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14 results on '"Ellsworth, Kenneth"'

4. Steroid 5α-Reductase: Comparative Study of Mechanism of Inhibition by Nonsteroids ONO-3805 and LY191704

Author

Harris, Georgianna S., Ellsworth, Kenneth, Witzel, Bruce E., and Tolman, Richard L.

Abstract

Two nonsteroids, ONO-3805 and LY191704, were evaluated as inhibitors of the human and rat 5α-reductases (5αR). ONO-3805 was prepared in a 12-step convergent synthesis. This compound is a potent inhibitor of the human and rat 5αRs, with more potent inhibition seen against the rat enzymes. The inhibition patterns of this compound were best fit to an uncompetitive model which suggests binding in a ternary complex with enzyme and NADP+. ApparentKivalues of 27, 31, 1, and 0.5 n$of5$M versus testosterone were obtained with human type 1, human type 2, rat type 1, and rat type 2 5αR, respectively. Multiple inhibition studies with ONO-3805 and NADP+support synergistic binding of these two inhibitors with all isozymes. LY191704 was also evaluated as an inhibitor of the human and rat 5αRs. This compound is a selective, competitive inhibitor of human type 1 5αR. Poor inhibition was observed with human type 2 and rat types 1 and 2 5αR.

Published
1996
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5. 4-AZASTEROIDS AS 5α-REDUCTASE INHIBITORS: IDENTIFICATION OF 4,7β-DIMETHYL-4-AZA-5α-CHOLESTAN-3-ONE (MK-386) AS A SCALP ISOZYME SELECTIVE INHIBITOR

Author

Tolman, Richard L., Aster, Susan, Bakshi, Raman K., Bergman, Jeffrey P., Bull, Herb G., Chang, Benedict, Cimis, George, Dolenga, Michael P., Durette, Phillippe, Ellsworth, Kenneth, Esser, Craig, Graham, Donald W., Hagmann, William K., Harris, Georgianna, Kopka, Ihor, Lanza, Thomas, Patel, Gool, Polo, Scott, Rasmusson, Gary H., Sahoo, Soumya, Toney, Jeffrey H., Von Langen, Derek, and Witzel, Bruce

Published
1995
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6. Vancouver gets ready for space-age transit

Author

Ellsworth, Kenneth G.

Subjects
Light rail transit -- Innovations, Railroads, Elevated -- Innovations, Local transit -- Innovations, Vancouver, British Columbia -- Transportation, Metro Canada Ltd. -- Innovations
Published
1982

10. NYCTA: the story behind a good track record

Author

Ellsworth, Kenneth G.

Subjects
New York, New York. Transit Authority -- Equipment and supplies, Subways -- Design and construction, Railroads, Elevated -- Design and construction
Published
1977

11. Computer-aided dispatching on the L&N

Author

Ellsworth, Kenneth G.

Subjects
Railroads -- Technology application, Louisville & Nashville Railroad -- Technology application
Published
1978

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