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'If there's anything I think of most, it's proportion,' Mitski Miyawaki said on a recent afternoon at Silver Rice, a small Japanese cafe in Brooklyn. She was dressed in a [...]

GO AHEAD, BE BASIC IN BED. HERE'S WHY THE HOTTEST SEX YOU'LL EVER HAVE MIGHT ALSO BE THE SIMPLEST. My preferred sexual positions can skew toward the ambitiously acrobatic. Should [...]

When we were teenagers, no one in our lives celebrated Pride. There might have been a few parades in far-off and magically accepting places, but the idea that an entire [...]

The COVID-19 pandemic caused by SARS-CoV-2 has made the development of safe and effective vaccines a critical priority. To date, four vaccines have been approved by European and American authorities for preventing COVID-19, but the development of additional vaccine platforms with improved supply and logistics profiles remains a pressing need. Here we report the preclinical evaluation of a novel COVID-19 vaccine candidate based on the electroporation of engineered, synthetic cDNA encoding a viral antigen in the skeletal muscle. We constructed a set of prototype DNA vaccines expressing various forms of the SARS-CoV-2 spike (S) protein and assessed their immunogenicity in animal models. Among them, COVID-eVax—a DNA plasmid encoding a secreted monomeric form of SARS-CoV-2 S protein receptor-binding domain (RBD)—induced the most potent anti-SARS-CoV-2 neutralizing antibody responses (including against the current most common variants of concern) and a robust T cell response. Upon challenge with SARS-CoV-2, immunized K18-hACE2 transgenic mice showed reduced weight loss, improved pulmonary function, and lower viral replication in the lungs and brain. COVID-eVax conferred significant protection to ferrets upon SARS-CoV-2 challenge. In summary, this study identifies COVID-eVax as an ideal COVID-19 vaccine candidate suitable for clinical development. Accordingly, a combined phase I-II trial has recently started.

This article discusses various health-related questions about the reality show Survivor. It addresses topics such as menstruation, medication use, dental hygiene, access to sunscreen and bug spray, encounters with toxic plants and venomous animals, and the effects of alcohol consumption. The article includes insights from former contestants and provides information about the show's medical support and mental health resources. [Extracted from the article]

This article provides 14 non-corny ways to feel closer to your partner. The strategies include sharing your sense of humor, surprising them with a candy bar, discussing first memories, taking on each other's chores, preparing a special dinner, balancing efforts in the relationship, remembering details about their life, bearing witness to the minutiae of their day, engaging with their recommendations, aligning on efforts to serve something greater, asking for advice, sleeping in their clothes, visiting their hometown, and taking photos of them doing something they love. These suggestions aim to deepen the connection and understanding between partners. [Extracted from the article]

This article provides a comprehensive guide on how to use a vibrator for the first time. It explains the different types of vibrators available, such as external vibrators, internal vibrators, and dual vibrators. The article also discusses the importance of reading the instructions, engaging in foreplay, using lubrication, and finding the right settings and techniques for individual pleasure. It emphasizes the need for safe and hygienic practices, including using condoms and cleaning the vibrator after each use. Overall, the article aims to provide helpful information for individuals looking to explore the use of vibrators for sexual pleasure. [Extracted from the article]

Victor Vazquez knows how to get things done. He's released no fewer than 16 solo mixtapes over the past five years while also rapping with Das Racist, the aggressively witty [...]

When Whitney's chief songwriting duo first met in 2011, they were both members1 of critical-darling rock bands. Max Kakacek was a guitarist for the now-dissolved garage-pop crew Smith Westerns, and [...]

Morgan hardly even touched the piano at home. You know, too busy with soccer, homework and tutors. Karen had an attitude that would make any teacher cringe. I was ready [...]

I Read Music 1.0, (2 CD-Rom set). Midisoft Music Software (24325 Crenshaw Blvd., 108, Los Angeles, CA 90505). $35. Beginning and intermediate. I Read Music 1.0 offers theory drills in [...]

Twenty-year-old Lorine Chia is a Cameroon- born singer with a complex voice and a gaggle of bass-centric jams about keeping insecurity in check and spreading love to your people. We're [...]

Kesha Knows Exactly What She Wants to Say: A decade of litigation. This means Gag Order, a record that squares with the limitations she endures related to these circumstances, is itself a Kemosabe product: Because of the way her contract was structured, Dr. Luke will profit from the songs Kesha wrote about her pain. And in emails submitted to a New York court by Kesha's legal team in 2017, he claimed that other people in the industry wouldn't want to work with her if she didn't lose weight: Dr. Luke wrote to Kesha's then manager, "We all get concerned when she is breaking her diet plan We have seen it happen multiple times almost every day. In 2016, a judge denied Kesha's request to be released from her Kemosabe contract, citing "no showing of irreparable harm" to Kesha's career. [Extracted from the article]

Some languages showing morphological ergativity in case and/or agreement also show ergative patterns in core syntactic domains—syntactic ergativity. The most-studied type of syntactic ergativity is a ban on the Ā movement of ergative subjects; an additional type concerns the distribution of absolutives in nonfinite clauses. This article first presents the standard view of syntactic ergativity, which is closely connected to the treatment of ergative as an inherent case. Evidence from Shipibo suggests that a ban on ergative Ā extraction does not require inherent ergative. This points to a view of syntactic ergativity centered around morphological case discrimination. One consequence is that pure head-marking languages cannot feature a true ban on ergative extraction, because ergative morphological case is not in use. This conclusion highlights the challenging tasks of diagnosing extraction restrictions in pure head-marking languages, as in the Mayan and Salish families, and of distinguishing extraction restrictions from instances where extraction merely interacts with agreement. A variety of crosslinguistic evidence suggests that agreement/extraction interactions are fully possible in morphologically ergative languages, and not only for ergative arguments. Special morphology in the context of transitive subject extraction is therefore not necessarily evidence of syntactic ergativity.

The article presents details of an interview with singer Mitski Miyawaki, who talks about her metal-fork-in-an-outlet approach to pop song structures. According to the singer, her sense of balance is not quite symmetrical. It mentions that the music of Miyawaki featured symphonic arrangements informed by her time studying at a classical music conservatory.

The article focuses on the utilization of music theory software in music teaching for adults. The theory software is often a perfect fit since many adults thrive in a self-paced and self-directed situation. The Disklavier is used to record the students' performance for them to listen. It was stated that the computer is wonderful for music theory.

Protein degradation is known to be a key component of expression regulation for individual genes, but its global impact on gene expression has been difficult to determine. We analyzed a parallel gene expression dataset of yeast meiotic differentiation, identifying instances of coordinated protein-level decreases to identify new cases of regulated meiotic protein degradation, including of ribosomes and targets of the meiosis-specific anaphase-promoting complex adaptor Ama1. Comparison of protein and translation measurements over time also revealed that, although meiotic cells are capable of synthesizing protein complex members at precisely matched levels, they typically do not. Instead, the members of most protein complexes are synthesized imprecisely, but their protein levels are matched, indicating that wild-type eukaryotic cells routinely use post-translational adjustment of protein complex partner levels to achieve proper stoichiometry. Outlier cases, in which specific complex components show divergent protein-level trends, suggest timed regulation of these complexes.

The article profiles the American country rock band Whitney and presents views of its founding members and songwriters Max Kakacek and Julien Ehrlich. It cites Kakacek opine that the disbanding of the rock band Smith Westerns, which he and Ehrlich were members of, played an important part in setting up of Whitney. It discusses the struggles of songwriters, the challenges under which the band is recording its release album, and its aspiration in terms of music genre and audience appeal.

The article describes the efficacy of a comprehensive teaching method called Celebrate Piano! which was used to elevate the progress of teaching efforts with students particularly one with a slow-learning capability like Natalie. The practice plan which was used with Natalie, under the comprehensive method is outlined. The method is recommended for those who prepare students for the entry level to the National Music Certificate Program (NMCP), giving students in the U.S. wider opportunities.

Ganguly: Onyx: Speakers Bureau; Seattle Genetics: Speakers Bureau; Janssen: Research Funding.

The article describes the collage on the February 2006 issue's cover which features award-winning original compositions by Jessica Petri and Houman Safai, two composition students of Amy Immerman of Cincinnati, Ohio. The author extends appreciation to the school and its composers for granting them permission to use those works for the publication's cover art.

Background

The article outlines the top five things that keep Cameroon-born singer Lorine Chia happy and motivated. These include snacks such as the Flamin' Hot Cheetos and ginger ale, playing the piano and the guitar with her younger sisters, and hip hop recording artist Travis Scott's debut mixtape "Owl Pharaoh."