1. Steroidal Glycosides from the Rhizomes of Anemarrhena asphodeloides and Their Antiplatelet Aggregation Activity.
- Author
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Li-ping Kang, Jie Zhang, Yue Cong, Bin Li, Cheng-qi Xiong, Yang Zhao, Da-wei Tan, He-shui Yu, Zu-yin Yu, Yu-wen Cong, Chao Liu, and Bai-ping Ma
- Subjects
ANIMAL experimentation ,BIOLOGICAL assay ,GLYCOSIDES ,HIGH performance liquid chromatography ,MASS spectrometry ,MICE ,MOLECULAR structure ,PHARMACEUTICAL chemistry ,PLANT stems ,PLATELET aggregation inhibitors ,DESCRIPTIVE statistics ,MAGNETIC resonance angiography - Abstract
Five new steroidal glycosides, timosaponin J (1), timosaponin K (2), (25S)-karatavioside C (5), timosaponin L (6), and (25S)-officinalisnin-I (8), together with eight known steroidal saponins, timosaponin E
1 (3), purpureagitosid (4), timosaponin BII (7), timosaponin B III (9), anemarrhenasaponin I (10), anemarrhenasaponin III (11), anemarrhenasaponin A2 (12), and timosaponin A III (13), were isolated from the rhizomes of Anemarrhena asphodeloides. Their structures were elucidated on the basis of spectroscopic and chemical evidence. The aglycones of compounds 1 and 2 are new aglycones. Compounds 1-13 were evaluated for their platelet aggregation activities, and compound 13 exhibited the strongest inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation. [ABSTRACT FROM AUTHOR]- Published
- 2012
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