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The cytokine storm caused by SARS-CoV-2 infection threatens the condition of patients, even leading to death. In a recent issue of Matter , Prof. Wenguo Cui and co-workers have prepared lung-sweeper inhaled hydrogel microspheres for intratracheal neutralization of COVID-19 and cytokine storm calming, which could be applied for antiviral tissue regeneration, drug delivery, and disease diagnosis., Competing Interests: The authors declare no competing interests., (© 2022 Elsevier Inc.)