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Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.

Further experimental results are given on the influence of combined orthogonal transverse electric and magnetic fields on the mobility of the carriers in the space charge layer at the surface of a semiconductor. In particular, it is shown that the Hall field could change the type of surface layer. It is found that for weak field the mobility of the carriers is proportional to the Hall field. By combining the electric and magnetic field effects in different ambients several regions of the Schrieffer curve could be explored. Temperature effects are also studied and it was found that it was more difficult to inverse the surface at a high temperature.