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1. Vanucizumab mode of action: Serial biomarkers in plasma, tumor, and skin-wound-healing biopsies

Author

Heil, Florian, Babitzki, Galina, Julien-Laferriere, Alice, Ooi, Chia-Huey, Hidalgo, Manuel, Massard, Christophe, Martinez-Garcia, Maria, Le Tourneau, Christophe, Kockx, Mark, Gerber, Peter, Rossomanno, Simona, Krieter, Oliver, Lahr, Angelika, Wild, Norbert, Harring, Suzana Vega, and Lechner, Katharina

Abstract

•Angiogenesis is critical to the development and survival of solid tumors.•Vanucizumab inhibits both vascular endothelial growth factor and angiopoietin-2.•Vanucizumab exhibits anti-tumor, anti-angiogenic and anti-metastatic effects.•It markedly reduced blood-vessel markers in tumor/skin samples in cancer patients.•Skin biopsies are a valuable surrogate for studying angiogenesis-related mechanisms.

Published
2021
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