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1. Minocycline microspheres did not significantly improve outcomes after collagenase injection of tendon

Author

Allen, Andrew D., Bassil, Alex M., Berkoff, David J., Al Maliki, Mohammed, Draeger, Reid W., and Weinhold, Paul S.

Abstract

Tetracycline antibiotics inhibit matrix metalloproteinases and pro-inflammatory cytokines implicated in the pathogenesis of tendinopathy, while microsphere formulations allow sustained release of drug contents. The purpose of this study was to evaluate the ability of a local minocycline microsphere injection to restore normal tendon properties in a rat model of collagenase-induced patellar tendinopathy.

Published
2019
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