40 results on '"Xu, JianZhong"'
Search Results
2. A Novel Decoupled EMT Approach and Parallel Simulation Framework for Modularized Solid-state Transformers
- Author
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Feng, Moke, Gao, Chenxiang, Xu, Jianzhong, Zhao, Chengyong, Li, Gen, Feng, Moke, Gao, Chenxiang, Xu, Jianzhong, Zhao, Chengyong, and Li, Gen
- Abstract
Electromagnetic transient (EMT) modeling for the modularized solid-state transformer (MSST) faces critical difficulties because the dynamics of the complex-structured submodules, which contain dual active bridges (DAB) and multiple active bridges (MAB), are hard to be described in analytical formulas. Existing models have problems of a narrow dynamic frequency band, insufficient simulation accuracy, or are unable to operate under fast transients. This paper proposes a parallel simulation framework for MSST that preserves the original model’s broadband characteristics and remarkably improves the simulation efficiency. The main novelty towards previous work is the detailed modeling of the multi-winding transformer, the decoupled modeling of the submodules, and the parallel design of simulation processes. Finally, the proposed framework is verified through the accuracy and efficiency analysis carried out in PSCAD/EMTDC. The simulation results verify that the proposed framework has excellent accuracy and time efficiency.
- Published
- 2023
3. SOC Balancing Control Based on Predictive Power Model Amongst Supercapacitor Packs in MMC with Embedded Energy Storage System
- Author
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Xu, Jianzhong, Wang, Jin’an, Wang, Feng, Wang, Junxin, Li, Gen, Xu, Jianzhong, Wang, Jin’an, Wang, Feng, Wang, Junxin, and Li, Gen
- Abstract
Modular multilevel converter with supercapacitor (SC) packs-based energy storage system (MMC-SESS) can play a role in energy transition and renewable energy consumption. However, SESS’s imbalance problem is caused by the inconsistency of its packs, which has a negative effect on the utilization of the MMC-SESS and has become a hot research topic. Confronting this problem, this paper proposes a state of charge (SOC) balancing control strategy amongst SC packs based on a discrete time-domain predictive power model in MMC-SESS based medium-voltage direct-current (MVDC). It is a double-loop control to accurately control the charging and discharging power. The outer power control establishes a discrete time-domain predictive power model for the SOC differences. The inner current loop designs a hybrid controller based on the continuous control set-model prediction control (CCS-MPC) and the feedback control strategy to accurately track the dynamic current reference. Simulations in PSCAD/EMTDC have shown that the proposed control can achieve SOC balancing amongst SC packs and improve the dynamic response as well as mitigate the SC pack current ripples.
- Published
- 2023
4. Parental involvement in homework during Covid-19 confinement
- Author
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Universidade de Santiago de Compostela. Departamento de Pedagoxía e Didáctica, Suárez, Natalia, Fernández Alba, María Estrella, Regueiro, Bibiana, Rosário, Pedro, Xu, Jianzhong, Núñez Pérez, José Carlos, Universidade de Santiago de Compostela. Departamento de Pedagoxía e Didáctica, Suárez, Natalia, Fernández Alba, María Estrella, Regueiro, Bibiana, Rosário, Pedro, Xu, Jianzhong, and Núñez Pérez, José Carlos
- Abstract
The purpose of this study was to compare parents’ involvement in students’ homework during COVID-19 confinement and their involvement in normal circumstances. Method: 628 parents of elementary and high school students completed a questionnaire about their family and family involvement in their children’s homework. To address the objective, data were examined using mean differences and analysis of variance. Results: As predicted, the COVID-19 situation led to more time spent doing homework for students, as well as higher levels of conflict and stress within the family. In addition, parents reported having increased their homework management during confinement in terms of emotional and motivational support for their children compared to normal circumstances. Finally, the data showed more conflicts and family involvement in the families of children with special needs compared to families of children without special needs. Conclusions: The time spent in confinement posed many challenges to families’ routines and the data indicated a lack of resources available for families to manage their children’s tasks, as well as an increase in family stress and conflicts, El propósito de este estudio fue comparar la implicación de los padres en los deberes de los hijos durante el período de confinamiento por Covid-19 con la implicación en circunstancias normales. Método: 628 padres de alumnos de Primaria y Secundaria respondieron a cuestiones sobre características de la familia y su implicación en los deberes escolares de los hijos. Para abordar el objetivo, los datos se estudiaron mediante diferencias de medias y análisis de varianza. Resultados: La situación de confinamiento llevó a que los estudiantes dedicaran más tiempo a hacer los deberes, así como a niveles más altos de conflictos y estrés dentro de la familia. Además, los padres informaron haber aumentado su implicación en los deberes en cuanto a apoyo emocional y motivacional dedicado a sus hijos en comparación con las circunstancias normales. Finalmente, se obtuvieron datos que muestran mayor cantidad de conflictos y estrés en familias con niños con necesidades especiales. Conclusiones: El confinamiento planteó muchos desafíos para las rutinas de las familias, observándose una falta de recursos disponibles de las familias para implicarse adecuadamente en las tareas escolares de sus hijos, así como un aumento del estrés y los conflictos familiares
- Published
- 2022
5. A database of radiogenic Sr-Nd isotopes at the 'three poles'
- Author
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Du, Zhiheng, Yang, Jiao, Wang, Lei, Wang, Ninglian, Svensson, Anders, Zhang, Zhen, Ma, Xiangyu, Liu, Yaping, Wang, Shimeng, Xu, Jianzhong, Xiao, Cunde, Du, Zhiheng, Yang, Jiao, Wang, Lei, Wang, Ninglian, Svensson, Anders, Zhang, Zhen, Ma, Xiangyu, Liu, Yaping, Wang, Shimeng, Xu, Jianzhong, and Xiao, Cunde
- Abstract
The radiogenic isotope compositions of strontium (Sr) and neodymium (Nd) on the surface of the Earth are powerful tools for tracing dust sources and sinks on the Earth's surface. To differentiate between the spatial variabilities in eolian dust sources in key cryospheric regions at the three poles (the Arctic; Antarctica; and the "third pole ", covering the high mountainous area in Asia), a dataset of Sr-Nd isotopic compositions from extremely cold or arid terrestrial environments was compiled, similar to the method of Blanchet (2019). The database includes Holocene and Quaternary snow, ice, sand, soil (loess), sediment, and rock samples from the three poles based on 90 different references and our own measurement data, with a total of 1989 data points, comprising 206 data points with different grain sizes and 212 data points with fraction measurements. There are 485 data points from the third pole, 727 data points from the Arctic, and 777 data points from Antarctica. The sampling and measurement methods of these data are introduced. For each pole, geographical coordinates and other information are provided. The main scientific purpose of this dataset is to provide a Sr-Nd dataset based on collective documentation and our own measurements, which will be useful for determining the sources and transport pathways of dust in snow, ice, rivers, and oceans at or near the three poles as well as to investigate whether multiple dust sources are present at each of the poles. This dataset provides exhaustive detailed documentation of the isotopic signatures at the three poles during specific time intervals in the Quaternary period, which are useful for understanding the sources or sinks of eolian dust and sediments at the three poles. The dataset is available from the National Tibetan Plateau Data Center (, Du, 2022).
- Published
- 2022
6. A database of radiogenic Sr-Nd isotopes at the 'three poles'
- Author
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Du, Zhiheng, Yang, Jiao, Wang, Lei, Wang, Ninglian, Svensson, Anders, Zhang, Zhen, Ma, Xiangyu, Liu, Yaping, Wang, Shimeng, Xu, Jianzhong, Xiao, Cunde, Du, Zhiheng, Yang, Jiao, Wang, Lei, Wang, Ninglian, Svensson, Anders, Zhang, Zhen, Ma, Xiangyu, Liu, Yaping, Wang, Shimeng, Xu, Jianzhong, and Xiao, Cunde
- Abstract
The radiogenic isotope compositions of strontium (Sr) and neodymium (Nd) on the surface of the Earth are powerful tools for tracing dust sources and sinks on the Earth's surface. To differentiate between the spatial variabilities in eolian dust sources in key cryospheric regions at the three poles (the Arctic; Antarctica; and the "third pole ", covering the high mountainous area in Asia), a dataset of Sr-Nd isotopic compositions from extremely cold or arid terrestrial environments was compiled, similar to the method of Blanchet (2019). The database includes Holocene and Quaternary snow, ice, sand, soil (loess), sediment, and rock samples from the three poles based on 90 different references and our own measurement data, with a total of 1989 data points, comprising 206 data points with different grain sizes and 212 data points with fraction measurements. There are 485 data points from the third pole, 727 data points from the Arctic, and 777 data points from Antarctica. The sampling and measurement methods of these data are introduced. For each pole, geographical coordinates and other information are provided. The main scientific purpose of this dataset is to provide a Sr-Nd dataset based on collective documentation and our own measurements, which will be useful for determining the sources and transport pathways of dust in snow, ice, rivers, and oceans at or near the three poles as well as to investigate whether multiple dust sources are present at each of the poles. This dataset provides exhaustive detailed documentation of the isotopic signatures at the three poles during specific time intervals in the Quaternary period, which are useful for understanding the sources or sinks of eolian dust and sediments at the three poles. The dataset is available from the National Tibetan Plateau Data Center (, Du, 2022).
- Published
- 2022
7. Perceived parental involvement and student engagement with homework in secondary school: The mediating role of self-handicapping
- Author
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Núñez, José Carlos, Freire, Carlos, Ferradás, María del Mar, Valle, Antonio, Xu, Jianzhong, Núñez, José Carlos, Freire, Carlos, Ferradás, María del Mar, Valle, Antonio, and Xu, Jianzhong
- Abstract
[Abstract] Research in the field of homework has confirmed the significant association between students’ perceptions of their parents’ involvement and their motivation and engagement with these tasks. In this study we analyzed the possible mediating role of selfhandicapping strategies in the relationship between perceptions of parental support (content-oriented and autonomy-oriented support) when doing homework and the students’ behavioral engagement (time spent, effort made, amount of homework done, level of procrastination). The participants were 643 students in compulsory secondary education (between 7th and 10th grade). The results showed that the lower the perceptions of support from parents when doing homework, the greater the students’ use of self-handicapping strategies and the worse their behavioral engagement (less effort, less amount of homework done, more procrastination) and vice versa. These findings seem to indicate that self-handicapping is a motivational strategy that would partially explain students’ poor behavioral engagement with homework in the absence of parental support.
- Published
- 2021
8. One-Step in Situ Preparation of Polymeric Selenium Sulfide Composite as a Cathode Material for Enhanced Sodium/Potassium Storage
- Author
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Zhang, Wenchao, Wang, Hongqiang, Zhang, Na, Liu, Huaguang, Chen, Zhou, Zhang, Lijuan, Guo, Shaopeng, Li, Dan, Xu, Jianzhong, Zhang, Wenchao, Wang, Hongqiang, Zhang, Na, Liu, Huaguang, Chen, Zhou, Zhang, Lijuan, Guo, Shaopeng, Li, Dan, and Xu, Jianzhong
- Abstract
Alkali metal-sulfur/selenium batteries have attracted much attention because they offer promising high energy density. However, the shuttle effect of the polysulfide dissolutions, poor electrical conductivity, and relatively large volume variations greatly hinder their potential applications. Herein, a novel organic carbon/selenium sulfide (OC/SeS2) composite has been prepared by a one-step in situ method by heating the mixture of commercial polyacrylonitrile (PAN) with selenium sulfide powder in vacuum. The carbonized PAN matrix with an N-doped carbon ring structure could effectively confine SeS2 in the form of small molecules and regulate its electronic structure. The superior sodium/potassium storage performance of the OC/SeS2 composite electrodes stems from their rational chemical structure design, including high electrical conductivity of the N-doped organic carbon network and chemical binding with SeS2 molecules. As a result, the OC/SeS2 cathode delivers a reversible capacity of 416 mAh g-1 after 700 cycles for sodium-ion batteries and 216 mAh g-1 after 500 cycles for potassium-ion batteries at 0.5 A g-1, respectively. These findings could open a new window to develop selenium sulfide cathode for metal-sulfur/selenium batteries.
- Published
- 2019
9. One-Step in Situ Preparation of Polymeric Selenium Sulfide Composite as a Cathode Material for Enhanced Sodium/Potassium Storage
- Author
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Zhang, Wenchao, Wang, Hongqiang, Zhang, Na, Liu, Huaguang, Chen, Zhou, Zhang, Lijuan, Guo, Shaopeng, Li, Dan, Xu, Jianzhong, Zhang, Wenchao, Wang, Hongqiang, Zhang, Na, Liu, Huaguang, Chen, Zhou, Zhang, Lijuan, Guo, Shaopeng, Li, Dan, and Xu, Jianzhong
- Abstract
Alkali metal-sulfur/selenium batteries have attracted much attention because they offer promising high energy density. However, the shuttle effect of the polysulfide dissolutions, poor electrical conductivity, and relatively large volume variations greatly hinder their potential applications. Herein, a novel organic carbon/selenium sulfide (OC/SeS2) composite has been prepared by a one-step in situ method by heating the mixture of commercial polyacrylonitrile (PAN) with selenium sulfide powder in vacuum. The carbonized PAN matrix with an N-doped carbon ring structure could effectively confine SeS2 in the form of small molecules and regulate its electronic structure. The superior sodium/potassium storage performance of the OC/SeS2 composite electrodes stems from their rational chemical structure design, including high electrical conductivity of the N-doped organic carbon network and chemical binding with SeS2 molecules. As a result, the OC/SeS2 cathode delivers a reversible capacity of 416 mAh g-1 after 700 cycles for sodium-ion batteries and 216 mAh g-1 after 500 cycles for potassium-ion batteries at 0.5 A g-1, respectively. These findings could open a new window to develop selenium sulfide cathode for metal-sulfur/selenium batteries.
- Published
- 2019
10. Finite element analysis of forward slip in micro flexible rolling of thin aluminium strips
- Author
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Qu, Feijun, Xu, Jianzhong, Jiang, Zhengyi, Qu, Feijun, Xu, Jianzhong, and Jiang, Zhengyi
- Abstract
This study delineates a novel finite element model to consider a pattern of process parameters affecting the forward slip in micro flexible rolling, which focuses on the thickness transition area of the rolled strip with thickness in the micrometre range. According to the strip marking method, the forward slip is obtained by comparison between the distance of the bumped ridges on the roll and that of the markings indented by the ridges, which not only simplifies the calculation process, but also maintains the accuracy as compared with theoretical estimates. The simulation results identify the qualitative and quantitative variations of forward slip with regard to the variations in the reduction, rolling speed, estimated friction coefficient and the ratio of strip thickness to grain size, respectively, which also locate the cases wherein the relative sliding happens between the strip and the roll. The developed grain-based finite element model featuring 3D Voronoi tessellations allows for the investigation of the scatter effect of forward slip, which gets strengthened by the enhanced effect of every single grain attributed to the dispersion of fewer grains in a thinner strip with respect to constant grain size. The multilinear regression analysis is performed to establish a statistical model based upon the simulation results, which has been proven to be accurate in quantitatively describing the relationship between the forward slip and the aforementioned process parameters by considering both correlation and error analyses. The magnitudes of each process parameter affecting forward slip are also determined by variance analysis.
- Published
- 2019
11. One-Step in Situ Preparation of Polymeric Selenium Sulfide Composite as a Cathode Material for Enhanced Sodium/Potassium Storage
- Author
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Zhang, Wenchao, Wang, Hongqiang, Zhang, Na, Liu, Huaguang, Chen, Zhou, Zhang, Lijuan, Guo, Shaopeng, Li, Dan, Xu, Jianzhong, Zhang, Wenchao, Wang, Hongqiang, Zhang, Na, Liu, Huaguang, Chen, Zhou, Zhang, Lijuan, Guo, Shaopeng, Li, Dan, and Xu, Jianzhong
- Abstract
Alkali metal-sulfur/selenium batteries have attracted much attention because they offer promising high energy density. However, the shuttle effect of the polysulfide dissolutions, poor electrical conductivity, and relatively large volume variations greatly hinder their potential applications. Herein, a novel organic carbon/selenium sulfide (OC/SeS2) composite has been prepared by a one-step in situ method by heating the mixture of commercial polyacrylonitrile (PAN) with selenium sulfide powder in vacuum. The carbonized PAN matrix with an N-doped carbon ring structure could effectively confine SeS2 in the form of small molecules and regulate its electronic structure. The superior sodium/potassium storage performance of the OC/SeS2 composite electrodes stems from their rational chemical structure design, including high electrical conductivity of the N-doped organic carbon network and chemical binding with SeS2 molecules. As a result, the OC/SeS2 cathode delivers a reversible capacity of 416 mAh g-1 after 700 cycles for sodium-ion batteries and 216 mAh g-1 after 500 cycles for potassium-ion batteries at 0.5 A g-1, respectively. These findings could open a new window to develop selenium sulfide cathode for metal-sulfur/selenium batteries.
- Published
- 2019
12. One-Step in Situ Preparation of Polymeric Selenium Sulfide Composite as a Cathode Material for Enhanced Sodium/Potassium Storage
- Author
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Zhang, Wenchao, Wang, Hongqiang, Zhang, Na, Liu, Huaguang, Chen, Zhou, Zhang, Lijuan, Guo, Shaopeng, Li, Dan, Xu, Jianzhong, Zhang, Wenchao, Wang, Hongqiang, Zhang, Na, Liu, Huaguang, Chen, Zhou, Zhang, Lijuan, Guo, Shaopeng, Li, Dan, and Xu, Jianzhong
- Abstract
Alkali metal-sulfur/selenium batteries have attracted much attention because they offer promising high energy density. However, the shuttle effect of the polysulfide dissolutions, poor electrical conductivity, and relatively large volume variations greatly hinder their potential applications. Herein, a novel organic carbon/selenium sulfide (OC/SeS2) composite has been prepared by a one-step in situ method by heating the mixture of commercial polyacrylonitrile (PAN) with selenium sulfide powder in vacuum. The carbonized PAN matrix with an N-doped carbon ring structure could effectively confine SeS2 in the form of small molecules and regulate its electronic structure. The superior sodium/potassium storage performance of the OC/SeS2 composite electrodes stems from their rational chemical structure design, including high electrical conductivity of the N-doped organic carbon network and chemical binding with SeS2 molecules. As a result, the OC/SeS2 cathode delivers a reversible capacity of 416 mAh g-1 after 700 cycles for sodium-ion batteries and 216 mAh g-1 after 500 cycles for potassium-ion batteries at 0.5 A g-1, respectively. These findings could open a new window to develop selenium sulfide cathode for metal-sulfur/selenium batteries.
- Published
- 2019
13. Advances in Polar Materials for Lithium-Sulfur Batteries
- Author
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Wang, Hongqiang, Zhang, Wenchao, Xu, Jianzhong, Guo, Zaiping, Wang, Hongqiang, Zhang, Wenchao, Xu, Jianzhong, and Guo, Zaiping
- Abstract
Lithium-sulfur batteries are regarded as promising candidates for energy storage devices due to their high theoretical energy density. Various approaches are proposed to break through the obstacles that are preventing Li-S batteries from realizing practical application. Recently, the importance of the strong chemical interaction between polar materials and polysulfides is recognized by researchers to improve the performance of Li-S batteries, especially with respect to the shuttle effect. Polar materials, unlike nonpolar materials, exhibit strong interactions with polysulfides without any modification or doping because of their intrinsic polarity, absorbing the polar polysulfides and thus suppressing the notorious shuttle effect. The recent advances on polar materials for Li-S batteries are reviewed here, especially the chemical polar-polar interaction effects toward immobilizing dissolved polysulfides, and the relationship between the intrinsic properties of the polar materials and the electrochemical performance of the Li-S batteries are discussed. Polar materials, including polar inorganics in the cathode and polar organics as binder for the Li-S batteries are respectively described. Finally, future directions and prospects for the polar materials used in Li-S batteries are also proposed.
- Published
- 2018
14. Advances in Polar Materials for Lithium-Sulfur Batteries
- Author
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Wang, Hongqiang, Zhang, Wenchao, Xu, Jianzhong, Guo, Zaiping, Wang, Hongqiang, Zhang, Wenchao, Xu, Jianzhong, and Guo, Zaiping
- Abstract
Lithium-sulfur batteries are regarded as promising candidates for energy storage devices due to their high theoretical energy density. Various approaches are proposed to break through the obstacles that are preventing Li-S batteries from realizing practical application. Recently, the importance of the strong chemical interaction between polar materials and polysulfides is recognized by researchers to improve the performance of Li-S batteries, especially with respect to the shuttle effect. Polar materials, unlike nonpolar materials, exhibit strong interactions with polysulfides without any modification or doping because of their intrinsic polarity, absorbing the polar polysulfides and thus suppressing the notorious shuttle effect. The recent advances on polar materials for Li-S batteries are reviewed here, especially the chemical polar-polar interaction effects toward immobilizing dissolved polysulfides, and the relationship between the intrinsic properties of the polar materials and the electrochemical performance of the Li-S batteries are discussed. Polar materials, including polar inorganics in the cathode and polar organics as binder for the Li-S batteries are respectively described. Finally, future directions and prospects for the polar materials used in Li-S batteries are also proposed.
- Published
- 2018
15. Advances in Polar Materials for Lithium-Sulfur Batteries
- Author
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Wang, Hongqiang, Zhang, Wenchao, Xu, Jianzhong, Guo, Zaiping, Wang, Hongqiang, Zhang, Wenchao, Xu, Jianzhong, and Guo, Zaiping
- Abstract
Lithium-sulfur batteries are regarded as promising candidates for energy storage devices due to their high theoretical energy density. Various approaches are proposed to break through the obstacles that are preventing Li-S batteries from realizing practical application. Recently, the importance of the strong chemical interaction between polar materials and polysulfides is recognized by researchers to improve the performance of Li-S batteries, especially with respect to the shuttle effect. Polar materials, unlike nonpolar materials, exhibit strong interactions with polysulfides without any modification or doping because of their intrinsic polarity, absorbing the polar polysulfides and thus suppressing the notorious shuttle effect. The recent advances on polar materials for Li-S batteries are reviewed here, especially the chemical polar-polar interaction effects toward immobilizing dissolved polysulfides, and the relationship between the intrinsic properties of the polar materials and the electrochemical performance of the Li-S batteries are discussed. Polar materials, including polar inorganics in the cathode and polar organics as binder for the Li-S batteries are respectively described. Finally, future directions and prospects for the polar materials used in Li-S batteries are also proposed.
- Published
- 2018
16. Advances in Polar Materials for Lithium-Sulfur Batteries
- Author
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Wang, Hongqiang, Zhang, Wenchao, Xu, Jianzhong, Guo, Zaiping, Wang, Hongqiang, Zhang, Wenchao, Xu, Jianzhong, and Guo, Zaiping
- Abstract
Lithium-sulfur batteries are regarded as promising candidates for energy storage devices due to their high theoretical energy density. Various approaches are proposed to break through the obstacles that are preventing Li-S batteries from realizing practical application. Recently, the importance of the strong chemical interaction between polar materials and polysulfides is recognized by researchers to improve the performance of Li-S batteries, especially with respect to the shuttle effect. Polar materials, unlike nonpolar materials, exhibit strong interactions with polysulfides without any modification or doping because of their intrinsic polarity, absorbing the polar polysulfides and thus suppressing the notorious shuttle effect. The recent advances on polar materials for Li-S batteries are reviewed here, especially the chemical polar-polar interaction effects toward immobilizing dissolved polysulfides, and the relationship between the intrinsic properties of the polar materials and the electrochemical performance of the Li-S batteries are discussed. Polar materials, including polar inorganics in the cathode and polar organics as binder for the Li-S batteries are respectively described. Finally, future directions and prospects for the polar materials used in Li-S batteries are also proposed.
- Published
- 2018
17. Advances in Polar Materials for Lithium-Sulfur Batteries
- Author
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Wang, Hongqiang, Zhang, Wenchao, Xu, Jianzhong, Guo, Zaiping, Wang, Hongqiang, Zhang, Wenchao, Xu, Jianzhong, and Guo, Zaiping
- Abstract
Lithium-sulfur batteries are regarded as promising candidates for energy storage devices due to their high theoretical energy density. Various approaches are proposed to break through the obstacles that are preventing Li-S batteries from realizing practical application. Recently, the importance of the strong chemical interaction between polar materials and polysulfides is recognized by researchers to improve the performance of Li-S batteries, especially with respect to the shuttle effect. Polar materials, unlike nonpolar materials, exhibit strong interactions with polysulfides without any modification or doping because of their intrinsic polarity, absorbing the polar polysulfides and thus suppressing the notorious shuttle effect. The recent advances on polar materials for Li-S batteries are reviewed here, especially the chemical polar-polar interaction effects toward immobilizing dissolved polysulfides, and the relationship between the intrinsic properties of the polar materials and the electrochemical performance of the Li-S batteries are discussed. Polar materials, including polar inorganics in the cathode and polar organics as binder for the Li-S batteries are respectively described. Finally, future directions and prospects for the polar materials used in Li-S batteries are also proposed.
- Published
- 2018
18. Concerted effects of heterogeneous nuclear ribonucleoprotein C1/C2 to control vitamin D-directed gene transcription and RNA splicing in human bone cells.
- Author
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Zhou, Rui, Zhou, Rui, Park, Juw Won, Chun, Rene F, Lisse, Thomas S, Garcia, Alejandro J, Zavala, Kathryn, Sea, Jessica L, Lu, Zhi-Xiang, Xu, Jianzhong, Adams, John S, Xing, Yi, Hewison, Martin, Zhou, Rui, Zhou, Rui, Park, Juw Won, Chun, Rene F, Lisse, Thomas S, Garcia, Alejandro J, Zavala, Kathryn, Sea, Jessica L, Lu, Zhi-Xiang, Xu, Jianzhong, Adams, John S, Xing, Yi, and Hewison, Martin
- Abstract
Traditionally recognized as an RNA splicing regulator, heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNPC1/C2) can also bind to double-stranded DNA and function in trans as a vitamin D response element (VDRE)-binding protein. As such, hnRNPC1/C2 may couple transcription induced by the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D) with subsequent RNA splicing. In MG63 osteoblastic cells, increased expression of the 1,25(OH)2D target gene CYP24A1 involved immunoprecipitation of hnRNPC1/C2 with CYP24A1 chromatin and RNA. Knockdown of hnRNPC1/C2 suppressed expression of CYP24A1, but also increased expression of an exon 10-skipped CYP24A1 splice variant; in a minigene model the latter was attenuated by a functional VDRE in the CYP24A1 promoter. In genome-wide analyses, knockdown of hnRNPC1/C2 resulted in 3500 differentially expressed genes and 2232 differentially spliced genes, with significant commonality between groups. 1,25(OH)2D induced 324 differentially expressed genes, with 187 also observed following hnRNPC1/C2 knockdown, and a further 168 unique to hnRNPC1/C2 knockdown. However, 1,25(OH)2D induced only 10 differentially spliced genes, with no overlap with differentially expressed genes. These data indicate that hnRNPC1/C2 binds to both DNA and RNA and influences both gene expression and RNA splicing, but these actions do not appear to be linked through 1,25(OH)2D-mediated induction of transcription.
- Published
- 2017
19. Concerted effects of heterogeneous nuclear ribonucleoprotein C1/C2 to control vitamin D-directed gene transcription and RNA splicing in human bone cells.
- Author
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Zhou, Rui, Zhou, Rui, Park, Juw Won, Chun, Rene F, Lisse, Thomas S, Garcia, Alejandro J, Zavala, Kathryn, Sea, Jessica L, Lu, Zhi-Xiang, Xu, Jianzhong, Adams, John S, Xing, Yi, Hewison, Martin, Zhou, Rui, Zhou, Rui, Park, Juw Won, Chun, Rene F, Lisse, Thomas S, Garcia, Alejandro J, Zavala, Kathryn, Sea, Jessica L, Lu, Zhi-Xiang, Xu, Jianzhong, Adams, John S, Xing, Yi, and Hewison, Martin
- Abstract
Traditionally recognized as an RNA splicing regulator, heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNPC1/C2) can also bind to double-stranded DNA and function in trans as a vitamin D response element (VDRE)-binding protein. As such, hnRNPC1/C2 may couple transcription induced by the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D) with subsequent RNA splicing. In MG63 osteoblastic cells, increased expression of the 1,25(OH)2D target gene CYP24A1 involved immunoprecipitation of hnRNPC1/C2 with CYP24A1 chromatin and RNA. Knockdown of hnRNPC1/C2 suppressed expression of CYP24A1, but also increased expression of an exon 10-skipped CYP24A1 splice variant; in a minigene model the latter was attenuated by a functional VDRE in the CYP24A1 promoter. In genome-wide analyses, knockdown of hnRNPC1/C2 resulted in 3500 differentially expressed genes and 2232 differentially spliced genes, with significant commonality between groups. 1,25(OH)2D induced 324 differentially expressed genes, with 187 also observed following hnRNPC1/C2 knockdown, and a further 168 unique to hnRNPC1/C2 knockdown. However, 1,25(OH)2D induced only 10 differentially spliced genes, with no overlap with differentially expressed genes. These data indicate that hnRNPC1/C2 binds to both DNA and RNA and influences both gene expression and RNA splicing, but these actions do not appear to be linked through 1,25(OH)2D-mediated induction of transcription.
- Published
- 2017
20. Effects of hydraulic pressure on wrinkling and earing in micro hydro deep drawing of SUS304 circular cups
- Author
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Luo, Liang, Wei, Dongbin, Wang, Xiaogang, Zhou, Cunlong, Huang, Qingxue, Xu, Jianzhong, Wu, Di, Jiang, Zhengyi, Luo, Liang, Wei, Dongbin, Wang, Xiaogang, Zhou, Cunlong, Huang, Qingxue, Xu, Jianzhong, Wu, Di, and Jiang, Zhengyi
- Abstract
Influences of hydraulic pressure on forming features in micro hydro deep drawing are different from those in normal drawing due to the small size of specimens. In this study, micro hydro deep drawing of SUS304 sheets was carried out in order to study the impacts of the hydraulic pressure on the quality of the drawn cup. Experimental results indicate that there is a critical hydraulic pressure range from 3 to 6 % of the blank's initial yield stress, where wrinkling and earing development trends change twice. The wrinkling and the earing of the drawn cup also reach their local extremes in the critical pressure range. The cup earing value moves in the opposite direction from the wrinkling value. Hydraulic pressure affects the wrinkling and the earing of the drawn cup through changes in the micro-frictional condition, the shape of the blank and its strain-stress state. Micro-finite element (FE) simulation which takes these factors as well as the material size effects into consideration showed similar results to the experimental ones, thus validating the experimental results and the suitability of the micro-simulation model for micro-forming FE simulation. The experimental and simulation results indicate that the critical hydraulic pressure based on the blank's initial yield stress can restrict the wrinkling and the earing of the drawn cup. Ultra-high pressure has the potential to avoid the cup wrinkling and earing.
- Published
- 2016
21. Effects of hydraulic pressure on wrinkling and earing in micro hydro deep drawing of SUS304 circular cups
- Author
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Luo, Liang, Wei, Dongbin, Wang, Xiaogang, Zhou, Cunlong, Huang, Qingxue, Xu, Jianzhong, Wu, Di, Jiang, Zhengyi, Luo, Liang, Wei, Dongbin, Wang, Xiaogang, Zhou, Cunlong, Huang, Qingxue, Xu, Jianzhong, Wu, Di, and Jiang, Zhengyi
- Abstract
Influences of hydraulic pressure on forming features in micro hydro deep drawing are different from those in normal drawing due to the small size of specimens. In this study, micro hydro deep drawing of SUS304 sheets was carried out in order to study the impacts of the hydraulic pressure on the quality of the drawn cup. Experimental results indicate that there is a critical hydraulic pressure range from 3 to 6 % of the blank's initial yield stress, where wrinkling and earing development trends change twice. The wrinkling and the earing of the drawn cup also reach their local extremes in the critical pressure range. The cup earing value moves in the opposite direction from the wrinkling value. Hydraulic pressure affects the wrinkling and the earing of the drawn cup through changes in the micro-frictional condition, the shape of the blank and its strain-stress state. Micro-finite element (FE) simulation which takes these factors as well as the material size effects into consideration showed similar results to the experimental ones, thus validating the experimental results and the suitability of the micro-simulation model for micro-forming FE simulation. The experimental and simulation results indicate that the critical hydraulic pressure based on the blank's initial yield stress can restrict the wrinkling and the earing of the drawn cup. Ultra-high pressure has the potential to avoid the cup wrinkling and earing.
- Published
- 2016
22. Effects of hydraulic pressure on wrinkling and earing in micro hydro deep drawing of SUS304 circular cups
- Author
-
Luo, Liang, Wei, Dongbin, Wang, Xiaogang, Zhou, Cunlong, Huang, Qingxue, Xu, Jianzhong, Wu, Di, Jiang, Zhengyi, Luo, Liang, Wei, Dongbin, Wang, Xiaogang, Zhou, Cunlong, Huang, Qingxue, Xu, Jianzhong, Wu, Di, and Jiang, Zhengyi
- Abstract
Influences of hydraulic pressure on forming features in micro hydro deep drawing are different from those in normal drawing due to the small size of specimens. In this study, micro hydro deep drawing of SUS304 sheets was carried out in order to study the impacts of the hydraulic pressure on the quality of the drawn cup. Experimental results indicate that there is a critical hydraulic pressure range from 3 to 6 % of the blank's initial yield stress, where wrinkling and earing development trends change twice. The wrinkling and the earing of the drawn cup also reach their local extremes in the critical pressure range. The cup earing value moves in the opposite direction from the wrinkling value. Hydraulic pressure affects the wrinkling and the earing of the drawn cup through changes in the micro-frictional condition, the shape of the blank and its strain-stress state. Micro-finite element (FE) simulation which takes these factors as well as the material size effects into consideration showed similar results to the experimental ones, thus validating the experimental results and the suitability of the micro-simulation model for micro-forming FE simulation. The experimental and simulation results indicate that the critical hydraulic pressure based on the blank's initial yield stress can restrict the wrinkling and the earing of the drawn cup. Ultra-high pressure has the potential to avoid the cup wrinkling and earing.
- Published
- 2016
23. Effects of hydraulic pressure on wrinkling and earing in micro hydro deep drawing of SUS304 circular cups
- Author
-
Luo, Liang, Wei, Dongbin, Wang, Xiaogang, Zhou, Cunlong, Huang, Qingxue, Xu, Jianzhong, Wu, Di, Jiang, Zhengyi, Luo, Liang, Wei, Dongbin, Wang, Xiaogang, Zhou, Cunlong, Huang, Qingxue, Xu, Jianzhong, Wu, Di, and Jiang, Zhengyi
- Abstract
Influences of hydraulic pressure on forming features in micro hydro deep drawing are different from those in normal drawing due to the small size of specimens. In this study, micro hydro deep drawing of SUS304 sheets was carried out in order to study the impacts of the hydraulic pressure on the quality of the drawn cup. Experimental results indicate that there is a critical hydraulic pressure range from 3 to 6 % of the blank's initial yield stress, where wrinkling and earing development trends change twice. The wrinkling and the earing of the drawn cup also reach their local extremes in the critical pressure range. The cup earing value moves in the opposite direction from the wrinkling value. Hydraulic pressure affects the wrinkling and the earing of the drawn cup through changes in the micro-frictional condition, the shape of the blank and its strain-stress state. Micro-finite element (FE) simulation which takes these factors as well as the material size effects into consideration showed similar results to the experimental ones, thus validating the experimental results and the suitability of the micro-simulation model for micro-forming FE simulation. The experimental and simulation results indicate that the critical hydraulic pressure based on the blank's initial yield stress can restrict the wrinkling and the earing of the drawn cup. Ultra-high pressure has the potential to avoid the cup wrinkling and earing.
- Published
- 2016
24. Strengthening mechanisms of graphene sheets in aluminium matrix nanocomposites
- Author
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Fadavi Boostani, Alireza, Yazdani, Siamak, Mousavian, R Taherzadeh, Tahamtan, S, Azari Khosroshahi, R, Wei, Dongbin, Brabazon, D, Xu, Jianzhong, Zhang, Xiaoming, Jiang, Zhengyi, Fadavi Boostani, Alireza, Yazdani, Siamak, Mousavian, R Taherzadeh, Tahamtan, S, Azari Khosroshahi, R, Wei, Dongbin, Brabazon, D, Xu, Jianzhong, Zhang, Xiaoming, and Jiang, Zhengyi
- Abstract
Uniform dispersion of SiC nanoparticles with a high propensity to agglomerate within a thixoformed aluminium matrix was attained using a graphene encapsulating approach. The analytical model devised in this study has demonstrated the significant role of shear lag and thermally activated dislocation mechanisms in strengthening aluminium metal matrix composites due to the exceptional negative thermal expansion coefficient of graphene sheets. This, in turn, triggers the pinning capacity of nano-sized rod-liked aluminium carbide, prompting strong interface bonding for SiC nanoparticles with the matrix, thereby enhancing tensile elongation.
- Published
- 2015
25. Surface asperity evolution and microstructure analysis of Al 6061T5 alloy in a quasi-static cold uniaxial planar compression (CUPC)
- Author
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Li, Hejie, Jiang, Zhengyi, Wei, Dongbin, Gao, Xingjian, Xu, Jianzhong, Zhang, Xiaoming, Li, Hejie, Jiang, Zhengyi, Wei, Dongbin, Gao, Xingjian, Xu, Jianzhong, and Zhang, Xiaoming
- Abstract
In a quasi-static cold uniaxial planar compression, surface asperity evolution and microstructure analysis of Al 6061T5 alloy are carried out by employing Atomic Force Microscope (AFM) and Electron Backscattered Diffraction (EBSD) methods. Strain rate affects the surface asperity evolution obviously. While lubrication can hinder the surface asperity flattening by constraining the surface localized deformation. Lubrication can accelerate the crystallization in CUPC process. It also impedes the activation of some orientation components by hindering the activation of related slip systems in light metal Al alloy. (C) 2015 Elsevier B.V. All rights reserved.
- Published
- 2015
26. Enhanced tensile properties of aluminium matrix composites reinforced with graphene encapsulated SiC nanoparticles
- Author
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Fadavi Boostani, Alireza, Tahamtan, S, Jiang, Zhengyi, Wei, Dongbin, Yazdani, Siamak, Azari Khosroshahi, R, Mousavian, R Taherzadeh, Xu, Jianzhong, Zhang, X M, Gong, Dianyao, Fadavi Boostani, Alireza, Tahamtan, S, Jiang, Zhengyi, Wei, Dongbin, Yazdani, Siamak, Azari Khosroshahi, R, Mousavian, R Taherzadeh, Xu, Jianzhong, Zhang, X M, and Gong, Dianyao
- Abstract
Due to a high propensity of nano-particles to agglomerate, making aluminium matrix composites with a uniform dispersion of the nano-particles using liquid routes is an exceptionally difficult task. In this study, an innovative approach was utilised to prevent agglomeration of nano-particle by encapsulating SiC nano-particles using graphene sheets during ball milling. Subsequently, the milled mixture was incorporated into A356 molten alloy using non-contact ultrasonic vibration method. Two different shapes for graphene sheets were characterised using HRTEM, including onion-like shells encapsulating SiC particles and disk-shaped graphene nanosheets. This resulted in 45% and 84% improvement in yield strength and tensile ductility, respectively. The former was ascribed to the Orowan strengthening mechanism, while the latter is due primarily to the fiber pull-out mechanism, brought about by the alteration of the solidification mechanism from particle pushing to particle engulfment during solidification as a consequence of high thermal conductive graphene sheets encapsulating SiC particles.
- Published
- 2015
27. Enhanced tensile properties of aluminium matrix composites reinforced with graphene encapsulated SiC nanoparticles
- Author
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Fadavi Boostani, Alireza, Tahamtan, S, Jiang, Zhengyi, Wei, Dongbin, Yazdani, Siamak, Azari Khosroshahi, R, Mousavian, R Taherzadeh, Xu, Jianzhong, Zhang, X M, Gong, Dianyao, Fadavi Boostani, Alireza, Tahamtan, S, Jiang, Zhengyi, Wei, Dongbin, Yazdani, Siamak, Azari Khosroshahi, R, Mousavian, R Taherzadeh, Xu, Jianzhong, Zhang, X M, and Gong, Dianyao
- Abstract
Due to a high propensity of nano-particles to agglomerate, making aluminium matrix composites with a uniform dispersion of the nano-particles using liquid routes is an exceptionally difficult task. In this study, an innovative approach was utilised to prevent agglomeration of nano-particle by encapsulating SiC nano-particles using graphene sheets during ball milling. Subsequently, the milled mixture was incorporated into A356 molten alloy using non-contact ultrasonic vibration method. Two different shapes for graphene sheets were characterised using HRTEM, including onion-like shells encapsulating SiC particles and disk-shaped graphene nanosheets. This resulted in 45% and 84% improvement in yield strength and tensile ductility, respectively. The former was ascribed to the Orowan strengthening mechanism, while the latter is due primarily to the fiber pull-out mechanism, brought about by the alteration of the solidification mechanism from particle pushing to particle engulfment during solidification as a consequence of high thermal conductive graphene sheets encapsulating SiC particles.
- Published
- 2015
28. Effects of temperature and strain rate on microstructure and mechanical properties of high chromium cast iron/low carbon steel bimetal prepared by hot diffusion-compression bonding
- Author
-
Gao, Xingjian, Jiang, Zhengyi, Wei, Dongbin, Jiao, Sihai, Chen, Dengfu, Xu, Jianzhong, Zhang, Xiaoming, Gong, Dianyao, Gao, Xingjian, Jiang, Zhengyi, Wei, Dongbin, Jiao, Sihai, Chen, Dengfu, Xu, Jianzhong, Zhang, Xiaoming, and Gong, Dianyao
- Abstract
The objective of this study is to develop a hot diffusion-compression bonding process for cladding low carbon steel (LCS) to high chromium cast iron (HCCI) in solid-state. The influence of temperature (950-1150 degrees C) and strain rate (0.001-1 s (1)) on microstructure, hardness and bond strength of the HCCI/LCS bimetal were investigated. The interface microstructure reveals that the unbonded region can only be found for 950 degrees C due to lack of diffusion, while the intergrowth between the constituent metals occurred at and above 1100 degrees C. When bonding temperature increases to 1150 degrees C, a carbide-free zone was observed near the interface on the HCCI layer, and the thickness of the zone decreases with an increase of bonding strain rate. These evolutions indicate that the bond quality was improved by raising temperature and reducing strain rate due to the increase of element diffusion. The hot compression process of the bonding treatment not only changes the carbide orientation of the HCCI, but also increases the volume fraction of Cr-carbide. Based on the microstructural examinations and mechanical tests, the optimum bonding temperature and bonding strain rate are determined to be 1150 degrees C and 0.001 s (1), respectively.
- Published
- 2014
29. Effects of temperature and strain rate on microstructure and mechanical properties of high chromium cast iron/low carbon steel bimetal prepared by hot diffusion-compression bonding
- Author
-
Gao, Xingjian, Jiang, Zhengyi, Wei, Dongbin, Jiao, Sihai, Chen, Dengfu, Xu, Jianzhong, Zhang, Xiaoming, Gong, Dianyao, Gao, Xingjian, Jiang, Zhengyi, Wei, Dongbin, Jiao, Sihai, Chen, Dengfu, Xu, Jianzhong, Zhang, Xiaoming, and Gong, Dianyao
- Abstract
The objective of this study is to develop a hot diffusion-compression bonding process for cladding low carbon steel (LCS) to high chromium cast iron (HCCI) in solid-state. The influence of temperature (950-1150 degrees C) and strain rate (0.001-1 s (1)) on microstructure, hardness and bond strength of the HCCI/LCS bimetal were investigated. The interface microstructure reveals that the unbonded region can only be found for 950 degrees C due to lack of diffusion, while the intergrowth between the constituent metals occurred at and above 1100 degrees C. When bonding temperature increases to 1150 degrees C, a carbide-free zone was observed near the interface on the HCCI layer, and the thickness of the zone decreases with an increase of bonding strain rate. These evolutions indicate that the bond quality was improved by raising temperature and reducing strain rate due to the increase of element diffusion. The hot compression process of the bonding treatment not only changes the carbide orientation of the HCCI, but also increases the volume fraction of Cr-carbide. Based on the microstructural examinations and mechanical tests, the optimum bonding temperature and bonding strain rate are determined to be 1150 degrees C and 0.001 s (1), respectively.
- Published
- 2014
30. Effects of temperature and strain rate on microstructure and mechanical properties of high chromium cast iron/low carbon steel bimetal prepared by hot diffusion-compression bonding
- Author
-
Gao, Xingjian, Jiang, Zhengyi, Wei, Dongbin, Jiao, Sihai, Chen, Dengfu, Xu, Jianzhong, Zhang, Xiaoming, Gong, Dianyao, Gao, Xingjian, Jiang, Zhengyi, Wei, Dongbin, Jiao, Sihai, Chen, Dengfu, Xu, Jianzhong, Zhang, Xiaoming, and Gong, Dianyao
- Abstract
The objective of this study is to develop a hot diffusion-compression bonding process for cladding low carbon steel (LCS) to high chromium cast iron (HCCI) in solid-state. The influence of temperature (950-1150 degrees C) and strain rate (0.001-1 s (1)) on microstructure, hardness and bond strength of the HCCI/LCS bimetal were investigated. The interface microstructure reveals that the unbonded region can only be found for 950 degrees C due to lack of diffusion, while the intergrowth between the constituent metals occurred at and above 1100 degrees C. When bonding temperature increases to 1150 degrees C, a carbide-free zone was observed near the interface on the HCCI layer, and the thickness of the zone decreases with an increase of bonding strain rate. These evolutions indicate that the bond quality was improved by raising temperature and reducing strain rate due to the increase of element diffusion. The hot compression process of the bonding treatment not only changes the carbide orientation of the HCCI, but also increases the volume fraction of Cr-carbide. Based on the microstructural examinations and mechanical tests, the optimum bonding temperature and bonding strain rate are determined to be 1150 degrees C and 0.001 s (1), respectively.
- Published
- 2014
31. Effects of temperature and strain rate on microstructure and mechanical properties of high chromium cast iron/low carbon steel bimetal prepared by hot diffusion-compression bonding
- Author
-
Gao, Xingjian, Jiang, Zhengyi, Wei, Dongbin, Jiao, Sihai, Chen, Dengfu, Xu, Jianzhong, Zhang, Xiaoming, Gong, Dianyao, Gao, Xingjian, Jiang, Zhengyi, Wei, Dongbin, Jiao, Sihai, Chen, Dengfu, Xu, Jianzhong, Zhang, Xiaoming, and Gong, Dianyao
- Abstract
The objective of this study is to develop a hot diffusion-compression bonding process for cladding low carbon steel (LCS) to high chromium cast iron (HCCI) in solid-state. The influence of temperature (950-1150 degrees C) and strain rate (0.001-1 s (1)) on microstructure, hardness and bond strength of the HCCI/LCS bimetal were investigated. The interface microstructure reveals that the unbonded region can only be found for 950 degrees C due to lack of diffusion, while the intergrowth between the constituent metals occurred at and above 1100 degrees C. When bonding temperature increases to 1150 degrees C, a carbide-free zone was observed near the interface on the HCCI layer, and the thickness of the zone decreases with an increase of bonding strain rate. These evolutions indicate that the bond quality was improved by raising temperature and reducing strain rate due to the increase of element diffusion. The hot compression process of the bonding treatment not only changes the carbide orientation of the HCCI, but also increases the volume fraction of Cr-carbide. Based on the microstructural examinations and mechanical tests, the optimum bonding temperature and bonding strain rate are determined to be 1150 degrees C and 0.001 s (1), respectively.
- Published
- 2014
32. A tissue-engineered subcutaneous pancreatic cancer model for antitumor drug evaluation
- Author
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He,Qingyi, Wang,Xiaohui, Zhang,Xing, Han,Huifang, Han,Baosan, Xu,Jianzhong, Tang,Kanglai, Fu,Zhiren, Yin,Hao, He,Qingyi, Wang,Xiaohui, Zhang,Xing, Han,Huifang, Han,Baosan, Xu,Jianzhong, Tang,Kanglai, Fu,Zhiren, and Yin,Hao
- Abstract
Qingyi He,2,* Xiaohui Wang,3,* Xing Zhang,4 Huifang Han,4 Baosan Han,5 Jianzhong Xu,2 Kanglai Tang,2 Zhiren Fu,1 Hao Yin1,4 1Department of Surgery, Organ Transplant Center, Shanghai Changzheng Hospital, Shanghai Second Military Medical School, 2Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University, Chongqing, 3Department of General Surgery, Bayinguoleng Mengguzizhizhou People's Hospital, Korla, Xinjiang, People's Republic of China; 4Department of Surgery, The University of Chicago, Chicago, IL, USA; 5Department of Surgery, Shanghai Xinhua Hospital, Shanghai, People's Republic of China*These authors contributed equally to this workAbstract: The traditional xenograft subcutaneous pancreatic cancer model is notorious for its low incidence of tumor formation, inconsistent results for the chemotherapeutic effects of drug molecules of interest, and a poor predictive capability for the clinical efficacy of novel drugs. These drawbacks are attributed to a variety of factors, including inoculation of heterogeneous tumor cells from patients with different pathological histories, and use of poorly defined Matrigel®. In this study, we aimed to tissue-engineer a pancreatic cancer model that could readily cultivate a pancreatic tumor derived from highly homogenous CD24+CD44+ pancreatic cancer stem cells delivered by a well defined electrospun scaffold of poly(glycolide-co-trimethylene carbonate) and gelatin. The scaffold supported in vitro tumorigenesis from CD24+CD44+ cancer stem cells for up to 7 days without inducing apoptosis. Moreover, CD24+CD44+ cancer stem cells delivered by the scaffold grew into a native-like mature pancreatic tumor within 8 weeks in vivo and exhibited accelerated tumorigenesis as well as a higher incidence of tumor formation than the traditional model. In the scaffold model, we discovered that oxaliplatin-gemcitabine (OXA-GEM), a chemotherapeutic regimen, induced tumor regression whereas
- Published
- 2013
33. A tissue-engineered subcutaneous pancreatic cancer model for antitumor drug evaluation
- Author
-
He,Qingyi, Wang,Xiaohui, Zhang,Xing, Han,Huifang, Han,Baosan, Xu,Jianzhong, Tang,Kanglai, Fu,Zhiren, Yin,Hao, He,Qingyi, Wang,Xiaohui, Zhang,Xing, Han,Huifang, Han,Baosan, Xu,Jianzhong, Tang,Kanglai, Fu,Zhiren, and Yin,Hao
- Abstract
Qingyi He,2,* Xiaohui Wang,3,* Xing Zhang,4 Huifang Han,4 Baosan Han,5 Jianzhong Xu,2 Kanglai Tang,2 Zhiren Fu,1 Hao Yin1,4 1Department of Surgery, Organ Transplant Center, Shanghai Changzheng Hospital, Shanghai Second Military Medical School, 2Department of Orthopedic Surgery, Southwest Hospital, Third Military Medical University, Chongqing, 3Department of General Surgery, Bayinguoleng Mengguzizhizhou People's Hospital, Korla, Xinjiang, People's Republic of China; 4Department of Surgery, The University of Chicago, Chicago, IL, USA; 5Department of Surgery, Shanghai Xinhua Hospital, Shanghai, People's Republic of China*These authors contributed equally to this workAbstract: The traditional xenograft subcutaneous pancreatic cancer model is notorious for its low incidence of tumor formation, inconsistent results for the chemotherapeutic effects of drug molecules of interest, and a poor predictive capability for the clinical efficacy of novel drugs. These drawbacks are attributed to a variety of factors, including inoculation of heterogeneous tumor cells from patients with different pathological histories, and use of poorly defined Matrigel®. In this study, we aimed to tissue-engineer a pancreatic cancer model that could readily cultivate a pancreatic tumor derived from highly homogenous CD24+CD44+ pancreatic cancer stem cells delivered by a well defined electrospun scaffold of poly(glycolide-co-trimethylene carbonate) and gelatin. The scaffold supported in vitro tumorigenesis from CD24+CD44+ cancer stem cells for up to 7 days without inducing apoptosis. Moreover, CD24+CD44+ cancer stem cells delivered by the scaffold grew into a native-like mature pancreatic tumor within 8 weeks in vivo and exhibited accelerated tumorigenesis as well as a higher incidence of tumor formation than the traditional model. In the scaffold model, we discovered that oxaliplatin-gemcitabine (OXA-GEM), a chemotherapeutic regimen, induced tumor regression whereas
- Published
- 2013
34. Mechanics of design and model development of CVC-plus roll curve
- Author
-
Xu, Jianzhong, Gong, Dianyao, Jiang, Zhengyi, Liu, Xianghua, Wang, Guodong, Xu, Jianzhong, Gong, Dianyao, Jiang, Zhengyi, Liu, Xianghua, and Wang, Guodong
- Abstract
The mathematic model of CVC-Plus work roll curve is built. The ratio of the initial shifting value to the target crown is determined, and the mathematical model considering the relationship between the coefficients A2, A3, A4, A5 and is established. According to the theoretical analysis, the distance between the maximum or minimum point of the high order equivalent crown for work roll with CVC-plus roll curve and the rolling central point is the times of the roll barrel length. In general, the initial shifting value of the CVC-plus roll curve is not equal to the initial shifting value of the 3-order CVC roll curve . The coefficient A1 can also be obtained by optimizing the target function with minimizing the axial force.
- Published
- 2012
35. Effect of asymmetrical stand stiffness on hot rolled strip shape
- Author
-
Gong, Dianyao, Xu, Jianzhong, Jiang, Zhengyi, Zhang, Xiaoming, Liu, Xianghua, Wang, Guodong, Gong, Dianyao, Xu, Jianzhong, Jiang, Zhengyi, Zhang, Xiaoming, Liu, Xianghua, and Wang, Guodong
- Abstract
The difference of elastic springs between the operating side (OS) and driving side (DS) of rolling mill has a significant influence on the strip shape not just the strip thickness. Based on the slit beam and roll deformation theories, the roll force distribution was analysed considering the asymmetric stiffness of the OS and DS of rolling mill, and the work roll and backup roll deformation equations were deduced respectively, and the thickness distribution in lateral direction of the hot rolled strip at exit was discussed. Using the roll elastic deformation analysis software which was developed previously based on the influence coefficient method, the roll flattening distribution, roll pressure distribution and the rolling force distribution caused by the asymmetric stand stiffness were calculated and analysed, and the exit strip profile of the rolling mill was also presented. The relationship between the mill stiffness difference and the strip wedge shape or single wave was obtained. Effect of the upstream asymmetric mill on strip crown and flatness of the downstream stands was discussed.
- Published
- 2008
36. Effect of asymmetrical stand stiffness on hot rolled strip shape
- Author
-
Gong, Dianyao, Xu, Jianzhong, Jiang, Zhengyi, Zhang, Xiaoming, Liu, Xianghua, Wang, Guodong, Gong, Dianyao, Xu, Jianzhong, Jiang, Zhengyi, Zhang, Xiaoming, Liu, Xianghua, and Wang, Guodong
- Abstract
The difference of elastic springs between the operating side (OS) and driving side (DS) of rolling mill has a significant influence on the strip shape not just the strip thickness. Based on the slit beam and roll deformation theories, the roll force distribution was analysed considering the asymmetric stiffness of the OS and DS of rolling mill, and the work roll and backup roll deformation equations were deduced respectively, and the thickness distribution in lateral direction of the hot rolled strip at exit was discussed. Using the roll elastic deformation analysis software which was developed previously based on the influence coefficient method, the roll flattening distribution, roll pressure distribution and the rolling force distribution caused by the asymmetric stand stiffness were calculated and analysed, and the exit strip profile of the rolling mill was also presented. The relationship between the mill stiffness difference and the strip wedge shape or single wave was obtained. Effect of the upstream asymmetric mill on strip crown and flatness of the downstream stands was discussed.
- Published
- 2008
37. Effect of asymmetrical stand stiffness on hot rolled strip shape
- Author
-
Gong, Dianyao, Xu, Jianzhong, Jiang, Zhengyi, Zhang, Xiaoming, Liu, Xianghua, Wang, Guodong, Gong, Dianyao, Xu, Jianzhong, Jiang, Zhengyi, Zhang, Xiaoming, Liu, Xianghua, and Wang, Guodong
- Abstract
The difference of elastic springs between the operating side (OS) and driving side (DS) of rolling mill has a significant influence on the strip shape not just the strip thickness. Based on the slit beam and roll deformation theories, the roll force distribution was analysed considering the asymmetric stiffness of the OS and DS of rolling mill, and the work roll and backup roll deformation equations were deduced respectively, and the thickness distribution in lateral direction of the hot rolled strip at exit was discussed. Using the roll elastic deformation analysis software which was developed previously based on the influence coefficient method, the roll flattening distribution, roll pressure distribution and the rolling force distribution caused by the asymmetric stand stiffness were calculated and analysed, and the exit strip profile of the rolling mill was also presented. The relationship between the mill stiffness difference and the strip wedge shape or single wave was obtained. Effect of the upstream asymmetric mill on strip crown and flatness of the downstream stands was discussed.
- Published
- 2008
38. Effect of asymmetrical stand stiffness on hot rolled strip shape
- Author
-
Gong, Dianyao, Xu, Jianzhong, Jiang, Zhengyi, Zhang, Xiaoming, Liu, Xianghua, Wang, Guodong, Gong, Dianyao, Xu, Jianzhong, Jiang, Zhengyi, Zhang, Xiaoming, Liu, Xianghua, and Wang, Guodong
- Abstract
The difference of elastic springs between the operating side (OS) and driving side (DS) of rolling mill has a significant influence on the strip shape not just the strip thickness. Based on the slit beam and roll deformation theories, the roll force distribution was analysed considering the asymmetric stiffness of the OS and DS of rolling mill, and the work roll and backup roll deformation equations were deduced respectively, and the thickness distribution in lateral direction of the hot rolled strip at exit was discussed. Using the roll elastic deformation analysis software which was developed previously based on the influence coefficient method, the roll flattening distribution, roll pressure distribution and the rolling force distribution caused by the asymmetric stand stiffness were calculated and analysed, and the exit strip profile of the rolling mill was also presented. The relationship between the mill stiffness difference and the strip wedge shape or single wave was obtained. Effect of the upstream asymmetric mill on strip crown and flatness of the downstream stands was discussed.
- Published
- 2008
39. A hybrid h-bridge fault current limiter for HVDC grid protection
- Author
-
Xu, Jianzhong, Wu, Dongyi, Yan, Jun, Li, Gen, Zhao, Chengyong, Xu, Jianzhong, Wu, Dongyi, Yan, Jun, Li, Gen, and Zhao, Chengyong
- Abstract
For half-bridge modular multilevel converter (MMC) based HVDC grids, the fast clearance of DC faults can be achieved by DC circuit breakers (DCCBs). The hybrid fault current limiter (FCL) can be used to assist DCCBs for faster interruption less capacity. Thus, this paper proposes a novel Hbridge hybrid FCL to realize a tradeoff of comprehensive performance. The current commutation branch in the FCL can bidirectionally limit the rate-of-rise of the fault current during the current transfer stage. The working principle and the electrical stress analysis are presented and the impact of the hybrid FCL on the transient energy transfer is analyzed. These approaches are validated by simulations of a ± 500 kV bipolar HVDC grid in PSCAD/EMTDC. Results show that the proposed FCL can reduce the application of IGBTs and the requirement of MOV with the fast speed of fault isolation.
40. Strategy for switchover between the ground return and the metallic return operation modes of MTDC systems
- Author
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Huang, Manxi, Pan, Hengy, Li, Gen, Xu, Jianzhong, Jia, Xiufang, Huang, Manxi, Pan, Hengy, Li, Gen, Xu, Jianzhong, and Jia, Xiufang
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