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Possible Association of Maternal Haemorrhoid with Congenital Abnormalities in their Children - a Population-Based Case-Control StudyObjectives:To look for a possible association of maternal haemorrhoid during pregnancy with a risk of congenital abnormalities in their children.Methods:Comparison of the prevalence of medically-recorded haemorrhoid in pregnant women who had fetuses/newborns (cases) with congenital abnormalities and healthy babies (controls) in the population-based Hungarian Case-Control Surveillance System of Congenital Abnormalities.Results:Of 22,843 cases with congenital abnormalities, 798 (3.49%), while of 38,151 controls, 1,624 (4.26%) had mothers with recorded and usually treated severe haemorrhoids. We found a higher risk for exomphalos (OR with 95% CI: 4.9, 1.7-7.9), and malposition-malrotation of gut (OR with 95% CI: 17.2, 2.1-142.0) which were present in 14 and 8 children of pregnant women with haemorrhoid, respectively. These associations could not be explained by teratogenic effect of maternal haemorrhoid or by drug treatments, so we hypothesized a possible common genetic background.Conclusions:The higher frequency of exomphalos and malposition-malrotation of gut found in the children of mothers with haemorrhoid during pregnancy requires further study.

Anterior colporrhaphy (Kelly-Stoeckel suture) was performed on 22 women suffering from grade-I or grade-II genuine stress incontinence. Urodynamic investigation was performed on every patient before surgery and 6 months postoperatively. 21 patients were cured and 1 patient improved. After operation the functional urethral length was increased by 28.8%, and urethrovesical pressure transmission was improved by 22.9%. Maximum urethral closure pressure decreased postoperatively by 21.1%. Pressure transmission was clearly improved by the surgical intervention and urinary continence was restored in spite of the fact that maximal urethral closure pressure decreased. Based on these results it is suggested to consider performing anterior colporrhaphy in cases of weak urethral closure pressure, because of the increased risk of worsening the complaints of these patients.

The administration of folic acid (FA) or multivitamin (MV) supplements during preconception to prevent neural tube defects is well established. Most pregnant women in Hungary use high doses of FA early in pregnancy, but it is unclear whether continuing these supplements after the first trimester reduces the rate of preterm delivery and low birth weight. The results of 2 meta-analyses on supplementation were inconclusive as to the benefits of continuation and recommended further investigation. Some practitioners have suggested that increased birth weight resulting from supplementation may increase the risk of complications.