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Research conducted at Menoufia University explores the potential therapeutic approach of targeting glutamine synthetase with amino acid analogs in breast cancer treatment. The study found that Acivicin and Azaserine showed potent inhibition of cancer cell proliferation without harming normal cells, unlike Sorafenib. These amino acid analogs also activated programmed cell death and promoted the production of anti-inflammatory cytokines, offering novel insights into potential therapeutic strategies for breast cancer. The research highlights the promising anticancer activity of Acivicin and Azaserine as antagonists of glutamine synthetase, providing valuable information for future treatment options. [Extracted from the article]