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ABSTRACTBackground: An MZ phenotype alpha-1 antitrypsin AAT deficiency and fibromyalgia syndrome FMS patient participated in a trial with AAT-intravenous augmentation-therapy AAT-IV-AT after failure of conventional therapeutic measures. Three quadricep biopsies were performed at different stages. The first one showed large aggregates of AAT and ubiquitin in myocytes and blood vessels, and moderate muscle atrophy, before AAT-IV-AT. The two remaining biopsies were performed while receiving AAT-IV-AT.Findings: Remarkably good clinical response and histological improvement in the follow-up biopsies.Conclusions: The clinical and histopathological efficacy of AAT-IV-AT evidenced in this patient should open new perspectives of research and management of AAT deficiency and FMS patients.

The metropolis made full and very exacting regulations for everything that referred to the obtaining and control of precious metals and stones. Even in the first days of Spanish colonial expansion in America, the regulations contained in capitulations and instructions were innumerable. Later on, laws, royal cedulas, ordinances, and other juridical norms ordained in a detailed manner the requisites to which all had to submit who proposed to exploit the deposits of precious metals or the pearl fisheries. They regulated the manner in which they were to be established, the work of the Indians in them, and, above all, the control of production and the participation of the crown in the benefit obtained.