1. Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial
- Author
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Ford, Alexander C, Wright-Hughes, Alexandra, Alderson, Sarah L, Ow, Pei-Loo, Ridd, Matthew J, Foy, Robbie, Bianco, Gina, Bishop, Felicity L, Chaddock, Matthew, Cook, Heather, Cooper, Deborah, Fernandez, Catherine, Guthrie, Elspeth A, Hartley, Suzanne, Herbert, Amy, Howdon, Daniel, Muir, Delia P, Nath, Taposhi, Newman, Sonia, Smith, Thomas, Taylor, Christopher A, Teasdale, Emma J, Thornton, Ruth, Farrin, Amanda J, Everitt, Hazel A, Ford, Alexander C., Wright-Hughes, Alex, Alderson, Sarah L., Ow, Pei-Loo, Ridd, Matthew J., Foy, Robbie, Barratt, Maggie, Bianco, Gina, Bishop, Felicity L., Brindle, Richard, Brown, Sarah, Chaddock, Matthew, Christodoulou, Aimee, Cook, Heather, Cooper, Deborah, Day, Florence, Dowse, Aaron, Durnell, Jill, Emmerson, Jake, Fellows, Alasdair, Fernandez, Catherine, Guthrie, Elspeth A., Hartley, Suzanne, Herbert, Amy, Hindmarch, Damien, Howdon, Daniel, Malik, Aminah, Morris, Tom, Muir, Delia P., Longo, Roberta, Lopes Goncalves Graca, Sandra, Nath, Taposhi, Newman, Sonia, Parker, Catriona, Smith, Thomas, Taylor, Christopher A., Teasdale, Emma J., Thornton, Ruth, Tubeuf, Sandy, West, Amy, Williamson, Emma-Jane, Farrin, Amanda J., and Everitt, Hazel A.
- Abstract
Most patients with irritable bowel syndrome (IBS) are managed in primary care. When first-line therapies for IBS are ineffective, the UK National Institute for Health and Care Excellence guideline suggests considering low- dose tricyclic antidepressants as second-line treatment, but their effectiveness in primary care is unknown, and they are infrequently prescribed in this setting.
- Published
- 2023
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