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138 results on '"van Santen, Hanneke M."'

1. Differences in checkpoint-inhibitor-induced hypophysitis: mono- versus combination therapy induced hypophysitis

Author: MS Interne Geneeskunde, MS Medische Oncologie, Cancer, Infection & Immunity, MS Endocriene Oncologie, MS Radiologie, Brain, Circulatory Health, Endocrinologie patientenzorg, Child Health, van der Leij, Stephanie, Suijkerbuijk, Karijn P M, van den Broek, Medard F M, Valk, Gerlof D, Dankbaar, Jan Willem, van Santen, Hanneke M, MS Interne Geneeskunde, MS Medische Oncologie, Cancer, Infection & Immunity, MS Endocriene Oncologie, MS Radiologie, Brain, Circulatory Health, Endocrinologie patientenzorg, Child Health, van der Leij, Stephanie, Suijkerbuijk, Karijn P M, van den Broek, Medard F M, Valk, Gerlof D, Dankbaar, Jan Willem, and van Santen, Hanneke M
Published: 2024

2. A 14-year-old girl with premature ovarian insufficiency but with a positive pregnancy test

Author: Touwslager, Robbert N.H., Zwaan, C. Michel, Bakker, Boudewijn, Lentjes, Eef G.W.M., Looijenga, Leendert H.J., Van Santen, Hanneke M., Touwslager, Robbert N.H., Zwaan, C. Michel, Bakker, Boudewijn, Lentjes, Eef G.W.M., Looijenga, Leendert H.J., and Van Santen, Hanneke M.
Abstract: Objectives: Childhood cancer survivors are at risk for premature ovarian insufficiency, especially after treatment with alkylating agents. The objective of this report is to highlight a case in which this phenomenon caused a false-positive pregnancy test. Case presentation: A workup was performed in a 14-year-old girl with a positive pregnancy test. She was diagnosed with stage IV neuroblastoma of the left adrenal gland at the age of 4 years. She received extensive treatment, including alkylating agents, and had been diagnosed with premature ovarian insufficiency. An LH/hCG suppression test was performed using high dose 17 bèta-estradiol: hCG levels normalized. Conclusions: The pregnancy test was false-positive due to production of low amounts of hCG by the pituitary gland as a result of high LH concentrations following premature ovarian insufficiency. It may be helpful to perform the LH/hCG suppression test to prove pituitary origin of the hCG overproduction.
Published: 2024

3. The development of fatigue after treatment for pediatric brain tumors does not differ between tumor locations

Author: P&O Programma's, Flex en UMCU-breed, Endocrinologie patientenzorg, Brain, Cancer, Child Health, Highfield Research Group, Speerpunt, Zorg en O&O, Irestorm, Elin, Schouten-van Meeteren, Antoinette Y.N., van Gorp, Marloes, Twisk, Jos W.R., van Santen, Hanneke M., Partanen, Marita, Grootenhuis, Martha A., van Litsenburg, Raphaele R.L., P&O Programma's, Flex en UMCU-breed, Endocrinologie patientenzorg, Brain, Cancer, Child Health, Highfield Research Group, Speerpunt, Zorg en O&O, Irestorm, Elin, Schouten-van Meeteren, Antoinette Y.N., van Gorp, Marloes, Twisk, Jos W.R., van Santen, Hanneke M., Partanen, Marita, Grootenhuis, Martha A., and van Litsenburg, Raphaele R.L.
Published: 2024

4. A 14-year-old girl with premature ovarian insufficiency but with a positive pregnancy test

Author: Endocrinologie patientenzorg, CDL Poli WKZ, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), Pathologie Groep Van Diest, Pathologie patiënten zorg, Brain, Cancer, Child Health, Touwslager, Robbert N.H., Michel Zwaan, C., Bakker, Boudewijn, Lentjes, Eef G.W.M., Looijenga, Leendert H.J., van Santen, Hanneke M., Endocrinologie patientenzorg, CDL Poli WKZ, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), Pathologie Groep Van Diest, Pathologie patiënten zorg, Brain, Cancer, Child Health, Touwslager, Robbert N.H., Michel Zwaan, C., Bakker, Boudewijn, Lentjes, Eef G.W.M., Looijenga, Leendert H.J., and van Santen, Hanneke M.
Published: 2024

5. Primary Hypothyroidism in Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review

Author: Klinische Fysica RT, Endocrinologie patientenzorg, Brain, Child Health, Cancer, Milano, Michael T, Vargo, John A, Yorke, Ellen D, Ronckers, Cécile M, Kremer, Leontien C, Chafe, Susan M J, van Santen, Hanneke M, Marks, Lawrence B, Bentzen, Søren M, Constine, Louis S, Vogelius, Ivan R, Klinische Fysica RT, Endocrinologie patientenzorg, Brain, Child Health, Cancer, Milano, Michael T, Vargo, John A, Yorke, Ellen D, Ronckers, Cécile M, Kremer, Leontien C, Chafe, Susan M J, van Santen, Hanneke M, Marks, Lawrence B, Bentzen, Søren M, Constine, Louis S, and Vogelius, Ivan R
Published: 2024

6. Overview of European standard clinical practice recommendations for multidiscplinary teams involved in the treatment of central nervous system tumours in children and adolescents – SIOPE Brain Tumour Group

Author: MS Radiotherapie, Cancer, Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Brain, Endocrinologie patientenzorg, Child Health, Otth, Maria, Scheinemann, Katrin, Ajithkumar, Thankamma, Aquilina, Kristian, Avula, Shivaram, Gan, Hoong Wei, Janssens, Geert O., Lemiere, Jurgen, Morana, Giovanni, Opocher, Enrico, Pfister, Stefan M., Porro, Giorgio, Sahm, Felix, Thomale, Ulrich Wilhelm, van Egmond-Ebbeling, Michelle, van Santen, Hanneke M., Pizer, Barry, Rutkowski, Stefan, MS Radiotherapie, Cancer, Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Brain, Endocrinologie patientenzorg, Child Health, Otth, Maria, Scheinemann, Katrin, Ajithkumar, Thankamma, Aquilina, Kristian, Avula, Shivaram, Gan, Hoong Wei, Janssens, Geert O., Lemiere, Jurgen, Morana, Giovanni, Opocher, Enrico, Pfister, Stefan M., Porro, Giorgio, Sahm, Felix, Thomale, Ulrich Wilhelm, van Egmond-Ebbeling, Michelle, van Santen, Hanneke M., Pizer, Barry, and Rutkowski, Stefan
Published: 2024

7. The cumulative burden of self-reported, clinically relevant outcomes in long-term childhood cancer survivors and implications for survivorship care: A DCCSS LATER study

Author: Klinische Fysica RT, Speerpunt, Zorg en O&O, Cancer, Child Health, SCT patientenzorg, Haematologie patientenzorg, Endocrinologie patientenzorg, Brain, PMC Medisch specialisten, Streefkerk, Nina, Teepen, Jop C., Feijen, Elizabeth A.M., Jóźwiak, Katarzyna, van der Pal, Helena J.H., Ronckers, Cecile M., De Vries, Andrica C.H., Van der Heiden-van Der Loo, Margriet, Hollema, Nynke, van den Berg, Marleen, Loonen, Jacqueline, Grootenhuis, Martha A., Bresters, Dorine, Versluys, A. Brigitta, van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M., van Leeuwen, Flora E., Neggers, Sebastian J.C.M.M., Van Santen, Hanneke M., Hawkins, Mike, Hauptmann, Michael, Yoneoka, Daisuke, Korevaar, Joke C., Tissing, Wim J.E., Kremer, Leontien C.M., Klinische Fysica RT, Speerpunt, Zorg en O&O, Cancer, Child Health, SCT patientenzorg, Haematologie patientenzorg, Endocrinologie patientenzorg, Brain, PMC Medisch specialisten, Streefkerk, Nina, Teepen, Jop C., Feijen, Elizabeth A.M., Jóźwiak, Katarzyna, van der Pal, Helena J.H., Ronckers, Cecile M., De Vries, Andrica C.H., Van der Heiden-van Der Loo, Margriet, Hollema, Nynke, van den Berg, Marleen, Loonen, Jacqueline, Grootenhuis, Martha A., Bresters, Dorine, Versluys, A. Brigitta, van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M., van Leeuwen, Flora E., Neggers, Sebastian J.C.M.M., Van Santen, Hanneke M., Hawkins, Mike, Hauptmann, Michael, Yoneoka, Daisuke, Korevaar, Joke C., Tissing, Wim J.E., and Kremer, Leontien C.M.
Published: 2024

8. Hydrocortisone to reduce dexamethasone-induced neurobehavioral side-effects in children with acute lymphoblastic leukaemia—results of a double-blind, randomised controlled trial with cross-over design

Author: van Hulst, Annelienke M., van den Akker, Erica L.T., Fiocco, Marta, Verwaaijen, Emma J., Rensen, Niki, van Litsenburg, Raphaële R.L., Pluijm, Saskia M.F., zwaan, c, van Santen, Hanneke M., Pieters, Rob, Evers, Andrea W.M., Grootenhuis, Martha A., van den Heuvel-Eibrink, Marry M., van Hulst, Annelienke M., van den Akker, Erica L.T., Fiocco, Marta, Verwaaijen, Emma J., Rensen, Niki, van Litsenburg, Raphaële R.L., Pluijm, Saskia M.F., zwaan, c, van Santen, Hanneke M., Pieters, Rob, Evers, Andrea W.M., Grootenhuis, Martha A., and van den Heuvel-Eibrink, Marry M.
Abstract: Background: Dexamethasone is a cornerstone of paediatric acute lymphoblastic leukaemia (ALL) treatment, although it can induce serious side-effects. Our previous study suggests that children who suffer most from neurobehavioural side-effects might benefit from physiological hydrocortisone in addition to dexamethasone treatment. This study aimed to validate this finding. Methods: Our phase three, double-blind, randomised controlled trial with cross-over design included ALL patients (3–18 years) during medium-risk maintenance therapy in a national tertiary hospital between 17th May 2018 and 5th August 2020. A baseline measurement before and after a 5-day dexamethasone course was performed, whereafter 52 patients with clinically relevant neurobehavioural problems were randomised to receive an intervention during four subsequent dexamethasone courses. The intervention consisted of two courses hydrocortisone (physiological dose 10 mg/m2/d in circadian rhythm), followed by two courses placebo, or vice versa. Neurobehavioural problems were assessed before and after each course using the parent-reported Strengths and Difficulties Questionnaire (SDQ) as primary end-point. Secondary end-points were sleep problems, health-related quality of life (HRQoL), hunger feeling, and parental stress, measured with questionnaires and actigraphy. A generalised mixed model was estimated to study the intervention effect. Results: The median age was 5.5 years (range 3.0–18.8) and 61.5% were boys. The SDQ filled in by 51 primary caregivers showed no difference between hydrocortisone and placebo in reducing dexamethasone-induced neurobehavioral problems (estimated effect -2.05 (95% confidence interval (CI) -6.00–1.90). Also, no benefit from hydrocortisone compared to placebo was found for reducing sleep problems, hunger, parental stress or improving HRQoL. Conclusions: Hydrocortisone, when compared to placebo, had no additional effect in reducing clinically relevant dexamethasone-induced ne
Published: 2023

9. Frailty and sarcopenia within the earliest national Dutch childhood cancer survivor cohort (DCCSS-LATER):a cross-sectional study

Author: van Atteveld, Jenneke E, de Winter, Demi T C, Pluimakers, Vincent G, Fiocco, Marta, Nievelstein, Rutger A J, Hobbelink, Monique G G, Kremer, Leontien C M, Grootenhuis, Martha A, Maurice-Stam, Heleen, Tissing, Wim J E, de Vries, Andrica C H, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, van der Pal, Helena J H, Pluijm, Saskia M F, van der Heiden-van der Loo, Margriet, Versluijs, A Birgitta, Louwerens, Marloes, Bresters, Dorine, van Santen, Hanneke M, Hoefer, Imo, van den Berg, Sjoerd A A, den Hartogh, Jaap, Hoeijmakers, Jan H J, Neggers, Sebastian J C M M, van den Heuvel-Eibrink, Marry M, van Atteveld, Jenneke E, de Winter, Demi T C, Pluimakers, Vincent G, Fiocco, Marta, Nievelstein, Rutger A J, Hobbelink, Monique G G, Kremer, Leontien C M, Grootenhuis, Martha A, Maurice-Stam, Heleen, Tissing, Wim J E, de Vries, Andrica C H, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, van der Pal, Helena J H, Pluijm, Saskia M F, van der Heiden-van der Loo, Margriet, Versluijs, A Birgitta, Louwerens, Marloes, Bresters, Dorine, van Santen, Hanneke M, Hoefer, Imo, van den Berg, Sjoerd A A, den Hartogh, Jaap, Hoeijmakers, Jan H J, Neggers, Sebastian J C M M, and van den Heuvel-Eibrink, Marry M
Abstract: BACKGROUND: Childhood cancer survivors appear to be at increased risk of frailty and sarcopenia, but evidence on the occurrence of and high-risk groups for these aging phenotypes is scarce, especially in European survivors. The aim of this cross-sectional study was to assess the prevalence of and explore risk factors for pre-frailty, frailty, and sarcopenia in a national cohort of Dutch childhood cancer survivors diagnosed between 1963 and 2001.METHODS: Eligible individuals (alive at the time of study, living in the Netherlands, age 18-45 years, and had not previously declined to participate in a late-effects study) from the Dutch Childhood Cancer Survivor Study (DCCSS-LATER) cohort were invited to take part in this cross-sectional study. We defined pre-frailty and frailty according to modified Fried criteria, and sarcopenia according to the European Working Group on Sarcopenia in Older People 2 definition. Associations between these conditions and demographic and treatment-related as well as endocrine and lifestyle-related factors were estimated with two separate multivariable logistic regression models in survivors with any frailty measurement or complete sarcopenia measurements.FINDINGS: 3996 adult survivors of the DCCSS-LATER cohort were invited to participate in this cross-sectional study. 1993 non-participants were excluded due to lack of response or a decline to participate and 2003 (50·1%) childhood cancer survivors aged 18-45 years were included. 1114 (55·6%) participants had complete frailty measurements and 1472 (73·5%) participants had complete sarcopenia measurements. Mean age at participation was 33·1 years (SD 7·2). 1037 (51·8%) participants were male, 966 (48·2%) were female, and none were transgender. In survivors with complete frailty measurements or complete sarcopenia measurements, the percentage of pre-frailty was 20·3% (95% CI 18·0-22·7), frailty was 7·4% (6·0-9·0), and sarcopenia was 4·4% (3·5-5·6). In the models for pre-frai
Published: 2023

10. Clinical evaluation of late outcomes in Dutch childhood cancer survivors:Methodology of the DCCSS LATER 2 study

Author: Feijen, Elizabeth A.M., Teepen, Jop C., van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M., van der Heiden-van der Loo, Margriet, van der Pal, Helena J.H., de Vries, Andrica C.H., Louwerens, Marloes, Bresters, Dorine, Versluys, Birgitta, de Ridder, Hanneke, Veening, Margreet, van Leeuwen, Flora E., Grootenhuis, Martha, Maurice-Stam, Heleen, van Santen, Hanneke M., Neggers, Sebastian J.C.M.M., Pluijm, Saskia, den Hartogh, Jaap, Ronckers, Cécile M., Tissing, Wim J.E., Loonen, Jacqueline J., Kremer, Leontien C.M., Feijen, Elizabeth A.M., Teepen, Jop C., van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M., van der Heiden-van der Loo, Margriet, van der Pal, Helena J.H., de Vries, Andrica C.H., Louwerens, Marloes, Bresters, Dorine, Versluys, Birgitta, de Ridder, Hanneke, Veening, Margreet, van Leeuwen, Flora E., Grootenhuis, Martha, Maurice-Stam, Heleen, van Santen, Hanneke M., Neggers, Sebastian J.C.M.M., Pluijm, Saskia, den Hartogh, Jaap, Ronckers, Cécile M., Tissing, Wim J.E., Loonen, Jacqueline J., and Kremer, Leontien C.M.
Abstract: Background: Childhood cancer survivors face late health problems; despite advances in research, details on risk remain unclear. We describe the methodological aspects of the Dutch Childhood Cancer Survivor Study (DCCSS) cross-sectional clinical study (LATER 2 study). Procedure: From the multi-center DCCSS LATER cohort of 6165 five-year survivors diagnosed during 1963–2001, we invited 4735 eligible survivors in 2016, as well as siblings and parents of survivors. Gaps in evidence identified during development of surveillance guidelines were translated into clinical research questions for 16 outcome-specific subprojects. The regular care visit to the LATER outpatient clinic forms the backbone of outcome assessment complemented with research-defined measurements (physical examination, clinical tests, questionnaires). Furthermore, blood/saliva samples were taken for deoxyribonucleic acid (DNA) extraction. Results: In total, 2519 (53.2%) survivors participated in the LATER 2 study. When comparing participants with nonparticipants, we observed that males, CNS survivors, and those treated with surgery only were less likely to participate. Of the participating survivors, 49.3% were female. Median time since childhood cancer diagnosis was 26.9 years (range 14.8–54.7 years) and median attained age was 34.4 years (range 15.4–66.6 years). Conclusions: The high-quality data generated in the LATER 2 study will provide valuable insights into risks of and risk factors for clinical and physical and psychosocial health outcomes and factors for early recognition of those health outcomes in long-term childhood cancer survivors. This will contribute to fill in important gaps in knowledge and improve the quality of life and care for childhood cancer survivors.
Published: 2023

11. Questionnaire- and linkage-based outcomes in Dutch childhood cancer survivors:Methodology of the DCCSS LATER study part 1

Author: Teepen, Jop C., Kok, Judith L., Feijen, Elizabeth A.M., Loonen, Jacqueline J., van den Heuvel-Eibrink, Marry M., van der Pal, Helena J., Tissing, Wim J.E., Bresters, Dorine, Versluys, Birgitta, Grootenhuis, Martha A., Louwerens, Marloes, Neggers, Sebastian J.C.M.M., van Santen, Hanneke M., de Vries, Andrica, Janssens, Geert O., den Hartogh, Jaap G., van Leeuwen, Flora E., Hollema, Nynke, Streefkerk, Nina, Kilsdonk, Ellen, van der Heiden-van der Loo, Margriet, van Dulmen-den Broeder, Eline, Ronckers, Cécile M., Kremer, Leontien C.M., Teepen, Jop C., Kok, Judith L., Feijen, Elizabeth A.M., Loonen, Jacqueline J., van den Heuvel-Eibrink, Marry M., van der Pal, Helena J., Tissing, Wim J.E., Bresters, Dorine, Versluys, Birgitta, Grootenhuis, Martha A., Louwerens, Marloes, Neggers, Sebastian J.C.M.M., van Santen, Hanneke M., de Vries, Andrica, Janssens, Geert O., den Hartogh, Jaap G., van Leeuwen, Flora E., Hollema, Nynke, Streefkerk, Nina, Kilsdonk, Ellen, van der Heiden-van der Loo, Margriet, van Dulmen-den Broeder, Eline, Ronckers, Cécile M., and Kremer, Leontien C.M.
Abstract: Background: Childhood cancer survivors are at risk for developing long-term adverse health outcomes. To identify the risk of and risk factors for specific health outcomes, well-established cohorts are needed with detailed information on childhood cancer diagnosis, treatment, and health outcomes. We describe the design, methodology, characteristics, and data availability of the Dutch Childhood Cancer Survivor Study LATER cohort (1963–2001) part 1; questionnaire and linkage studies. Methods: The LATER cohort includes 5-year childhood cancer survivors, diagnosed in the period 1963–2001, and before the age of 18 in any of the seven former pediatric oncology centers in the Netherlands. Information on health outcomes from survivors and invited siblings of survivors was collected by questionnaires and linkages to medical registries. Results: In total, 6165 survivors were included in the LATER cohort. Extensive data on diagnosis and treatment have been collected. Information on a variety of health outcomes has been ascertained by the LATER questionnaire study and linkages with several registries for subsequent tumors, health care use, and hospitalizations. Conclusion: Research with data of the LATER cohort will provide new insights into risks of and risk factors for long-term health outcomes. This can enhance risk stratification for childhood cancer survivors and inform surveillance guidelines and development of interventions to prevent (the impact of) long-term adverse health outcomes. The data collected will be a solid baseline foundation for future follow-up studies.
Published: 2023

12. Could setmelanotide be the game-changer for acquired hypothalamic obesity?

Author: Cancer, Brain, Child Health, Endocrinologie patientenzorg, van Santen, Hanneke M, Denzer, Christian, Müller, Hermann Lothar, Cancer, Brain, Child Health, Endocrinologie patientenzorg, van Santen, Hanneke M, Denzer, Christian, and Müller, Hermann Lothar
Published: 2023

13. Pediatric body composition based on automatic segmentation of computed tomography scans: a pilot study

Author: Researchgr. Nucleaire Geneeskunde, Cancer, Arts-assistenten Radiologie, Researchgr. Cardiovasculaire Radiologie, MS Radiologie, Researchgr. Systems Radiology, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Beeldverwerking ISI, Endocrinologie patientenzorg, Brain, Child Health, Samim, Atia, Spijkers, Suzanne, Moeskops, Pim, Littooij, Annemieke S, de Jong, Pim A, Veldhuis, Wouter B, de Vos, Bob D, van Santen, Hanneke M, Nievelstein, Rutger A J, Researchgr. Nucleaire Geneeskunde, Cancer, Arts-assistenten Radiologie, Researchgr. Cardiovasculaire Radiologie, MS Radiologie, Researchgr. Systems Radiology, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Beeldverwerking ISI, Endocrinologie patientenzorg, Brain, Child Health, Samim, Atia, Spijkers, Suzanne, Moeskops, Pim, Littooij, Annemieke S, de Jong, Pim A, Veldhuis, Wouter B, de Vos, Bob D, van Santen, Hanneke M, and Nievelstein, Rutger A J
Published: 2023

14. Tocilizumab for the fifth progression of cystic childhood craniopharyngioma-a case report

Author: MS Radiologie, Circulatory Health, Pathologie, Cancer, Endocrinologie patientenzorg, Brain, Child Health, de Vos-Kerkhof, Evelien, Buis, Dennis R, Lequin, Maarten H, Bennebroek, Carlien A, Aronica, Eleonora, Hulleman, Esther, Zwaveling-Soonawala, Nitash, van Santen, Hanneke M, Schouten-van Meeteren, Antoinette Y N, MS Radiologie, Circulatory Health, Pathologie, Cancer, Endocrinologie patientenzorg, Brain, Child Health, de Vos-Kerkhof, Evelien, Buis, Dennis R, Lequin, Maarten H, Bennebroek, Carlien A, Aronica, Eleonora, Hulleman, Esther, Zwaveling-Soonawala, Nitash, van Santen, Hanneke M, and Schouten-van Meeteren, Antoinette Y N
Published: 2023

15. Elevated IGF-1 concentrations in children with low grade glioma: A descriptive analysis in a retrospective national cohort

Author: Endocrinologie onderzoek, Cancer, Child Health, Endocrinologie patientenzorg, Zorg en O&O, Brain, van Schaik, Jiska, van Roessel, Ichelle M A A, Bos, Iris D, Claashen-van der Grinten, Hedi L, Clement, Sarah C, van Iersel, Laura, Bakker, Boudewijn, Meijer, Lisethe, Kremer, Leontien, Schouten-van Meeteren, A Y Netteke, van Santen, Hanneke M, Endocrinologie onderzoek, Cancer, Child Health, Endocrinologie patientenzorg, Zorg en O&O, Brain, van Schaik, Jiska, van Roessel, Ichelle M A A, Bos, Iris D, Claashen-van der Grinten, Hedi L, Clement, Sarah C, van Iersel, Laura, Bakker, Boudewijn, Meijer, Lisethe, Kremer, Leontien, Schouten-van Meeteren, A Y Netteke, and van Santen, Hanneke M
Published: 2023

16. Could deep brain stimulation be a possible solution for acquired hypothalamic obesity?

Author: Neurochirurgen, Cancer, Endocrinologie patientenzorg, Brain, Child Health, Dassen, Amber R, van Schaik, Jiska, van den Munckhof, Pepijn, Schuurman, P R, Hoving, Eelco W, van Santen, Hanneke M, Neurochirurgen, Cancer, Endocrinologie patientenzorg, Brain, Child Health, Dassen, Amber R, van Schaik, Jiska, van den Munckhof, Pepijn, Schuurman, P R, Hoving, Eelco W, and van Santen, Hanneke M
Published: 2023

17. Hydrocortisone to reduce dexamethasone-induced neurobehavioral side-effects in children with acute lymphoblastic leukaemia—results of a double-blind, randomised controlled trial with cross-over design

Author: Kinderbewegingszorg patientenzorg, Arts-assistenten Kinderen, PMC Research, Speerpunt, Endocrinologie patientenzorg, Brain, Cancer, Child Health, Zorg en O&O, MS Verloskunde, van Hulst, Annelienke M., van den Akker, Erica L.T., Verwaaijen, Emma J., Fiocco, Marta, Rensen, Niki, van Litsenburg, Raphaële R.L., Pluijm, Saskia M.F., Zwaan, C. Michel, van Santen, Hanneke M., Pieters, Rob, Evers, Andrea W.M., Grootenhuis, Martha A., van den Heuvel-Eibrink, Marry M., Kinderbewegingszorg patientenzorg, Arts-assistenten Kinderen, PMC Research, Speerpunt, Endocrinologie patientenzorg, Brain, Cancer, Child Health, Zorg en O&O, MS Verloskunde, van Hulst, Annelienke M., van den Akker, Erica L.T., Verwaaijen, Emma J., Fiocco, Marta, Rensen, Niki, van Litsenburg, Raphaële R.L., Pluijm, Saskia M.F., Zwaan, C. Michel, van Santen, Hanneke M., Pieters, Rob, Evers, Andrea W.M., Grootenhuis, Martha A., and van den Heuvel-Eibrink, Marry M.
Published: 2023

18. Thyroid Profile in the First Three Months after Starting Treatment in Children with Newly Diagnosed Cancer

Author: Endocrinologie onderzoek, Cluster C, Endocrinologie, Child Health, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), PMC Medisch specialisten, Endocrinologie patientenzorg, Brain, Cancer, Lebbink, Chantal A, van den Bos, Cor, Dierselhuis, Miranda P, Fiocco, Marta, Verrijn Stuart, Annemarie A, Lentjes, Eef G W M, Plasschaert, Sabine L A, Tissing, Wim J E, van Santen, Hanneke M, Endocrinologie onderzoek, Cluster C, Endocrinologie, Child Health, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), PMC Medisch specialisten, Endocrinologie patientenzorg, Brain, Cancer, Lebbink, Chantal A, van den Bos, Cor, Dierselhuis, Miranda P, Fiocco, Marta, Verrijn Stuart, Annemarie A, Lentjes, Eef G W M, Plasschaert, Sabine L A, Tissing, Wim J E, and van Santen, Hanneke M
Published: 2023

19. Thyroid dysfunction during treatment with systemic antineoplastic therapy for childhood cancer: a systematic review

Author: MS Interne Geneeskunde, Endocrinologie onderzoek, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), PMC Medisch specialisten, Cluster C, Endocrinologie, Child Health, Speerpunt, Zorg en O&O, Cancer, Endocrinologie patientenzorg, Brain, van der Leij, Stephanie, Lebbink, Chantal A, Lentjes, Eef Gwm, Tissing, Wim Je, Stuart, Annemarie Verrijn, van den Heuvel-Eibrink, Marry M, van Santen, Hanneke M, van Dalen, Elvira C, MS Interne Geneeskunde, Endocrinologie onderzoek, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), PMC Medisch specialisten, Cluster C, Endocrinologie, Child Health, Speerpunt, Zorg en O&O, Cancer, Endocrinologie patientenzorg, Brain, van der Leij, Stephanie, Lebbink, Chantal A, Lentjes, Eef Gwm, Tissing, Wim Je, Stuart, Annemarie Verrijn, van den Heuvel-Eibrink, Marry M, van Santen, Hanneke M, and van Dalen, Elvira C
Published: 2023

20. Diagnostic criteria for the hypothalamic syndrome in childhood

Author: Cancer, Brain, Child Health, Endocrinologie patientenzorg, Endocrinologie onderzoek, van Santen, Hanneke M., van Schaik, Jiska, van Roessel, Ichelle M.A.A., Beckhaus, Julia, Boekhoff, Svenja, Müller, Hermann L., Cancer, Brain, Child Health, Endocrinologie patientenzorg, Endocrinologie onderzoek, van Santen, Hanneke M., van Schaik, Jiska, van Roessel, Ichelle M.A.A., Beckhaus, Julia, Boekhoff, Svenja, and Müller, Hermann L.
Published: 2023

21. Clinical evaluation of late outcomes in Dutch childhood cancer survivors: Methodology of the DCCSS LATER 2 study

Author: Speerpunt, Zorg en O&O, Cancer, Child Health, SCT patientenzorg, Endocrinologie patientenzorg, Brain, PMC Research, Klinische Fysica RT, PMC Medisch specialisten, Feijen, Elizabeth A.M., Teepen, Jop C., van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M., van der Heiden-van der Loo, Margriet, van der Pal, Helena J.H., de Vries, Andrica C.H., Louwerens, Marloes, Bresters, Dorine, Versluys, Birgitta, de Ridder, Hanneke, Veening, Margreet, van Leeuwen, Flora E., Grootenhuis, Martha, Maurice-Stam, Heleen, van Santen, Hanneke M., Neggers, Sebastian J.C.M.M., Pluijm, Saskia, den Hartogh, Jaap, Ronckers, Cécile M., Tissing, Wim J.E., Loonen, Jacqueline J., Kremer, Leontien C.M., Speerpunt, Zorg en O&O, Cancer, Child Health, SCT patientenzorg, Endocrinologie patientenzorg, Brain, PMC Research, Klinische Fysica RT, PMC Medisch specialisten, Feijen, Elizabeth A.M., Teepen, Jop C., van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M., van der Heiden-van der Loo, Margriet, van der Pal, Helena J.H., de Vries, Andrica C.H., Louwerens, Marloes, Bresters, Dorine, Versluys, Birgitta, de Ridder, Hanneke, Veening, Margreet, van Leeuwen, Flora E., Grootenhuis, Martha, Maurice-Stam, Heleen, van Santen, Hanneke M., Neggers, Sebastian J.C.M.M., Pluijm, Saskia, den Hartogh, Jaap, Ronckers, Cécile M., Tissing, Wim J.E., Loonen, Jacqueline J., and Kremer, Leontien C.M.
Published: 2023

22. Pharmacological protection of the thyroid gland against radiation damage from radioactive iodine labeled compounds in children: a systematic review

Author: Apotheek Klinische Farmacie, MS Radiologie, Cancer, Endocrinologie patientenzorg, Brain, Child Health, de Lijster, Bas, de Kanter, Clara T.M.M., de Keizer, Bart, Tytgat, Godelieve A.M., Vulsma, Thomas, Offringa, Martin, van Santen, Hanneke M., Apotheek Klinische Farmacie, MS Radiologie, Cancer, Endocrinologie patientenzorg, Brain, Child Health, de Lijster, Bas, de Kanter, Clara T.M.M., de Keizer, Bart, Tytgat, Godelieve A.M., Vulsma, Thomas, Offringa, Martin, and van Santen, Hanneke M.
Published: 2023

23. 2022 European Thyroid Association Guidelines for the Management of Pediatric Thyroid Nodules and Differentiated Thyroid Carcinoma

Author: Verburg, Frederik Anton, Lebbink, Chantal A., Links, Thera P., Czarniecka, Agnieszka, Dias, Renuka P., Elisei, Rossella, Izatt, Louise, Krude, Heiko, Lorenz, Kerstin, Luster, Markus, Newbold, Kate, Piccardo, Arnoldo, Sobrinho-Simões, Manuel, Takano, Toru, van Trotsenburg, Paul A.S., van Santen, Hanneke M., Verburg, Frederik Anton, Lebbink, Chantal A., Links, Thera P., Czarniecka, Agnieszka, Dias, Renuka P., Elisei, Rossella, Izatt, Louise, Krude, Heiko, Lorenz, Kerstin, Luster, Markus, Newbold, Kate, Piccardo, Arnoldo, Sobrinho-Simões, Manuel, Takano, Toru, van Trotsenburg, Paul A.S., and van Santen, Hanneke M.
Abstract: At present, no European recommendations for the management of pediatric thyroid nodules and differentiated thyroid carcinoma (DTC) exist. Differences in clinical, molecular, and pathological characteristics between pediatric and adult DTC emphasize the need for specific recommendations for the pediatric population. An expert panel was instituted by the executive committee of the European Thyroid Association including an international community of experts from a variety of disciplines including pediatric and adult endocrinology, pathology, endocrine surgery, nuclear medicine, clinical genetics, and oncology. The 2015 American Thyroid Association Pediatric Guideline was used as framework for the present guideline. Areas of discordance were identified, and clinical questions were formulated. The expert panel members discussed the evidence and formulated recommendations based on the latest evidence and expert opinion. Children with a thyroid nodule or DTC require expert care in an experienced center. The present guideline provides guidance for healthcare professionals to make well-considered decisions together with patients and parents regarding diagnosis, treatment, and follow-up of pediatric thyroid nodules and DTC.
Published: 2022

24. Shrunken pore syndrome in childhood cancer survivors treated with potentially nephrotoxic therapy

Author: Kooijmans, Esmee C. M., van der Pal, Helena J. H., Pilon, Maxime C. F., Pluijm, Saskia M. F., van der van der Loo, Margriet, Kremer, Leontien C. M., Bresters, Dorine, van Dulmen-den Broeder, Eline, van den Heuvel-eibrink, Marry M., Loonen, Jacqueline J., Louwerens, Marloes, Neggers, Sebastian J. C., van Santen, Hanneke M., Tissing, Wim J. E., de Vries, Andrica C. H., Kaspers, Gertjan J. L., Veening, Margreet A., Bokenkamp, Arend, Kooijmans, Esmee C. M., van der Pal, Helena J. H., Pilon, Maxime C. F., Pluijm, Saskia M. F., van der van der Loo, Margriet, Kremer, Leontien C. M., Bresters, Dorine, van Dulmen-den Broeder, Eline, van den Heuvel-eibrink, Marry M., Loonen, Jacqueline J., Louwerens, Marloes, Neggers, Sebastian J. C., van Santen, Hanneke M., Tissing, Wim J. E., de Vries, Andrica C. H., Kaspers, Gertjan J. L., Veening, Margreet A., and Bokenkamp, Arend
Abstract: Childhood cancer survivors (CCS) are at risk of kidney dysfunction. Recently, the shrunken pore syndrome (SPS) has been described, which is characterized by selectively impaired filtration of larger molecules like cystatin C, while filtration of smaller molecules like creatinine is unaltered. It has been associated with increased mortality, even in the presence of a normal estimated glomerular filtration rate (eGFR). The aim of this study was to evaluate the prevalence of SPS in CCS exposed to potentially nephrotoxic therapy. In the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER 2 Renal study, a nationwide cross-sectional cohort study, 1024 CCS ≥5 years after diagnosis, aged ≥18 years at study, treated between 1963-2001 with nephrectomy, abdominal radiotherapy, total body irradiation, cisplatin, carboplatin, ifosfamide, high-dose cyclophosphamide or hematopoietic stem cell transplantation participated, and 500 age- and sex-matched controls form Lifelines. SPS was defined as an eGFR cys/eGFR cr ratio <0.6 in the absence of non-GFR determinants of cystatin C and creatinine metabolism (i.e. hyperthyroidism, corticosteroids, underweight). Three pairs of eGFR-equations were used; CKD-EPI cys/CKD-EPI cr, CAPA/LMR, and FAS cys/FAS age. Median age was 32 years. Although an eGFR cys/eGFR cr ratio <0.6 was more common in CCS (1.0%) than controls (0%) based on the CKD-EPI equations, most cases were explained by non-GFR determinants. The prevalence of SPS in CCS was 0.3% (CKD-EPI equations), 0.2% (CAPA/LMR) and 0.1% (FAS equations), and not increased compared to controls. CCS treated with nephrotoxic therapy are not at increased risk for SPS compared to controls. Yet, non-GFR determinants are more common and should be taken into account when estimating GFR.
Published: 2022

25. The effect of surveillance for differentiated thyroid carcinoma in childhood cancer survivors on survival rates: a decision-tree-based analysis

Author: Heinzel, Alexander, Mueller, Dirk, van Santen, Hanneke M., Clement, Sarah C., Schneider, Arthur B., Verburg, Frederik A., Heinzel, Alexander, Mueller, Dirk, van Santen, Hanneke M., Clement, Sarah C., Schneider, Arthur B., and Verburg, Frederik A.
Abstract: BackgroundChildhood cancer survivors (CCS) who received radiation therapy exposing the thyroid gland are at increased risk of developing differentiated thyroid cancer (DTC). Therefore, the International Guideline Harmonization Group (IGHG) on late effects of childhood cancer therefore recommends surveillance. It is unclear whether surveillance reduces mortality. AimThe aim of this study was to compare four strategies for DTC surveillance in CCS with the aim of reducing mortality: Strategy-1, no surveillance; Strategy-2, ultrasound alone; Strategy-3, ultrasound followed by fine-needle biopsy (FNB); Strategy-4, palpation followed by ultrasound and FNB. Materials and methodsA decision tree was formulated with 10-year thyroid cancer-specific survival as the endpoint, based on data extracted from literature. ResultsIt was calculated that 12.6% of CCS will develop DTC. Using Strategy-1, all CCS with DTC would erroneously not be operated upon, but no CCS would have unnecessary surgery. With Strategy-2, all CCS with and 55.6% of CCS without DTC would be operated. Using Strategy-3, 11.1% of CCS with DTC would be correctly operated upon, 11.2% without DTC would be operated upon and 1.5% with DTC would not be operated upon. With Strategy-4, these percentages would be 6.8, 3.9 and 5.8%, respectively. Median 10-year survival rates would be equal across strategies (0.997). ConclusionDifferent surveillance strategies for DTC in CCS all result in the same high DTC survival. Therefore, the indication for surveillance may lie in a reduction of surgery-related morbidity rather than DTC-related mortality. In accordance with the IGHG guidelines, the precise strategy should be decided upon in a process of shared decision-making.
Published: 2022

26. Fasting Intervention for Children With Unilateral Renal Tumors to Reduce Toxicity

Author: Oudmaijer, Christiaan A. J., van den Boogaard, Winnie M. C., Komninos, Daphne S. J., Verwaaijen, Emma J., van Santen, Hanneke M., Lilien, Marc R., Hoeijmakers, Jan H. J., Wijnen, Marc H. W., van den Heuvel-Eibrink, Marry M., Vermeij, Wilbert P., Oudmaijer, Christiaan A. J., van den Boogaard, Winnie M. C., Komninos, Daphne S. J., Verwaaijen, Emma J., van Santen, Hanneke M., Lilien, Marc R., Hoeijmakers, Jan H. J., Wijnen, Marc H. W., van den Heuvel-Eibrink, Marry M., and Vermeij, Wilbert P.
Abstract: Childhood renal tumors account for around 6% of all childhood cancers and 90% of these cases are Wilms tumor. In Europe, the SIOP-RTSG approach is considered standard of care and has resulted in five-year survival rates of over 90%. Efforts to decrease toxicity are now being pursued. Short-term fasting (STF), a short but strong reduction in calorie-intake, is associated with improved fitness, enhanced coping with acute physical stress and a lower risk of age-associated diseases. STF temporarily reduces growth to boost resilience, maintenance, and defense-mechanisms, by which toxic side-effects of (oxidative) damage and inflammation are largely prevented. Renal surgery for Wilms tumor carries a risk of acute kidney injury (AKI) and pediatric patients that had an episode of AKI are at increased risk for developing chronic renal disease. STF could mitigate surgery-induced stress and could further improve outcomes. We aim to investigate the effect of STF on renal function recovery after renal tumor surgery by conducting a single-center, prospective, randomized, non-blinded, intervention study. Children diagnosed with a unilateral renal tumor and opting for curative treatment are eligible for inclusion. The main study objective is to investigate the potential decrease in occurrence of AKI due to STF. Secondary objectives include renal function recovery, child's wellbeing, physical functioning, and feasibility of and adherence to STF in children with cancer.
Published: 2022

27. Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours:a consensus statement

Author: Boguszewski, Margaret C.S., Boguszewski, Cesar L., Chemaililly, Wassim, Cohen, Laurie E., Gebauer, Judith, Higham, Claire, Hoffman, Andrew R., Polak, Michel, Yuen, Kevin C.J., Alos, Nathalie, Antal, Zoltan, Bidlingmaier, Martin, Biller, Beverley M.K., Brabant, George, Choong, Catherine S.Y., Cianfarani, Stefano, Clayton, Peter E., Coutant, Regis, Cardoso-Demartini, Adriane A., Fernandez, Alberto, Grimberg, Adda, Guðmundsson, Kolbeinn, Guevara-Aguirre, Jaime, K Y Ho, Ken, Horikawa, Reiko, Isidori, Andrea M., Otto Lunde Jørgensen, Jens, Kamenicky, Peter, Karavitaki, Niki, Kopchick, John J., Lodish, Maya, Luo, Xiaoping, McCormack, Ann I., Meacham, Lillian, Melmed, Shlomo, Moab, Sogol Mostoufi, Müller, Hermann L., Neggers, Sebastian J.C.M.M., Aguiar Oliveira, Manoel H., Ozono, Keiichi, Pennisi, Patricia A., Popovic, Vera, Radovick, Sally, Savendahl, Lars, Touraine, Philippe, van Santen, Hanneke M., Johannsson, Gudmundur, Boguszewski, Margaret C.S., Boguszewski, Cesar L., Chemaililly, Wassim, Cohen, Laurie E., Gebauer, Judith, Higham, Claire, Hoffman, Andrew R., Polak, Michel, Yuen, Kevin C.J., Alos, Nathalie, Antal, Zoltan, Bidlingmaier, Martin, Biller, Beverley M.K., Brabant, George, Choong, Catherine S.Y., Cianfarani, Stefano, Clayton, Peter E., Coutant, Regis, Cardoso-Demartini, Adriane A., Fernandez, Alberto, Grimberg, Adda, Guðmundsson, Kolbeinn, Guevara-Aguirre, Jaime, K Y Ho, Ken, Horikawa, Reiko, Isidori, Andrea M., Otto Lunde Jørgensen, Jens, Kamenicky, Peter, Karavitaki, Niki, Kopchick, John J., Lodish, Maya, Luo, Xiaoping, McCormack, Ann I., Meacham, Lillian, Melmed, Shlomo, Moab, Sogol Mostoufi, Müller, Hermann L., Neggers, Sebastian J.C.M.M., Aguiar Oliveira, Manoel H., Ozono, Keiichi, Pennisi, Patricia A., Popovic, Vera, Radovick, Sally, Savendahl, Lars, Touraine, Philippe, van Santen, Hanneke M., and Johannsson, Gudmundur
Abstract: Growth hormone (GH) has been used for over 35 years, and its safety and efficacy has been studied extensively. Experimental studies showing the permissive role of GH/insulin-like growth factor 1 (IGF-I) in carcinogenesis have raised concerns regarding the safety of GH replacement in children and adults who have received treatment for cancer and those with intracranial and pituitary tumours. A consensus statement was produced to guide decision-making on GH replacement in children and adult survivors of cancer, in those treated for intracranial and pituitary tumours and in patients with increased cancer risk. With the support of the European Society of Endocrinology, the Growth Hormone Research Society convened a Workshop, where 55 international key opinion leaders representing 10 professional societies were invited to participate. This consensus statement utilized: (1) a critical review paper produced before the Workshop, (2) five plenary talks, (3) evidence-based comments from four breakout groups, and (4) discussions during report-back sessions. Current evidence reviewed from the proceedings from the Workshop does not support an association between GH replacement and primary tumour or cancer recurrence. The effect of GH replacement on secondary neoplasia risk is minor compared to host- and tumour treatment-related factors. There is no evidence for an association between GH replacement and increased mortality from cancer amongst GH-deficient childhood cancer survivors. Patients with pituitary tumour or craniopharyngioma remnants receiving GH replacement do not need to be treated or monitored differently than those not receiving GH. GH replacement might be considered in GH-deficient adult cancer survivors in remission after careful individual risk/benefit analysis. In children with cancer predisposition syndromes, GH treatment is generally contraindicated but may be considered cautiously in select patients.
Published: 2022

28. Hormone replacement in survivors of childhood cancer and brain tumors: safety and controversies

Author: Endocrinologie onderzoek, Cancer, Endocrinologie patientenzorg, Brain, Child Health, van Roessel, Ichelle M A A, Bakker, Boudewijn, van Santen, Hanneke M, Chemaitilly, Wassim, Endocrinologie onderzoek, Cancer, Endocrinologie patientenzorg, Brain, Child Health, van Roessel, Ichelle M A A, Bakker, Boudewijn, van Santen, Hanneke M, and Chemaitilly, Wassim
Published: 2022

29. 2022 European Thyroid Association Guidelines for the management of pediatric thyroid nodules and differentiated thyroid carcinoma

Author: Endocrinologie onderzoek, Endocrinologie patientenzorg, Brain, Child Health, Cancer, Lebbink, Chantal A, Links, Thera P, Czarniecka, Agnieszka, Dias, Renuka P, Elisei, Rossella, Izatt, Louise, Krude, Heiko, Lorenz, Kerstin, Luster, Markus, Newbold, Kate, Piccardo, Arnoldo, Sorinho-Simoes, Manuel, Takano, Toru, Trotsenburg, A S Paul van, Verburg, Frederik A, van Santen, Hanneke M, Endocrinologie onderzoek, Endocrinologie patientenzorg, Brain, Child Health, Cancer, Lebbink, Chantal A, Links, Thera P, Czarniecka, Agnieszka, Dias, Renuka P, Elisei, Rossella, Izatt, Louise, Krude, Heiko, Lorenz, Kerstin, Luster, Markus, Newbold, Kate, Piccardo, Arnoldo, Sorinho-Simoes, Manuel, Takano, Toru, Trotsenburg, A S Paul van, Verburg, Frederik A, and van Santen, Hanneke M
Published: 2022

30. The effect of surveillance for differentiated thyroid carcinoma in childhood cancer survivors on survival rates: a decision-tree-based analysis

Author: Endocrinologie patientenzorg, Brain, Child Health, Cancer, Endocrinologie onderzoek, Heinzel, Alexander, Müller, Dirk, van Santen, Hanneke M, Clement, Sarah C, Schneider, Arthur B, Verburg, Frederik A, Endocrinologie patientenzorg, Brain, Child Health, Cancer, Endocrinologie onderzoek, Heinzel, Alexander, Müller, Dirk, van Santen, Hanneke M, Clement, Sarah C, Schneider, Arthur B, and Verburg, Frederik A
Published: 2022

31. Long-Term Oncological Outcomes of Papillary Thyroid Cancer and Follicular Thyroid Cancer in Children: A Nationwide Population-Based Study

Author: Endocrinologie patientenzorg, Brain, Child Health, Cancer, PMC Medisch specialisten, CTC, Heelkunde Opleiding, MS CGO, van de Berg, Daniël J., Kuijpers, Anke M.J., Engelsman, Anton F., Drukker, Caroline A., van Santen, Hanneke M., Terwisscha van Scheltinga, Sheila C.E.J., van Trotsenburg, A. S.Paul, Mooij, Christiaan F., Vriens, Menno R., Nieveen van Dijkum, Els J.M., Derikx, Joep P.M., Endocrinologie patientenzorg, Brain, Child Health, Cancer, PMC Medisch specialisten, CTC, Heelkunde Opleiding, MS CGO, van de Berg, Daniël J., Kuijpers, Anke M.J., Engelsman, Anton F., Drukker, Caroline A., van Santen, Hanneke M., Terwisscha van Scheltinga, Sheila C.E.J., van Trotsenburg, A. S.Paul, Mooij, Christiaan F., Vriens, Menno R., Nieveen van Dijkum, Els J.M., and Derikx, Joep P.M.
Published: 2022

32. Progressive diastolic dysfunction in survivors of pediatric differentiated thyroid carcinoma

Author: PMC Medisch specialisten, Speerpunt, Zorg en O&O, Cancer, Child Health, Endocrinologie patientenzorg, Brain, Reichert, Antoinette D., Nies, Marloes, Tissing, Wim J.E., Muller Kobold, Anneke C., Klein Hesselink, Mariëlle S., Brouwers, Adrienne H., Havekes, Bas, van den Heuvel-Eibrink, Marry M., van der Pal, Helena J.H., Plukker, John T.M., van Santen, Hanneke M., Corssmit, Eleonora P.M., Netea-Maier, Romana T., Peeters, Robin P., van Dam, Eveline W.C.M., Burgerhof, Johannes G.M., van der Meer, Peter, Bocca, Gianni, Links, Thera P., PMC Medisch specialisten, Speerpunt, Zorg en O&O, Cancer, Child Health, Endocrinologie patientenzorg, Brain, Reichert, Antoinette D., Nies, Marloes, Tissing, Wim J.E., Muller Kobold, Anneke C., Klein Hesselink, Mariëlle S., Brouwers, Adrienne H., Havekes, Bas, van den Heuvel-Eibrink, Marry M., van der Pal, Helena J.H., Plukker, John T.M., van Santen, Hanneke M., Corssmit, Eleonora P.M., Netea-Maier, Romana T., Peeters, Robin P., van Dam, Eveline W.C.M., Burgerhof, Johannes G.M., van der Meer, Peter, Bocca, Gianni, and Links, Thera P.
Published: 2022

33. Correction: Lebbink et al. Opposite Incidence Trends for Differentiated and Medullary Thyroid Cancer in Young Dutch Patients over a 30-Year Time Span. Cancers 2021, 13, 5104.: Lebbink et al. Opposite Incidence Trends for Differentiated and Medullary Thyroid Cancer in Young Dutch Patients over a 30-Year Time Span. (Cancers 2021, 13, 5104)

Author: Endocrinologie onderzoek, Unit Opleiding Aios, Arts-assistenten Kinderen, MS Endocriene Oncologie, Cancer, Heelkunde Opleiding, MS CGO, Cluster C, Endocrinologie, Child Health, Endocrinologie patientenzorg, Brain, Lebbink, Chantal A, van den Broek, Medard F M, Kwast, Annemiek B G, Derikx, Joep P M, Dierselhuis, Miranda P, Kruijff, Schelto, Links, Thera P, van Trotsenburg, A S Paul, Valk, Gerlof D, Vriens, Menno R, Verrijn Stuart, Annemarie A, van Santen, Hanneke M, Karim-Kos, Henrike E, Endocrinologie onderzoek, Unit Opleiding Aios, Arts-assistenten Kinderen, MS Endocriene Oncologie, Cancer, Heelkunde Opleiding, MS CGO, Cluster C, Endocrinologie, Child Health, Endocrinologie patientenzorg, Brain, Lebbink, Chantal A, van den Broek, Medard F M, Kwast, Annemiek B G, Derikx, Joep P M, Dierselhuis, Miranda P, Kruijff, Schelto, Links, Thera P, van Trotsenburg, A S Paul, Valk, Gerlof D, Vriens, Menno R, Verrijn Stuart, Annemarie A, van Santen, Hanneke M, and Karim-Kos, Henrike E
Published: 2022

34. Second primary malignancies induced by radioactive iodine treatment of differentiated thyroid carcinoma - a critical review and evaluation of the existing evidence

Author: Endocrinologie patientenzorg, Brain, Child Health, Cancer, Reinecke, Maximilian J., Ahlers, Gerrit, Burchert, Andreas, Eilsberger, Friederike, Flux, Glenn D., Marlowe, Robert J., Mueller, Hans Helge, Reiners, Christoph, Rohde, Fenja, van Santen, Hanneke M., Luster, Markus, Endocrinologie patientenzorg, Brain, Child Health, Cancer, Reinecke, Maximilian J., Ahlers, Gerrit, Burchert, Andreas, Eilsberger, Friederike, Flux, Glenn D., Marlowe, Robert J., Mueller, Hans Helge, Reiners, Christoph, Rohde, Fenja, van Santen, Hanneke M., and Luster, Markus
Published: 2022

35. Dextroamphetamine Treatment in Children With Hypothalamic Obesity

Author: Endocrinologie onderzoek, Activity&Health sectie exercise, Endocrinologie patientenzorg, PMC Medisch specialisten, Brain, Child Health, Cancer, van Schaik, Jiska, Welling, Mila S., de Groot, Corjan J., van Eck, Judith P., Juriaans, Alicia, Burghard, Marcella, Oude Ophuis, Sebastianus B.J., Bakker, Boudewijn, Tissing, Wim J.E., Schouten-van Meeteren, Antoinette Y.N., van den Akker, Erica L.T., van Santen, Hanneke M., Endocrinologie onderzoek, Activity&Health sectie exercise, Endocrinologie patientenzorg, PMC Medisch specialisten, Brain, Child Health, Cancer, van Schaik, Jiska, Welling, Mila S., de Groot, Corjan J., van Eck, Judith P., Juriaans, Alicia, Burghard, Marcella, Oude Ophuis, Sebastianus B.J., Bakker, Boudewijn, Tissing, Wim J.E., Schouten-van Meeteren, Antoinette Y.N., van den Akker, Erica L.T., and van Santen, Hanneke M.
Published: 2022

36. FDG PET/CT in differentiated thyroid cancer patients with low thyroglobulin levels

Author: Endocrinologie onderzoek, CTC, Cancer, MS CGO, Regenerative Medicine and Stem Cells, MS Radiologie, MS Endocriene Oncologie, Heelkunde Opleiding, Endocrinologie patientenzorg, Brain, Child Health, Lebbink, Chantal A., de Vries, Lisa H., Borel Rinkes, Inne H.M., Braat, Arthur J.A.T., van Leeuwaarde, Rachel S., Lodewijk, Lutske, van Treijen, Mark J.C., Vriens, Menno R., Valk, Gerlof D., van Santen, Hanneke M., de Keizer, Bart, Endocrinologie onderzoek, CTC, Cancer, MS CGO, Regenerative Medicine and Stem Cells, MS Radiologie, MS Endocriene Oncologie, Heelkunde Opleiding, Endocrinologie patientenzorg, Brain, Child Health, Lebbink, Chantal A., de Vries, Lisa H., Borel Rinkes, Inne H.M., Braat, Arthur J.A.T., van Leeuwaarde, Rachel S., Lodewijk, Lutske, van Treijen, Mark J.C., Vriens, Menno R., Valk, Gerlof D., van Santen, Hanneke M., and de Keizer, Bart
Published: 2022

37. Safety of growth hormone replacement in survivors of cancer and intra-cranial and pituitary tumours - A consensus statement

Author: Endocrinologie patientenzorg, Brain, Child Health, Cancer, Boguszewski, Margaret C S, Boguszewski, Cesar L, Chemaitilly, Wassim, Cohen, Laurie E, Gebauer, Judith, Higham, Claire, Hoffman, Andrew R, Polak, Michel, Yuen, Kevin C J, Alos, Nathalie, Antal, Zoltan, Bidlingmaier, Martin, Biller, Beverly M K, Brabant, Georg, Choong, Catherine S Y, Cianfarani, Stefano, Clayton, Peter E, Coutant, Regis, Cardoso-Demartini, Adriane A, Fernandez, Alberto, Grimberg, Adda, Gudmundsson, Kolbeinn, Guevara-Aquirre, Jamie, Ho, Ken K Y, Horikawa, Reiko, Isidori, Andrea M, Jorgensen, Jens Otto Lunde, Kamenicky, Peter, Karavitaki, Niki, Kopchick, John J, Lodish, Maya, Luo, Xiao-Ping, McCormack, Ann I, Meacham, Lillian, Melmed, Shlomo, Sogol Mostoufi-Moab, Sogol, Müller, Hermann L, Neggers, Sebastian J C M M, Aguiar-Oliveira, Manuel H, Ozono, Keiichi, Pennisi, Patricia A, Popovic, Vera, Radovick, Sally, Savendahl, Lars, Touraine, Philippe, van Santen, Hanneke M, Johannsson, Gudmundur, Endocrinologie patientenzorg, Brain, Child Health, Cancer, Boguszewski, Margaret C S, Boguszewski, Cesar L, Chemaitilly, Wassim, Cohen, Laurie E, Gebauer, Judith, Higham, Claire, Hoffman, Andrew R, Polak, Michel, Yuen, Kevin C J, Alos, Nathalie, Antal, Zoltan, Bidlingmaier, Martin, Biller, Beverly M K, Brabant, Georg, Choong, Catherine S Y, Cianfarani, Stefano, Clayton, Peter E, Coutant, Regis, Cardoso-Demartini, Adriane A, Fernandez, Alberto, Grimberg, Adda, Gudmundsson, Kolbeinn, Guevara-Aquirre, Jamie, Ho, Ken K Y, Horikawa, Reiko, Isidori, Andrea M, Jorgensen, Jens Otto Lunde, Kamenicky, Peter, Karavitaki, Niki, Kopchick, John J, Lodish, Maya, Luo, Xiao-Ping, McCormack, Ann I, Meacham, Lillian, Melmed, Shlomo, Sogol Mostoufi-Moab, Sogol, Müller, Hermann L, Neggers, Sebastian J C M M, Aguiar-Oliveira, Manuel H, Ozono, Keiichi, Pennisi, Patricia A, Popovic, Vera, Radovick, Sally, Savendahl, Lars, Touraine, Philippe, van Santen, Hanneke M, and Johannsson, Gudmundur
Published: 2022

38. Transition From Diencephalic Syndrome to Hypothalamic Obesity in Children With Suprasellar Low Grade Glioma: A Case Series

Author: Endocrinologie onderzoek, Cancer, Neurochirurgen, Endocrinologie patientenzorg, Brain, Child Health, van Roessel, Ichelle M.A.A., Schouten-van Meeteren, Antoinette Y.N., Meijer, Lisethe, Hoving, Eelco W., Bakker, Boudewijn, van Santen, Hanneke M., Endocrinologie onderzoek, Cancer, Neurochirurgen, Endocrinologie patientenzorg, Brain, Child Health, van Roessel, Ichelle M.A.A., Schouten-van Meeteren, Antoinette Y.N., Meijer, Lisethe, Hoving, Eelco W., Bakker, Boudewijn, and van Santen, Hanneke M.
Published: 2022

39. Hypothalamic syndrome

Author: Endocrinologie patientenzorg, Brain, Child Health, Cancer, Müller, Hermann L., Tauber, Maithé, Lawson, Elizabeth A., Özyurt, Jale, Bison, Brigitte, Martinez-Barbera, Juan Pedro, Puget, Stephanie, Merchant, Thomas E., van Santen, Hanneke M., Endocrinologie patientenzorg, Brain, Child Health, Cancer, Müller, Hermann L., Tauber, Maithé, Lawson, Elizabeth A., Özyurt, Jale, Bison, Brigitte, Martinez-Barbera, Juan Pedro, Puget, Stephanie, Merchant, Thomas E., and van Santen, Hanneke M.
Published: 2022

40. Oncofertility Perspectives for Girls with Cancer

Author: MS VPG/Gynaecologie, Cancer, Child Health, Endocrinologie patientenzorg, Brain, Speerpunt, Zorg en O&O, van der Perk, M. E.Madeleine, van der Kooi, Anne Lotte L.F., Bos, Annelies M.E., Broer, Simone L., Veening, Margreet A., van Leeuwen, Jeanette, van Santen, Hanneke M., van Dorp, Wendy, van den Heuvel-Eibrink, Marry M., MS VPG/Gynaecologie, Cancer, Child Health, Endocrinologie patientenzorg, Brain, Speerpunt, Zorg en O&O, van der Perk, M. E.Madeleine, van der Kooi, Anne Lotte L.F., Bos, Annelies M.E., Broer, Simone L., Veening, Margreet A., van Leeuwen, Jeanette, van Santen, Hanneke M., van Dorp, Wendy, and van den Heuvel-Eibrink, Marry M.
Published: 2022

41. Mineralocorticoid receptor status in the human brain after dexamethasone treatment: a single case study

Author: Endocrinologie patientenzorg, Brain, Child Health, Cancer, Koning, Anne Sophie C.A.M., Habets, Philippe C., Bogaards, Marit, Kroon, Jan, van Santen, Hanneke M., de Bont, Judith M., Meijer, Onno C., Endocrinologie patientenzorg, Brain, Child Health, Cancer, Koning, Anne Sophie C.A.M., Habets, Philippe C., Bogaards, Marit, Kroon, Jan, van Santen, Hanneke M., de Bont, Judith M., and Meijer, Onno C.
Published: 2022

42. Fasting Intervention for Children With Unilateral Renal Tumors to Reduce Toxicity

Author: Kinderbewegingszorg patientenzorg, Endocrinologie patientenzorg, Brain, Child Health, Cancer, Nefrologie, Zorgeenheid Kinderchirurgie Medisch, Zorg en O&O, Oudmaijer, Christiaan A J, van den Boogaard, Winnie M C, Komninos, Daphne S J, Verwaaijen, Emma J, van Santen, Hanneke M, Lilien, Marc R, Hoeijmakers, Jan H J, Wijnen, Marc H W, van den Heuvel-Eibrink, Marry M, Vermeij, Wilbert P, Kinderbewegingszorg patientenzorg, Endocrinologie patientenzorg, Brain, Child Health, Cancer, Nefrologie, Zorgeenheid Kinderchirurgie Medisch, Zorg en O&O, Oudmaijer, Christiaan A J, van den Boogaard, Winnie M C, Komninos, Daphne S J, Verwaaijen, Emma J, van Santen, Hanneke M, Lilien, Marc R, Hoeijmakers, Jan H J, Wijnen, Marc H W, van den Heuvel-Eibrink, Marry M, and Vermeij, Wilbert P
Published: 2022

43. Thyroid function after diagnostic I-123-metaiodobenzylguanidine in children with neuroblastic tumors

Author: Endocrinologie onderzoek, Zorg en O&O, Child Health, Endocrinologie patientenzorg, Brain, Cancer, Clement, Sarah C, Tytgat, Godelieve A M, van Trotsenburg, A S Paul, Kremer, Leontien C M, van Santen, Hanneke M, Endocrinologie onderzoek, Zorg en O&O, Child Health, Endocrinologie patientenzorg, Brain, Cancer, Clement, Sarah C, Tytgat, Godelieve A M, van Trotsenburg, A S Paul, Kremer, Leontien C M, and van Santen, Hanneke M
Published: 2022

44. Hypothalamic-Pituitary and Other Endocrine Surveillance Among Childhood Cancer Survivors

Author: Endocrinologie onderzoek, Child Health, Cancer, Neurochirurgen, MS Interne Geneeskunde, MS Radiotherapie, Endocrinologie patientenzorg, Brain, van Iersel, Laura, Mulder, Renee L., Denzer, Christian, Cohen, Laurie E., Spoudeas, Helen A., Meacham, Lillian R., Sugden, Elaine, Schouten-van Meeteren, Antoinette Y.N., Hoving, Eelco W., Packer, Roger J., Armstrong, Gregory T., Mostoufi-Moab, Sogol, Stades, Aline M., van Vuurden, Dannis, Janssens, Geert O., Thomas-Teinturier, Cécile, Murray, Robert D., Di Iorgi, Natascia, Neggers, Sebastian J.C.M.M., Thompson, Joel, Toogood, Andrew A., Gleeson, Helena, Follin, Cecilia, Bardi, Edit, Torno, Lilibeth, Patterson, Briana, Morsellino, Vera, Sommer, Grit, Clement, Sarah C., Srivastava, Deokumar, Kiserud, Cecilie E., Fernandez, Alberto, Scheinemann, Katrin, Raman, Sripriya, Yuen, Kevin C.J., Wallace, W. Hamish, Constine, Louis S., Skinner, Roderick, Hudson, Melissa M., Kremer, Leontien C.M., Chemaitilly, Wassim, van Santen, Hanneke M., Endocrinologie onderzoek, Child Health, Cancer, Neurochirurgen, MS Interne Geneeskunde, MS Radiotherapie, Endocrinologie patientenzorg, Brain, van Iersel, Laura, Mulder, Renee L., Denzer, Christian, Cohen, Laurie E., Spoudeas, Helen A., Meacham, Lillian R., Sugden, Elaine, Schouten-van Meeteren, Antoinette Y.N., Hoving, Eelco W., Packer, Roger J., Armstrong, Gregory T., Mostoufi-Moab, Sogol, Stades, Aline M., van Vuurden, Dannis, Janssens, Geert O., Thomas-Teinturier, Cécile, Murray, Robert D., Di Iorgi, Natascia, Neggers, Sebastian J.C.M.M., Thompson, Joel, Toogood, Andrew A., Gleeson, Helena, Follin, Cecilia, Bardi, Edit, Torno, Lilibeth, Patterson, Briana, Morsellino, Vera, Sommer, Grit, Clement, Sarah C., Srivastava, Deokumar, Kiserud, Cecilie E., Fernandez, Alberto, Scheinemann, Katrin, Raman, Sripriya, Yuen, Kevin C.J., Wallace, W. Hamish, Constine, Louis S., Skinner, Roderick, Hudson, Melissa M., Kremer, Leontien C.M., Chemaitilly, Wassim, and van Santen, Hanneke M.
Published: 2022

45. Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves' hyperthyroidism

Author: van der Vaart, Jelte, Bosmans, Lynn, Sijbesma, Stijn F, Knoops, Kèvin, van de Wetering, Willine J, Otten, Henny G, Begthel, Harry, Borel Rinkes, Inne H M, Korving, Jeroen, Lentjes, Eef G W M, Lopez-Iglesias, Carmen, Peters, Peter J, van Santen, Hanneke M, Vriens, Menno R, Clevers, Hans, van der Vaart, Jelte, Bosmans, Lynn, Sijbesma, Stijn F, Knoops, Kèvin, van de Wetering, Willine J, Otten, Henny G, Begthel, Harry, Borel Rinkes, Inne H M, Korving, Jeroen, Lentjes, Eef G W M, Lopez-Iglesias, Carmen, Peters, Peter J, van Santen, Hanneke M, Vriens, Menno R, and Clevers, Hans
Abstract: The thyroid maintains systemic homeostasis by regulating serum thyroid hormone concentrations. Here we report the establishment of three-dimensional (3D) organoids from adult thyroid tissue representing murine and human thyroid follicular cells (TFCs). The TFC organoids (TFCOs) harbor the complete machinery of hormone production as visualized by the presence of colloid in the lumen and by the presence of essential transporters and enzymes in the polarized epithelial cells that surround a central lumen. Both the established murine as human thyroid organoids express canonical thyroid markers PAX8 and NKX2.1, while the thyroid hormone precursor thyroglobulin is expressed at comparable levels to tissue. Single-cell RNA sequencing and transmission electron microscopy confirm that TFCOs phenocopy primary thyroid tissue. Thyroid hormones are readily detectable in conditioned medium of human TFCOs. We show clinically relevant responses (increased proliferation and hormone secretion) of human TFCOs toward a panel of Graves' disease patient sera, demonstrating that organoids can model human autoimmune disease.
Published: 2021

46. Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves' hyperthyroidism

Author: van der Vaart, Jelte, van der Vaart, Jelte, Bosmans, Lynn, Sijbesma, Stijn F., Knoops, Kevin, van de Wetering, Willine J., Otten, Henny G., Begthel, Harry, Rinkes, Inne H. M. Borel, Korving, Jeroen, Lentjes, Eef G. W. M., Lopez-Iglesias, Carmen, Peters, Peter J., van Santen, Hanneke M., Vriens, Menno R., Clevers, Hans, van der Vaart, Jelte, van der Vaart, Jelte, Bosmans, Lynn, Sijbesma, Stijn F., Knoops, Kevin, van de Wetering, Willine J., Otten, Henny G., Begthel, Harry, Rinkes, Inne H. M. Borel, Korving, Jeroen, Lentjes, Eef G. W. M., Lopez-Iglesias, Carmen, Peters, Peter J., van Santen, Hanneke M., Vriens, Menno R., and Clevers, Hans
Abstract: The thyroid maintains systemic homeostasis by regulating serum thyroid hormone concentrations. Here we report the establishment of three-dimensional (3D) organoids from adult thyroid tissue representing murine and human thyroid follicular cells (TFCs). The TFC organoids (TFCOs) harbor the complete machinery of hormone production as visualized by the presence of colloid in the lumen and by the presence of essential transporters and enzymes in the polarized epithelial cells that surround a central lumen. Both the established murine as human thyroid organoids express canonical thyroid markers PAX8 and NKX2.1, while the thyroid hormone precursor thyroglobulin is expressed at comparable levels to tissue. Single-cell RNA sequencing and transmission electron microscopy confirm that TFCOs phenocopy primary thyroid tissue. Thyroid hormones are readily detectable in conditioned medium of human TFCOs. We show clinically relevant responses (increased proliferation and hormone secretion) of human TFCOs toward a panel of Graves' disease patient sera, demonstrating that organoids can model human autoimmune disease.
Published: 2021

47. Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves' hyperthyroidism

Author: van der Vaart, Jelte, Bosmans, Lynn, Sijbesma, Stijn F, Knoops, Kèvin, van de Wetering, Willine J, Otten, Henny G, Begthel, Harry, Borel Rinkes, Inne H M, Korving, Jeroen, Lentjes, Eef G W M, Lopez-Iglesias, Carmen, Peters, Peter J, van Santen, Hanneke M, Vriens, Menno R, Clevers, Hans, van der Vaart, Jelte, Bosmans, Lynn, Sijbesma, Stijn F, Knoops, Kèvin, van de Wetering, Willine J, Otten, Henny G, Begthel, Harry, Borel Rinkes, Inne H M, Korving, Jeroen, Lentjes, Eef G W M, Lopez-Iglesias, Carmen, Peters, Peter J, van Santen, Hanneke M, Vriens, Menno R, and Clevers, Hans
Abstract: The thyroid maintains systemic homeostasis by regulating serum thyroid hormone concentrations. Here we report the establishment of three-dimensional (3D) organoids from adult thyroid tissue representing murine and human thyroid follicular cells (TFCs). The TFC organoids (TFCOs) harbor the complete machinery of hormone production as visualized by the presence of colloid in the lumen and by the presence of essential transporters and enzymes in the polarized epithelial cells that surround a central lumen. Both the established murine as human thyroid organoids express canonical thyroid markers PAX8 and NKX2.1, while the thyroid hormone precursor thyroglobulin is expressed at comparable levels to tissue. Single-cell RNA sequencing and transmission electron microscopy confirm that TFCOs phenocopy primary thyroid tissue. Thyroid hormones are readily detectable in conditioned medium of human TFCOs. We show clinically relevant responses (increased proliferation and hormone secretion) of human TFCOs toward a panel of Graves' disease patient sera, demonstrating that organoids can model human autoimmune disease.
Published: 2021

48. Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves' hyperthyroidism

Author: van der Vaart, Jelte, Bosmans, Lynn, Sijbesma, Stijn F., Knoops, Kevin, van de Wetering, Willine J., Otten, Henny G., Begthel, Harry, Rinkes, Inne H. M. Borel, Korving, Jeroen, Lentjes, Eef G. W. M., Lopez-Iglesias, Carmen, Peters, Peter J., van Santen, Hanneke M., Vriens, Menno R., Clevers, Hans, van der Vaart, Jelte, Bosmans, Lynn, Sijbesma, Stijn F., Knoops, Kevin, van de Wetering, Willine J., Otten, Henny G., Begthel, Harry, Rinkes, Inne H. M. Borel, Korving, Jeroen, Lentjes, Eef G. W. M., Lopez-Iglesias, Carmen, Peters, Peter J., van Santen, Hanneke M., Vriens, Menno R., and Clevers, Hans
Abstract: The thyroid maintains systemic homeostasis by regulating serum thyroid hormone concentrations. Here we report the establishment of three-dimensional (3D) organoids from adult thyroid tissue representing murine and human thyroid follicular cells (TFCs). The TFC organoids (TFCOs) harbor the complete machinery of hormone production as visualized by the presence of colloid in the lumen and by the presence of essential transporters and enzymes in the polarized epithelial cells that surround a central lumen. Both the established murine as human thyroid organoids express canonical thyroid markers PAX8 and NKX2.1, while the thyroid hormone precursor thyroglobulin is expressed at comparable levels to tissue. Single-cell RNA sequencing and transmission electron microscopy confirm that TFCOs phenocopy primary thyroid tissue. Thyroid hormones are readily detectable in conditioned medium of human TFCOs. We show clinically relevant responses (increased proliferation and hormone secretion) of human TFCOs toward a panel of Graves' disease patient sera, demonstrating that organoids can model human autoimmune disease.
Published: 2021

49. Oncofertility care for newly diagnosed girls with cancer in a national pediatric oncology setting, the first full year experience from the Princess Máxima Center, the PEARL study

Author: Madeleine van der Perk, M. E., van der Kooi, Anne Lotte L.F., van de Wetering, Marianne D., IJgosse, Irene M., van Dulmen-Den Broeder, Eline, Broer, Simone L., Klijn, Aart J., Versluys, A. Birgitta, Arends, Brigitte, Oude Ophuis, Ralph J.A., van Santen, Hanneke M., van der Steeg, Alida F.W., Veening, Margreet A., van den Heuvel-Eibrink, Marry M., Bos, Annelies M.E., Madeleine van der Perk, M. E., van der Kooi, Anne Lotte L.F., van de Wetering, Marianne D., IJgosse, Irene M., van Dulmen-Den Broeder, Eline, Broer, Simone L., Klijn, Aart J., Versluys, A. Birgitta, Arends, Brigitte, Oude Ophuis, Ralph J.A., van Santen, Hanneke M., van der Steeg, Alida F.W., Veening, Margreet A., van den Heuvel-Eibrink, Marry M., and Bos, Annelies M.E.
Abstract: Background Childhood cancer patients often remain uninformed regarding their potential risk of gonadal damage. In our hospital we introduced a five step standard oncofertility care plan for all newly diagnosed female patients aiming to identify, inform and triage 100% of patients and counsel 100% of patients at high risk (HR) of gonadal damage. This observational retrospective study (PEARL study) evaluated the use of this standard oncofertility care plan in the first full year in a national cohort. Methods The steps consist of 1)timely (preferably before start of gonadotoxic treatment) identification of all new patients, 2)triage of gonadal damage risk using a standardized gonadal damage risk stratification tool, 3)informing all patients and families, 4)counseling of a selected subset of girls, and 5) fertility preservation including ovarian tissue cryopreservation (OTC) in HR patients using amended Edinburgh criteria. A survey of the medical records of all girls newly diagnosed with cancer the first year (1-1-2019 until 31-12-2019) was conducted. Results Of 261 girls, 228 (87.4%) were timely identified and triaged. Triage resulted in 151 (66%) low(LR), 32 (14%) intermediate(IR) and 45 (20%) high risk(HR) patients. Ninety-nine families were documented to be timely informed regarding gonadal damage risk. In total, 35 girls (5 LR, 5 IR, 25 HR) were counseled by an oncofertility expert. 16/25 HR patients underwent fertility preservation (1 ovariopexy + OTC, oocyte cryopreservation (1 with and 1 without OTC) and 13 OTC). Fertility preservation did not lead to complications or delay of cancer treatment in any patient. Conclusion We timely identified and triaged most girls (88%) with cancer with a high risk of gonadal damage to be counseled for fertility preservation. We aim to optimize the oncofertility care plan and the standardized gonadal damage risk stratification tool based on this experience and these may be of value to other pediatric oncology centers.
Published: 2021

50. Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves’ hyperthyroidism

Author: CDL Patiëntenzorg MI, Infection & Immunity, MS CGO, Regenerative Medicine and Stem Cells, Cancer, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), Endocrinologie patientenzorg, Brain, Child Health, Heelkunde Opleiding, CMM Sectie Molecular Cancer Research, van der Vaart, Jelte, Bosmans, Lynn, Sijbesma, Stijn F, Knoops, Kèvin, van de Wetering, Willine J, Otten, Henny G, Begthel, Harry, Borel Rinkes, Inne H M, Korving, Jeroen, Lentjes, Eef G W M, Lopez-Iglesias, Carmen, Peters, Peter J, van Santen, Hanneke M, Vriens, Menno R, Clevers, Hans, CDL Patiëntenzorg MI, Infection & Immunity, MS CGO, Regenerative Medicine and Stem Cells, Cancer, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), Endocrinologie patientenzorg, Brain, Child Health, Heelkunde Opleiding, CMM Sectie Molecular Cancer Research, van der Vaart, Jelte, Bosmans, Lynn, Sijbesma, Stijn F, Knoops, Kèvin, van de Wetering, Willine J, Otten, Henny G, Begthel, Harry, Borel Rinkes, Inne H M, Korving, Jeroen, Lentjes, Eef G W M, Lopez-Iglesias, Carmen, Peters, Peter J, van Santen, Hanneke M, Vriens, Menno R, and Clevers, Hans
Published: 2021

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