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ABSTRACTAccumulating studies have suggested that microRNAs (miRNAs) play vital roles in the pathogenesis of osteoarthritis (OA). Nevertheless, the specific function of miR-128-3p in OA remains unknown. In this study, we demonstrated that miR-128-3p was decreased and ZEB1 was increased in OA. Additionally, miR-128-3p expression was negatively correlated with ZEB1. miR-128-3p overexpression or ZEB1 silencing attenuated extracellular matrix degradation and cell apoptosis, and increased the proliferation of IL-1β-activated CHON-001 cells. Furthermore, ZEB1 was directly targeted by miR-128-3p. In addition, ZEB1 upregulation restored the effects of miR-128-3p overexpression on OA progression. Overall, our findings suggested that miR-128-3p might regulate the development of OA via targeting ZEB1.

Rolling-wheel method is an effective way of measuring big diameter. After amending the temperature error and pressure error, the uncertainty of measurement can not be =5um/mstably because of the influence of skid. The traditional method of identifying skid loses sight of the influences of the unstable motor speed, the appearance form error and the eccentric of installation of the big axis and rolling wheel and so on, so the method has its limitation. In this paper, a new method of multiple identification and repair is introduced, namely n diameters are measured and Chauvenet standard is used for identifying the anomalous measurements one by one, and then the average value of the remaining data is used for repairing identified anomalous measurements, and the next round identification and repair is carried out until the accuracy requirement of the measurement is satisfied. The result of experiments indicates that the method can identify anomalous measurements whose offsets caused by the skid are greater than 0.2 , and the uncertainty of measurement has improved substantially.