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The article compares outcomes of pulmonary vein isolation (PVI) in patients with heart failure with preserved ejection fraction (HFpEF) versus those with reduced ejection fraction (HFrEF). Topics include differences in hospitalizations for heart failure and arrhythmias post-PVI, varying long-term outcomes between HFpEF and HFrEF patients, and overall effectiveness of PVI in these heart failure subtypes.

A report from the University of Sydney discusses research on diastolic heart failure, a growing global concern. The study examined the levels of oxidized nicotinamide adenine dinucleotide (NAD+) in human and murine models of heart failure and explored NAD+ repletion as a potential therapy. The researchers found significant depletion of NAD+ in human diastolic heart failure myocardium, but restoration was successful with nicotinamide riboside (NR). In murine heart failure with preserved ejection fraction, NR improved metabolic and antioxidant profiles. The study suggests that NAD+ repletion may have potential in managing diastolic heart failure. [Extracted from the article]

A patent application has been filed for a shunt system designed to reduce left atrial pressure in patients with heart failure. The shunt includes a central flow portion that fits within an opening in a tissue wall, creating a blood flow path between two anatomical chambers. The shunt also includes a barrier to prevent tissue growth around it. The method involves creating an opening in the tissue wall, treating the surrounding tissue to prevent tissue growth, and placing the shunt at the opening. This invention aims to provide a potential treatment option for diastolic heart failure and other conditions with elevated left atrial pressure. [Extracted from the article]

A recent study on diastolic heart failure, conducted by researchers at the University of California Riverside School of Medicine, highlights the importance of understanding the mechanisms and assessment of this condition. Diastolic heart failure, also known as heart failure with preserved ejection fraction (HFpEF), accounts for approximately half of the heart failure population. The study emphasizes the need for early recognition and treatment of diastolic heart failure, as there are currently limited treatment options available. The researchers review the fundamental mechanisms of HFpEF and discuss how comprehensive measurement of left ventricular diastolic function can aid in its early detection and treatment. [Extracted from the article]

This patent application presents a method and device for treating heart failure by reducing left atrial and pulmonary venous pressure. The invention involves creating an opening in the atrial septum to relieve pressure and treating the surrounding tissue to keep the opening intact. The device includes a catheter with tools to create the opening and a mechanism to treat the atrial septum. The method aims to lower atrial and pulmonary venous pressure without the need for a mechanical implant. This invention offers a straightforward and effective approach to addressing elevated pulmonary venous pressures associated with heart failure, particularly diastolic heart failure. [Extracted from the article]

According to a preprint abstract, a phenomenon known as the obesity paradox has been observed in patients with heart failure, suggesting that higher weight may be associated with lower mortality. A study using a large database of adult patients found that all-cause inpatient mortality was lowest in overweight patients, followed by those with obesity and morbid obesity. However, cachexia, a condition characterized by severe weight loss and muscle wasting, had the highest mortality. These findings remained consistent even after adjusting for comorbidities. The study suggests that while overweight and obesity may have a protective effect, increasing weight beyond overweight diminishes this benefit. [Extracted from the article]

A patent application by inventor Robert Alan Hirsh has been made available online for a non-invasive system and method for detecting and accurately quantifying subclinical and clinical systolic and diastolic heart failure. The current methods of diagnosis and quantification only serve to characterize and quantify symptoms in people who are already stricken with the illness, and are not sensitive or reliable enough to serve as a screening test for people who have subclinical or preclinical disease. The invention aims to provide a new way to process and derive clinical meaning and prognoses from physiomic data, using the Wiggers Diagram to extract data related to electrical and mechanical cardiac activity. The system includes non-invasive electronic and mechanical heart function measurement devices, a computer platform, and a processing unit to determine inotropic and lusitropic electrical mechanical time intervals and calibration curves for the patient's heart function. The system compares these calibration curves to universal intercept-slope tradeoff functions stored in memory to assess myocardial well-being or pathology. The method also includes determining universal intercept-slope tradeoff functions for inotropic and lusitropic function by measuring strain rates and electrical mechanical intervals in healthy patients. The patent application includes 14 claims related to the system, method, and computer-readable medium storing the universal tradeoff functions. [Extracted from the article]

A recent study conducted at Boston Children's Hospital has found that survivors of pediatric hematopoietic stem cell transplantation (HSCT) are at a higher risk of developing diastolic heart failure (HF). The study followed a cohort of patients who underwent HSCT between 2005 and 2008 and found that diastolic function declined over time in both the left and right ventricles. Exposure to total body irradiation (TBI) was associated with worsening diastolic function, while treatment with anthracyclines was associated with a mild decline in left ventricular ejection fraction (LVEF). These findings highlight the importance of long-term surveillance and disease management for this population. [Extracted from the article]

A recent report discusses the findings of research on diastolic heart failure (DHF), a condition in which impaired ventricular filling leads to heart failure symptoms. DHF is prevalent and is associated with risk factors such as metabolic syndrome, hypertension, diabetes, and aging. Despite its high prevalence, there are currently no effective therapeutic agents available for DHF treatment. The report highlights the need for a better understanding of the molecular mechanisms of diastolic dysfunction and proposes new targets for treatment. The research has been peer-reviewed and provides valuable insights for further study. [Extracted from the article]

Keywords for this news article include: Boston, Hematology, Pediatrics, Massachusetts, United States, Bone Marrow Cells, Stem Cell Research, Health and Medicine, Risk and Prevention, Diastolic Heart Failure, Hematopoietic Stem Cells, North and Central America, Heart Disorders and Diseases. Keywords: Boston; Massachusetts; United States; North and Central America; Bone Marrow Cells; Diastolic Heart Failure; Health and Medicine; Heart Disorders and Diseases; Hematology; Hematopoietic; Hematopoietic Stem Cells; Pediatrics; Risk and Prevention; Stem Cell Research EN Boston Massachusetts United States North and Central America Bone Marrow Cells Diastolic Heart Failure Health and Medicine Heart Disorders and Diseases Hematology Hematopoietic Hematopoietic Stem Cells Pediatrics Risk and Prevention Stem Cell Research 105 105 1 09/19/23 20230922 NES 230922 2023 SEP 23 (NewsRx) -- By a News Reporter-Staff News Editor at Pediatrics Week -- New research on Heart Disorders and Diseases - Diastolic Heart Failure is the subject of a report. [Extracted from the article]

Of 123,211 patients with pneumonia and HF, 41,196 (33.4%) had systolic HF, 69,982 (56.8%) diastolic HF, and 12,033 (9.8%) had combined HF. Keywords: Angiotensins; Autacoids; Biological Factors; Cardiology; Cardiovascular Diseases and Conditions; Diastolic Heart Failure; Health and Medicine; Heart Disease; Heart Disorders and Diseases; Heart Failure; Hospitals; Infectious Disease; Lung Diseases and Conditions; Pneumonia; Pulmonology; Respiratory Tract Diseases and Conditions; Respiratory Tract Infections EN Angiotensins Autacoids Biological Factors Cardiology Cardiovascular Diseases and Conditions Diastolic Heart Failure Health and Medicine Heart Disease Heart Disorders and Diseases Heart Failure Hospitals Infectious Disease Lung Diseases and Conditions Pneumonia Pulmonology Respiratory Tract Diseases and Conditions Respiratory Tract Infections 116 116 1 06/05/23 20230605 NES 230605 2023 JUN 5 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Fresh data on diastolic heart failure are presented in a new report. [Extracted from the article]

Cardiology, Cardiovascular Diseases and Conditions, Diastolic Heart Failure, Health and Medicine, Heart Disease, Heart Disorders and Diseases, Heart Failure, Mayo Foundation for Medical Education and Research, Pericardial, Professional Education, Medical Education For example, this document provides devices and methods for treating heart failure with preserved ejection fraction, including diastolic heart failure, by performing a pericardial modification procedure. Keywords: Cardiology; Cardiovascular Diseases and Conditions; Diastolic Heart Failure; Health and Medicine; Heart Disease; Heart Disorders and Diseases; Heart Failure; Mayo Foundation for Medical Education and Research; Medical Education; Pericardial; Professional Education EN Cardiology Cardiovascular Diseases and Conditions Diastolic Heart Failure Health and Medicine Heart Disease Heart Disorders and Diseases Heart Failure Mayo Foundation for Medical Education and Research Medical Education Pericardial Professional Education 1212 1212 1 04/17/23 20230417 NES 230417 2023 APR 17 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Mayo Foundation for Medical Education and Research (Rochester, Minnesota, United States) has been issued patent number 11612405, according to news reporting originating out of Alexandria, Virginia, by NewsRx editors. [Extracted from the article]