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Bacterial endophthalmitis (BE) is an acute eye infection and potentially irreversible blinding ocular disease. The empirical intravitreous injection of antibiotic is the primary treatment once diagnosed as BE. However, the overuse of antibiotic contributes to the drug resistance of pathogens and the retinal toxicity of antibiotic limits its application in clinic. Herein, a cationic aggregation‐induced emission luminogens named with triphenylamine thiophen pyridinium (TTPy) is reported for photodynamic treatment of BE. TTPy can selectively discriminate and kill bacteria efficiently over normal ocular cells. More importantly, TTPy shows excellent antibacterial ability in BE rat models infected by Staphylococcus aureus. Meanwhile, the bacterial killing behavior triggered by TTPy induces innate immune response at an early stage of infection, limiting subsequent robust inflammation and protecting retina from bacterial toxins and inflammation‐induced bystander damage. In addition, TTPy performs better antibacterial ability than commercially used Rose Bengal, suggesting its excellent capability of vision salvage in acute BE. This study exhibits an efficient photodynamic antibacterial treatment to BE, which induces an early intraocular immune response and saves useful vision, endowing TTPy a promising potential for clinical application of ocular infections. [ABSTRACT FROM AUTHOR]

The purposeful modulation of the optoelectronic properties was realised on the basis of a series of the large, conjugated, phosphine oxide hosts 9,9-bis-{4′-[2-(diphenylphosphinoyl)phenoxy]biphenyl-4-yl}-9 H-fluorene (DDPESPOF), 9,9-bis-{3′-(diphenylphosphinoyl)-4′-[2-(diphenylphosphinoyl)phenoxy]biphenyl-4-yl}-9 H-fluorene (DDPEPOF), 9-[4′-(9-{4′-[2-(diphenylphosphoryl)phenoxy]biphenyl-4-yl}-9 H-fluoren-9-yl)biphenyl-4-yl]-9 H-carbazole (DPESPOFPhCz) and 9-[4′-(9-{3′-(diphenylphosphoryl)-4′-[2-(diphenylphosphoryl)phenoxy]biphenyl-4-yl}-9 H-fluoren-9-yl)biphenyl-4-yl]-9 H-carbazole (DPEPOFPhCz). The last two are quaternary with fluorenyls as linking bridges, diphenylphosphine oxide (DPPO) moieties as electron acceptors and diphenylethers and carbazolyls as two different kinds of electron donors. Owing to the fine-organised molecular structures and the mixed indirect and multi-insulating linkages, all of these hosts achieve the same first triplet energy levels (T1) of 2.86 eV for exothermic energy transfer to phosphorescent dopants. The first singlet energy levels (S1) and the carrier injection/transportation ability of the hosts were accurately modulated, so that DPESPOFPhCz and DPEPOFPhCz revealed extremely similar optoelectronic properties. However, the T1 state of the former is localised on fluorenyl, whereas the carbazolyl mainly contributes to the T1 state of the latter. A lower driving voltages and much higher efficiencies of the devices based on DPESPOFPhCz indicated that the chromophore-localised T1 state can suppress the quenching effects through realising independent contributions from the different functional groups to the optoelectronic properties and the embedding and protecting effect on the T1 states by peripheral carrier transporting groups. [ABSTRACT FROM AUTHOR]

Layered nickel silicate nanoflowers (NSFs) with a hierarchical nanostructure have been successfully fabricated by a template-free solvothermal method. The as-prepared nanoflowers were composed of many interconnected edge-curving lamellae with a thickness of about 15 nm and had a high specific surface area (279 m2 g−1) and large pore volume (0.67 cm3 g−1). The highly dispersed small silver nanoparticles (AgNPs) were immobilized on the surface of NSFs through the in situ reduction of Ag+ by Sn2+. The AgNP/NSF nanocomposites showed a high performance in the catalytic reduction of 4-nitrophenol. In particular, there was no visible decrease in the catalytic activity of the reused catalysts even after being recycled four times. The as-prepared AgNP/NSF nanocomposites might be an excellent catalyst owing to their availability, formability, chemical and thermal stability, and high specific surface area. [ABSTRACT FROM AUTHOR]