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2025 JAN 18 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Heart Disorders and Diseases - Heart Disease have [...]

2025 JAN 11 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on laboratory medicine are presented in a new report. According [...]

Mineralys Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension, chronic kidney disease (CKD) and other diseases driven by dysregulated aldosterone, announced that the US Food [...]

2024 NOV 9 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in peptide hormones. According to news reporting originating [...]

2024 OCT 12 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Peptide Proteins - Peptide Hormones. According to [...]

2024 SEP 30 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Fresh data on peptide hormones are presented in a new report. According to news [...]

2024 SEP 14 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 SEP 7 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 MAY 18 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

The novel selective aldosterone synthase inhibitor BI 690517 (up to 10 mg daily) with concurrent renin-angiotensin-system (RAS) inhibition, with or without the SGLT2 inhibitor empagliflozin, dose-dependently improved albuminuria reduction in [...]

2024 JAN 6 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on Drugs and Therapies - Hormones have been presented. According [...]

The article presents the discussion on hormonal fluctuations with aging can lead to various health issues, but there are effective ways to manage them. Topics include impact of reduced vitamin D production in older adults, the potential for hypothyroidism due to increased thyroid stimulating hormone; and the importance of regular blood tests and supplements to address these hormonal changes.

A patent has been issued for adeno-associated virus gene therapy for 21-hydroxylase deficiency by Adrenas Therapeutics Inc. The therapy aims to address the challenges faced by patients with severe forms of 21-hydroxylase deficiency, which can lead to adrenal crisis and other complications. The therapy involves a recombinant adeno-associated virus vector encoding a 21-hydroxylase protein, offering a potential solution for persistent correction of the deficiency. [Extracted from the article]

A study conducted at the University of Virginia explored the impact of Renin-angiotensin system inhibitors (RAASI) on patients with metastatic renal cell carcinoma (mRCC) receiving immunotherapy (IO). The research found that concurrent use of RAASI was associated with a significantly increased likelihood of tumor regression in mRCC patients. The study suggests the potential therapeutic advantage of combining RAASI with IO for mRCC patients, highlighting the need for further exploration in prospective studies to improve treatment outcomes for this patient population. [Extracted from the article]

Recent studies from Universitas Muhammadiyah Magelang focus on the role of the renin angiotensin aldosterone system in cardiovascular diseases, particularly stroke. The research highlights how risk factors like hyperglycemia and hypertension can lead to endothelial dysfunction and oxidative stress. The study suggests that inhibiting the angiotensin converting enzyme may offer cardioprotection and neuroprotection, potentially opening new avenues for managing cardiovascular diseases. [Extracted from the article]

A recent study conducted at Ohio State University focused on the staining patterns of aldosterone synthase in patients undergoing surgery for primary aldosteronism. The researchers developed a system of categorization for different staining patterns and analyzed clinical and biochemical outcomes post-surgery. The study found various staining patterns, including in nonadenomatous tissue, but did not observe significant correlations with early clinical or biochemical outcomes. The researchers concluded that a uniform categorization of staining patterns would facilitate consistent reporting across studies. [Extracted from the article]

Researchers at Zhejiang University School of Medicine conducted a study on hyperaldosteronism, a condition characterized by autonomous aldosterone overproduction leading to secondary hypertension and cardiovascular complications. The study utilized bioinformatics and experimental validation to identify potential drug targets for hyperaldosteronism, with a focus on SHMT1 as a promising therapeutic candidate. Through systematic screening and prioritization, the researchers identified 163 PA-associated genes, with SHMT1 emerging as the most promising target, supported by drug repurposing analysis and molecular docking studies. The findings offer new opportunities for developing causative treatments for hyperaldosteronism, although further clinical validation is needed. [Extracted from the article]

Researchers at Chiba University Hospital in Japan have published a study on hyperaldosteronism, a condition involving excessive production of aldosterone. The study challenges traditional classifications of primary aldosteronism (PA) and emphasizes the need for updated screening strategies based on pathophysiological insights. Recent advancements in understanding PA pathogenesis, including aldosterone driver mutations, suggest a more complex spectrum of the condition. The study discusses the importance of reevaluating screening methods to improve case detection rates. [Extracted from the article]

A recent study from the University of South Carolina explores the Renin-angiotensin-aldosterone system (RAAS), a complex regulator involving hormones, proteins, and enzymes. The research highlights the importance of RAAS inhibition in managing cardiovascular diseases, such as hypertension, heart failure, atherosclerosis, and kidney disease. The study delves into the history, mechanism, cardiovascular benefits, affordability, and potential future pharmacological therapies related to RAAS inhibition. [Extracted from the article]

A recent study from Arabian Gulf University examined the potential interaction between dipeptidyl peptidase-4 inhibitors (DPP-4is) and drugs affecting the renin-angiotensin-aldosterone system (RAAS) in relation to angioedema. The researchers analyzed data from the United States Food and Drug Administration Adverse Event Reporting System (USFDA AERS) and found significant safety signals for angioedema with specific DPP-4i combinations with RAAS-interfering drugs. The study highlights the importance of careful patient monitoring, especially in vulnerable populations, when prescribing these drug combinations. Further research is needed to confirm these findings and establish definitive causal relationships. [Extracted from the article]

The article "Adipocyte Aldosterone in Obstructive Sleep Apnea" explores the potential role of aldosterone, a hormone produced by the adrenal glands, in regulating blood pressure and cardiovascular risk in patients with obstructive sleep apnea (OSA). The study compared aldosterone levels in fat tissue between OSA patients and healthy individuals, finding no significant differences. Additionally, the research did not observe variations in aldosterone production in human fat cells under normal conditions versus conditions mimicking OSA. This preprint has not undergone peer review and can be accessed for further information at biorxiv.org/content/10.1101/2025.01.07.631499v1. [Extracted from the article]

Researchers at National Taiwan University Hospital conducted a study on the relationship between tissue inhibitor of metalloproteinases-1 (TIMP-1) and KCNJ5 mutation in aldosterone-producing adenoma (APA) patients. The study found that KCNJ5 somatic mutations in APA are associated with higher plasma TIMP-1 levels, making TIMP-1 an effective biomarker for detecting the presence of KCNJ5 mutations in APA patients. This research provides new insights into the genetic factors influencing aldosterone-producing adenomas. [Extracted from the article]

A recent study from the Faculty of Medicine State University Sao Paulo focused on the use of plasma metanephrine in adrenal venous sampling (AVS) to assess lateralization in primary aldosteronism (PA) with or without mild autonomous cortisol secretion (MACS). The research found that metanephrine was superior to cortisol in assessing selectivity and equivalent in determining lateralization after cosyntropin stimulation. The study concluded that MACS generally did not impact lateralization in AVS under cosyntropin, except in cases where aldosterone and cortisol were secreted by different adrenal lesions. [Extracted from the article]

The article discusses a study conducted at Indiana University School of Medicine on the effects of aldosterone on hypertension-associated kidney injury in a mouse model. The research found that high-salt diets increased blood pressure in mice carrying the human aldosterone synthase gene, leading to kidney inflammation and injury. By using aldosterone synthase inhibitors and mineralocorticoid receptor antagonists, the study demonstrated potential treatments for aldosterone-mediated hypertension and related kidney complications. The findings provide insights into the pathogenic mechanisms of aldosterone and its receptor, offering avenues for further research and potential therapeutic development. [Extracted from the article]

A recent study conducted at the First Affiliated Hospital of Chongqing Medical University focused on the use of Liquid chromatography-tandem mass spectrometry (LC-MS/MS) in subtyping primary aldosteronism (PA) when apparent bilateral aldosterone suppression (ABAS) occurs. The research found that LC-MS/MS reduced the occurrence of ABAS compared to immunoassay, leading to more accurate subtyping of PA. The study concluded that LC-MS/MS measurement of aldosterone and cortisol is a valuable tool in cases of ABAS. [Extracted from the article]

The article from Genomics & Genetics Weekly discusses a case report on aldosterone synthase deficiency (ASD), a rare inherited disease. Mutations in the CYP11B2 gene are responsible for ASD, leading to symptoms such as failure to thrive, dehydration, and electrolyte imbalances. The research highlights the importance of comprehensive hormonal investigation and genetic confirmation for clinical management. Treatment with oral fludrocortisone showed positive outcomes in a newborn with isolated ASD. The study emphasizes the challenges in genetic sequencing due to homology with other genes. [Extracted from the article]

A recent study conducted by researchers at Universite de Sousse reported a rare case of a 61-year-old man with concurrent adrenal adenoma, unilateral adrenal hyperplasia, and bilateral renal artery stenosis. The patient presented with hypertension, severe hypokalemia, and metabolic alkalosis, leading to a diagnosis of primary aldosteronism. Treatment with anti-aldosterone agents successfully controlled blood pressure and potassium levels. The study highlights the importance of thorough assessment for hyperaldosteronism in cases of arterial hypertension with hypokalemia. [Extracted from the article]

A clinical trial, NCT06746753, aims to evaluate the benefits of exogenous Angiotensin II versus norepinephrine treatment in septic shock patients to improve outcomes. The trial focuses on determining better predictors of septic shock severity and aims to restore the renin-angiotensin-aldosterone system in sepsis. The study will provide insights into treatment regimens and may enhance patient care for those with septic shock. [Extracted from the article]

Researchers from the Federal State Budgetary Educational Institution of Higher Education have published a new report on hyperaldosteronism, focusing on a patient with autonomous cortisol secretion and bilateral adrenal adenomas. The study highlights the increasing number of cases with combined secretion of aldosterone and cortisol, known as Conching syndrome, and discusses the clinical implications of such cases. The research emphasizes the importance of identifying mixed hormonal secretion in adrenal gland formations and the need for specialized management due to metabolic disorders. The study concludes with the detection of primary hyperaldosteronism in the patient, with distinct lateralization of aldosterone secretion on the right side. [Extracted from the article]

A recent study from the University of Mississippi Medical Center explores the role of aldosterone and potassium in heart failure. The research highlights the impact of dyskalaemia (abnormal serum potassium levels) on heart failure outcomes and discusses potential management strategies, including the use of novel potassium binders. The study also addresses the implications of aldosterone-modulating therapies in optimizing heart failure treatment. For more information, readers can access the full article titled "Aldosterone and Potassium in Heart Failure: Overcoming This Major Impediment in Clinical Practice" in Cardiac Failure Review. [Extracted from the article]

A recent study conducted by researchers at the University of Barcelona examined the impact of chronic treatment with angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) on short-term outcomes in patients with acute heart failure (AHF). The study, which included 17,920 patients diagnosed with AHF in Spanish Emergency Departments, found that patients receiving chronic ACEI/ARB treatment had better short-term outcomes, including lower in-hospital mortality rates and reduced need for hospital admission. The research concluded that chronic use of ACEI/ARB was associated with improved short-term outcomes for patients with AHF attending Emergency Departments. [Extracted from the article]

The article discusses a hub model developed using data from the VICTAS Trial to analyze components of the Renin-Angiotensin-Aldosterone System (RAAS) in relation to sepsis. The study found that controls had levels of renin similar to sepsis patients in quartile 1 (Q1) for calculated AT1 receptor, and levels similar to sepsis patients in quartile 3 (Q4) for measured aldosterone levels. The research suggests that AT1, aldosterone, and renin are major hub nodes in the metabolic data inputs model. This preprint has not yet undergone peer review. [Extracted from the article]

A recent study from McGill University examined the impact of exposure to a mixture of organophosphate esters (OPEs) on the adrenal glands of Sprague Dawley rats. The research found that OPE exposure led to sex-specific effects on adrenal gland function, with male rats experiencing reduced adrenal gland weight and decreased levels of aldosterone and corticosterone. Female rats, on the other hand, showed an increase in adrenal gland weight. The study concluded that OPE exposure affects adrenal function in a sex-specific manner, with different pathways being affected in male and female rats. [Extracted from the article]

A study conducted at Oslo University Hospital in Norway developed an LC-MS/MS method to simultaneously determine 13 steroid hormones and two synthetic steroids in saliva samples, which could be particularly useful for pediatric populations. The research focused on adapting the method for neonatal populations, with a special emphasis on low sample volumes and selectivity of analytes. The study concluded that the non-invasiveness, small saliva volume requirement, on-swab stability, and analytical performance of the method make it relevant for both research and diagnostics, especially in neonatal intensive care units. [Extracted from the article]

A recent report from the University of California San Francisco (UCSF) discusses the dysregulation of the renin-angiotensin-aldosterone-system (RAAS) in sepsis and its potential impact on patient outcomes. The research highlights the use of exogenous angiotensin II as a new therapeutic agent in septic shock. A multinational expert panel provided guidance on patient selection and treatment options with exogenous angiotensin II, suggesting the need for further research in this area. [Extracted from the article]

Researchers from the Division of Endocrinology have conducted a study on hyperaldosteronism, focusing on the origins of primary aldosteronism (PA) and its role in hypertension. The study found that normotensive individuals can have renin-independent aldosterone production, which increases the risk of developing hypertension. The research also highlighted a continuum of aldosterone production and mineralocorticoid receptor activation in normotensive individuals, providing mechanistic explanations for the link between PA and hypertension. This study sheds light on the pathophysiological aspects of PA and its implications for hypertension. [Extracted from the article]

New research from Universite Paris Cite explores the potential of aldosterone synthase inhibitors (ASIs) as an alternative to mineralocorticoid receptor antagonists (MRAs) in treating cardiovascular, endocrine, and renal diseases. While MRAs like spironolactone are effective, they have limitations such as sexual adverse effects and the risk of hyperkalemia. ASIs have shown promise in reducing aldosterone production without affecting cortisol synthesis, with early trials indicating potential benefits for hypertension and chronic kidney disease. Further research will evaluate their efficacy in lowering blood pressure and reducing kidney disease progression and cardiovascular outcomes. [Extracted from the article]

A recent study conducted by a researcher at Texas Tech University Health Sciences Center focused on salt-sensitive blood pressure and the role of the immune system in hypertension. The study highlighted the impact of chronic inflammatory responses and immune cell accumulation in various organs on the development of hypertension. Factors such as renin-angiotensin-aldosterone system dysfunction and immune cell involvement were identified as key contributors to salt-sensitive hypertension. The research emphasized the importance of understanding these immunological and inflammatory factors in managing hypertension effectively. [Extracted from the article]

A recent study conducted at Teikyo University in Tokyo, Japan, has focused on updating our understanding of Hyperaldosteronism, specifically in relation to MR signaling in Primary Aldosteronism. The research explored the potential of urinary extracellular vesicles (uEVs) as a noninvasive indicator of MR signaling in patients with Primary Aldosteronism. The study identified ENaC gamma in uEVs as a promising biomarker for renal MR signaling, suggesting its potential use in guiding treatment for this condition. This research has been peer-reviewed and provides valuable insights into the biomarkers associated with Primary Aldosteronism. [Extracted from the article]

The article discusses the comparison of transcriptional activation by corticosteroids of human mineralocorticoid receptors (MR) with different haplotypes, specifically focusing on the MR rs5522 haplotype containing valine at codon 180. The study examines the EC50 and fold-activation by cortisol, aldosterone, and other corticosteroids of MR rs5522 compared to wild-type MR in HEK293 cells with different promoters. The research highlights differences in EC50, affinity, and fold-activation for various corticosteroids between MR rs5522 and wild-type MR, as well as the similar antagonist activity of spironolactone and progesterone for both haplotypes. [Extracted from the article]

A study conducted at Adichunchanagiri University in Karnataka, India, investigated the effects of Tribulus terrestris fruit extract and an isolated compound on metyrapone-induced adrenal insufficiency in Wistar rats. The research focused on the adrenal glands' role in managing various bodily processes through hormone production and explored potential treatments for adrenal insufficiency. The study found that treatment with Tribulus extract and hecogenin led to significant increases in hormone levels in the rats, indicating potential therapeutic benefits. This peer-reviewed research sheds light on the potential efficacy of natural compounds in addressing adrenal insufficiency. [Extracted from the article]

Researchers from Mayo Clinic conducted a retrospective cohort study to investigate the relationship between N-terminal atrial natriuretic peptide (NT-ANP) levels and the risk of developing metabolic syndrome and type 2 diabetes mellitus in healthy adults. The study, which included 2042 participants, found that higher baseline NT-ANP levels were associated with a lower risk of metabolic disease, while higher baseline insulin and aldosterone levels were linked to a higher risk. The research concluded that NT-ANP levels could serve as a sensitive biomarker for predicting the future risk of metabolic disease when combined with insulin and aldosterone levels into a composite score. [Extracted from the article]

A research report from the American University of Beirut discusses the connection between obesity, aldosterone excess, and poor health outcomes such as hypertension and diabetes. The study highlights the need for further clarification on the association between aldosterone and obesity, emphasizing the potential benefits of interfering with aldosterone pathophysiology to reduce adverse clinical impacts. The research suggests that mineralocorticoid antagonists could play a role in mitigating the effects of aldosterone in conditions like myocardial infarction, heart failure, and kidney dysfunction. [Extracted from the article]

A clinical trial, NCT06721507, is being conducted to assess the impact of preoperative tirzepatide treatment on outcomes after bariatric surgery. The study aims to evaluate whether tirzepatide reduces inflammation and improves health outcomes post-surgery by analyzing changes in inflammatory markers, weight loss, metabolic profiles, and surgical complications. Participants will either take tirzepatide or not for three months before their planned bariatric surgery, followed by regular check-ups and diary documentation. The trial is set to enroll 50 participants and is expected to be completed by December 31, 2026. [Extracted from the article]

Researchers at Queen Mary University of London have identified somatic mutations in genes GNAQ, CTNNB1, and CACNA1C in cats with aldosterone-secreting tumors, shedding light on the pathophysiology of primary aldosteronism (PA) in humans. These mutations were found to have a significant effect on protein function and aldosterone secretion, similar to mutations observed in human PA cases. The study suggests shared underlying selection pressures for mutations that increase aldosterone secretion in both cats and humans, providing valuable insights into adrenal gland physiology. [Extracted from the article]

Researchers at the People's Hospital of Henan University in China conducted a study on left ventricular hypertrophy in hypertensive patients with elevated aldosterone levels. The study found that patients with post-saline infusion test aldosterone concentrations between 50-100 ng/L may indicate early primary aldosteronism and could be an independent predictor of left ventricular hypertrophy. The research highlighted the correlation between aldosterone levels and left ventricular mass index, suggesting a potential link between autonomously secreted aldosterone and heart health. The study provides valuable insights into the clinical and biochemical characteristics of patients with indeterminate saline infusion test results and their risk of developing cardiovascular complications. [Extracted from the article]

A study on hyperaldosteronism conducted by researchers at the Hospital of the Ludwig Maximilians University of Munich found that discordant results from confirmatory tests occurred in approximately 23% of cases. Patients with discordant test results had similar rates of lateralized primary aldosteronism and underwent adrenalectomy with comparable long-term outcomes. The study highlights the impact of confirmatory test results on subtype classification and biochemical outcomes following unilateral adrenalectomy in patients with primary aldosteronism. [Extracted from the article]

A study discussed in Health & Medicine Week explores the impact of maternal sucrose consumption on steroid levels in mothers, placentas, and fetuses. The research suggests that a high-sucrose diet during pregnancy can lead to significant changes in hormone levels, potentially affecting offspring neuroendocrinology and behavior in the long term. The study, conducted on rats, found alterations in corticosterone levels in adult female offspring and increased motivation for sugar rewards in adult male offspring. These findings highlight the importance of maternal diet in shaping offspring development and behavior. [Extracted from the article]

A study conducted in Lagos, Nigeria, focused on assessing the levels of various compounds in individuals with hypertension, including serum calcium, parathyroid hormone, vitamin D, renin, angiotensin II, angiotensin I converting enzyme, and aldosterone. The study found that hypertensive individuals had higher levels of parathyroid hormone, renin, angiotensin II, angiotensin I converting enzyme, and aldosterone, but lower levels of vitamin D compared to the control group. The research concluded that abnormalities in these hormones and calcium levels were associated with the pathophysiology of hypertension. For more information, readers can refer to the study titled "Assessment of Parathyroid Hormone, Vitamin D, Calcium, and Renin-angiotensin-aldosterone System in Nigerians With Hypertension." [Extracted from the article]