1. Complex genetics of drug resistance in Mycobacterium tuberculosis.
- Author
-
Warner DF and Mizrahi V
- Subjects
- Antitubercular Agents therapeutic use, Arabinose biosynthesis, Drug Resistance, Microbial genetics, Ethambutol therapeutic use, Evolution, Molecular, Genome, Bacterial, Mutation, Mycobacterium tuberculosis drug effects, Mycobacterium tuberculosis genetics, Selection, Genetic
- Abstract
Three new studies have used whole-genome sequencing of M. tuberculosis to demonstrate unexpected complexity in the modern evolution of drug-resistant tuberculosis, and a fourth study suggests a close evolutionary relationship between the pathogen and its human host over a period of 70,000 years. Collectively, the observations in these studies suggest that future strategies to tackle drug-resistant tuberculosis must integrate host genetics with detailed strain epidemiology.
- Published
- 2013
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