double-wave modulation and the low mass ratio. The inferred low mass ratio and location in the $\varepsilon-P_{\mathrm{orb}}$ diagram suggest that GWAC\,181211A is a WZ sge-type dwarf novae candidate. The measured Balmer decrements suggest the Balmer line emission is produced from an optical thick region in GWAC\,180415A and GWAC\,181017A, and from an optical thin region in GWAC\,181211A., Comment: 15 pages, 13 figures and 5 tables, to appear in AJ

The second observational campaign of gravitational waves organized by the LIGO/Virgo Collaborations has led to several breakthroughs such as the detection of gravitational wave signals from merger systems involving black holes or neutrons stars. During O2,14 gravitational wave alerts were sent to the astronomical community with sky regions covering mostly over hundreds of square degrees. Among them, 6 have been finally confirmed as real astrophysical events. Since 2013, a new set of ground-based robotic telescopes called GWAC and its pathfinder mini-GWAC have been developed to contribute to the various challenges of themulti-messenger and time domain astronomy. The GWAC system is built up in the framework of the ground-segment system of the SVOM mission that will be devoted to the study of the multi-wavelength transient sky in the next decade. During O2, only the mini-GWAC telescopenetwork was fully operational. Due to the wide field of view and fast automatic follow-up capabilities of the mini-GWAC telescopes, they were well adapted to efficiently cover the sky localization areas of the gravitational wave event candidates. In this paper, we present the mini-GWAC pipeline we have set up to respond to the GW alerts and we report our optical follow-up observations of 8 GW alerts detected during the O2 run. Our observations provided the largest coverage of the GW localization areas in a short latency made by any optical facility. We found tens of optical transient candidates in our images, but none of those could be securely associated with any confirmed black hole-black hole merger event. Based on this first experience and the near future technical improvements of our network system, we will be more competitive to detect the optical counterparts from some gravitational wave events that will be detected during the upcoming O3 run, especially those emerging from binary neutron star mergers., Comment: 17 pages, 10 figures, 11 tables

Mantle cell lymphoma (MCL) is an uncommon and typically aggressive form of lymphoma. Although often initially chemosensitive, relapse is common. Several induction and conditioning regimens are used in transplant-eligible patients, and the optimal approach remains unknown. We performed an international, retrospective study of transplant-eligible patients to assess impact of induction chemoimmunotherapy and conditioning regimens on clinical outcomes. We identified 228 patients meeting inclusion criteria. Baseline characteristics were similar among the induction groups except for some variation in age. The type of induction chemoimmunotherapy received did not influence overall response rates (ORRs) (0.43), progression-free survival (PFS) (P >.67), or overall survival (OS) (P >.35) on multivariate analysis (PFS and OS). Delivery of autologous stem cell transplant (ASCT) was associated with favorable PFS and OS (0.01) on univariate analysis only; this benefit was not seen on multivariate analysis-PFS (0.36) and OS (0.21). Compared with busulfan and melphalan (BuMel), the use of the carmustine, etoposide, cytarabine, melphalan (BEAM)-conditioning regimen was associated with inferior PFS (HR = 2.0 [95% CI 1.1-3.6], 0.02) but not OS (HR = 1.1 [95% CI 0.5-2.3], 0.81) on univariate analysis only. Within the limits of a retrospective study and modest power for some comparisons, type of induction therapy did not influence ORR, PFS, or OS for transplant-eligible patients with MCL. International efforts are required to perform randomized clinical trials evaluating chemoimmunotherapy induction regimens.Copyright © 2019 John Wiley & Sons, Ltd.

Mantle cell lymphoma (MCL) is an uncommon and typically aggressive form of lymphoma. Although often initially chemosensitive, relapse is common. Several induction and conditioning regimens are used in transplant-eligible patients, and the optimal approach remains unknown. We performed an international, retrospective study of transplant-eligible patients to assess impact of induction chemoimmunotherapy and conditioning regimens on clinical outcomes. We identified 228 patients meeting inclusion criteria. Baseline characteristics were similar among the induction groups except for some variation in age. The type of induction chemoimmunotherapy received did not influence overall response rates (ORRs) (0.43), progression-free survival (PFS) (P > .67), or overall survival (OS) (P > .35) on multivariate analysis (PFS and OS). Delivery of autologous stem cell transplant (ASCT) was associated with favorable PFS and OS (0.01) on univariate analysis only; this benefit was not seen on multivariate analysis-PFS (0.36) and OS (0.21). Compared with busulfan and melphalan (BuMel), the use of the carmustine, etoposide, cytarabine, melphalan (BEAM)-conditioning regimen was associated with inferior PFS (HR = 2.0 [95% CI 1.1-3.6], 0.02) but not OS (HR = 1.1 [95% CI 0.5-2.3], 0.81) on univariate analysis only. Within the limits of a retrospective study and modest power for some comparisons, type of induction therapy did not influence ORR, PFS, or OS for transplant-eligible patients with MCL. International efforts are required to perform randomized clinical trials evaluating chemoimmunotherapy induction regimens.

BACKGROUND: There is increasing evidence that redox dysregulation, which can lead to oxidative stress and eventually to impairment of oligodendrocytes and parvalbumin interneurons, may underlie brain connectivity alterations in schizophrenia. Accordingly, we previously reported that levels of brain antioxidant glutathione in the medial prefrontal cortex were positively correlated with increased functional connectivity along the cingulum bundle in healthy controls but not in early psychosis patients. In a recent randomized controlled trial, we observed that 6-month supplementation with a glutathione precursor, N-acetyl-cysteine, increased brain glutathione levels and improved symptomatic expression and processing speed. METHODS: We investigated the effect of N-acetyl-cysteine supplementation on the functional connectivity between regions of the cingulate cortex, which have been linked to positive symptoms and processing speed decline. In this pilot study, we compared structural connectivity and resting-state functional connectivity between early psychosis patients treated with 6-month N-acetyl-cysteine (n = 9) or placebo (n = 11) supplementation with sex- and age-matched healthy control subjects (n = 74). RESULTS: We observed that 6-month N-acetyl-cysteine supplementation increases functional connectivity along the cingulum and more precisely between the caudal anterior part and the isthmus of the cingulate cortex. These functional changes can be partially explained by an increase of centrality of these regions in the functional brain network. CONCLUSIONS: N-acetyl-cysteine supplementation has a positive effect on functional connectivity within the cingulate cortex in early psychosis patients. To our knowledge, this is the first study suggesting that increased brain glutathione levels via N-acetyl-cysteine supplementation may improve brain functional connectivity.

Ascochyta blight (AB) is one of the major biotic stresses known to limit the chickpea production worldwide. To dissect the complex mechanisms of AB resistance in chickpea, three approaches, namely, transcriptome, small RNA and degradome sequencing were used. The transcriptome sequencing of 20 samples including two resistant genotypes, two susceptible genotypes and one introgression line under control and stress conditions at two time points (3rd and 7th day post inoculation) identified a total of 6767 differentially expressed genes (DEGs). These DEGs were mainly related to pathogenesis‐related proteins, disease resistance genes like NBS‐LRR, cell wall biosynthesis and various secondary metabolite synthesis genes. The small RNA sequencing of the samples resulted in the identification of 651 miRNAs which included 478 known and 173 novel miRNAs. A total of 297 miRNAs were differentially expressed between different genotypes, conditions and time points. Using degradome sequencing and in silico approaches, 2131 targets were predicted for 629 miRNAs. The combined analysis of both small RNA and transcriptome datasets identified 12 miRNA‐mRNA interaction pairs that exhibited contrasting expression in resistant and susceptible genotypes and also, a subset of genes that might be post‐transcriptionally silenced during AB infection. The comprehensive integrated analysis in the study provides better insights into the transcriptome dynamics and regulatory network components associated with AB stress in chickpea and, also offers candidate genes for chickpea improvement.

The second observational campaign of gravitational waves organized by the LIGO/Virgo Collaborations has led to several breakthroughs such as the detection of gravitational wave signals from merger systems involving black holes or neutrons stars. During O2,14 gravitational wave alerts were sent to the astronomical community with sky regions covering mostly over hundreds of square degrees. Among them, 6 have been finally confirmed as real astrophysical events. Since 2013, a new set of ground-based robotic telescopes called GWAC and its pathfinder mini-GWAC have been developed to contribute to the various challenges of themulti-messenger and time domain astronomy. The GWAC system is built up in the framework of the ground-segment system of the SVOM mission that will be devoted to the study of the multi-wavelength transient sky in the next decade. During O2, only the mini-GWAC telescopenetwork was fully operational. Due to the wide field of view and fast automatic follow-up capabilities of the mini-GWAC telescopes, they were well adapted to efficiently cover the sky localization areas of the gravitational wave event candidates. In this paper, we present the mini-GWAC pipeline we have set up to respond to the GW alerts and we report our optical follow-up observations of 8 GW alerts detected during the O2 run. Our observations provided the largest coverage of the GW localization areas in a short latency made by any optical facility. We found tens of optical transient candidates in our images, but none of those could be securely associated with any confirmed black hole-black hole merger event. Based on this first experience and the near future technical improvements of our network system, we will be more competitive to detect the optical counterparts from some gravitational wave events that will be detected during the upcoming O3 run, especially those emerging from binary neutron star mergers., Comment: 17 pages, 10 figures, 11 tables

We report our photometric and spectroscopic follow-up observations of the superoutbursts of three dwarf novae (GWAC\,180415A, GWAC\,181017A and GWAC\,181211A) identified independently by the Ground Wide-angle Cameras system, one of the ground-based instruments of the China-France SVOM mission. Based on a combination of our photometry and that taken from the AAVSO, our period analysis of the superhumps enables us to determine the mass ratios to be 0.0967-0.1163, 0.1879-0.1883 and 0.0981-0.1173 for GWAC\,180415A, GWAC\,181017A and GWAC\,181211A, respectively. GWAC\,180415A can be firmly identified as a WZ sge-type dwarf novae due to its long duration ($\sim2$ weeks) multiple rebrightenings with amplitudes of 3-4 magnitudes, the early superhump associated with a double-wave modulation and the low mass ratio. The inferred low mass ratio and location in the $\varepsilon-P_{\mathrm{orb}}$ diagram suggest that GWAC\,181211A is a WZ sge-type dwarf novae candidate. The measured Balmer decrements suggest the Balmer line emission is produced from an optical thick region in GWAC\,180415A and GWAC\,181017A, and from an optical thin region in GWAC\,181211A., Comment: 15 pages, 13 figures and 5 tables, to appear in AJ

Introduction: The optimal induction and conditioning regimen for patients with transplant eligible mantle cell lymphoma (MCL) remains unknown. Common approaches include the Nordic MCL2 regimen (rituximab (R), cyclophosphamide, vincristine, doxorubicin, prednisone (R-maxi-CHOP)) alternating with high-dose cytarabine (Geisler, Blood 2006) and R-Hyper CVAD/R-MA (hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone alternating with high dose methotrexate/cytarabine) (Romaguera JCO 2005). The aim of this study was to compare the efficacy of different induction and conditioning regimens in transplant eligible MCL patients. Method(s): We performed a multi-center retrospective analysis of MCL patients treated with induction chemo-immunotherapy and deemed fit enough for autologous stem cell transplant (ASCT) between December 2001 and December 2015. Patients were excluded if they did not receive rituximab with induction chemotherapy. Transplant eligibility was determined by the treating physician and patients were included if fit enough to undergo ASCT regardless of whether it was subsequently performed. Patient characteristics, prognostic factors and outcomes following treatment were collected. We used appropriate descriptive statistics to compare baseline characteristics between treatment groups, and calculated progression free (PFS), overall survival (OS) and follow up from date of diagnosis to date of disease progression or death from any cause, or death from any cause, respectively. Patients alive at last observation were censored. We used univariate Cox regression to identify associations between prognostic factors and outcomes, and covariates with P-values <0.1 were included in a Cox multivariate regression. Result(s): We identified 228 patients and grouped them according to induction regimen received. Their baseline characteristics, treatment and outcomes are summarized in Table 1. Overall, the 5 groups were mostly balanced in terms of baseli

We here report a spectroscopic monitor for the supernova SN\,2017iuk associated with the long-duration low-luminosity gamma-ray burst GRB\,171205A at a redshift of 0.037, which is up to now the third GRB-SN event away from us. Our spectroscopic observations and spectral analysis allow us to identify SN\,2017iuk as a typical broad-line type Ic SN. A comparison study suggests that the type-IcBL SN\,2017iuk resembles to SN\,2006aj in following aspects: 1) similar spectra at the nearby epochs, 2) comparable evolution of the photospheric velocity obtained from the measurements based on both \ion{Si}{2}$\lambda$6355 line and spectral modeling, and 3) comparable explosion parameters. This analogy could imply a formation of a neutron star in the core-collapse of GRB\,171205A/SN\,2017iuk as previously suggested in GRB\,060218/SN\,2006aj. The properties of the host galaxy is discussed, which suggests that GRB\,171205A/SN\,2017iuk occurred in an early type (S0), high-mass, starforming galaxy with low specific SFR and solar metallicity., Comment: 9 pages, 7 figures and 1 table. To be published in ApJ

By using the line ratio \ion{C}{4}$\lambda1549$/\ion{C}{2}$\lambda1335$ as a tracer of ionization ratio of the interstellar medium (ISM) illuminated by a long gamma-ray burst (LGRB), we identify a global photoionization response of the ionization ratio to the photon luminosity of the prompt emission assessed by either $L_{\mathrm{iso}}/E_{\mathrm{peak}}$ or $L_{\mathrm{iso}}/E^2_{\mathrm{peak}}$. The ionization ratio increases with both $L_{\mathrm{iso}}/E_{\mathrm{peak}}$ and $L_{\mathrm{iso}}/E^2_{\mathrm{peak}}$ for a majority of the LGRBs in our sample, although there are a few outliers. The identified dependence of \ion{C}{4}/\ion{C}{2} on $L_{\mathrm{iso}}/E^2_{\mathrm{peak}}$ suggests that the scatter of the widely accepted Amati relation is related with the ionization ratio in ISM. The outliers tend to have relatively high \ion{C}{4}/\ion{C}{2} values as well as relatively high \ion{C}{4}$\lambda1549$/\ion{Si}{4}$\lambda1403$ ratios, which suggests an existence of Wolf-Rayet stars in the environment of these LGRBs. We finally argue that the outliers and the LGRBs following the identified \ion{C}{4}/\ion{C}{2}$-L_{\mathrm{iso}}/E_{\mathrm{peak}}$ ($L_{\mathrm{iso}}/E^2_{\mathrm{peak}}$) correlation might come from different progenitors with different local environments., Comment: 7 pages, 3 figures and 2 tables, to be published in ApJ

Introduction: The optimal induction and conditioning regimen for patients with transplant eligible mantle cell lymphoma (MCL) remains unknown. Common approaches include the Nordic MCL2 regimen (rituximab (R), cyclophosphamide, vincristine, doxorubicin, prednisone (R-maxi-CHOP)) alternating with high-dose cytarabine (Geisler, Blood 2006) and R-Hyper CVAD/R-MA (hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone alternating with high dose methotrexate/cytarabine) (Romaguera JCO 2005). The aim of this study was to compare the efficacy of different induction and conditioning regimens in transplant eligible MCL patients. Method(s): We performed a multi-center retrospective analysis of MCL patients treated with induction chemo-immunotherapy and deemed fit enough for autologous stem cell transplant (ASCT) between December 2001 and December 2015. Patients were excluded if they did not receive rituximab with induction chemotherapy. Transplant eligibility was determined by the treating physician and patients were included if fit enough to undergo ASCT regardless of whether it was subsequently performed. Patient characteristics, prognostic factors and outcomes following treatment were collected. We used appropriate descriptive statistics to compare baseline characteristics between treatment groups, and calculated progression free (PFS), overall survival (OS) and follow up from date of diagnosis to date of disease progression or death from any cause, or death from any cause, respectively. Patients alive at last observation were censored. We used univariate Cox regression to identify associations between prognostic factors and outcomes, and covariates with P-values <0.1 were included in a Cox multivariate regression. Result(s): We identified 228 patients and grouped them according to induction regimen received. Their baseline characteristics, treatment and outcomes are summarized in Table 1. Overall, the 5 groups were mostly balanced in terms of baseli

Mechanism-based treatments for schizophrenia are needed, and increasing evidence suggests that oxidative stress may be a target. Previous research has shown that N-acetylcysteine (NAC), an antioxidant and glutathione (GSH) precursor almost devoid of side effects, improved negative symptoms, decreased the side effects of antipsychotics, and improved mismatch negativity and local neural synchronization in chronic schizophrenia. In a recent double-blind randomized placebo-controlled trial by Conus et al., early psychosis patients received NAC add-on therapy (2700 mg/day) for 6 months. Compared with placebo-treated controls, NAC patients showed significant improvements in neurocognition (processing speed) and a reduction of positive symptoms among patients with high peripheral oxidative status. NAC also led to a 23% increase in GSH levels in the medial prefrontal cortex (GSHmPFC) as measured by 1H magnetic resonance spectroscopy. A subgroup of the patients in this study were also scanned with multimodal MR imaging (spectroscopy, diffusion, and structural) at baseline (prior to NAC/placebo) and after 6 months of add-on treatment. Based on prior translational research, we hypothesized that NAC would protect white matter integrity in the fornix. A group × time interaction indicated a difference in the 6-month evolution of white matter integrity (as measured by generalized fractional anisotropy, gFA) in favor of the NAC group, which showed an 11% increase. The increase in gFA correlated with an increase in GSHmPFC over the same 6-month period. In this secondary study, we suggest that NAC add-on treatment may be a safe and effective way to protect white matter integrity in early psychosis patients.

Biomarker-guided treatments are needed in psychiatry, and previous data suggest oxidative stress may be a target in schizophrenia. A previous add-on trial with the antioxidant N-acetylcysteine (NAC) led to negative symptom reductions in chronic patients. We aim to study NAC's impact on symptoms and neurocognition in early psychosis (EP) and to explore whether glutathione (GSH)/redox markers could represent valid biomarkers to guide treatment. In a double-blind, randomized, placebo-controlled trial in 63 EP patients, we assessed the effect of NAC supplementation (2700 mg/day, 6 months) on PANSS, neurocognition, and redox markers (brain GSH [GSHmPFC], blood cells GSH levels [GSHBC], GSH peroxidase activity [GPxBC]). No changes in negative or positive symptoms or functional outcome were observed with NAC, but significant improvements were found in favor of NAC on neurocognition (processing speed). NAC also led to increases of GSHmPFC by 23% (P = .005) and GSHBC by 19% (P = .05). In patients with high-baseline GPxBC compared to low-baseline GPxBC, subgroup explorations revealed a link between changes of positive symptoms and changes of redox status with NAC. In conclusion, NAC supplementation in a limited sample of EP patients did not improve negative symptoms, which were at modest baseline levels. However, NAC led to some neurocognitive improvements and an increase in brain GSH levels, indicating good target engagement. Blood GPx activity, a redox peripheral index associated with brain GSH levels, could help identify a subgroup of patients who improve their positive symptoms with NAC. Thus, future trials with antioxidants in EP should consider biomarker-guided treatment.

We here report a spectroscopic monitor for the supernova SN\,2017iuk associated with the long-duration low-luminosity gamma-ray burst GRB\,171205A at a redshift of 0.037, which is up to now the third GRB-SN event away from us. Our spectroscopic observations and spectral analysis allow us to identify SN\,2017iuk as a typical broad-line type Ic SN. A comparison study suggests that the type-IcBL SN\,2017iuk resembles to SN\,2006aj in following aspects: 1) similar spectra at the nearby epochs, 2) comparable evolution of the photospheric velocity obtained from the measurements based on both \ion{Si}{2}$\lambda$6355 line and spectral modeling, and 3) comparable explosion parameters. This analogy could imply a formation of a neutron star in the core-collapse of GRB\,171205A/SN\,2017iuk as previously suggested in GRB\,060218/SN\,2006aj. The properties of the host galaxy is discussed, which suggests that GRB\,171205A/SN\,2017iuk occurred in an early type (S0), high-mass, starforming galaxy with low specific SFR and solar metallicity., Comment: 9 pages, 7 figures and 1 table. To be published in ApJ

By using the line ratio \ion{C}{4}$\lambda1549$/\ion{C}{2}$\lambda1335$ as a tracer of ionization ratio of the interstellar medium (ISM) illuminated by a long gamma-ray burst (LGRB), we identify a global photoionization response of the ionization ratio to the photon luminosity of the prompt emission assessed by either $L_{\mathrm{iso}}/E_{\mathrm{peak}}$ or $L_{\mathrm{iso}}/E^2_{\mathrm{peak}}$. The ionization ratio increases with both $L_{\mathrm{iso}}/E_{\mathrm{peak}}$ and $L_{\mathrm{iso}}/E^2_{\mathrm{peak}}$ for a majority of the LGRBs in our sample, although there are a few outliers. The identified dependence of \ion{C}{4}/\ion{C}{2} on $L_{\mathrm{iso}}/E^2_{\mathrm{peak}}$ suggests that the scatter of the widely accepted Amati relation is related with the ionization ratio in ISM. The outliers tend to have relatively high \ion{C}{4}/\ion{C}{2} values as well as relatively high \ion{C}{4}$\lambda1549$/\ion{Si}{4}$\lambda1403$ ratios, which suggests an existence of Wolf-Rayet stars in the environment of these LGRBs. We finally argue that the outliers and the LGRBs following the identified \ion{C}{4}/\ion{C}{2}$-L_{\mathrm{iso}}/E_{\mathrm{peak}}$ ($L_{\mathrm{iso}}/E^2_{\mathrm{peak}}$) correlation might come from different progenitors with different local environments., Comment: 7 pages, 3 figures and 2 tables, to be published in ApJ

Railway turnouts are important components of railway infrastructure as they provide flexibility and guidance to the rail traffic. Because of geometrical discontinuities in the crossing area of the turnouts, high impact forces due to passing wheels acting on the crossing nose can occur. In the field, severe rail damage problems are found in crossing areas. Statistical evidence shows that turnout failures cause major operational disturbances in a railway network, which lead to higher maintenance costs as compared with other track components. The research presented here was motivated by the short service life of the turnout crossing observed in the Dutch railway network and by the need to improve the performance of railway turnouts. Moreover, there is a lack of advanced numerical tools such as dynamic three-dimensional (3-D) models to analyse wheel–rail interactions in crossings on the stress and strain levels, particularly for models that are coupled with life estimation of the crossing. Therefore, the goal of this study is to develop numerical tools for the analysis of the dynamic interaction between the wheel and turnout crossing, and the prediction of fatigue life of crossings, aiming to improve the crossing performance and prolong its service life., Railway Engineering

In China intensification of agriculture has been achieved at a cost to the environment. The extension service is the leading public resource to address this but remains focused by a historic national ethos for food security, production and economic growth, whilst its administrative structure is hierarchical, slow to change and lacking in relevant functional integration. Investigation of three case study farming systems identifies how to rebalance productivity with stewardship of farm inputs and natural resources. Substance flow analyses for each case demonstrate that crop nutrient management can potentially be improved to reduce environmental risk without yield loss. Complementary stakeholder surveys and social network analyses identify barriers to change relating to the knowledge, attitudes, practices and operational constraints of farmers and extension agents, and to the structure and performance of agricultural knowledge and innovation systems. This combination of analyses offers an original synthesis of needs, planning priorities and strategies.

In China intensification of agriculture has been achieved at a cost to the environment. The extension service is the leading public resource to address this but remains focused by a historic national ethos for food security, production and economic growth, whilst its administrative structure is hierarchical, slow to change and lacking in relevant functional integration. Investigation of three case study farming systems identifies how to rebalance productivity with stewardship of farm inputs and natural resources. Substance flow analyses for each case demonstrate that crop nutrient management can potentially be improved to reduce environmental risk without yield loss. Complementary stakeholder surveys and social network analyses identify barriers to change relating to the knowledge, attitudes, practices and operational constraints of farmers and extension agents, and to the structure and performance of agricultural knowledge and innovation systems. This combination of analyses offers an original synthesis of needs, planning priorities and strategies.

Railway turnouts are important components of railway infrastructure as they provide flexibility and guidance to the rail traffic. Because of geometrical discontinuities in the crossing area of the turnouts, high impact forces due to passing wheels acting on the crossing nose can occur. In the field, severe rail damage problems are found in crossing areas. Statistical evidence shows that turnout failures cause major operational disturbances in a railway network, which lead to higher maintenance costs as compared with other track components. The research presented here was motivated by the short service life of the turnout crossing observed in the Dutch railway network and by the need to improve the performance of railway turnouts. Moreover, there is a lack of advanced numerical tools such as dynamic three-dimensional (3-D) models to analyse wheel–rail interactions in crossings on the stress and strain levels, particularly for models that are coupled with life estimation of the crossing. Therefore, the goal of this study is to develop numerical tools for the analysis of the dynamic interaction between the wheel and turnout crossing, and the prediction of fatigue life of crossings, aiming to improve the crossing performance and prolong its service life., Railway Engineering

To take advantage of the astrophysical potential of Gamma-Ray Bursts (GRBs), Chinese and French astrophysicists have engaged the SVOM mission (Space-based multi-band astronomical Variable Objects Monitor). Major advances in GRB studies resulting from the synergy between space and ground observations, the SVOM mission implements space and ground instrumentation. The scientific objectives of the mission put a special emphasis on two categories of GRBs: very distant GRBs at z$>$5 which constitute exceptional cosmological probes, and faint/soft nearby GRBs which allow probing the nature of the progenitors and the physics at work in the explosion. These goals have a major impact on the design of the mission: the on-board hard X-ray imager is sensitive down to 4 keV and computes on line image and rate triggers, and the follow-up telescopes on the ground are sensitive in the NIR. At the beginning of the next decade, SVOM will be the main provider of GRB positions and spectral parameters on very short time scale. The SVOM instruments will operate simultaneously with a wide range of powerful astronomical devices. This rare instrumental conjunction, combined with the relevance of the scientific topics connected with GRB studies, warrants a remarkable scientific return for SVOM. In addition, the SVOM instrumentation, primarily designed for GRB studies, composes a unique multi-wavelength observatory with rapid slew capability that will find multiple applications for the whole astronomy community beyond the specific objectives linked to GRBs. This report lists the scientific themes that will benefit from observations made with SVOM, whether they are specific GRB topics, or more generally all the issues that can take advantage of the multi-wavelength capabilities of SVOM., Comment: 67 pages, 1 frontispiece, 21 figures. Report on the Scientific prospects of the SVOM mission. Proceedings of the Workshop held from 11th to 15th April 2016 at Les Houches School of Physics, France

Paper 119, Railway Engineering

To take advantage of the astrophysical potential of Gamma-Ray Bursts (GRBs), Chinese and French astrophysicists have engaged the SVOM mission (Space-based multi-band astronomical Variable Objects Monitor). Major advances in GRB studies resulting from the synergy between space and ground observations, the SVOM mission implements space and ground instrumentation. The scientific objectives of the mission put a special emphasis on two categories of GRBs: very distant GRBs at z$>$5 which constitute exceptional cosmological probes, and faint/soft nearby GRBs which allow probing the nature of the progenitors and the physics at work in the explosion. These goals have a major impact on the design of the mission: the on-board hard X-ray imager is sensitive down to 4 keV and computes on line image and rate triggers, and the follow-up telescopes on the ground are sensitive in the NIR. At the beginning of the next decade, SVOM will be the main provider of GRB positions and spectral parameters on very short time scale. The SVOM instruments will operate simultaneously with a wide range of powerful astronomical devices. This rare instrumental conjunction, combined with the relevance of the scientific topics connected with GRB studies, warrants a remarkable scientific return for SVOM. In addition, the SVOM instrumentation, primarily designed for GRB studies, composes a unique multi-wavelength observatory with rapid slew capability that will find multiple applications for the whole astronomy community beyond the specific objectives linked to GRBs. This report lists the scientific themes that will benefit from observations made with SVOM, whether they are specific GRB topics, or more generally all the issues that can take advantage of the multi-wavelength capabilities of SVOM., Comment: 67 pages, 1 frontispiece, 21 figures. Report on the Scientific prospects of the SVOM mission. Proceedings of the Workshop held from 11th to 15th April 2016 at Les Houches School of Physics, France