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A new derivative of triterpene named Erigeronol 1was isolated from the EtOH extract of the aerial part of Conyza canadensistogether with 15 known compounds for the first time from this plant. The structure of Erigeronol 1was elucidated as 3-O-(hydroxy-acetyl)-23,28-dihydroxy-β-amyrin by hydrolysis and spectroscopic analysis. Erigeronol 1showed potent cytotoxic activity with IC50value of 7.77±0.47μg/mL against melanoma B16 determined by the 3-(4,5-dimethylthiazo-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method.