Search

Gamma-ray Transient Monitor (GTM) is an all-sky monitor onboard the Distant Retrograde Orbit-A (DRO-A) satellite with the scientific objective of detecting gamma-ray transients ranging from 20 keV to 1 MeV. GTM is equipped with 5 Gamma-ray Transient Probe (GTP) detector modules, utilizing the NaI(Tl) scintillator coupled with a SiPM array. To reduce the SiPM noise, GTP makes use of a dedicated dual-channel coincident readout design. In this work, we firstly studied the impact of different coincidence times on detection efficiency and ultimately selected the 500 ns time coincidence window for offline data processing. To test the performance of GTPs and validate the Monte Carlo simulated energy response, we conducted comprehensive ground calibration tests using Hard X-ray Calibration Facility (HXCF) and radioactive sources, including energy response, detection efficiency, spatial response, bias-voltage response, and temperature dependence. We extensively presented the ground calibration results, and validated the design and mass model of GTP detector. These work paved the road for the in-flight observation and science data analysis., Comment: 13 pages, 25 figures

As the brightest gamma-ray burst ever observed, GRB 221009A provided a precious opportunity to explore spectral line features. In this paper, we performed a comprehensive spectroscopy analysis of GRB 221009A jointly with GECAM-C and Fermi/GBM data to search for emission and absorption lines. For the first time we investigated the line feature throughout this GRB including the most bright part where many instruments suffered problems, and identified prominent emission lines in multiple time intervals. The central energy of the Gaussian emission line evolves from about 37 MeV to 6 MeV, with a nearly constant ratio (about 10\%) between the line width and central energy. Particularly, we find that both the central energy and the energy flux of the emission line evolve with time as a power law decay with power law index of -1 and -2 respectively. We suggest that the observed emission lines most likely originate from the blue-shifted electron positron pair annihilation 511 keV line. We find that a standard high latitude emission scenario cannot fully interpret the observation, thus we propose that the emission line comes from some dense clumps with electron positron pairs traveling together with the jet. In this scenario, we can use the emission line to directly, for the first time, measure the bulk Lorentz factor of the jet ($\Gamma$) and reveal its time evolution (i.e. $\Gamma \sim t^{-1}$) during the prompt emission. Interestingly, we find that the flux of the annihilation line in the co-moving frame keeps constant. These discoveries of the spectral line features shed new and important lights on the physics of GRB and relativistic jet., Comment: Accepted by SCIENCE CHINA Physics, Mechanics & Astronomy (SCPMA)

Gamma-ray Transient Monitor (GTM) is an all-sky monitor onboard the Distant Retrograde Orbit-A (DRO-A) satellite with the scientific objective of detecting gamma-ray transients ranging from 20 keV to 1 MeV. GTM is equipped with 5 Gamma-ray Transient Probe (GTP) detector modules, utilizing the NaI(Tl) scintillator coupled with a SiPM array. To reduce the SiPM noise, GTP makes use of a dedicated dual-channel coincident readout design. In this work, we firstly studied the impact of different coincidence times on detection efficiency and ultimately selected the 500 ns time coincidence window for offline data processing. To test the performance of GTPs and validate the Monte Carlo simulated energy response, we conducted comprehensive ground calibration tests using Hard X-ray Calibration Facility (HXCF) and radioactive sources, including energy response, detection efficiency, spatial response, bias-voltage response, and temperature dependence. We extensively presented the ground calibration results, and validated the design and mass model of GTP detector. These work paved the road for the in-flight observation and science data analysis., Comment: 13 pages, 25 figures

The intrinsic resolution is the primary limitation on the total energy resolution of LaBr$_3$(Ce) crystal. This intrinsic resolution arises from two effects: fluctuations occurring in the process of energy transfer to luminescent centers within the LaBr$_3$(Ce) crystal and the LaBr$_3$(Ce) crystal's non-proportional luminescence. Presently, experimental measurements regarding the intrinsic resolution of LaBr$_3$(Ce) crystal are scarce, and the underlying physical mechanisms remain incompletely understood. In this paper, we aim to elucidate the concept of intrinsic resolution. We investigated the entire physical process of luminescence following energy deposition in the LaBr$_3$(Ce) crystal, quantifying the various components in the total energy resolution. We conducted a series of experimental measurements and Geant4 simulations, determining the intrinsic resolution of LaBr$_3$(Ce) crystal to 100 keV electrons as 2.12%. The non-proportionality contributes significantly at 1.43%, while fluctuations in the energy transfer process accounted for 0.27%. It is evident that non-proportionality in light output constitutes the primary source of intrinsic resolution. Horizontal and vertical unevenness in light collection contributed 0.25% and 0.07%, respectively. Statistical fluctuations showed the largest impact on the total energy resolution, at 2.86%. The contribution from fluctuations in single-photoelectron events was 0.77%. Furthermore, we reconstructed the photon response using Geant4, and the consistency between the simulated relative light yield and the experimentally measured one confirmed the reliability of the LaBr$_3$(Ce) detector mass model employed in the simulation., Comment: 11 pages, 16 figures

The early afterglow of a Gamma-ray burst (GRB) can provide critical information on the jet and progenitor of the GRB. The extreme brightness of GRB 221009A allows us to probe its early afterglow in unprecedented detail. In this letter, we report comprehensive observation results of the early afterglow of GRB 221009A (from $T_0$+660 s to $T_0$+1860 s, where $T_0$ is the \textit{Insight}-HXMT/HE trigger time) in X/$\gamma$-ray energy band (from 20 keV to 20 MeV) by \textit{Insight}-HXMT/HE, GECAM-C and \textit{Fermi}/GBM. We find that the spectrum of the early afterglow in 20 keV-20 MeV could be well described by a cutoff power-law with an extra power-law which dominates the low and high energy bands respectively. The cutoff power-law $E_{\rm peak}$ is $\sim$ 30 keV and the power-law photon index is $\sim$ 1.8 throughout the early afterglow phase. By fitting the light curves in different energy bands, we find that a significant achromatic break (from keV to TeV) is required at $T_0$ + 1246$^{+27}_{-26}$ s (i.e. 1021 s since the afterglow starting time $T_{\rm AG}$=$T_0$+225 s), providing compelling evidence of a jet break. Interestingly, both the pre-break and post-break decay slopes vary with energy, and these two slopes become closer in the lower energy band, making the break less identifiable. Intriguingly, the spectrum of the early afterglow experienced a slight hardening before the break and a softening after the break. These results provide new insights into the understanding of this remarkable GRB., Comment: Accepted for publication in ApJ Letters on 19-Jan-2024, 11 pages, 7 figures and 2 tables

As a new member of the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM) after GECAM-A and GECAM-B, GECAM-C (originally called HEBS), which was launched on board the SATech-01 satellite on July 27, 2022, aims to monitor and localize X-ray and gamma-ray transients from $\sim$ 6 keV to 6 MeV. GECAM-C utilizes a similar design to GECAM but operates in a more complex orbital environment. In this work, we utilize the secondary particles simultaneously produced by the cosmic-ray events on orbit and recorded by multiple detectors, to calibrate the relative timing accuracy between all detectors of GECAM-C. We find the result is 0.1 $\mu \rm s$, which is the highest time resolution among all GRB detectors ever flown and very helpful in timing analyses such as minimum variable timescale and spectral lags, as well as in time delay localization. Besides, we calibrate the absolute time accuracy using the one-year Crab pulsar data observed by GECAM-C and Fermi/GBM, as well as GECAM-C and GECAM-B. The results are $2.02\pm 2.26\ \mu \rm s$ and $5.82\pm 3.59\ \mu \rm s$, respectively. Finally, we investigate the spectral lag between the different energy bands of Crab pulsar observed by GECAM and GBM, which is $\sim -0.2\ {\rm \mu s\ keV^{-1}}$., Comment: submitted

The minimum variation timescale (MVT) of soft gamma-ray repeaters can be an important probe to estimate the emission region in pulsar-like models, as well as the Lorentz factor and radius of the possible relativistic jet in gamma-ray burst (GRB)-like models, thus revealing their progenitors and physical mechanisms. In this work, we systematically study the MVTs of hundreds of X-ray bursts (XRBs) from SGR J1935+2154 observed by {\it Insight}-HXMT, GECAM and Fermi/GBM from July 2014 to Jan 2022 through the Bayesian Block algorithm. We find that the MVTs peak at $\sim$ 2 ms, corresponding to a light travel time size of about 600 km, which supports the magnetospheric origin in pulsar-like models. The shock radius and the Lorentz factor of the jet are also constrained in GRB-like models. Interestingly, the MVT of the XRB associated with FRB 200428 is $\sim$ 70 ms, which is longer than that of most bursts and implies its special radiation mechanism. Besides, the median of MVTs is 7 ms, shorter than the median MVTs of 40 ms and 480 ms for short GRBs or long GRBs, respectively. However, the MVT is independent of duration, similar to GRBs. Finally, we investigate the energy dependence of MVT and suggest that there is a marginal evidence for a power-law relationship like GRBs but the rate of variation is at least about an order of magnitude smaller. These features may provide an approach to identify bursts with a magnetar origin., Comment: accepted for publication in ApJS

The determination of the absolute and relative position of a spacecraft is critical for its operation, observations, data analysis, scientific studies, as well as deep space exploration in general. A spacecraft that can determine its own absolute position autonomously may perform more than that must rely on transmission solutions. In this work, we report an absolute navigation accuracy of $\sim$ 20 km using 16-day Crab pulsar data observed with $Fermi$ Gamma ray Burst Monitor (GBM). In addition, we propose a new method with the inverse process of the triangulation for joint navigation using repeated bursts like that from the magnetar SGR J1935+2154 observed by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM) and GBM., Comment: accepted for publication in ApJS

Spectral lag of the low-energy photons with respect to the high-energy ones is a common astrophysical phenomenon (such as Gamma-ray bursts and the Crab pulsar) and may serve as a key probe to the underlying radiation mechanism. However, spectral lag in keV range of the magnetar bursts has not been systematically studied yet. In this work, we perform a detailed spectral lag analysis with the Li-CCF method for SGR J1935+2154 bursts observed by {\it Insight}-HXMT, GECAM and Fermi/GBM from July 2014 to Jan 2022. We discover that the spectral lags of about 61\% (non-zero significance >1$\sigma$) bursts from SGR J1935+2154 are linearly dependent on the photon energy ($E$) with $t_{\rm lag}(E)=\alpha (E/{\rm keV})+C$, which may be explained by a linear change of the temperature of the blackbody-emitting plasma with time. The distribution of the slope ($\alpha$) approximately follows a Gaussian function with mean and standard deviation of 0.02 ms/keV (i.e. high-energy photons arrive earlier) and 0.02 ms/keV, respectively. We also find that the distribution can be well fitted with three Gaussians with mean values of $\sim$ -0.009, 0.013 and 0.039 ms/keV, which may correspond to different origins of the bursts. These spectral lag features may have important implications on the magnetar bursts., Comment: accepted for publication in MNRAS

The brightest Gamma-ray burst, GRB 221009A, has spurred numerous theoretical investigations, with particular attention paid to the origins of ultra-high energy TeV photons during the prompt phase. However, analyzing the mechanism of radiation of photons in the $\sim$MeV range has been difficult because the high flux causes pile-up and saturation effects in most GRB detectors. In this letter, we present systematic modeling of the time-resolved spectra of the GRB using unsaturated data obtained from Fermi/GBM (precursor) and SATech-01/GECAM-C (main emission and flare). Our approach incorporates the synchrotron radiation model, which assumes an expanding emission region with relativistic speed and a global magnetic field that decays with radius, and successfully fits such a model to the observational data. Our results indicate that the spectra of the burst are fully in accordance with a synchrotron origin from relativistic electrons accelerated at a large emission radius. The lack of thermal emission in the prompt emission spectra supports a Poynting-flux-dominated jet composition., Comment: 12 pages, 6 figures, 2 tables. Accepted for publication in ApJL

The gamma-ray detectors (GRDs) of GECAM-C onborad SATech-01 satellite is designed to monitor gamma-ray transients all over the sky from 6 keV to 6 MeV. The energy response matrix is the key to do spectral measurements of bursts, which is usually generated from GEANT4 simulation and partially verified by the ground calibration. In this work, energy response matrix of GECAM-C GRD is cross-calibrated with Fermi/GBM and Swift/BAT using a sample of Gamma-Ray Bursts (GRBs) and Soft Gamma-Ray Repeaters (SGRs). The calibration results show there is a good agreement between GECAM-C and other reasonably well calibrated instrument (i.e. Fermi/GBM and Swift/BAT). We also find that different GRD detectors of GECAM-C also show consistency with each other. All these results indicate that GECAM-C GRD can provide reliable spectral measurements., Comment: preliminary version, will be updated soon

GRB 221009A is the brightest gamma-ray burst ever detected since the discovery of this kind of energetic explosions. However, an accurate measurement of the prompt emission properties of this burst is very challenging due to its exceptional brightness. With joint observations of \textit{Insight}-HXMT and GECAM-C, we made an unprecedentedly accurate measurement of the emission during the first $\sim$1800 s of GRB 221009A, including its precursor, main emission (ME, which dominates the burst in flux), flaring emission and early afterglow, in the hard X-ray to soft gamma-ray band from $\sim$ 10 keV to $\sim$ 6 MeV. Based on the GECAM-C unsaturated data of the ME, we measure a record-breaking isotropic equivalent energy ($E_{\rm iso}$) of $\bf \sim 1.5 \times 10^{55}$ erg, which is about eight times the total rest-mass energy of the Sun. The early afterglow data require a significant jet break between 650 s and 1100 s, most likely at $\sim950$ s from the afterglow starting time $T_{AG}$, which corresponds to a jet opening angle of $\sim {0.7^\circ} \ (\eta_\gamma n)^{1/8}$, where $n$ is the ambient medium density in units of $\rm cm^{-3}$ and $\eta_\gamma$ is the ratio between $\gamma$-ray energy and afterglow kinetic energy. The beaming-corrected total $\gamma$-ray energy $E_{\gamma}$ is $\sim 1.15 \times10^{51} \ (\eta_\gamma n)^{1/4}$ erg, which is typical for long GRBs. These results suggest that this GRB may have a special central engine, which could launch and collimate a very narrowly beamed jet with an ordinary energy budget, leading to exceptionally luminous gamma-ray radiation per unit solid angle. Alternatively, more GRBs might have such a narrow and bright beam, which are missed by an unfavorable viewing angle or have been detected without distance measurement., Comment: Submitted to National Science Review. This paper is under press embargo, contact the corresponding author for details

Searching for X-ray and gamma-ray bursts, including Gamma-ray bursts (GRBs), Soft Gamma-ray Repeaters (SGRs) and high energy transients associated with Gravitational wave (GW) events or Fast radio bursts (FRBs), is of great importance in the multi-messenger and multi-wavelength era. Although a coherent search based on the likelihood ratio and Gaussian statistics has been established and utilized in many studies, this Gaussian-based method could be problematic for weak and short bursts which usually have very few counts. To deal with all bursts including weak ones, here we propose the coherent search in Poisson statistics. We studied the difference between Poisson-based and Gaussian-based search methods by Monte Carlo simulations, and find that the Poisson-based search method has advantages compared to the Gaussian case especially for weak bursts. Our results show that, for very weak bursts with very low number of counts, the Poisson-based search can provide higher significance than the Gaussian-based search, and its likelihood ratio (for background fluctuation) still generally follows the chi2 distribution, making the significance estimation of searched bursts very convenient. Thus, we suggest that the coherent search based on Poisson likelihood ratio is more appropriate in the search for generic transients including very weak ones., Comment: 10 pages, 10 figures

As a new member of GECAM mission, GECAM-C (also named High Energy Burst Searcher, HEBS) was launched onboard the SATech-01 satellite on July 27th, 2022, which is capable to monitor gamma-ray transients from $\sim$ 6 keV to 6 MeV. As the main detector, there are 12 gamma-ray detectors (GRDs) equipped for GECAM-C. In order to verify the GECAM-C GRD detector performance and to validate the Monte Carlo simulations of detector response, comprehensive on-ground calibration experiments have been performed using X-ray beam and radioactive sources, including Energy-Channel relation, energy resolution, detection efficiency, SiPM voltage-gain relation and the non-uniformity of positional response. In this paper, the detailed calibration campaigns and data analysis results for GECAM-C GRDs are presented, demonstrating the excellent performance of GECAM-C GRD detectors., Comment: third version

Fast radio bursts (FRBs) are highly dispersed millisecond-duration radio bursts, of which the physical origin is still not fully understood. FRB 20201124A is one of the most actively repeating FRBs. In this paper, we present the collection of 1863 burst dynamic spectra of FRB 20201124A measured with the Five-hundred-meter Aperture Spherical radio Telescope (FAST). The current collection, taken from the observation during the FRB active phase from April to June 2021, is the largest burst sample detected in any FRB so far. The standard PSRFITs format is adopted, including dynamic spectra of the burst, and the time information of the dynamic spectra, in addition, mask files help readers to identify the pulse positions are also provided.

The intrinsic resolution is the primary limitation on the total energy resolution of LaBr$_3$(Ce) crystal. This intrinsic resolution arises from two effects: fluctuations occurring in the process of energy transfer to luminescent centers within the LaBr$_3$(Ce) crystal and the LaBr$_3$(Ce) crystal's non-proportional luminescence. Presently, experimental measurements regarding the intrinsic resolution of LaBr$_3$(Ce) crystal are scarce, and the underlying physical mechanisms remain incompletely understood. In this paper, we aim to elucidate the concept of intrinsic resolution. We investigated the entire physical process of luminescence following energy deposition in the LaBr$_3$(Ce) crystal, quantifying the various components in the total energy resolution. We conducted a series of experimental measurements and Geant4 simulations, determining the intrinsic resolution of LaBr$_3$(Ce) crystal to 100 keV electrons as 2.12%. The non-proportionality contributes significantly at 1.43%, while fluctuations in the energy transfer process accounted for 0.27%. It is evident that non-proportionality in light output constitutes the primary source of intrinsic resolution. Horizontal and vertical unevenness in light collection contributed 0.25% and 0.07%, respectively. Statistical fluctuations showed the largest impact on the total energy resolution, at 2.86%. The contribution from fluctuations in single-photoelectron events was 0.77%. Furthermore, we reconstructed the photon response using Geant4, and the consistency between the simulated relative light yield and the experimentally measured one confirmed the reliability of the LaBr$_3$(Ce) detector mass model employed in the simulation., Comment: 11 pages, 16 figures

The GECAM series of satellites utilize LaBr3(Ce), LaBr3(Ce,Sr), and NaI(Tl) crystals as sensitive materials for gamma-ray detectors (GRDs). To investigate the non-linearity in the detection of low-energy gamma rays and address errors in the E-C relationship calibration, comprehensive tests and comparative studies of the non-linearity of these three crystals were conducted using Compton electrons, radioactive sources, and mono-energetic X-rays. The non-linearity test results for Compton electrons and X-rays displayed substantial differences, with all three crystals showing higher non-linearity for X-rays and gamma-rays than for Compton electrons. Despite LaBr3(Ce) and LaBr3(Ce,Sr) crystals having higher absolute light yields, they exhibited a noticeable non-linear decrease in light yield, especially at energies below 400 keV. The NaI(Tl) crystal demonstrated excess light output in the 6~200 keV range, reaching a maximum excess of 9.2% at 30 keV in X-ray testing and up to 15.5% at 14 keV during Compton electron testing, indicating a significant advantage in the detection of low-energy gamma rays. Furthermore, this paper explores the underlying causes of the observed non-linearity in these crystals. This study not only elucidates the detector responses of GECAM, but also marks the inaugural comprehensive investigation into the non-linearity of domestically produced lanthanum bromide and sodium iodide crystals., Comment: 12pages, 16 figures

Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM) is a pair of microsatellites (i.e. GECAM-A and GECAM-B) dedicated to monitoring gamma-ray transients including gravitational waves high-energy electromagnetic counterparts, Gamma-ray Bursts, Soft Gamma-ray Repeaters, Solar Flares and Terrestrial Gamma-ray Flashes. Since launch in December 2020, GECAM-B has detected hundreds of astronomical and terrestrial events. For these bursts, localization is the key for burst identification and classification as well as follow-up observations in multi-wavelength. Here, we propose a Bayesian localization method with Poisson data with Gaussian background profile likelihood to localize GECAM bursts based on the burst counts distribution in detectors with different orientations. We demonstrate that this method can work well for all kinds of bursts, especially for extremely short ones. In addition, we propose a new method to estimate the systematic error of localization based on a confidence level test, which can overcome some problems of the existing method in literature. We validate this method by Monte Carlo simulations, and then apply it to a burst sample with accurate location and find that the mean value of the systematic error of GECAM-B localization is $\sim 2.5^{\circ}$. By considering this systematic error, we can obtain a reliable localization probability map for GECAM bursts. Our methods can be applied to other gamma-ray monitors., Comment: The paper has been accepted by Astrophysical Journal Supplement Series

Since FRB 200428 has been found to be associated with an X-ray burst from the Galactic magnetar SGR J1935+2154, it is interesting to explore whether the magnetar bursts also follow the similar active periodic behavior as some repeating FRBs. Previous studies show that there is possible period about 230 day in SGR J1935+2154 bursts. Here, we collected an updated burst sample from SGR J1935+2154, including all bursts reported by Fermi/GBM and GECAM till 2022 January. We also developed a targeted search pipeline to reveal more bursts from SGR J1935+2154 in the Fermi/GBM data from 2008 August to 2014 December (i.e. before the first burst detected by Swift/BAT). With this burst sample, we re-analyzed the possible periodicity of SGR J1935+2154 bursts using the Period Folding and Lomb-Scargle Periodogram methods. Our results show that the periodicity $\sim$238 day reported in literature is probably fake and the observation effects may introduce false periods (i.e. 55 day) according to simulation tests. We find that, for the current burst sample, the most probable period is 126.88$\pm$2.05 day, which could be interpreted as the precession of the magnetar. However, we note that the whole burst history is very complicated and difficult to be perfectly accommodated with any period reported thus far, therefore more monitoring observations of SGR J1935+2154 are required to test any periodicity hypothesis.

Realtime trigger and localization of bursts are the key functions of GECAM, which is an all-sky gamma-ray monitor launched in Dec 10, 2020. We developed a multifunctional trigger and localization software operating on the CPU of the GECAM electronic box (EBOX). This onboard software has the following features: high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation, dedicated localization algorithm optimized for short and long bursts respetively, short time latency of the trigger information which is downlinked throught the BeiDou satellite navigation System (BDS). This paper presents the detailed design and development of this trigger and localization software system of GECAM, including the main functions, general design, workflow and algorithms, as well as the verification and demonstration of this software, including the on-ground trigger tests with simulated gamma-ray bursts made by a dedicated X-ray tube and the in-flight performance to real gamma-ray bursts and magnetar bursts., Comment: Draft, comments welcome

Realtime trigger and localization of bursts are the key functions of GECAM, which is an all-sky gamma-ray monitor launched in Dec 10, 2020. We developed a multifunctional trigger and localization software operating on the CPU of the GECAM electronic box (EBOX). This onboard software has the following features: high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation, dedicated localization algorithm optimized for short and long bursts respetively, short time latency of the trigger information which is downlinked throught the BeiDou satellite navigation System (BDS). This paper presents the detailed design and deveopment of this trigger and localization software system of GECAM, including the main functions, general design, workflow and algorithms, as well as the verification and demonstration of this software, including the on-ground trigger tests with simulated gamma-ray bursts made by a dedicated X-ray tube and the in-flight performance to real gamma-ray bursts and magnetar bursts., Comment: Draft, comments welcome

Xin-Qiao Tian,1,2,* Xian-Wei Ni,3,* He-Lin Xu,2,* Lei Zheng,4 De-Li ZhuGe,2 Bin Chen,4 Cui-Tao Lu,2 Jian-Jun Yuan,1 Ying-Zheng Zhao2 1Department of Ultrasonography, Henan Provincial People’s Hospital (People’s Hospital of Zhengzhou University), Zhengzhou, 2Department of Pharmacology, College of Pharmaceutical Sciences, Wenzhou Medical University, 3Department of Ultrasonography, The Second Affiliated Hospital of Wenzhou Medical University, 4Department of Ultrasonography, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China *These authors contributed equally to this work Abstract: The present study seeks to observe the preventive effects of doxorubicin-induced cardiomyopathy (DOX-CM) in rats using targeted non-mitogenic acidic fibroblast growth factor (MaFGF) mediated by nanoparticles (NP) combined with ultrasound-targeted MB destruction (UTMD). DOX-CM rats were induced by intraperitoneally injected doxorubicin. Six weeks after intervention, the indices from the transthoracic echocardiography and velocity vector imaging showed that the left ventricular function in the MaFGF-loaded NP (MaFGF-NP) + UTMD group was significantly improved compared with the DOX-CM group. The increased malondialdehyde and decreased superoxide dismutase were observed in the DOX-CM group, while a significant increase in superoxide dismutase and a decrease in malondialdehyde were detected in the groups treated with MaFGF-NP + UTMD. From the Masson staining, the MaFGF-NP + UTMD group showed a significant difference from the DOX-CM group. The cardiac collagen volume fraction and the ratio of the perivascular collagen area to the luminal area number of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelling positive cells in the MaFGF-NP + UTMD group decreased to 8.9%, 0.55-fold, compared with the DOX-CM group (26.5%, 1.7-fold). From terminal deoxynucleotidyl transferase-med

Xin-Qiao Tian,1,2,* Xian-Wei Ni,3,* He-Lin Xu,2,* Lei Zheng,4 De-Li ZhuGe,2 Bin Chen,4 Cui-Tao Lu,2 Jian-Jun Yuan,1 Ying-Zheng Zhao2 1Department of Ultrasonography, Henan Provincial People’s Hospital (People’s Hospital of Zhengzhou University), Zhengzhou, 2Department of Pharmacology, College of Pharmaceutical Sciences, Wenzhou Medical University, 3Department of Ultrasonography, The Second Affiliated Hospital of Wenzhou Medical University, 4Department of Ultrasonography, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China *These authors contributed equally to this work Abstract: The present study seeks to observe the preventive effects of doxorubicin-induced cardiomyopathy (DOX-CM) in rats using targeted non-mitogenic acidic fibroblast growth factor (MaFGF) mediated by nanoparticles (NP) combined with ultrasound-targeted MB destruction (UTMD). DOX-CM rats were induced by intraperitoneally injected doxorubicin. Six weeks after intervention, the indices from the transthoracic echocardiography and velocity vector imaging showed that the left ventricular function in the MaFGF-loaded NP (MaFGF-NP) + UTMD group was significantly improved compared with the DOX-CM group. The increased malondialdehyde and decreased superoxide dismutase were observed in the DOX-CM group, while a significant increase in superoxide dismutase and a decrease in malondialdehyde were detected in the groups treated with MaFGF-NP + UTMD. From the Masson staining, the MaFGF-NP + UTMD group showed a significant difference from the DOX-CM group. The cardiac collagen volume fraction and the ratio of the perivascular collagen area to the luminal area number of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelling positive cells in the MaFGF-NP + UTMD group decreased to 8.9%, 0.55-fold, compared with the DOX-CM group (26.5%, 1.7-fold). From terminal deoxynucleotidyl transferase-med

Potassium and nitrogen are essential macronutrients for plant growth and have a positive impact on crop yield. Previous studies have indicated that the absorption and translocation of K+ and NO3 2 are correlated with each other in plants; however, the molecular mechanism that coordinates K+ and NO3 2 transport remains unknown. In this study, using a forward genetic approach, we isolated a low-K+-sensitive Arabidopsis thaliana mutant, lks2, that showed a leaf chlorosis phenotype under low-K+ conditions. LKS2 encodes the transporter NRT1.5/NPF7.3, a member of the NRT1/PTR (Nitrate Transporter 1/Peptide Transporter) family. The lks2/nrt1.5 mutants exhibit a remarkable defect in both K+ and NO3 2 translocation from root to shoot, especially under low-K+ conditions. This study demonstrates that LKS2 (NRT1.5) functions as a proton-coupled H+/K+ antiporter. Proton gradient can promote NRT1.5-mediated K+ release out of root parenchyma cells and facilitate K+ loading into the xylem. This study reveals that NRT1.5 plays a crucial role in K+ translocation from root to shoot and is also involved in the coordination of K+/NO3 2 distribution in plants

Ying-Zheng Zhao,1,2 Ming Zhang,1 Xin-Qiao Tian,3 Lei Zheng,4 Cui-Tao Lu1,2 1College of Pharmaceutical Sciences, Wenzhou Medical University, 2Department of Ultrasonography, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 3Department of Ultrasonic Diagnosis, Henan Provincial People’s Hospital, Zhengzhou City, Henan, 4Department of Ultrasonography, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China Abstract: Basic fibroblast growth factor (bFGF)-loaded liposome (bFGF-lip) combined with ultrasound-targeted microbubble destruction (UTMD) technique was investigated to prevent diabetic cardiomyopathy (DCM). Cardiac function and myocardial ultrastructure were assessed. Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) staining, immunohistochemistry staining, and Western blot assay were used to investigate the signal pathway underlying the expression of bFGF in DCM treatment. From Mason staining and TUNEL staining, bFGF-lip + UTMD group showed significant differences from the diabetes group and other groups treated with bFGF or bFGF-lip. The diabetes group showed similar results (myocardial capillary density, collagen volume fraction, and cardiac myocyte apoptosis index) to other bFGF treatment groups. Indexes from transthoracic echocardiography and hemodynamic evaluation also proved the same conclusion. These results confirmed that the abnormalities including diastolic dysfunctions, myocardial fibrosis, and metabolic disturbances could be suppressed by the different extents of twice-weekly bFGF treatments for 12 consecutive weeks (free bFGF or bFGF-lip +/- UTMD), with the strongest improvements observed in the bFGF-lip + UTMD group. The group combining bFGF-lip with UTMD demonstrated the highest level of bFGF expression among all the groups. The bFGF activated the PI3K/AKT signal pathway, causing the reduction of myocardial cell apop

Ying-Zheng Zhao,1,2 Ming Zhang,1 Xin-Qiao Tian,3 Lei Zheng,4 Cui-Tao Lu1,2 1College of Pharmaceutical Sciences, Wenzhou Medical University, 2Department of Ultrasonography, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 3Department of Ultrasonic Diagnosis, Henan Provincial People’s Hospital, Zhengzhou City, Henan, 4Department of Ultrasonography, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China Abstract: Basic fibroblast growth factor (bFGF)-loaded liposome (bFGF-lip) combined with ultrasound-targeted microbubble destruction (UTMD) technique was investigated to prevent diabetic cardiomyopathy (DCM). Cardiac function and myocardial ultrastructure were assessed. Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) staining, immunohistochemistry staining, and Western blot assay were used to investigate the signal pathway underlying the expression of bFGF in DCM treatment. From Mason staining and TUNEL staining, bFGF-lip + UTMD group showed significant differences from the diabetes group and other groups treated with bFGF or bFGF-lip. The diabetes group showed similar results (myocardial capillary density, collagen volume fraction, and cardiac myocyte apoptosis index) to other bFGF treatment groups. Indexes from transthoracic echocardiography and hemodynamic evaluation also proved the same conclusion. These results confirmed that the abnormalities including diastolic dysfunctions, myocardial fibrosis, and metabolic disturbances could be suppressed by the different extents of twice-weekly bFGF treatments for 12 consecutive weeks (free bFGF or bFGF-lip +/- UTMD), with the strongest improvements observed in the bFGF-lip + UTMD group. The group combining bFGF-lip with UTMD demonstrated the highest level of bFGF expression among all the groups. The bFGF activated the PI3K/AKT signal pathway, causing the reduction of myocardial cell apop

The silicon-strip tracker of the China Seismo-Electromagnetic Satellite (CSES) consists of two double-sided silicon strip detectors (DSSDs) which provide incident particle tracking information. The low-noise analog ASIC VA140 was used in this study for DSSD signal readout. A beam test on the DSSD module was performed at the Beijing Test Beam Facility of the Beijing Electron Positron Collider (BEPC) using a 400~800 MeV/c proton beam. The pedestal analysis results, RMSE noise, gain correction, and particle incident position reconstruction of the DSSD module are presented., Comment: 9 pages, 10 figures. This article is submitted to Chinese Physics C

Cui-Tao Lu,1 Ying-Zheng Zhao,2,3 Ho Lun Wong,4 Jun Cai,5 Lei Peng,2 Xin-Qiao Tian1 1The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, People’s Republic of China; 2Hainan Medical College, Haikou City, Hainan Province, People’s Republic of China; 3College of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang Province, People’s Republic of China; 4School of Pharmacy, Temple University, Philadelphia, PA, USA; 5Departments of Pediatrics and Anatomical Sciences and Neurobiology, University of Louisville School of Medicine Louisville, KY, USA Abstract: Although many agents have therapeutic potentials for central nervous system (CNS) diseases, few of these agents have been clinically used because of the brain barriers. As the protective barrier of the CNS, the blood–brain barrier and the blood–cerebrospinal fluid barrier maintain the brain microenvironment, neuronal activity, and proper functioning of the CNS. Different strategies for efficient CNS delivery have been studied. This article reviews the current approaches to open or facilitate penetration across these barriers for enhanced drug delivery to the CNS. These approaches are summarized into three broad categories: noninvasive, invasive, and miscellaneous techniques. The progresses made using these approaches are reviewed, and the associated mechanisms and problems are discussed. Keywords: drug delivery system, blood–brain barrier (BBB), central nervous system, brain-targeted therapy, cerebrospinal fluid (CSF)A Letter to the editor has been published about this paper

Cui-Tao Lu,1 Ying-Zheng Zhao,2,3 Ho Lun Wong,4 Jun Cai,5 Lei Peng,2 Xin-Qiao Tian1 1The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, People’s Republic of China; 2Hainan Medical College, Haikou City, Hainan Province, People’s Republic of China; 3College of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang Province, People’s Republic of China; 4School of Pharmacy, Temple University, Philadelphia, PA, USA; 5Departments of Pediatrics and Anatomical Sciences and Neurobiology, University of Louisville School of Medicine Louisville, KY, USA Abstract: Although many agents have therapeutic potentials for central nervous system (CNS) diseases, few of these agents have been clinically used because of the brain barriers. As the protective barrier of the CNS, the blood–brain barrier and the blood–cerebrospinal fluid barrier maintain the brain microenvironment, neuronal activity, and proper functioning of the CNS. Different strategies for efficient CNS delivery have been studied. This article reviews the current approaches to open or facilitate penetration across these barriers for enhanced drug delivery to the CNS. These approaches are summarized into three broad categories: noninvasive, invasive, and miscellaneous techniques. The progresses made using these approaches are reviewed, and the associated mechanisms and problems are discussed. Keywords: drug delivery system, blood–brain barrier (BBB), central nervous system, brain-targeted therapy, cerebrospinal fluid (CSF)A Letter to the editor has been published about this paper

In this study, Astragalus polysaccharides were concentrated by ultrafiltation membranes prepared by blending polysulfone (PSF) with activated carbon modified with nitric acid(HAC) by immersion precipitation phase inversion method. Water flux and retention to bovine serum albumin of the membranes were investigated. The morphology of membranes were also observed by scanning electron microscopy (SEM). In order to obtain best concentration performance, effects of operating pressure, feeding temperature, operating time, feeding concentration and pH value on concentration and extraction of astragalus polysaccharide were studied. The best conditions for concentration were as follows: operating pressure is 0.4 MPa, feeding temperature is 25 °C, feeding concentration is 1 g·L-1, pH value is neutral. Under these conditions, the ultrafiltration membrane flux was 62.6 L·m-2·h-1, the retention to astragalus polysaccharide was 91.2%, and the attenuation rate of water flux was 12.5% in one hour.