1. Acute pancreatitis following organophosphate intoxication
- Author
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Cheng-Ting Hsiao, Chen-Chang Yang, Jou-Feng Deng, Bullard, Michael J., and Shiumn-Jen Liaw
- Subjects
Pancreatitis -- Causes of ,Insecticides -- Health aspects ,Environmental issues ,Health ,Pharmaceuticals and cosmetics industries - Abstract
Background: Acute pancreatitis as a complication of organophosphate intoxication has been infrequently addressed. Previous reports have suggested that acute pancreatitis may follow the oral ingestion of several organophosphates, including parathion, malathion, difonate, coumaphos, and diazinon, or after cutaneous exposure to dimethoate. No cases of acute pancreatitis following mevinphos (CAS 7786-34-71) poisoning have been reported to date. The possible pathogeneses of the pancreatic insult in organophosphate intoxication are excessive cholinergic stimulation of the pancreas and ductular hypertension. Case Report: We describe a patient presenting with painless acute pancreatitis following an intentional ingestion of large amounts of mevinphos. Serum amylase and lipase values were increased and determination of amylase isoenzymes confirmed a pancreatic origin. A computerized tomograph of the abdomen showed diffuse swelling of the pancreas. the patient was discharged after a seven week clinical course, complicated by a delayed neuropathy. Conclusions: As acute pancreatitis in organophosphate intoxication may be more common than reported, serum pancreatic enzymes and appropriate imaging studies should be more liberally utilized. Early recognition and appropriate therapy for acute pancreatitis may lead to an improved prognosis., INTRODUCTION Organophosphate compounds are frequently used as insecticides in agricultural areas. Due to their high degree of toxicity, severe morbidity and even mortality following organophosphate intoxication is frequently reported. Acute [...]
- Published
- 1996