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Background/objectives: To examine prevalence of failed visual assessment at 8–10 years in children born to methadone-maintained opioid dependent (MMOD) mothers and relate this to known in utero substance exposure. Subjects/methods: Follow up of observational cohort study of methadone-exposed and comparison children matched for birthweight, gestation and postcode of residence at birth. Participants were 144 children (98 exposed, 46 comparison). Prenatal drug exposure was previously established via comprehensive maternal and neonatal toxicology. Children were invited to attend for visual assessment and casenotes were reviewed. Presence of acuity poorer than 0.2 logMAR, strabismus, nystagmus and/or impaired stereovision constituted a ‘fail’. Fail rates were compared between methadone-exposed and comparison children after adjusting for known confounding variables. Results: 33 children attended in person: data were also derived from casenote review for all children. After controlling for maternal reported tobacco use, methadone-exposed children were more likely to have a visual ‘fail’ outcome, adjusted odds ratio 2.6, 95% CI 1.1–6.2; adjusted relative risk 1.8 (95% CI 1.1–3.4). Visual ‘fail’ outcome rates did not differ between methadone-exposed children who had (n= 47) or had not (n= 51) received pharmacological treatment for neonatal abstinence/opioid withdrawal syndrome (NAS/NOWS); fail rate 62% vs 53% (95% CI of difference—11–27%). Conclusions: Children born to MMOD mothers are almost twice as likely as unexposed peers to have significant visual abnormalities at primary school age. Prenatal methadone exposure should be considered in the differential diagnosis of nystagmus. Findings support visual assessment prior to school entry for children with any history of prenatal opioid exposure. Trial registration: The study was prospectively registered on ClinicalTrials.gov (NCT03603301), https://clinicaltrials.gov/ct2/show/NCT03603301.

women who were screened divided by the number of deliveries. The number of deliveries was shown to be a reasonable estimate of the number of women who booked for antenatal [...]

MILLER, Sam J. The Art of Starving. 384p. HarperCollins/HarperTeen. Jul. 2017. Tr $17.99. ISBN 9780062456717. Gr 10 Up-The less Matt eats, the more control he has over his body. The [...]

BLAKE, Ashley H. How To Make a Wish. 336p. ebook available. HMH. May 2017. Tr $17.99. ISBN 9780544815193. Gr 9 Up--For Grace, moving in with yet another of her mom's [...]

Background: To date, no attempt has been made to collate literature on the relationship between the social environmental impact of COVID-19 and erectile dysfunction. The aim of this explorative review was to assess and compare the prevalence of erectile dysfunction (ED) in male healthcare workers and males during the COVID-19 pandemic. Methods: A systematic review of major databases from inception to February 2021 was conducted. Prevalence data were extracted, and a random-effects meta-analysis was undertaken. Outcomes: The pooled prevalence of ED amongst healthcare workers working in COVID-19 specific environments, and non-healthcare during the COVID-19 pandemic. Results: Of 52 initial studies, six were included for the final analysis. The pooled prevalence of ED in healthcare workers working in a COVID-19 environment was 63.6% (95% CI 20.3–92.3%), and in non-healthcare workers during the COVID-19 pandemic was 31.9% (95% CI 19.5–47.6%). Conclusion: The prevalence of ED in healthcare workers working in COVID-19 environments was higher than representative samples and is of concern. Sexual health (and by extension, overall health), should be a priority when considering ways to care for this population. Considering the social environmental impact of COVID-19 on sexual health and in particular on ED, it is important to provide adequate psychological support systems and to promote quality of life with particular attention to sexual health.

COMBS, Sarah. The Light Fantastic. 320p. ebook available. Candlewick. Sept. 2016. Tr $17.99. ISBN 9780763678517. Gr 9 Up--April, Lincoln, Gavin, Ms. Heslip, The Mastermind, Phoebe, and Delaware each tell their [...]

The Year We Thought About Love. 69 min. w/59 page discussion guide. Spanish & Haitian Subtitles. Dist. by New Day Films. 2015. $75. Rental $60. ISBN 9781574484069. Gr 9 Up--This [...]

NAZEM IAN, Abdi. The Authentics. 288p. HarperCollins/Balzer + Bray. Aug. 2017. Tr $17.99. ISBN 9780062486462. Gr 9 Up--When a DNA test shows that Daria, proud Iranian American, isn't Iranian at [...]

* SILVERA, Adam. They Both Die at the End. 384p. HarperCollins/HarperTeen. Sept. 2017. Tr $17.99. ISBN 9780062457790. Gr 9 Up--Everyone who is going to die on a given day gets [...]

GARDNER, Whitney. You're Welcome, Universe. 304p. ebook available. Knopf. Mar. 2017. Tr $17.99. ISBN 9780399551413. Gr 8 Up--After executing her best-ever graffiti, to cover up an insult written about her [...]

* SILVERA, Adam. History Is All You Left Me. 320p. ebook available. Soho Teen. Jan. 2017. Tr $18.99. ISBN 9781616956929. POP Gr 10 Up--No one understands what Griffin is going [...]

CONSTABLE, Kate. New Guinea Moon. 288p. Allen & Unwin. Nov. 2014. pap. $13.99. ISBN 9781743315033. Gr 7-10--During the Christmas holidays of 1974, Julie's mother ships her off to New Guinea [...]

DEMAS, Corinne. Returning to Shore. 208p. Carolrhoda Lab. 2014. Tr $17.95. ISBN 9781467713283; ebk. $12.95. ISBN 9781467724036. LC 2013018618. Gr 6-9--While her mother goes off for her honeymoon with her [...]

Fly by Light. 83 min. and 60-min. classroom version. Dist. by the Video Project. 2015. $89. ISBN unavail. Gr 9 Up--This documentary follows a nine-month West Virginian wilderness retreat and [...]

KESSLER, Liz. Read Me Like a Book. 304p. ebook available. Candlewick. Jun. 2016. Tr $16.99. ISBN 9780763681319. Gr 9 Up--Ashleigh is entering her sixth-form year, and her life is in [...]

LINN, Laurent. Draw the Line. 528p. ebook available. S. & S./Margaret K. McElderry Bks. May 2016. Tr $17.99. ISBN 9781481452809. Gr 9 Up--Gay, geeky, artistic: all traits that Adrian feels [...]

GREGORY, Robin. The Improbable Wonders of Moojie Littleman. 294p. Mad Mystical Journey. 2015. Tr $14. ISBN 9781942545002; ebk. $6. ISBN 9781942545019. Gr 6-9--Abandoned as a baby with only his name, [...]

PurposeTo investigate whether the observed international differences in retinopathy of prematurity (ROP) treatment rates within the Benefits of Oxygen Saturation Targeting (BOOST) II trials might have been caused by international variation in ROP disease grading.MethodsGroups of BOOST II trial ophthalmologists in UK, Australia, and New Zealand (ANZ), and an international reference group (INT) used a web based system to grade a selection of RetCam images of ROP acquired during the BOOST II UK trial. Rates of decisions to treat, plus disease grading, ROP stage grading, ROP zone grading, inter-observer variation within groups and intra-observer variation within groups were measured.ResultsForty-two eye examinations were graded. UK ophthalmologists diagnosed treat-requiring ROP more frequently than ANZ ophthalmologists, 13.9 (3.49) compared to 9.4 (4.46) eye examinations, P=0.038. UK ophthalmologists diagnosed plus disease more frequently than ANZ ophthalmologists, 14.1 (6.23) compared to 8.5 (3.24) eye examinations, P=0.021. ANZ ophthalmologists diagnosed stage 2 ROP more frequently than UK ophthalmologists, 20.2 (5.8) compared to 12.7 (7.1) eye examinations, P=0.026. There were no other significant differences in the grading of ROP stage or zone. Inter-observer variation was higher within the UK group than within the ANZ group. Intra-observer variation was low in both groups.ConclusionsWe have found evidence of international variation in the diagnosis of treatment-requiring ROP. Improved standardisation of the diagnosis of treatment-requiring ROP is required. Measures might include improved training in the grading of ROP, using an international approach, and further development of ROP image analysis software.

* MCGOVERN, Cammie. A Step Toward Falling. 384p. ebook available. HarperCollins/Harper. Oct. 2015. Tr $17.99. ISBN 9780062271136. Gr 9 Up--Emily knew when she saw Belinda, a classmate with developmental disabilities, [...]

MYERS, B.R. Asp of Ascension: A Nefertari Hughes Mystery. 300p. ebook available. Fierce Ink Press. 2015. Tr $16.99. ISBN 9781511732871. Gr 9 Up--Nothing is going right for Nefertari Hughes: her [...]

LAVOIE, Jennifer. The First Twenty. 240p. Bold Strokes. 2015. pap. $11.95. ISBN 9781626394148. Gr 7 Up--Twenty years after the collapse of civilization as we know it, two rival communities are [...]

ALTON, William. Flesh and Bone. 260p. Luminis. May 2015. Tr $24.95. ISBN 9781941311455; pap. $14.95. ISBN 9781941311462. Gr 10 Up--When his parents announce their divorce, Bill moves with his mother [...]

BARNES, David-Matthew. Fifty Yards and Holding. 192p. Bold Strokes. 2015. pap. $11.95. ISBN 9781626390812. Gr 9 Up--Victor is newly head of his gang after the murder of his cousin. Riley [...]

WILKE, Daria. Playing a Part. tr. from Russian by Marian Schwartz. 176p. Scholastic/Arthur A. Levine Bks. Mar. 2015. Tr $17.99. ISBN 9780545726078; ebk. ISBN 9780545726085. Gr 9 Up--Grisha has grown [...]

FREEMAN, Lisa. Honey Girl. 320p. ebook available. Sky Pony. Mar. 2015, Tr $16.99. ISBN 9781632204257. Gr 9 Up--It's the summer of 1972, and Nani has relocated from Hawaii to Santa [...]

HESIK, Annameekee. Driving Lessons. 264p. (The You Know Who Girls: Bk. 2). Bold Strokes. 2014. pap. $11.95. ISBN 9781626392281. Gr 9 Up--Abbey's sophomore year is already in trouble. She's scared [...]

RICH, Juliann. Searching for Grace. 264p. Bold Strokes. 2014. pap. $11.95. ISBN 9781626391963. Gr 9 Up--Jonathan has been through a lot in the last few months: coming to terms with [...]

SALISBURY, Graham. Hunt for the Bamboo Rat. 336p. Random/Wendy Lamb Bks. Sept. 2014. Tr $16.99. ISBN 9780375842665; lib. ed. $19.99. ISBN 9780375940705; ebk. ISBN 9780307979704. Gr 5 Up--Zenji Watanabe is […]

NERI, G. Knockout Games. 304p. Carol-rhoda Lab. Aug. 2014. Tr $17.95. ISBN 9781467732697; ebk. $12.95. ISBN 9781467746274. LC 2013036855. Gr 9 Up--When she is displaced by her parents' divorce, Erica […]

TREGAY, Sarah. Fan Art. 256p. HarperCollins/Katherine Tegen Bks. Jun. 2014. Tr $17.99. ISBN 9780062243157. Gr 9 Up--Jamie has problems on top of problems. He's not out at school, he's just […]

PATRICK, Denise Lewis. A Matter of Souls. 192p. Carolrhoda Lab. Apr. 2014. Tr $16.95. ISBN 9780761392804; ebk. $12.95. ISBN 9781467724029. LC 2013017597. Gr 7 Up--This collection of short stories examines [...]

TORDAY, Piers. The Last Wild. 336p. ebook available. Viking. Mar. 2014. Tr $16.99. ISBN 9780670015542. LC 2013044690. Gr 3-7--'When the rest of the world grew too hot, and cracked open [...]

MicroRNA-375 (miR-375) is frequently elevated in prostate tumors and cell-free fractions of patient blood, but its role in genesis and progression of prostate cancer is poorly understood. In this study, we demonstrated that miR-375 is inversely correlated with epithelial–mesenchymal transition signatures (EMT) in clinical samples and can drive mesenchymal–epithelial transition (MET) in model systems. Indeed, miR-375 potently inhibited invasion and migration of multiple prostate cancer lines. The transcription factor YAP1 was found to be a direct target of miR-375 in prostate cancer. Knockdown of YAP1 phenocopied miR-375 overexpression, and overexpression of YAP1 rescued anti-invasive effects mediated by miR-375. Furthermore, transcription of the miR-375 gene was shown to be directly repressed by the EMT transcription factor, ZEB1. Analysis of multiple patient cohorts provided evidence for this ZEB1-miR-375-YAP1 regulatory circuit in clinical samples. Despite its anti-invasive and anti-EMT capacities, plasma miR-375 was found to be correlated with circulating tumor cells in men with metastatic disease. Collectively, this study provides new insight into the function of miR-375 in prostate cancer, and more broadly identifies a novel pathway controlling epithelial plasticity and tumor cell invasion in this disease.