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The aim of this paper is to show the importance of the development of attitudes and values in young students as well as ways in which the newly-developed Romanian curriculum for Personal Development can be implemented. A study case was conducted in a school where a similar curriculum has been implemented and was focused on possible teaching and learning strategies related to this subject area. Our conclusion is that this subject area gives the students the opportunity to gain knowledge that is relevant, to develop an understanding of concepts which allows them to make connections throughout their learning.

Background and aimsPatients with persistent deficiencies in the complement pathway have an increased risk for meningococcal infection and can experience recurrent disease. In this group we can include genetic deficiencies, functional or anatomic asplenia and complement blocking therapies.MethodsTwo patients with atypical hemolytic uremic syndrome confirmed by genetic testing, one with Complement Factor H mutation, Homozygous Risk Haplotype and Hheterozygous Risk Haplotype in MCP, the other one with Anti-CFH Antibodies and Complement Factor H Related Protein 1 and 3 Homozygous Deletions, under long time complement blocking therapy with Eculizumab were vaccinated for Neisseria Meningitidis. We used the two commercially available vaccines in Europe for serotypes A, C, W135, Y and for serotype B.ResultsVaccine reaction was tested after one year by measuring the IgG antibody for Neisseria Meningitidis serotype A, C, W135, Y and B.In both patients we obtained good vaccine reaction for each Neisseria Meningitidis serotypes with IgG level over the upper laboratory limits.ConclusionsIn patients with terminal complement complex deficiency, congenital or acquired, Neisseria Meningitidis vaccination is mandatory.In Europe, Neisseria Meningitidis serotype B is involved in more than 75% of infections, so vaccination for this strain is important.Because Complement System is involved in the defense against these bacteria, even if we obtain a good vaccine reaction, we can not be sure if this assures adequate disease protection.Long time antibiotic prophylaxis and close monitoring of these patients may be required.

Background and aimsSystemic Lupus Eryhthematosus (SLE) is a chronic autoimmune inflammatory disease that follows a relapsing and remitting course. It carries a highly variable prognosis, depending on clinical and laboratory findings. Therefore, we aimed to evaluate the clinical presentation and predictors for flare at 6 months of SLE patients admitted in our refferal centre.MethodsWe performed a unicentric longitudinal retrospective study on a group of 20 patients diagnosed with SLE between 1stFebruary 2011-1stFebruary 2017. The including criteria were diagnosis of SLE, clinical and laboratory data available over a period of at least 6 months of follow-up. TheSystemic Lupus Eryhthematosus Disease Activity Index 2000 (SLEDAI 2K) score, an increase or decrease of more than 3 points, was used to assess the presence of flare or the remission, respectively.ResultsMedian age at diagnosis was 14.54 yo [13.02;15.81], 20% were boys. Median follow-up was 24 months [13.5; 24.75]. Out of 56 admissions studied we encountered 17 flares. Neurological involvement was present in 16 cases. In logistical multivariable regression analysis the determinant for flare over a 6 months period were neurological symptoms, explaining up to 28% of flare variability.ConclusionsIn our study only the presence of neurological involvement, but not immunologic, laboratory findings or other clinical manifestation, was associated with the presence of flare in the next 6 months. However, the relatively short period of observation and the small number of patients studied hamper a more accurate evaluation of the prognostic markers.