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1. Antineoplastic agents. Part 395.1 Isolation and structure of agelagalastatin from the Papua New Guinea marine sponge Agelas sp.

Author

R. Pettit, George, Xu, Jun-ping, E. Gingrich, Diane, D. Williams, Michael, L. Doubek, Dennis, Chapuis, Jean-Charles, and M. Schmidt, Jean

Abstract

A human cancer cell line bioassay-directed investigation of the Western Pacific marine sponge Agelas sp. led to isolation of a trace (7.42 × 10–6% yield) cancer cell growth inhibitor (lung NCI-H460 GI50 0.77 µg m–1 to ovary OVCAR-3 GI50 2.8 µg ml–1) designated agelagalastatin 6; it is the first example of a natural product containing a digalactofuranosyl unit.

Published
1999
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