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Start Over Author "Antonello Vidiri" Publication Type Magazines
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1. Pretreated EGFRdel19/BRAFV600Elung adenocarcinoma with leptomeningeal disease achieving long-lasting disease control on Osimertinib, Dabrafenib, and Trametinib: a case report

Author

Corrado, Orciuolo, Federico, Cappuzzo, Lorenza, Landi, Blerina, Resuli, Silvia, Carpano, Antonello, Vidiri, Simonetta, Buglioni, Chiara, Mandoj, Gennaro, Ciliberto, and Gabriele, Minuti

Abstract

Oncogene-addicted non-small cell lung cancer (NSCLC) inevitably becomes resistant to targeted therapy, by developing acquired resistance (AR), on- or off-target mechanisms, potentially detectable by liquid biopsy (LB). We present the first reported case of a pretreated EGFRdel19/BRAFV600Elung adenocarcinoma patient with symptomatic leptomeningeal metastasis (LM) obtaining durable clinical benefit on Osimertinib, Dabrafenib, and Trametinib treatment.

Published
2023
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