Search

Topological approach has been shown a promising study toward to the light ring in a generic black hole background. We in this paper generalize it to the study of timelike circular orbits in static, spherically symmetric, and asymptotic flat black holes. By making use of the equation of motion of the massive particles, we construct a vector with its zero points exactly relating with the timelike circular orbits. Since each zero point of the vector can be endowed with a winding number, the topology of the timelike circular orbits is established. Stable and unstable timelike circular orbits respectively have winding number +1 and -1. In particular, different from that of the light ring, the timelike circular orbits possess vanishing topological number and appear in pairs for given angular momentum. Moreover, we apply the study to the Schwarzschild, scalarized Einstein-Maxwell, and dyonic black holes, which have distinct topological configurations. It is shown that although the existence of scalar hair and quasi-topological term leads to richer topological configurations of the timelike circular orbits, whereas they have no influence on the topological number. These results indicate that the topological approach indeed provides us a novel way to understand the timelike circular orbits. More information is expected to be disclosed when other different topological configurations are present., Comment: 24 pages, 16 figures

Our knowledge of Giga-electron volt (GeV) radio galaxies has been revolutionized by the Fermi-LAT Telescope, which provides an excellent opportunity to study the physical properties of GeV radio galaxies. According to the radio power and morphology, radio galaxies can be separated into Fanaroff-Riley Type I radio galaxies (FR-Is) and Type II radio galaxies (FR-IIs). In this paper, we consider the unification of FR-Is and BL Lacertae objects (BL Lacs), and assume FR-Is to be a standard candle to discuss the beaming effect for Fermi-LAT-detected FR-Is. Our main conclusions are as follows: (1) The estimated Doppler factors for 30 Fermi-LAT-detected FR-Is are in a range of $\delta_{\rm{I}}=0.88-7.49$. The average Doppler factor ($<\delta_{\rm{I}}>=2.56\pm0.30$) of the 30 FR-Is is smaller than that ($<\delta_{\rm{BL}}>=10.28\pm2.03$) of the 126 Fermi-LAT-detected BL Lacs, supporting the unification model that FR-Is are regarded as the misaligned BL Lacs with smaller Doppler factors; (2) We propose that different regions of FR-Is in the plot of the $\gamma$-ray luminosity against the photon spectral index $(\log L_{\gamma}-\alpha_{\rm{ph}})$ may indicate the different beaming effects; (3) The average Doppler factor of the 6 TeV FR-Is is similar to that of the 24 non-TeV FR-Is, which implies that the difference between the TeV and GeV emissions is not driven by the beaming effect in the Fermi-LAT-detected FR-I samples., Comment: 15 pages, 6 figures, 2 tables. publication in PASP

Taking the quantum electrodynamics (QED) effect into account, we study the black hole phase transition and Ruppeiner geometry for the Euler-Heisenberg anti-de Sitter black hole in the extended phase space. For negative and small positive QED parameter, we observe a small/large black hole phase transition and reentrant phase transition, respectively. While a large positive value of the QED parameter ruins the phase transition. The phase diagrams for each case are explicitly exhibited. Then we construct the Ruppeiner geometry in the thermodynamic parameter space. Different features of the corresponding scalar curvature are shown for both the small/large black hole phase transition and reentrant phase transition cases. Of particular interest is that an additional region of positive scalar curvature indicating dominated repulsive interaction among black hole microstructure is present for the black hole with a small positive QED parameter. Furthermore, the universal critical phenomena are also observed for the scalar curvature of the Ruppeiner geometry. These results indicate that the QED parameter has a crucial influence on the black hole phase transition and microstructure., Comment: 19 pages, 14 figures

With the development of natural language processing techniques(NLP), automatic diagnosis of eye diseases using ophthalmology electronic medical records (OEMR) has become possible. It aims to evaluate the condition of both eyes of a patient respectively, and we formulate it as a particular multi-label classification task in this paper. Although there are a few related studies in other diseases, automatic diagnosis of eye diseases exhibits unique characteristics. First, descriptions of both eyes are mixed up in OEMR documents, with both free text and templated asymptomatic descriptions, resulting in sparsity and clutter of information. Second, OEMR documents contain multiple parts of descriptions and have long document lengths. Third, it is critical to provide explainability to the disease diagnosis model. To overcome those challenges, we present an effective automatic eye disease diagnosis framework, NEEDED. In this framework, a preprocessing module is integrated to improve the density and quality of information. Then, we design a hierarchical transformer structure for learning the contextualized representations of each sentence in the OEMR document. For the diagnosis part, we propose an attention-based predictor that enables traceable diagnosis by obtaining disease-specific information. Experiments on the real dataset and comparison with several baseline models show the advantage and explainability of our framework., Comment: 9 pages, accepted by SIAM International Conference on Data Mining (SDM) 2023

Using the Five-hundred-meter Aperture Spherical radio Telescope (FAST) 19-beam tracking observational mode, high sensitivity and high-velocity resolution HI spectral lines have been observed toward the high-mass star-forming region G176.51+00.20. This is a pilot study of searching for HI narrow-line self-absorption (HINSA) toward high-mass star-forming regions where bipolar molecular outflows have been detected. This work is confined to the central seven beams of FAST. Two HINSA components are detected in all seven beams, which correspond to a strong CO emission region (SCER; with a velocity of $\sim$ $-$18 km s$^{-1}$) and a weak CO emission region (WCER; with a velocity of $\sim$ $-$3 km s$^{-1}$). The SCER detected in Beam 3 is probably more suitably classified as a WCER. In the SCER, the HINSA is probably associated with the molecular material traced by the CO. The fractional abundance of HINSA ranges from $\sim 1.1 \times 10^{-3}$ to $\sim 2.6 \times 10^{-2}$. Moreover, the abundance of HINSA in Beam 1 is lower than that in the surrounding beams (i.e., Beams 2 and 4--7). This possible ring could be caused by ionization of HI or relatively rapid conversion from HI to H$_2$ in the higher-density inner region. In the WCER (including Beam 3 in the SCER), the HINSA is probably not associated with CO clouds, but with CO-dark or CO-faint gas., Comment: 20 pages, 6 figures

We observed the high-mass star-forming region G176.51+00.20 using the Five-hundred-meter Aperture Spherical radio Telescope (FAST) with the 19-beam tracking observational mode. This is a pilot work of searching for neutral stellar winds traced by atomic hydrogen (i.e., HI winds) using the high sensitivity HI line toward high-mass star-forming regions where bipolar molecular outflows have been detected with high sensitivity by Liu et al. HI wind was detected in this work only in Beam 1. We find here that, similar to low-mass star formation, no matter how large the inclination is, the HI wind is likely sufficiently strong to drive a molecular outflow. We also find that the abundance of HI in the HI wind is consistent with that of the HI narrow-line self-absorption (HINSA) in the same beam (i.e., Beam 1). This implies that there is probably an internal relationship between HI winds and HINSA. This result also reinforces the assertion that HI winds and detected molecular outflows are associated with each other., Comment: 21 pages, 6 figures, 4 tables, accepted to ApJ

In this work, we collected a sample of BL Lacs, FR I and FR II(G) radio galaxies with available core and extended emissions from published works to discuss the unified schemes and estimate the Doppler factor for BL Lacs. Wilcoxon rank-sum test and Kolmogorov-Smirnov test both suggest that the probabilities for the distribution of the extended luminosity of BL Lacs and that of FR I and FR II(G) radio galaxies to be from the same parent distribution are $p_{\rm{WRS}}=0.779$ and $p_{\rm{K-S}}=0.326$, suggesting they are unified. Based on this unified schemes, we propose to estimate the Doppler factors for BL Lacs. Comparing the Doppler factor estimated by the fitting/regression method with those for the common sources in the literatures, we found a good linear correlation for common sources., Comment: 20 pages, 9 figures, 3 tables

学位の種類: 博士（医学）. 報告番号: 甲第4247号. 学位記番号: 新大院博（医）甲第725号. 学位授与年月日: 平成29年3月23日, Anticancer Research 36(11) 6021-6029(2016), Background/Aim: Inhibition of glutaminolysis has been reported as a promising therapeutic strategy to target several solid carcinomas. We aimed to investigate the effects of glutaminolysis on cell proliferation in lung squamous cell carcinoma cell lines and to explore the potential of targeting glutaminolysis as an anticancer strategy. Materials and Methods: Glutamine (Gln) dependence was assessed in six lung squamous cell carcinoma cell lines. Cell proliferation, mammalian target of rapamycin complex 1 (mTORC1) activity and the induction of autophagy were assessed after inhibition of glutaminolysis via Gln depletion or glutaminase (GLS) inhibition. Results: Five of six lung squamous cell carcinoma cell lines exhibited glutamine-dependence. The extent of dependence was correlated with the mRNA levels of GLS1/GLS2. Inhibition of glutaminolysis inhibited cell proliferation by down-regulating of mTORC1 signaling and inducing autophagy in Gln-dependent lung squamous cell carcinoma cell lines. Conclusion: Targeting glutaminolysis may represent a potential therapeutic strategy for the treatment of Gln-dependent lung squamous cell carcinomas., 博士（医学）, 新潟大学

Purpose: The purpose of this study was to perform a meta-analysis comparing the rates of uterine rupture, and other maternal and neonatal complications, between women who undergo a trial of labour (TOL) after a prior Cesarean delivery and those to undergo elective repeat Cesarean delivery (ERCD). Source: Medline, Cochrane, EMBASE and Google Scholar were searched until May 6, 2015 using the keywords/phrases: trial of labour, Cesarean section, elective, repeat, pregnancy and vaginal birth. Randomized controlled trials (RCTs), two-arm prospective studies, one-arm studies and retrospective studies were included. The primary outcome was uterine rupture. Principal findings: Sixteen studies were included in the meta-analysis. TOL after prior Cesarean delivery was associated with higher odds of uterine rupture as compared with ERCD (Peto odds ratio [OR] = 4.685, 95% confidence interval [CI]: 3.077 to 7.133, p < 0.001). TOL was associated with a higher rate of endometritis, a lower rate of hysterectomy, and a lower rate of respiratory problems in newborns. There were no differences between the groups with respect to neonatal intensive care unit admissions, postpartum hemorrhage, thromboembolic disease, sepsis and neonatal mortality. Conclusions: TOL may be associated with a higher risk of uterine rupture and endometritis, but lower risk of hysterectomy and neonatal respiratory problems than ERCD.