Search

Subject: Reading, literature analysis Grade: 3-5 (Ages 8-10) Technology: Web; digital cameras; concept mapping, drawing, presentation, and word processing software. In her 2004 State of the State address, Michigan's Governor […]

AbstractThis paper focusses on peer education and specifically on young women peer educators working within the charity Home-Start in the north of England. This work is undertaken in a social context where educational achievement is increasingly measured by certification and occupational hierarchies have been ‘professionalised’ whilst notions of professionalism have been drained of meaning in ways which can be potentially democratising. State educational imperatives in the UK have focussed on concepts such as academic excellence and the promotion of vocational opportunities (for those from ‘hard-working families’). Within this paper, the peer educator is positioned as generally similar to the individuals and groups with which they work in that they are likely to share characteristics including age, gender, ethnicity, social class and educational attainment. The peer educators who participated in the study support each other in circumstances that lead to mutual benefits which are largely outside the educational mainstream. The paper considers motivations for involvement as a peer educator, peer educators’ perspectives on the benefits/value of this work, the impact on confidence and aspiration, as well as their experiences of engagement and encounters with professionals. The paper, which focusses on empowerment, is informed by thinking on the importance of recognition and suggests that peer education holds potential for propagating forms of pedagogy which are relatively free of the authoritative relationships typically associated with ‘teaching’.

Researchers question how to socialize children to nonviolent behavior. Evidence reveals that antisocial behavior in childhood and early adolescence leads to social deviance and criminality. Coercion theory provides insight into the possible causes of aggressive and antisocial behavior. These causes are important to the examination of antisocial and aggressive behavior in order to intervene.

A range of initiatives to promote well-being and empowerment have been introduced into English schools. These ostensibly support the citizenship curriculum that seeks to foster a more active and engaged populace. Whilst children are being encouraged to view their own well-being as a personal project (and as a badge of successful citizenship), this process is being undermined by an informal curriculum of citizenship, embedded within the culture of performativity, that is promoting a climate of misrecognition within schools. This form of “symbolic violence” (that affects working-class families disproportionately) is encroaching into the private sphere, traditionally a potential refuge providing opportunities for the development of forms of well-being that were not dependent on institutional endorsement. It is suggested that some of the counter-hegemonic values developed in the face of marginalisation might usefully inform issues of citizenship and well-being in schools in ways that would encourage genuinely empowered forms of citizenship.

Managing and performing emotions to support women service users and colleagues can leave midwives feeling emotionally drained. The necessity to 'perform' emotion, associated with reorganisations in the National Health Service (NHS) in the United Kingdom (UK), has contributed towards a prevailing understanding of clinical practice as performance based. In this paper, two types of emotional work within midwifery are explored: 'emotional labour' and 'philanthropic emotion work'. Data from two studies in the north of England are presented. In-depth interviews and focus groups were conducted with midwives and subsequently analysed using thematic analysis. The findings indicate that emotional labour and philanthropic emotional work are unacknowledged and undervalued within midwifery. In addition, this has negative repercussions for the quality of the service provided whilst also undermining the creation of an emotionally and intellectually sustaining working environment for midwives.

CYP2D6is a polymorphic gene. It has been observed to be deleted, to be duplicated and to undergo recombination events involving the CYP2D7pseudogene and surrounding sequences. The objective of this study was to discover the genomic structure of CYP2D6recombinants that interfere with clinical genotyping platforms that are available today.

Abstract: The immunosuppressive agent cyclosporin A (CsA), a calcineurin inhibitor which blocks T cell activation has provided the pharmacologic foundation for organ transplantation. CsA exerts additional effects on non-immune cell populations and may adversely effect microvascular endothelial cells, contributing to chronic rejection, a long-term clinical complication and significant cause of mortality in solid-organ transplants, including patients with small bowel allografts. Growth of new blood vessels, or angiogenesis, is a critical homeostatic mechanism in organs and tissues, and regulates vascular populations in response to physiologic requirements. We hypothesized that CsA would inhibit the angiogenic capacity of human gut microvessels. Primary cultures of human intestinal microvascular endothelial cells (HIMEC) were used to evaluate CsA’s effect on fourin vitro measures of angiogenesis, including endothelial stress fiber assembly, migration, proliferation and tube formation, in response to the endothelial growth factor VEGF. We characterized the effect of CsA on intracellular signaling mechanisms following VEGF stimulation. CsA affected all VEGF induced angiogenic events assessed in HIMEC. CsA differentially inhibited signaling pathways which mediated distinct steps of the angiogenic process. CsA blocked VEGF induced nuclear translocation of the transcription factor NFAT, activation of p44/42 MAPK, and partially inhibited JNK and p38 MAPK. CsA differentially affected signaling cascades in a dose dependent fashion and completely blocked expression of COX-2, which was integrally linked to HIMEC angiogenesis. These data suggest that CsA inhibits the ability of microvascular endothelial cells to undergo angiogenesis, impairing vascular homeostatic mechanisms and contributing to the vasculopathy associated with chronic rejection.

The calcineurin inhibitor cyclosporine A (CsA) modulates leukocyte cytokine production but may also effect nonimmune cells, including microvascular endothelial cells, which regulate the inflammatory process through leukocyte recruitment. We hypothesized that CsA would promote a proinflammatory phenotype in human intestinal microvascular endothelial cells (HIMEC), by inhibiting inducible nitric-oxide synthase (iNOS, NOS2)-derived NO, normally an important mechanism in limiting endothelial activation and leukocyte adhesion. Primary cultures of HIMEC were used to assess CsA effects on endothelial activation, leukocyte interaction, and the expression of iNOS as well as cell adhesion molecules. CsA significantly increased leukocyte binding to activated HIMEC, but paradoxically decreased endothelial expression of cell adhesion molecules (E-selectin, intercellular adhesion molecule 1, and vascular cell adhesion molecule-1). In contrast, CsA completely inhibited the expression of iNOS in tumor necrosis factor-alpha/lipopolysaccharide-activated HIMEC. CsA blocked p38 MAPK phosphorylation in activated HIMEC, a key pathway in iNOS expression, but failed to inhibit NFkappaB activation. These studies demonstrate that CsA exerts a proinflammatory effect on HIMEC by blocking iNOS expression. CsA exerts a proinflammatory effect on the microvascular endothelium, and this drug-induced endothelial dysfunction may help explain its lack of efficacy in the long-term treatment of chronically active inflammatory bowel disease.

This article explains the benefits from using educational technologies in teaching reading and literature analysis. In retrospect, it was realized that trying to incorporate technology without letting go of some traditional activities was too time consuming. However, the extra time was worthwhile, as engagement of students curtailed off-task behaviors. Personal connections to the characters and students' ability top verbalize many themes within the story were two indicators of strengthened comprehension. The unique approaches offered by technology gave students more opportunities to develop and demonstrate their ability to incorporate the writer's craft into their own writing. teachers felt that assessment of students' original work was more telling and enjoyable than paper-and-pencil essays. Teachers had a better understanding of students' personalities through voice development in their writing. Incorporating technology into the reading and writing curriculum gave students learning opportunities that were student centered, multisensory, collaborative, and active. The approach fostered a level of understanding that went beyond the traditional classroom practices of teacher-centered instruction that promotes passive learning. With careful planning, technology integration helps motivate students and is a stimulating way to teach reading and writing.

The article discusses the Mackinac Island's Lilac Festival to be held in Michigan on June 3-12, 2016, which will feature such events as horse-drawn carriage parade and a pup parade.

The article offers travel tips for Leelanau Peninsula, Michigan and includes recommendations for places to visit, dining, and activities to do.

The Editors welcome contributions to Picture of the Month and Radiological Case of the Month. Those who wish to contribute should send their manuscripts to Dr Feingold (Picture of the Month), National Birth Defects Center, Kennedy Memorial Hospital, 30 Warren St, Brighton, MA 02135, or Dr Wood (Radiological Case of the Month), Department of Radiology, Childrens Hospital of Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027. Articles and photographs accepted for publication will bearthe contributor's name. There is no charge for reproduction and printing of color illustrations. DENOUEMENT AND DISCUSSION ACROPUSTULOSIS OF INFANCY MANIFESTATIONS Acropustulosis of infancy is an uncommon but distinctive dermatosis often mistaken for pustular impetigo. The unusual cutaneous distribution is the principle distinguishing characteristic. Sterile, pruritic pustules appear mainly on the palms and soles and less frequently on the dorsum of the hands, feet, wrists, and ankles. Lesions evolve from pinpoint-sized erythematous papules that enlarge to

Offers expert advice on children's health questions. The possibility of getting a disease from sitting on a toilet seat; Why a child bruises easily; Whether children should eat snow; If it is okay to lick postage stamps; Fibroids during pregnancy; The condition of being `tongue-tied. INSET: Ho-ho for boo-boos (Curad Kid Size Santa Strips)..