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2. Zur Nierenaufnahme und intrarenalen Verteilung von Amilorid

Author

Bechtler, H. and Taugner, R.

Abstract

Summary The renal uptake and intrarenal distribution of14C-Amiloride was studied after intramuscular injection in mice. 30 min after injection of 0.5–5.0 mg Amiloride/kg body weight, renal activities were found corresponding to 30–650 ng Amiloride/g kidney. The ratio of renal/plasma activity ranged between 13:1 and 20:1. Neither renal concentration nor this ratio reached saturation levels with doses up to 5.0 mg Amiloride/kg body weight.

Published
1973
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