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Parkinson’s disease (PD) is a common neurodegenerative disorder with no cure. Astragalus membranaceusis used in Chinese culture as a food supplement to boost immunity. The present study aimed to explore the neuroprotective effects of total flavonoids extracted from A. membranaceus(TFA) and their protective mechanisms. TFA offered neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse model of Parkinsonism, by improving behavior performance in the gait analysis and pole test, and inhibiting the decline of tyrosine hydroxylase (TH) positive neurons and TH protein expression in substantia nigra of mice. TFA also prevented 1-methyl-4-phenylpyridinium (MPP+) induced neurotoxicity in SH-SY5Y cells, by increasing GSH and GSH/GSSG ratio, and reducing reactive oxygen species. In addition, the neuroprotective effects of TFA were associated with its ability to restore MPTP/MPP+induced downregulation of SLC7A11 and glutathione peroxidase 4 (GPX-4). In conclusion, we demonstrated that TFA exerted significant neuroprotection against MPTP/MPP+induced neurodegeneration by inhibiting ferroptosis through the regulation of SLC7A11/GPX-4 axis, suggesting the use of TFA as a possible food supplement in the prevention of PD.

ABSTRACTUnderstanding long-term trends in streamflow is important for water resource management. In this study, we investigate the long-term streamflow trends at 47 gauging sites within the southern Murray-Darling Basin (MDB), Australia. This study aims to estimate regional streamflow trends while understanding the impact of catchment characteristics on the spatial variation in these trends. To achieve this, we applied a Bayesian hierarchical model (BHM) to make the best use of available streamflow records from multiple sites and catchment characteristics such as climate, terrain, geology, land use and vegetation. The results show that streamflow trends from tested sites are consistently negative, with magnitudes of up to 2.7% per year relative to the annual average flow. We also find that spatial variability in trends can be best linked to differences in average climatic and terrain conditions. This finding can be used to inform future water planning for consumptive and environmental uses in the MDB.