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This article discusses the cryoEM structure of human serum albumin (HSA) in complex with two ligands, salicylic acid and teniposide. HSA is the most prevalent plasma protein in the human body and plays a major role in the distribution of endobiotics and xenobiotics. The study demonstrates that sub-4 Angstrom maps of ~60 kDa proteins can be obtained using a 200 kV microscope, allowing for the identification of small molecule ligands. This methodology has practical applicability and can serve as a starting point for subsequent computational modeling and in silico optimization. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

Keywords: Uttar Pradesh; India; Asia; Anticancer Agents; Cancer; Cancer Therapy; Drugs and Therapies; Health and Medicine; Oncology; Protective Agents EN Uttar Pradesh India Asia Anticancer Agents Cancer Cancer Therapy Drugs and Therapies Health and Medicine Oncology Protective Agents 214 214 1 06/26/23 20230627 NES 230627 2023 JUN 27 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in Drugs and Therapies - Anticancer Agents. Uttar Pradesh, India, Asia, Anticancer Agents, Cancer, Cancer Therapy, Drugs and Therapies, Health and Medicine, Oncology, Protective Agents According to news originating from Uttar Pradesh, India, by NewsRx correspondents, research stated, "Cisplatin-based metallodrugs are traditionally utilized as anticancer agents. [Extracted from the article]

A recent study conducted by the Ministry of Health in Moscow, Russia, has explored the potential of newly synthesized bis-benzimidazole-pyrroles molecules in the field of oncology. These molecules have shown the ability to form complexes with DNA and have demonstrated enhanced toxic properties against human tumor cells. The study suggests that further research is needed to understand the mechanisms of action and potential applications of these molecules in the treatment of cancer. The findings have been published in the journal Acta Naturae. [Extracted from the article]

A preprint abstract from biorxiv.org discusses a statistical method called LRnetST that aims to characterize the ligand-receptor interaction networks between tumor and stroma cells in ovarian cancer. The method utilizes spatial transcriptomic (ST) data and a directed acyclic graph (DAG) model to analyze the cell-cell communication in the tumor microenvironment. The study applied LRnetST to high-grade serous ovarian tumor samples and identified both common and distinct ligand-receptor regulations across different tumors. The findings shed light on the biological processes involved in the communication between tumor and immune/stromal cells in ovarian tumors. The preprint has not yet undergone peer review. [Extracted from the article]

A patent application titled "Cereblon Ligands and Uses Thereof" has been submitted by a group of inventors. The application discusses the role of cereblon (CRBN) in the degradation of target proteins and its connection to immunomodulatory agents like thalidomide and lenalidomide. The inventors propose compounds and conjugates that can bind to the cereblon E3 ubiquitin ligase protein complex, potentially leading to the degradation of specific proteins. The application also mentions the development of PROTACs molecules based on CRBN ligands. This information may be useful for researchers studying protein degradation and the treatment of diseases. [Extracted from the article]

The data suggested a more contracted structure for the SPhoMe-ligand gold-silver nanocluster (Au9Ag6-SPhoMe) compared to the SPhpOMe-ligand nanocluster (Au9Ag6-SPhpOMe). Keywords: Chemistry; Education; Emerging Technologies; Engineering; Metal Nanoclusters; Ministry Of Education; Nanoclusters; Nanomaterials; Nanoscience; Nanotechnology; Tsinghua University Press EN Chemistry Education Emerging Technologies Engineering Metal Nanoclusters Ministry Of Education Nanoclusters Nanomaterials Nanoscience Nanotechnology Tsinghua University Press 2855 2855 1 10/09/23 20231013 NES 231013 2023 OCT 13 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Metal nanoclusters are tiny, crystalline structures up to two nanometers (2 x 10-9 meters) in diameter that contain a few to hundreds of metal atoms. [Extracted from the article]

Preparation and investigation of new Co(II), Ni(II), Zn(II) and Cr(III) chelates with mixed ligands including Schiff base (L1) formed from the condensation of 4- dimethylaminobenzaldehyde with 2-aminophenol and anthranilic acid (L2) were studied. The obtained Schiff base and mixed ligand chelates were subjected to several physiochemical techniques, in terms of CHN elemental analyses, molar conductivity, magnetic moment measurements, infrared, proton nuclear magnetic resonance, electronic and mass spectra. The analytical data showed the formation of the Schiff base compound and the ratio of metal to ligands of the chelates are 1:1:1[M:L1:L2]. The infrared spectral data exhibited that the used ligands behaving as bidentate ligands towards the metal ions. The proton nuclear magnetic resonance spectral data showed the signals of the active groups in the ligands which entered in chelation with Zn(II) metal ion. The electronic spectral results showed the existence of π→π* (phenyl ring) and n→π*(C=N) of the ligands and suggested the geometrical structures of the chelates. Meanwhile, the mass spectral data revealed the fragmentations of the Schiff base, anthranilic acid and their Ni(II) mixed ligand chelate has been preformed the only chelate conducted for justification. All the prepared mixed chelates were non-electrolyte in nature. The antibacterial activity of the Schiff base, anthranilic acid, metal salts and mixed ligand chelates were studied and found to be that mixed ligand chelates have the most biological activity in comparison to the free ligands and salts. [ABSTRACT FROM AUTHOR]