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Six new lignans, 1-6, along with six known compounds were obtained from the flower buds of Magnolia liliflora Desr. The new lignans were elucidated as (1S*,2R*,5S*,6S*)-2-(3,5-dimethoxyphenyl)-6-(3,4-methylenedioxyphenyl)-3,7-dioxabicyclo[ 3.3.0]octane (1), (1R*,2R*,5R*,6S*)-2-(3,5-dimethoxyphenyl)-6-(3,4-methylenedioxyphenyl)- 3,7-dioxabicyclo[3.3.0]octane (2), (1R*,2R*, 5R*,6S*)-2,6-bis (3,5-dimethoxyphenyl)-3,7-dioxabicyclo[ 3.3.0]octane (3), (1R*,2S*,5R*,6R*)-2-(3,4-methylenedioxyphenyl)-6-(3,5-dimethoxyphenyl)- 3,7-dioxabicyclo[3.3.0]octane (4), (7'S*, 8R*,8'R*)-3,5'-dimethoxy-3',4,9'-trihydroxy-7',9- epoxy-8,8'-lignan (5), and (7'R*,8'S*)-3,3',4,5'-tetramethoxy- 7-en-7',9-epoxy-8,8'-lignan (6), by the analysis of 1D and 2D-NMR as well as HRE-SIMS data. The capacity of compound 1 to protect against damages to the DNA of rat lymphocyte cells induced by UV irradiation was assessed by the comet assay. It showed stronger antigenotoxicity than ascorbic acid from 6 × 10-3 mmol·L-1 to 6 × 10-6 mmol·L-1. [ABSTRACT FROM AUTHOR]