Search

2024 MAR 4 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Investigators discuss new findings in cloning. According to news reporting out of Tehran, Iran, [...]

A researcher named Jean Hébert has proposed a radical plan to replace all body parts, including the brain, as a means of avoiding death from old age. Hébert's work focuses on adding youthful tissue to the brain in a slow, progressive manner to potentially extend life indefinitely. While his ideas are not widely accepted, the US government has endorsed his work with a $110 million project to explore brain replacement in animals. Hébert's research is controversial but has gained attention from those interested in radical life extension. [Extracted from the article]

Phone scammers are using AI technology to clone people's voices and scam unsuspecting individuals. This technology has been available since 2018, but recent advancements have made it faster and more accurate. Scammers can obtain voice samples from social media or phone calls and then use voice cloning to impersonate someone, such as a grandchild, and request money for emergencies. To protect yourself, it is recommended to establish a code word with your family and have them confirm it during emergency calls to verify their identity. As AI-powered voice cloning becomes more widespread, this type of scam is expected to increase in popularity. [Extracted from the article]

The lawyers had also insisted we get all clients to sign an indemnity absolving us of any responsibility for harm should it occur, and a few clients had to be reminded of this as a last resort. We had to install some seriously large computing hardware in our new facility to be able to handle all the incoming dream data and then hire loads more technicians to keep it all running, but it's what the customers - and therefore the shareholders - wanted, so no one balked at it. A year after that, we made the next important breakthrough - improving the technology so that it could be housed in a portable unit and used by our clients at home. What if client Y had suffered an intense trauma, and their unconscious mind played it over and over again in an attempt to make sense of it?. [Extracted from the article]

This article from New Scientist recommends two science fiction novels: "The Power" by Naomi Alderman and "Never Let Me Go" by Kazuo Ishiguro. "The Power" explores a world where young women develop the ability to generate electricity, leading to a shift in global power dynamics and raising questions about the nature of power. "Never Let Me Go" is set in an alternate reality where human cloning is common, and follows the lives of children who are destined to become organ donors. Both novels offer thought-provoking perspectives on societal issues and the consequences of scientific advancements. [Extracted from the article]

A healthy rhesus monkey has been successfully cloned from fetal cells, but cloning an adult human would be much more difficult. The cloned monkey was born in China in July 2020 and has reached the age of 3 without any health issues. However, cloning primates remains challenging, and creating a clone of an adult human may not be technically possible, in addition to ethical and legal concerns. Cloning animals has had mixed results, with some species being more successful than others. The main obstacle is the addition of epigenetic markers to DNA as cells develop, which can cause problems when cloning adult cells. While this advancement in primate cloning is significant, the researchers do not intend to pursue human cloning due to ethical reasons. The purpose of cloning primates is to advance research in fields such as cognitive and biomedicine. [Extracted from the article]

But Klara also becomes complicit in Chrissie's cruelty toward Josie - a dynamic that first becomes apparent during a day trip to a waterfall. Klara and the Sun - British novelist Kazuo Ishiguro's latest novel, and his first since winning the Nobel Prize in 2017 - is narrated by a robot named Klara, created to serve as an AF, or Artificial Friend, to lonely children. Like Chrissie, who has Klara act as Josie when her daughter is sick, Rick will find someone else who can play the role of Josie in his life. Through Klara, Josie, and Chrissie, Ishiguro shows how care is often intertwined with exploitation, how love is often grounded in selfishness. [Extracted from the article]

The article discusses the manipulation of alternative splicing of the IKZF1 gene and its impact on gene regulation in T cells. By generating human T-cell clones with mutations in specific exons of IKZF1, researchers found differences in gene expression, chromatin accessibility, and protein abundance. The study suggests that even minor changes in IKZF1 splicing can lead to significant effects on gene expression and function in mature T cells, potentially contributing to autoimmune disorders in susceptible individuals. This preprint has not yet undergone peer review. [Extracted from the article]

Researchers from the National Research Council of Canada have found that histamine can stimulate human microglia cells to alter the expression of cellular prion protein (PrPC) via the HRH2 histamine receptor. The study showed that histamine exposure increased intracellular calcium levels, cytokine release, and modified PrPC localization in microglia cells. The findings suggest that PrPC may play a role in modulating microglial responses. This research was funded by the Canadian Institutes of Health Research and the National Research Council Canada. [Extracted from the article]

Researchers at Universite Libre de Bruxelles have conducted a study on Apolipoprotein-L1 (APOL1), a protein that plays a role in human resistance to African trypanosomes. The study found that mutations in APOL1 can lead to kidney podocyte dysfunctions affecting renal filtration. The research suggests that these dysfunctions are not caused by pore formation, but rather by increased interaction with cholesterol, enhancing cation channels activity. This study highlights the complex relationship between host and parasite adaptation. [Extracted from the article]

The patent issued for immunogenic sequences from a phage tail length tape measure protein, bacteria expressing the same, and their use in treating cancer highlights the complex interplay between gene regulation, the environment, and the immune system in cancer progression. The research focuses on the role of commensal bacteria in influencing tumorigenesis and the efficacy of cancer treatments, particularly in reshaping the tumor microenvironment. By identifying specific bacterial strains and their immunogenic properties, the study aims to develop new molecules or microorganisms for cancer treatment. The patent outlines methods for treating cancer by administering bacterial compositions with specific genetic sequences in combination with antineoplastic agents, emphasizing the potential of harnessing the microbiota ecosystem to enhance cancer therapy. [Extracted from the article]

A recent study conducted by researchers from the University of Padua in Italy explores the legality of human cloning in international law. The study examines the positions taken by member states in the United Nations General Assembly and the European legal framework on human cloning. The research concludes that reproductive cloning is prohibited globally and in Europe, while therapeutic cloning remains within the bounds of the law. This study has undergone peer review and is available for further exploration in the European Journal of International Law. [Extracted from the article]

This article discusses the importance of identifying suitable biomarkers for gene expression analysis of microglia polarization, which plays critical roles in the brain. The study focuses on validating and testing biomarkers in human microglia clone 3 (HMC3) cells, specifically looking at homeostatic, proinflammatory, and anti-inflammatory markers. The research provides a comprehensive list of biomarkers and methodology for gene selection and analysis in HMC3 cells. It aims to improve the accuracy and target selection in studying brain macrophages. Please note that this preprint has not been peer-reviewed. [Extracted from the article]

The article focuses on the science of cloning, exploring its applications and controversies, including its role in creating identical organisms and its potential for medical and conservation purposes. Topics discussed include the various types of cloning, ethical concerns surrounding human cloning, and the technological challenges of cloning extinct animals like mammoths.

A recent study conducted at the University of Southern California focused on the development and characterization of a library of human T cell receptor (TCR) alpha and beta clones. The researchers aimed to establish biological standards and resources for TCR sequencing and engineering, as well as to address the challenge of standardization in TCR repertoire analysis. The study utilized next-generation sequencing technologies and various alignment and assembly tools to validate the sensitivity, specificity, and accuracy of the TCR sequences. The findings of this research contribute to the advancement of TCR-based immunotherapies and will be further expanded to include a more diverse biological control. [Extracted from the article]

A new study on phototherapy conducted at the Roswell Park Comprehensive Cancer Center in Buffalo, New York, has found that photodynamic therapy (PDT) can reduce the burden of small ultraviolet-induced epidermal clones in human and mouse skin. Actinic keratoses (AKs) and keratinocyte carcinomas (KCs) are known to arise from prolonged UV exposure, with precursor UV-induced clonal mutations (CMs) appearing in sun-damaged skin. The study used targeted ultra-deep sequencing on epidermal samples and compared skin before and after PDT in five patients and a mouse model of chronic UV carcinogenesis. The research suggests that PDT has the potential to modify subclinical damage and proposes low-variant allele frequency CMs as biomarkers for field treatment efficacy. [Extracted from the article]

A recent study conducted at the University of the Punjab in Lahore, Pakistan, focused on the cloning and expression of human Interleukin 2 (IL-2) in E. coli and its antitumor activity. IL-2 is a cytokine that has been approved by the FDA for cancer immunotherapy, particularly for kidney and skin cancer. The study successfully achieved maximum expression of IL-2 in LB media with 0.5 mM IPTG for 6 hours post induction time. The purified IL-2 showed cytotoxic potential and inhibited the growth of HepG2 and MCF-7 cell lines. The researchers concluded that refolded IL-2 could be used as an immunotherapeutic agent for the treatment of hepatocellular carcinoma. [Extracted from the article]

A recent report from Washington University School of Medicine focuses on clonal hematopoiesis (CH), which is the expansion of mutated cells in the hematopoietic compartment of individuals without hematopoietic dysfunction. The study developed a method for spatially aware somatic mutation profiling and characterized the bone marrow of a patient with polycythemia vera. The researchers identified complex clonal distribution of somatic mutations in the hematopoietic compartment, restriction of somatic mutations to specific subpopulations of hematopoietic cells, and spatial constraints of these clones in the bone marrow. This research provides insights into the spatial organization and factors driving CH expansion and malignant transformation in the bone marrow. [Extracted from the article]

A study conducted by researchers from Xiamen University discusses the construction and characterization of an infectious clone of human rhinovirus A89. Rhinoviruses are a major cause of the common cold and can lead to severe respiratory tract diseases. The researchers successfully established an infectious clone of RV-A89 using reverse genetic technology, which will provide a framework for further studies on rhinoviruses. This research has important implications for the development of vaccines and therapeutic drugs for rhinovirus infections. [Extracted from the article]

A research article from the University of Northampton explores the impact of reproductive technology on female bodily autonomy and reproductive choice in Eva Hoffman's novel The Secret. The article suggests that while reproductive choice is important, it is not completely free from external influences and potential repercussions. The research also discusses the protagonist's cyborg identity as a manifestation of possibilities. The article provides further information on this topic and can be accessed for free. [Extracted from the article]

A recent report from Osaka University in Japan discusses the cloning of human interferon genes and their impact on cytokine gene research. In the late 1970s, interferon samples were discovered to have anti-tumor activity, leading to their use as a treatment for cancer patients. Various groups, including those in Tokyo, Zurich, and San Francisco, attempted to identify human interferon genes, and the cloning of these genes allowed for the production of recombinant interferon proteins on a large scale. The research also explored the biological functions of interferons and the molecular mechanisms behind virus-induced interferon gene expression. This study provides background information on interferon gene cloning and its significance in cytokine gene research. [Extracted from the article]

A recent study conducted by researchers at Columbia University explores the plasticity of intragraft alloreactive T cell clones in the human gut and its correlation with transplant outcomes. The study investigates the transition between tissue-resident memory (TRM) and circulating phenotypes of T cells, shedding light on TRM biology. The researchers integrated clonotype, alloreactivity, and gene expression profiles of graft-repopulating recipient T cells in the intestinal mucosa at the single-cell level after human intestinal transplantation. The findings provide valuable insights into the behavior of T cells in transplant rejection and tolerance. [Extracted from the article]

A study conducted by TheraSource LLC explores the potential of human cell-expressed tag-free rhMFG-E8 as a radiation mitigator. The researchers found that the tag-free rhMFG-E8 protein, produced by cloning the human MFG-E8 coding sequence into a mammalian vector and expressed in HEK293-derived cells, demonstrated superior biological activity compared to E. coli-expressed histidine-tagged rhMFG-E8. The tag-free rhMFG-E8 was also found to be safe, stable, and effective in treating radiation injury in a rodent model. The study suggests that tag-free rhMFG-E8 could be further developed as a therapy for severe acute radiation injury. [Extracted from the article]

The article reports on the downfall of Woo Suk Hwang, the South Korean scientist who earned world renown with the first therapeutic cloning of a human embryo, an achievement that now proves to be entirely fraudulent. The photographs of cloned cells proved to actually depict the same cell. Hwang claims that the photographs of the cells were switched without his knowledge. These findings have raised questions about Hwang's other achievements, including the first cloned dog, Snuppy.

Discusses the legal and ethical issues surrounding stem cell research in different parts of the world. Existence of a disparate and confusing patchwork of legislation around the world concerning stem cells, and lack of consensus on legal and ethical issues on stem cells in Europe and the United Nations; Debates over embryonic stem cell research, reproductive cloning and therapeutic cloning; Examples of the disparity seen between the U.S. and Great Britain, where scientists are allowed to use human embryos for stem cell research and therapeutic cloning.

This article presents information on the book "Genome War," by Jamie Shreeve. On the surface, it looked like a dry and somewhat technical report on stem cells. The guidelines for research on embryonic stem cells issued by the U.S. National Academy of Sciences in April took meticulous care to address a kind of experimentation that sounds more like science fiction than science. Already, researchers have created monkeys with brains that are partially human, mice with functioning human photoreceptor cells in their retinas and sheep with organs that are up to 40 per cent human.

Focuses on cloning, the outlook for human cloning, and "therapeutic cloning". The view of Shin Yong Moon of Seoul National University about reproductive cloning; Timeline on cloning from the July 1996 birth of the sheep, Dolly, to February 2004 when a South Korean group reveals they have cloned human embryos; Concern about regulating the procedure; The limited ban on human cloning in South Korea; Details of the research led by Woo Suk Hwang in South Korea, which extracted stem cells from a cloned embryo; Discussion of why the Korean team was successful; Benefits of cloning research; The role of Jose Cibelli, a cloning expert at Michigan State University, in the Korean study; The ban on this kind of embryo research in the United States; Concern that Hwang's embryos will be put in a woman's womb; Comments from various researchers.

The article focuses on a decline in abortion rates in the United States. The Alan Guttmacher Institute has announced that one in three women was having an abortion, totaling to 1.3 million abortions per year—the lowest rate in 29 years. There has been an increase in pro-life policy proposals as well, with bills such as the Child Custody Protection Act and those calling for a ban on partial-birth abortions and human embryonic cloning on their way to being passed in the U.S. Senate. In response to these actions, Republicans are taking steps to regain reproductive freedom.

Discusses the announcement by Raelian Bishop Brigitte Boisselier, the director of the Raelian-backed company Clonaid, that researchers had implanted a cloned embryo in an anonymous woman who gave birth to a baby girl. Skepticism in the scientific and theological community because there is no confirmation that cloning occurred; History of the Raelian sect, a UFO religion, and its compound in Quebec province; Religious reasons that sect leader Claude Vorilhon, who is also known as Raël, wants to perfect human cloning; Raelian mission of tearing down the myth of God which is seen as an obstacle to world peace.

Focuses on human cloning in light of the Raelian claim of success, according to chemist Brigitte Boisselier, president of the biotech company, Clonaid, and member of the order of Angels of the Raelian religious cult. Discussion of the moral issues and genetic risks associated with human cloning; Views of Arthur Caplan, director of the Center for Bioethics at the University of Pennsylvania, and others about the Raelian claim; Pros and cons for banning cloning; Other researchers attempting to clone humans; Reasons to challenge Boisselier's claims. INSET: HOW HARD IS IT TO CLONE A HUMAN?.

Reports on the birth of the first human clone Eve under the supervision of a U.S.-based company named Clonaid, set up by Raelians. Difficulty involved in cloning; Doubt regarding the safety involved in human cloning; Verification method of knowing whether a baby is a clone or not.

Discusses the cloning of a human embryo by Advanced Cell Technology through a process known as parthenogenesis. Ethical implications of the procedure; Effort to determine whether human eggs could be induced to divide into early embryos without being fertilized by sperm or being enucleated and injected with a donor cell; Outlook for offering therapeutic cloning or cell therapy to sick patients. INSETS: Therapeutic Cloning: How It's Done;Cloning and the Law.

Discusses the first successful cloning of a human embryo by Advanced Cell Technology (ACT) in Worcester, Massachusetts. Research efforts and biographical information of Robert Lanza, Michael West, and Jose Cibelli of ACT; Description of the cloning procedure; Controversies and ethical debate involving cloning; United States legislative decisions regarding cloning; Impact of cloned stem cells on curing diseases; Prospects for acceptance of therapeutic cloning. INSET: The art of cloning.

Discusses the decision of the United States Congress to pass a bill banning human cloning in summer 2001. Outlook for the legislation concerning the cloning of other materials which may provide cures for diseases; Outlook for a decision by President George W. Bush concerning stem cell research; Scientific and political aspects of the cloning debate; Discussion of the industrial use of human embryos. INSET: MORAL COMPASS.

Focuses on different aspects involved in the stem-cell research in the U.S. Research by two biologists John Gearhart of Johns Hopkins University, and James Thomson of the University of Wisconsin; Importance of stem cells in biology; Prior research; Benefits of research if stem cells can be converted into regular cells; Controversial use of fetuses and unwanted embryos for research; Legal aspects involved in the research; Expectations from the research; Ethical issues related with the research; Issue of allocating public fund for stem cells research; Question whether life begins at the moment sperm meets egg as believed by Catholics and Islamic scholars; Possibility of finding stem cells in adults; Research on human cloning.

Argues against the proposed practice of human cloning. Action taken by U.S. President Bill Clinton against human cloning in 1997; Background of the emergence of the issue of human cloning; Advantages and disadvantages of the scientific and technological breakthrough; Arguments raised by supporters of human cloning on the importance of the method to reproduction.

A new study conducted by researchers at the University of Massachusetts Amherst explores the resistance of Borrelia burgdorferi clones to human serum-mediated killing and its correlation with invasiveness. The study found that clones associated with human invasiveness did not show higher survival in human serum compared to noninvasive clones, indicating that differential complement-mediated killing of B. burgdorferi lineages is not a determinant of invasiveness in humans. The research suggests that mechanisms other than complement-mediated killing likely explain why only certain lineages cause the majority of disseminated human infections. [Extracted from the article]

2020 OCT 19 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Investigators discuss new findings in apoptosis. According to news originating from the Mayo Clinic [...]

2020 MAR 2 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- New research on stem cell research is the subject of a new report. According [...]

In this article the author talks about Gene reading, Gene synthesis, and Gene editing, and the technicians working with these tools might be driven by their determination to solve problems, by visions of societal good, or simply by their desire for riches beyond imagination. It mentions that Madonna, a research and innovation project funded by the European Commission, sees biotechnology as the key to a sustainable human future.

The article discusses the outlook for stem cell research, since South Korean researcher Hwang Woo Suk admitted that his team at Seoul National University did not extract stem cells from a cloned human embryo. His research was discredited in December, but previously published papers had suggested that the breakthrough could be applied to research on spinal-cord injuries and genetics. After Hwang's announcement, companies such as Advanced Cell Technology in Massachusetts lost funding for their biotech research. Hwang's approach to stem-cell research and the team's method of getting stem cells are mentioned, as well as ethical guidelines for embryonic stem cell research. Researchers Alison Murdoch and Robert Lanza say that the main obstacle to research is getting a supply of eggs. The article mentions how adult stem cells and umbilical cord blood are used in therapeutics.

The inspiration for the world's first human cloning company, Clonaid, came to former French journalist Claude Vorilhon in a flash. It was 1997, just after the birth of Dolly the cloned sheep, and Vorilhon was riding in his car, idly listening to the radio. Suddenly, he felt a stab of annoyance: A newscaster reported that Pope John Paul II had denounced any effort to clone humans. Vorilhon, known as the prophet Rael to followers of his UFO-based religion, loves science and considers the Roman Catholic Church his "worst enemy." He instantly thought of a way to annoy the pope and score a public-relations coup. According to Rael and Clonaid's head, chemist Brigitte Boisselier, many people called in search of real cloning services. Many of Rael's female followers would offer up both their eggs for the cloning process and their wombs for surrogate motherhood--Boisselier's own daughter has publicly volunteered. With that baby news on the way and the Raelian controversy continuing to rage, cloning will no doubt continue to make headlines--and perhaps legislation. At the moment, only a few states have laws against human cloning. A federal ban on all human cloning stalled in Congress last year because of concerns that it would restrict research, and a similar debate has stymied a push in the United Nations for a world ban. Many scientists, in fact, draw a sharp line between cloning to create babies and cloning to make early human embryos, which could yield new ways to study diseases like Alzheimer's or perfectly matched replacement tissues for transplants.

Criticizes the four-year moratorium proposed by the Council on Bioethics of the administration of U.S. President George W. Bush in 2002. Implication of the decision for scientists and patients with incurable diseases; Information on the process of reproductive and therapeutic cloning; Discussion of the foundation on which all other principles of justice are built; Ways pointed out by the council's minority in which accepted medical practice and federal law clash with the proposed sanctity of the undifferentiated zygote.

Keywords: Camden; State:New Jersey; United States; North and Central America; Cancer; Cancer Prevention; Carcinomas; Health and Medicine; Oncology; Risk and Prevention; Squamous Cell Carcinoma; Therapy EN Camden State:New Jersey United States North and Central America Cancer Cancer Prevention Carcinomas Health and Medicine Oncology Risk and Prevention Squamous Cell Carcinoma Therapy 951 951 1 08/28/23 20230901 NES 230901 2023 AUG 29 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on Oncology - Squamous Cell Carcinoma have been published. Our news editors obtained a quote from the research from Cooper University Hospital, "However, only a small proportion of such mutant clones will develop ESCC, and most ESCC patients develop only one cancer. In this review, we will explore the role of cell competition in carcinogenesis, cancer prevention, and therapy, using NRF2, NOTCH pathway, and TP53 as examples. [Extracted from the article]